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Diminished performance on neuropsychological testing in late life depression is correlated with microstructural white matter abnormalities

Joseph M. Mettenburg, Tammie L. Benzinger, Joshua S. Shimony, Abraham Z. Snyder, Yvette I. Sheline
2012 NeuroImage  
The correlations with neuropsychological testing indicate the essential effects of white matter injury on functional status.  ...  Background-Traditional T2 weighted MR imaging results are non-specific for the extent of underlying white matter structural abnormalities present in late life depression (LLD).  ...  in the cingulate bundle is independent of and compounded by late life depression. • Neuropsychological testing correlates with regional white matter abnormalities. • White matter abnormalities are more  ... 
doi:10.1016/j.neuroimage.2012.02.044 pmid:22487548 pmcid:PMC3337766 fatcat:2m2j272snbhybbbtsgv2yahfqu

Cognitive Deficits in Geriatric Depression

Sarah Shizuko Morimoto, George S. Alexopoulos
2013 Psychiatric Clinics of North America  
Last, we present evidence regarding whether the cognitive deficits in depression may be mitigated with medication or with computerized cognitive remediation.  ...  Synopsis The purpose of this article is to identify the cognitive deficits commonly associated with geriatric depression, and describe their clinical significance.  ...  Older patients with major depression having at least one short allele of the serotonin transporter 5-HTTLPR polymorphism had both microstructural white matter abnormalities in frontolimbic networks and  ... 
doi:10.1016/j.psc.2013.08.002 pmid:24229654 pmcid:PMC3830452 fatcat:crrhkyr72jbgzptxmr3gjkuygm

Neuropsychiatric applications of DTI - a review

K. O. Lim, J. A. Helpern
2002 NMR in Biomedicine  
Clinical research studies in alcoholism, HIV-1 infection, geriatric depression and schizophrenia using DTI have revealed abnormalities in white matter microstructure.  ...  White matter forms the basis of anatomical connectivity. Diffusion tensor imaging (DTI) is a useful tool for examining and quantifying white matter microstructure.  ...  be related to poorer performance on neurocognitive tests requiring attention and working memory.  ... 
doi:10.1002/nbm.789 pmid:12489105 fatcat:iotomnaixjf2fecywt7l7h7oe4

Correlations between Stroop task performance and white matter lesion measures in late-onset major depression

Rikke B. Dalby, Jesper Frandsen, M. Mallar Chakravarty, Jamila Ahdidan, Leif Sørensen, Raben Rosenberg, Leif Østergaard, Poul Videbech
2012 Psychiatry Research : Neuroimaging  
In this study we used diffusion tensor imaging-based (DTI-based) tractography to assess white matter fiber tracts affected by deep WMLs (DWMLs) in patients with late-onset major depression and age-and  ...  Cerebral white matter lesions (WMLs) are believed to play an important role in a subset of patients with lateonset depression by affecting the white matter connectivity in circuitries essential for mood  ...  The study was supported by the Danish Medical Research Council and the Research Fund for the Support of Psychiatric Research in the Central Denmark Region.  ... 
doi:10.1016/j.pscychresns.2011.12.009 pmid:22703621 fatcat:ahx72b65vjcq7i5tioioxcdkya

A multiplicity of approaches to characterize geriatric depression and its outcomes

David C Steffens
2009 Current Opinion in Psychiatry  
Those interested in cognitive neuroscience and basic neuroscience have more recently trained their sights on late-life depression.  ...  Summary Clinicians should become more aware of advances in detection of depression, the effect of psychiatric comorbidities, the poor mood and cognitive outcomes associated with late-life depression and  ...  [22] used magnetization transfer ratio (MTR) imaging, a technique that is thought primarily to reflect myelin integrity, to detect white matter abnormalities in frontostriatal and limbic regions in  ... 
doi:10.1097/yco.0b013e32832fcd93 pmid:19625967 pmcid:PMC2833219 fatcat:lx7iseevybbuhah2wtnnwpsufa

Mechanisms and treatment of late-life depression

George S. Alexopoulos
2019 Translational Psychiatry  
Targeting risk factors of vascular disease in mid-life is a logical approach in prevention of vascular depression.  ...  TMS targeting deep structures responsible for mood regulation is well tolerated by older adults and its efficacy in syndromes of late-life depression needs to be studied.  ...  Neuroimaging• White matter hyperintensities and microstructural abnormalities in white matter tracts connecting the prefrontal cortex with subcortical and posterior cortical regions • Hypoactivation of  ... 
doi:10.1038/s41398-019-0514-6 pmid:31383842 pmcid:PMC6683149 fatcat:c7bc6oy6lneu3pm55orv3tvsnq

Research advances in geriatric depression

2009 World Psychiatry  
Prefrontal white matter microstructural abnormalities have correlated with poorer performance on tasks of executive function, and have been hypothesized to reflect a disconnection state that can increase  ...  In one of our own recent late-life depression studies, we found that, compared with L-homozygotes, S-carriers had microstructural white matter abnormalities (lower fractional anisotropy, to be explained  ... 
doi:10.1002/j.2051-5545.2009.tb00234.x pmid:19812743 pmcid:PMC2755271 fatcat:5cjdfizv7fdt3lna6gv6ygncfy

Depression severity is correlated to the integrity of white matter fiber tracts in late-onset major depression

Rikke Beese Dalby, Jesper Frandsen, M. Mallar Chakravarty, Jamila Ahdidan, Leif Sørensen, Raben Rosenberg, Poul Videbech, Leif Østergaard
2010 Psychiatry Research : Neuroimaging  
WMLs have a pronounced effect on white matter integrity in the pathways they intersect.  ...  Cerebral white matter lesions (WMLs) are believed to play an important role in a subset of major depression (MD).  ...  Although previous studies of late-life MD have reported microstructural abnormalities in NAWM in depressed patients compared with healthy controls (Kumar et al., 2004) , even after excluding visible WMLs  ... 
doi:10.1016/j.pscychresns.2010.06.008 pmid:20832255 fatcat:jlprpa22vzbe7ebwsurxctsc3u

Brain volume abnormalities and neurocognitive deficits in diabetes mellitus: Points of pathophysiological commonality with mood disorders?

