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Whole genome sequencing of skull-base chordoma reveals genomic alterations associated with recurrence and chordoma-specific survival

Jiwei Bai, Jianxin Shi, Chuzhong Li, Shuai Wang, Tongwu Zhang, Xing Hua, Bin Zhu, Hela Koka, Ho-Hsiang Wu, Lei Song, Difei Wang, Mingyi Wang (+17 others)
2021 Nature Communications  
AbstractChordoma is a rare bone tumor with an unknown etiology and high recurrence rate. Here we conduct whole genome sequencing of 80 skull-base chordomas and identify PBRM1, a SWI/SNF (SWItch/Sucrose Non-Fermentable) complex subunit gene, as a significantly mutated driver gene. Genomic alterations in PBRM1 (12.5%) and homozygous deletions of the CDKN2A/2B locus are the most prevalent events. The combination of PBRM1 alterations and the chromosome 22q deletion, which involves another SWI/SNF
more » ... ne (SMARCB1), shows strong associations with poor chordoma-specific survival (Hazard ratio [HR] = 10.55, 95% confidence interval [CI] = 2.81-39.64, p = 0.001) and recurrence-free survival (HR = 4.30, 95% CI = 2.34-7.91, p = 2.77 × 10−6). Despite the low mutation rate, extensive somatic copy number alterations frequently occur, most of which are clonal and showed highly concordant profiles between paired primary and recurrence/metastasis samples, indicating their importance in chordoma initiation. In this work, our findings provide important biological and clinical insights into skull-base chordoma.
doi:10.1038/s41467-021-21026-5 pmid:33536423 fatcat:tksq27gojja5xbck53iq5yjqhi

Gut microbiota and drug-induced liver injury

Meng-Wei Niu, Peng Chen
2020 Chinese Medical Journal  
[2] The pathophysiological process of DILI is complicated, little is known about the detailed mechanism of DILI.  ...  Currently, the diagnosis and treatment of DILI are challenging, there are few specific diagnostic markers and specific treatment for DILI.  ... 
doi:10.1097/cm9.0000000000000651 pmid:31977551 pmcid:PMC7046259 fatcat:6wwfn7asqbgwbbjers3maiwf4q

An ensemble learning approach for modeling the systems biology of drug-induced injury

Joaquim Aguirre-Plans, Janet Piñero, Terezinha Souza, Giulia Callegaro, Steven J. Kunnen, Ferran Sanz, Narcis Fernandez-Fuentes, Laura I. Furlong, Emre Guney, Baldo Oliva
2021 Biology Direct  
and No-DILI-Concern drugs (as per DILIrank definitions).  ...  The impact of DILI is estimated to affect around 20 in 100,000 inhabitants worldwide each year.  ...  Availability of data and materials The code used during the current study is available in the following repository: Availability: https://github.com/structuralbioinformatics/CAMDA2019-DILI Ethics approval  ... 
doi:10.1186/s13062-020-00288-x pmid:33435983 fatcat:u2kaf6ruivghvk2jnwixlrkkhe

The role of hepatitis B infection in anti-tuberculosis drug-induced liver injury: a meta-analysis of cohort studies

Jing Zheng, Mei-Hong Guo, He-Wei Peng, Xiao-Ling Cai, Yun-Li Wu, Xian-E Peng
2020 Epidemiology and Infection  
Drug-induced liver injury (DILI) is a common adverse drug reaction leading to the interruption of tuberculosis (TB) therapy.  ...  We aimed to identify whether the hepatitis B virus (HBV) infection would increase the risk of DILI during first-line TB treatment.  ...  In the subgroup analyses, HBV infection showed a higher risk of anti-TB DILI in the group with a loose definition of DILI than in the other two groups with a strict definition of DILI.  ... 
doi:10.1017/s0950268820002861 pmid:33222713 pmcid:PMC7770377 fatcat:yddtltpnizbiznfu45rq6mhe64

Drug-Induced Liver Injury: Clinical and Etiologic Features at a Large Tertiary Teaching Hospital in China

