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AbstractChordoma is a rare bone tumor with an unknown etiology and high recurrence rate. Here we conduct whole genome sequencing of 80 skull-base chordomas and identify PBRM1, a SWI/SNF (SWItch/Sucrose Non-Fermentable) complex subunit gene, as a significantly mutated driver gene. Genomic alterations in PBRM1 (12.5%) and homozygous deletions of the CDKN2A/2B locus are the most prevalent events. The combination of PBRM1 alterations and the chromosome 22q deletion, which involves another SWI/SNFdoi:10.1038/s41467-021-21026-5 pmid:33536423 fatcat:tksq27gojja5xbck53iq5yjqhi
more »... ne (SMARCB1), shows strong associations with poor chordoma-specific survival (Hazard ratio [HR] = 10.55, 95% confidence interval [CI] = 2.81-39.64, p = 0.001) and recurrence-free survival (HR = 4.30, 95% CI = 2.34-7.91, p = 2.77 × 10−6). Despite the low mutation rate, extensive somatic copy number alterations frequently occur, most of which are clonal and showed highly concordant profiles between paired primary and recurrence/metastasis samples, indicating their importance in chordoma initiation. In this work, our findings provide important biological and clinical insights into skull-base chordoma.
 The pathophysiological process of DILI is complicated, little is known about the detailed mechanism of DILI. ... Currently, the diagnosis and treatment of DILI are challenging, there are few specific diagnostic markers and specific treatment for DILI. ...doi:10.1097/cm9.0000000000000651 pmid:31977551 pmcid:PMC7046259 fatcat:6wwfn7asqbgwbbjers3maiwf4q
and No-DILI-Concern drugs (as per DILIrank definitions). ... The impact of DILI is estimated to affect around 20 in 100,000 inhabitants worldwide each year. ... Availability of data and materials The code used during the current study is available in the following repository: Availability: https://github.com/structuralbioinformatics/CAMDA2019-DILI Ethics approval ...doi:10.1186/s13062-020-00288-x pmid:33435983 fatcat:u2kaf6ruivghvk2jnwixlrkkhe
Drug-induced liver injury (DILI) is a common adverse drug reaction leading to the interruption of tuberculosis (TB) therapy. ... We aimed to identify whether the hepatitis B virus (HBV) infection would increase the risk of DILI during first-line TB treatment. ... In the subgroup analyses, HBV infection showed a higher risk of anti-TB DILI in the group with a loose definition of DILI than in the other two groups with a strict definition of DILI. ...doi:10.1017/s0950268820002861 pmid:33222713 pmcid:PMC7770377 fatcat:yddtltpnizbiznfu45rq6mhe64
RESULTS A total of 1811 patients had been diagnosed with DILI, accounting for 0.248% of the total admissions during the same period. ... The profiles for each etiology were distinctive for age, sex, clinical features, laboratory features, and types and severity of DILI. ... Drug-Induced Liver Injury: Clinical and Etiologic Features at a Large Tertiary Teaching Hospital in China ADEG 1 Yao Liu B 1 Shi-peng Zhan C 2 Lin Song F 2 Yonggang Chen D 2 Yun-tao Jia BC 1 Fang ...doi:10.12659/msm.919435 pmid:32172275 pmcid:PMC7094059 fatcat:otcoynhsvndmpe4jpp6u2fc7li
Foda, Omar SE Dili sins nceuieclinerunanimintaitl 34075 ES Wa Ih. ... _ _ 51028-51029 SEC. dcdiinsitesinnntanvetigeiennial 81063 GR: WINE. cccvesacdncadsniccncce 11063 SES acto tinnadcindasennssancke 76041 PEL IL Ik: Sisecnmisecnsecses See 01028 Florens-Zmirou, Daniéle PENG ...
