A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf.
Filters
Whole genome sequencing of skull-base chordoma reveals genomic alterations associated with recurrence and chordoma-specific survival
2021
Nature Communications
Preserved Fulltext
AbstractChordoma is a rare bone tumor with an unknown etiology and high recurrence rate. Here we conduct whole genome sequencing of 80 skull-base chordomas and identify PBRM1, a SWI/SNF (SWItch/Sucrose Non-Fermentable) complex subunit gene, as a significantly mutated driver gene. Genomic alterations in PBRM1 (12.5%) and homozygous deletions of the CDKN2A/2B locus are the most prevalent events. The combination of PBRM1 alterations and the chromosome 22q deletion, which involves another SWI/SNF
doi:10.1038/s41467-021-21026-5
pmid:33536423
fatcat:tksq27gojja5xbck53iq5yjqhi
more »
... ne (SMARCB1), shows strong associations with poor chordoma-specific survival (Hazard ratio [HR] = 10.55, 95% confidence interval [CI] = 2.81-39.64, p = 0.001) and recurrence-free survival (HR = 4.30, 95% CI = 2.34-7.91, p = 2.77 × 10−6). Despite the low mutation rate, extensive somatic copy number alterations frequently occur, most of which are clonal and showed highly concordant profiles between paired primary and recurrence/metastasis samples, indicating their importance in chordoma initiation. In this work, our findings provide important biological and clinical insights into skull-base chordoma.
Gut microbiota and drug-induced liver injury
2020
Chinese Medical Journal
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
[2] The pathophysiological process of DILI is complicated, little is known about the detailed mechanism of DILI. ...
Currently, the diagnosis and treatment of DILI are challenging, there are few specific diagnostic markers and specific treatment for DILI. ...
doi:10.1097/cm9.0000000000000651
pmid:31977551
pmcid:PMC7046259
fatcat:6wwfn7asqbgwbbjers3maiwf4q
An ensemble learning approach for modeling the systems biology of drug-induced injury
2021
Biology Direct
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf.
and No-DILI-Concern drugs (as per DILIrank definitions). ...
The impact of DILI is estimated to affect around 20 in 100,000 inhabitants worldwide each year. ...
Availability of data and materials The code used during the current study is available in the following repository: Availability: https://github.com/structuralbioinformatics/CAMDA2019-DILI Ethics approval ...
doi:10.1186/s13062-020-00288-x
pmid:33435983
fatcat:u2kaf6ruivghvk2jnwixlrkkhe
The role of hepatitis B infection in anti-tuberculosis drug-induced liver injury: a meta-analysis of cohort studies
2020
Epidemiology and Infection
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
Drug-induced liver injury (DILI) is a common adverse drug reaction leading to the interruption of tuberculosis (TB) therapy. ...
We aimed to identify whether the hepatitis B virus (HBV) infection would increase the risk of DILI during first-line TB treatment. ...
In the subgroup analyses, HBV infection showed a higher risk of anti-TB DILI in the group with a loose definition of DILI than in the other two groups with a strict definition of DILI. ...
doi:10.1017/s0950268820002861
pmid:33222713
pmcid:PMC7770377
fatcat:yddtltpnizbiznfu45rq6mhe64
Drug-Induced Liver Injury: Clinical and Etiologic Features at a Large Tertiary Teaching Hospital in China
2020
Medical Science Monitor
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
RESULTS A total of 1811 patients had been diagnosed with DILI, accounting for 0.248% of the total admissions during the same period. ...
The profiles for each etiology were distinctive for age, sex, clinical features, laboratory features, and types and severity of DILI. ...
Drug-Induced Liver Injury: Clinical and Etiologic Features at a Large Tertiary Teaching Hospital in China ADEG 1 Yao Liu
B 1 Shi-peng Zhan
C 2 Lin Song
F 2 Yonggang Chen
D 2 Yun-tao Jia
BC 1 Fang ...
doi:10.12659/msm.919435
pmid:32172275
pmcid:PMC7094059
fatcat:otcoynhsvndmpe4jpp6u2fc7li
Page 4339 of Mathematical Reviews Vol. , Issue 90G
[page]
1990
Mathematical Reviews
Preserved Fulltext
The Internet Archive has digitized a microfilm copy of this work. It may be possible to borrow a copy for reading.
Foda, Omar
SE Dili sins nceuieclinerunanimintaitl 34075 ES Wa Ih. ...
_ _ 51028-51029 SEC. dcdiinsitesinnntanvetigeiennial 81063 GR: WINE. cccvesacdncadsniccncce 11063 SES acto tinnadcindasennssancke 76041
PEL IL Ik: Sisecnmisecnsecses See 01028 Florens-Zmirou, Daniéle
PENG ...
Signal Detection of Potentially Drug-Induced Liver Injury in Children Using Electronic Health Records
2020
Frontiers in Pediatrics
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2022; you can also visit the original URL.
The file type is application/pdf.
The other drug-DILI associations had been confirmed in previous studies. Conclusions: A quantitative algorithm to detect potential signals of DILI has been described. ...
A two-stage procedure was adopted: (i) stage 1: the drugs suspected of inducing DILI were selected and (ii) stage 2: the associations between the drugs and DILI were identified in a retrospective cohort ...