Roger S. McIntyre, Heather A. Kenna, Ha T. Nguyen, Candy W. Y. Law, Farah Sultan, Hanna O. Woldeyohannes, Mohammad T. Alsuwaidan, Joanna K. Soczynska, Amanda K. Adams, Jenny S. H. Cheng, Maria Lourenco, Sidney H. Kennedy (+1 others)
2010 Advances in Therapy  
Methods: A PubMed search of all English-language articles published between 1966 and March 2009 was performed with the following search terms: depression, mood disorders, hippocampus, amygdala, central  ...  It is hypothesized that diabetes mellitus (DM) and mood disorders share points of pathophysiological commonality in the central nervous system.  ...  Kodl et al. aimed to determine if fractional anisotropy correlated with neurocognitive test performance in patients with Type 1 DM (n=25) when compared with controls. 25 They reported that white  ... 
doi:10.1007/s12325-010-0011-z pmid:20390390 fatcat:y57nbrwz7fbivfhci2lwknv7gu

Mood disorders in the elderly: prevalence, functional impact, and management challenges

Orestes Vicente Forlenza, Leandro Valiengo, Florindo Stella
2016 Neuropsychiatric Disease and Treatment  
findings and treatment specificities in late-life depression and BD.  ...  Despite the lower prevalence of severe mood disorders in the elderly as compared to younger adults, late-life depression and bipolar disorder (BD) are more strongly associated with negative outcomes related  ...  Disclosure The authors report no conflicts of interest in this work.  ... 
doi:10.2147/ndt.s94643 pmid:27601905 pmcid:PMC5003566 fatcat:5okapoyfdndltbfpsnhpikzchu

Myelin copper and the cuprizone model of schizophrenia

Christine Konradi
2011 Frontiers in bioscience (Scholar edition)  
In recent years increasing evidence is pointing toward white matter abnormalities in schizophrenia and other psychiatric disorders.  ...  Cuprizone, a copper chelator, causes white matter abnormalities in rodents.  ...  Many of the cognitive deficits are mapped to the PFC with schizophrenic patients performing poorly on the Wisconsin Card Sorting Test (WCST), a test dependent on the PFC (233) .  ... 
doi:10.2741/s129 pmid:21196354 pmcid:PMC3058516 fatcat:4eounkpdyzdnxfhv2rteagcir4

Introduction to JINS Special Issue on Human Brain Connectivity in the Modern Era: Relevance to Understanding Health and Disease

Deanna M. Barch, Mieke Verfaellie, Stephen M. Rao
2016 Journal of the International Neuropsychological Society  
Mapping human whole-brain structural networks with diffusion MRI. PLoS One, 2(7), e597.  ...  ANOVA was performed to assess differences between groups on neuropsychological tests.  ...  There were no significant differences in performance between groups on all neuropsychological tests, see Table 2 .  ... 
doi:10.1017/s1355617716000047 fatcat:f2preenihbes5ftkrxbo7tgt64

Chemotherapy-related changes in cognitive functioning

Sanne B. Schagen, Jeffrey S. Wefel
2013 EJC Supplements  
; several studies observed correlations between abnormal diffusion properties and cognitive problems on neuropsychological testing [53] .  ...  Moreover there seems to be a link between the abnormal microstructural properties in white-matter regions and the cognitive impairments seen in breast cancer patients treated with chemotherapeutic agents  ... 
doi:10.1016/j.ejcsup.2013.07.007 pmid:26217131 pmcid:PMC4041313 fatcat:t6pzwf5gz5gtnkqgy5g6nko55i

HIV Encephalopathy - Now and Then [chapter]

Cristina Loredana, Ana-Maria Petrescu, Ruxandra Moroti-Constantinescu
2012 Miscellanea on Encephalopathies  
MRI findings are often but not always associated with performance on cognitive tests and are not always correlated with immunological function (CD4) or disease activity (viral load).  ...  Another common imaging finding, although not a defining MRI feature of HIVE, is the presence of T2-weighted hyperintenses images in white matter of the CNS (white matter signal abnormalities WMSA) (52  ... 
doi:10.5772/30547 fatcat:cd4exgcognd63dnxozcsxr4jai

Clinical translation of neuroimaging research in mood disorders

Jakub Z Konarski, Roger S McIntyre, Joanna K Soczynska, Alexandra Bottas, Sidney H Kennedy
2006 Psychiatry  
The localization of regional brain volumetric abnormalities with CT is enhanced with MRI techniques that allow for a separate assay of white and gray matter pathology (segmentation), cellular metabolism  ...  A priority research vista in mood disorders is the integration of neuroimaging investigations with other research methods (e.g., genetics, endocrinology, etc.).  ...  The Danish PET/depression project: Performance on Stroop's test linked to white matter lesions in the brain. Psychiatry Res 2004;130(2):117-30. 40. Buchsbaum MS, Wu J, DeLisi LE, et al.  ... 
pmid:21103155 pmcid:PMC2990553 fatcat:kdomrrfwabganjro5lxtjazjsa
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