The other drug-DILI associations had been confirmed in previous studies. Conclusions: A quantitative algorithm to detect potential signals of DILI has been described. ... A two-stage procedure was adopted: (i) stage 1: the drugs suspected of inducing DILI were selected and (ii) stage 2: the associations between the drugs and DILI were identified in a retrospective cohort ... Detection of DILI Signals Evaluation of Observed DILI Signals According to available knowledge at present, the novelty of 11 positive DILI signals observed in stage 2 were further evaluated (shown in ...doi:10.3389/fped.2020.00171 pmid:32373564 pmcid:PMC7177017 fatcat:e4pqqzs7ubfyxjcrlqep27qdbu
Tablo 8'de bulunan makaleler incelendiğinde TARTIŞMA Türk Dili ve Edebiyatı Dergisi, Cilt: 60, Sayı: 2, 2020 ... Bölümlerin isimlerinin ise yalnız birinin Türk Dili ve Edebiyatı diğer 11'inin Türkçe bölümü olarak belirtildiği görülmektedir. ...doi:10.26650/tuded2020-0046 fatcat:i7vddmrldjgdxphessp6mlrusa
Conclusions Bicyclol is the most cost-effective therapy and the preferred choice for treating anti-TB DILI. ... To evaluate the pharmacoeconomics of three therapeutic schemes in treating anti-tuberluosis therapy -induced liver injury (anti-TB DILI). ... According to the Chinese Society of Hepatology guidelines for the diagnosis and treatment of DILI, the principles for DILI treatment included treating DILI with appropriate anti-inflammatory and hepatoprotective ...doi:10.1515/med-2018-0010 pmid:29607414 pmcid:PMC5874510 fatcat:h5dkz5zpvnebrg3http3bp4agi
İşaret dili ise, engelli kişilerin hem kendi aralarında hem de bu dili bilen engelsiz kişilerle jest, mimik ve vücut hareketleriyle anlaşmalarını sağlayan bir dil olarak tanımlanır. ... Öz Günlük hayatta insanlar; duygularını, düşüncelerini ve yaşantılarını dili kullanarak ya da kullanmaksızın çevrelerindeki insanlara aktararak iletişime geçerler. ... Her ülkenin farklı dili olduğu gibi işaret dili de ülkeden ülkeye değişim göstermektedir. Meksika, Kore, Japon, İspanya, Norveç, Finlandiya ve Türk İşaret Dili bunlardan bazılarıdır. ...doi:10.18185/erzifbed.624887 fatcat:zglnuj4urvgddfoos4zfmwfaq4
First, not all the patients with DILI or TCM DILI have an ALT that is greater than 5 Â ULN. ... Careful assembly and review of the TCM DILI risk signals can help to effect the early detection and prevention of TCM DILI and control the TCM DILI risk. ...doi:10.1016/j.apsb.2018.12.003 pmid:31193760 pmcid:PMC6543019 fatcat:7sdxs6wvfbaihipz3cnzsmugrq
The Differtator then has been as negligent to procure fuf- ficient proofs, when he is right; as he has been dili- gent to coin proofs, whenever he.could not find any 4 tohis purpofe. ... H the $s eatewpne eee on ee CL see Se anew tele Halas o> RR Ra Cn MR a a SER ch ooh a ~ eA penn peng eee ee a FAO Se ape eer ee ee A 24 i a ah ee one — See ee ene eee Sine —_ , 2 all - alter ta “4 Allin ...
Idiosyncratic DILI is far more common than intrinsic DILI clinically and can be classified into hepatocellular injury, cholestatic injury, hepatocellular-cholestatic mixed injury, and vascular injury based ... Drug-induced liver injury (DILI) is an important clinical problem, which has received more attention in recent decades. ... Acute DILI and chronic DILI Based on the course of disease, DILI is classified into acute DILI and chronic DILI. ...doi:10.1007/s12072-017-9793-2 pmid:28405790 pmcid:PMC5419998 fatcat:wry7nx4lgfcxxentyupnvpajfu
Baptist Missionary Magazine
At the monthly concert to-day all were present but Chek Peng. ... The first forty-five years of his life were spent in his native land ; but finding there, that his utmost dili¬ gence with a rigid economy, could 1 ...
Louisiana Supreme Court: Reports
This court has + peng frequentiy held, that these certificates must be taken ag pg isfrima prima facie evidence, that due diligence was used to find the that due dili- yesidence of the drawer and endorser ...
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