Detection of DILI Signals
Evaluation of Observed DILI Signals According to available knowledge at present, the novelty of 11 positive DILI signals observed in stage 2 were further evaluated (shown in ...
doi:10.3389/fped.2020.00171
pmid:32373564
pmcid:PMC7177017
fatcat:e4pqqzs7ubfyxjcrlqep27qdbu
Çin'deki Türkoloji Çalışmaları
2020
Istanbul University Faculty of Letters Journal of Turkish Language and Literature
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf.
Tablo 8'de
bulunan makaleler incelendiğinde TARTIŞMA
Türk Dili ve Edebiyatı Dergisi, Cilt: 60, Sayı: 2, 2020 ...
Bölümlerin isimlerinin ise yalnız birinin Türk Dili ve Edebiyatı diğer 11'inin Türkçe bölümü olarak belirtildiği görülmektedir. ...
doi:10.26650/tuded2020-0046
fatcat:i7vddmrldjgdxphessp6mlrusa
Pharmacoeconomics of three therapeutic schemes for anti-tuberculosis therapy induced liver injury in China
2018
Open Medicine
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
Conclusions Bicyclol is the most cost-effective therapy and the preferred choice for treating anti-TB DILI. ...
To evaluate the pharmacoeconomics of three therapeutic schemes in treating anti-tuberluosis therapy -induced liver injury (anti-TB DILI). ...
According to the Chinese Society of Hepatology guidelines for the diagnosis and treatment of DILI, the principles for DILI treatment included treating DILI with appropriate anti-inflammatory and hepatoprotective ...
doi:10.1515/med-2018-0010
pmid:29607414
pmcid:PMC5874510
fatcat:h5dkz5zpvnebrg3http3bp4agi
Latis Tabanlı Anlam Çözümlenmesi İle Geliştirilen Türkçe İşaret Dili Tercüme Sisteminin Nesnelerin İnterneti Üzerinden Web Ortamında Uygulaması
2019
Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
İşaret dili ise, engelli kişilerin hem kendi aralarında hem de bu dili bilen engelsiz kişilerle jest, mimik ve vücut hareketleriyle anlaşmalarını sağlayan bir dil olarak tanımlanır. ...
Öz Günlük hayatta insanlar; duygularını, düşüncelerini ve yaşantılarını dili kullanarak ya da kullanmaksızın çevrelerindeki insanlara aktararak iletişime geçerler. ...
Her ülkenin farklı dili olduğu gibi işaret dili de ülkeden ülkeye değişim göstermektedir. Meksika, Kore, Japon, İspanya, Norveç, Finlandiya ve Türk İşaret Dili bunlardan bazılarıdır. ...
doi:10.18185/erzifbed.624887
fatcat:zglnuj4urvgddfoos4zfmwfaq4
Guidance for the clinical evaluation of traditional Chinese medicine-induced liver injuryIssued by China Food and Drug Administration
2019
Acta Pharmaceutica Sinica B
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf.
First, not all the patients with DILI or TCM DILI have an ALT that is greater than 5 Â ULN. ...
Careful assembly and review of the TCM DILI risk signals can help to effect the early detection and prevention of TCM DILI and control the TCM DILI risk. ...
doi:10.1016/j.apsb.2018.12.003
pmid:31193760
pmcid:PMC6543019
fatcat:7sdxs6wvfbaihipz3cnzsmugrq
Page 49 of None Vol. 3, Issue
[page]
1963
None
Preserved Fulltext
The Internet Archive has digitized a microfilm copy of this work. It may be possible to borrow a copy for reading.
The Differtator then has been as negligent to procure fuf- ficient proofs, when he is right; as he has been dili- gent to coin proofs, whenever he.could not find any 4 tohis purpofe. ...
H the
$s eatewpne eee on
ee CL see Se anew tele Halas o>
RR Ra Cn MR a a SER ch ooh a ~ eA penn peng eee ee a FAO Se ape eer ee ee A 24 i a ah ee one — See ee ene eee Sine —_ , 2 all - alter ta “4 Allin ...
CSH guidelines for the diagnosis and treatment of drug-induced liver injury
2017
Hepatology International
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
Idiosyncratic DILI is far more common than intrinsic DILI clinically and can be classified into hepatocellular injury, cholestatic injury, hepatocellular-cholestatic mixed injury, and vascular injury based ...
Drug-induced liver injury (DILI) is an important clinical problem, which has received more attention in recent decades. ...
Acute DILI and chronic DILI Based on the course of disease, DILI is classified into acute DILI and chronic DILI. ...
doi:10.1007/s12072-017-9793-2
pmid:28405790
pmcid:PMC5419998
fatcat:wry7nx4lgfcxxentyupnvpajfu
Page 40 of Baptist Missionary Magazine Vol. 17, Issue 2
[page]
1837
Baptist Missionary Magazine
Preserved Fulltext
The Internet Archive has digitized a microfilm copy of this work. It may be possible to borrow a copy for reading.
At the monthly concert to-day all were present but Chek Peng. ...
The first forty-five years of his life were spent in his native land ; but finding there, that his utmost dili¬ gence with a rigid economy, could
1 ...
Page 438 of Louisiana Supreme Court: Reports Vol. 14, Issue
[page]
1840
Louisiana Supreme Court: Reports
Preserved Fulltext
The Internet Archive has digitized a microfilm copy of this work. It may be possible to borrow a copy for reading.
This court has
+ peng frequentiy held, that these certificates must be taken ag
pg isfrima prima facie evidence, that due diligence was used to find the
that due dili- yesidence of the drawer and endorser ...
« Previous
Showing results 1 — 15 out of 516 results