Yao Liu, Shi-peng Zhan, Lin Song, Yonggang Chen, Yun-tao Jia, Fang Liu, Feng-jun Sun, Qian Wang, Pei-yuan Xia
2020 Medical Science Monitor  
RESULTS A total of 1811 patients had been diagnosed with DILI, accounting for 0.248% of the total admissions during the same period.  ...  The profiles for each etiology were distinctive for age, sex, clinical features, laboratory features, and types and severity of DILI.  ...  Drug-Induced Liver Injury: Clinical and Etiologic Features at a Large Tertiary Teaching Hospital in China ADEG 1 Yao Liu B 1 Shi-peng Zhan C 2 Lin Song F 2 Yonggang Chen D 2 Yun-tao Jia BC 1 Fang  ... 
doi:10.12659/msm.919435 pmid:32172275 pmcid:PMC7094059 fatcat:otcoynhsvndmpe4jpp6u2fc7li

Page 4339 of Mathematical Reviews Vol. , Issue 90G [page]

1990 Mathematical Reviews  
Foda, Omar SE Dili sins nceuieclinerunanimintaitl 34075 ES Wa Ih.  ...  _ _ 51028-51029 SEC. dcdiinsitesinnntanvetigeiennial 81063 GR: WINE. cccvesacdncadsniccncce 11063 SES acto tinnadcindasennssancke 76041 PEL IL Ik: Sisecnmisecnsecses See 01028 Florens-Zmirou, Daniéle PENG  ... 

Signal Detection of Potentially Drug-Induced Liver Injury in Children Using Electronic Health Records

Yuncui Yu, Xiaolu Nie, Ziyang Song, Yuefeng Xie, Xuan Zhang, Zhaoyang Du, Ran Wei, Duanfang Fan, Yiwei Liu, Qiuye Zhao, Xiaoxia Peng, Lulu Jia (+1 others)
2020 Frontiers in Pediatrics  
The other drug-DILI associations had been confirmed in previous studies. Conclusions: A quantitative algorithm to detect potential signals of DILI has been described.  ...  A two-stage procedure was adopted: (i) stage 1: the drugs suspected of inducing DILI were selected and (ii) stage 2: the associations between the drugs and DILI were identified in a retrospective cohort  ...  Detection of DILI Signals Evaluation of Observed DILI Signals According to available knowledge at present, the novelty of 11 positive DILI signals observed in stage 2 were further evaluated (shown in  ... 
doi:10.3389/fped.2020.00171 pmid:32373564 pmcid:PMC7177017 fatcat:e4pqqzs7ubfyxjcrlqep27qdbu

Çin'deki Türkoloji Çalışmaları

Ömer Faruk Işık
2020 Istanbul University Faculty of Letters Journal of Turkish Language and Literature  
Tablo 8'de bulunan makaleler incelendiğinde TARTIŞMA Türk Dili ve Edebiyatı Dergisi, Cilt: 60, Sayı: 2, 2020  ...  Bölümlerin isimlerinin ise yalnız birinin Türk Dili ve Edebiyatı diğer 11'inin Türkçe bölümü olarak belirtildiği görülmektedir.  ... 
doi:10.26650/tuded2020-0046 fatcat:i7vddmrldjgdxphessp6mlrusa

Pharmacoeconomics of three therapeutic schemes for anti-tuberculosis therapy induced liver injury in China

Yu Chen, Peng Ye, Chongwu Ren, Pengfei Ren, Zheng Ma, Lin Zhang, Wenliang Zhou, Changjie Jiang
2018 Open Medicine  
Conclusions Bicyclol is the most cost-effective therapy and the preferred choice for treating anti-TB DILI.  ...  To evaluate the pharmacoeconomics of three therapeutic schemes in treating anti-tuberluosis therapy -induced liver injury (anti-TB DILI).  ...  According to the Chinese Society of Hepatology guidelines for the diagnosis and treatment of DILI, the principles for DILI treatment included treating DILI with appropriate anti-inflammatory and hepatoprotective  ... 
doi:10.1515/med-2018-0010 pmid:29607414 pmcid:PMC5874510 fatcat:h5dkz5zpvnebrg3http3bp4agi

Latis Tabanlı Anlam Çözümlenmesi İle Geliştirilen Türkçe İşaret Dili Tercüme Sisteminin Nesnelerin İnterneti Üzerinden Web Ortamında Uygulaması

Yelda Fırat, Taşkın UĞURLU
2019 Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi  
İşaret dili ise, engelli kişilerin hem kendi aralarında hem de bu dili bilen engelsiz kişilerle jest, mimik ve vücut hareketleriyle anlaşmalarını sağlayan bir dil olarak tanımlanır.  ...  Öz Günlük hayatta insanlar; duygularını, düşüncelerini ve yaşantılarını dili kullanarak ya da kullanmaksızın çevrelerindeki insanlara aktararak iletişime geçerler.  ...  Her ülkenin farklı dili olduğu gibi işaret dili de ülkeden ülkeye değişim göstermektedir. Meksika, Kore, Japon, İspanya, Norveç, Finlandiya ve Türk İşaret Dili bunlardan bazılarıdır.  ... 
doi:10.18185/erzifbed.624887 fatcat:zglnuj4urvgddfoos4zfmwfaq4

Guidance for the clinical evaluation of traditional Chinese medicine-induced liver injuryIssued by China Food and Drug Administration

Xiaohe Xiao, Jianyuan Tang, Yimin Mao, Xiuhui Li, Jiabo Wang, Chenghai Liu, Kewei Sun, Yong'an Ye, Zhengsheng Zou, Cheng Peng, Ling Yang, Yuming Guo (+5 others)
2019 Acta Pharmaceutica Sinica B  
First, not all the patients with DILI or TCM DILI have an ALT that is greater than 5 Â ULN.  ...  Careful assembly and review of the TCM DILI risk signals can help to effect the early detection and prevention of TCM DILI and control the TCM DILI risk.  ... 
doi:10.1016/j.apsb.2018.12.003 pmid:31193760 pmcid:PMC6543019 fatcat:7sdxs6wvfbaihipz3cnzsmugrq

Page 49 of None Vol. 3, Issue [page]

1963 None  
The Differtator then has been as negligent to procure fuf- ficient proofs, when he is right; as he has been dili- gent to coin proofs, whenever he.could not find any 4 tohis purpofe.  ...  H the $s eatewpne eee on ee CL see Se anew tele Halas o> RR Ra Cn MR a a SER ch ooh a ~ eA penn peng eee ee a FAO Se ape eer ee ee A 24 i a ah ee one — See ee ene eee Sine —_ , 2 all - alter ta “4 Allin  ... 

CSH guidelines for the diagnosis and treatment of drug-induced liver injury

Yue-cheng Yu, Yi-min Mao, Cheng-wei Chen, Jin-jun Chen, Jun Chen, Wen-ming Cong, Yang Ding, Zhong-ping Duan, Qing-chun Fu, Xiao-yan Guo, Peng Hu, Xi-qi Hu (+24 others)
2017 Hepatology International  
Idiosyncratic DILI is far more common than intrinsic DILI clinically and can be classified into hepatocellular injury, cholestatic injury, hepatocellular-cholestatic mixed injury, and vascular injury based  ...  Drug-induced liver injury (DILI) is an important clinical problem, which has received more attention in recent decades.  ...  Acute DILI and chronic DILI Based on the course of disease, DILI is classified into acute DILI and chronic DILI.  ... 
doi:10.1007/s12072-017-9793-2 pmid:28405790 pmcid:PMC5419998 fatcat:wry7nx4lgfcxxentyupnvpajfu

Page 40 of Baptist Missionary Magazine Vol. 17, Issue 2 [page]

1837 Baptist Missionary Magazine  
At the monthly concert to-day all were present but Chek Peng.  ...  The first forty-five years of his life were spent in his native land ; but finding there, that his utmost dili¬ gence with a rigid economy, could 1  ... 

Page 438 of Louisiana Supreme Court: Reports Vol. 14, Issue [page]

1840 Louisiana Supreme Court: Reports  
This court has + peng frequentiy held, that these certificates must be taken ag pg isfrima prima facie evidence, that due diligence was used to find the that due dili- yesidence of the drawer and endorser  ... 
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