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Built-in Self-Test and Fault Diagnosis for Lab-on-Chip Using Digital Microfluidic Logic Gates

Yang Zhao, Tao Xu, K. Chakrabarty
2008 2008 IEEE International Test Conference  
This method utilizes digital microfluidic logic gates to implement the BIST architecture; AND, OR and NOT gates are used to compress test-outcome droplets into one droplet signature.  ...  We present a built-in self-test (BIST) method for digital microfluidic lab-on-chip.  ...  Richard Fair for help in carrying out the laboratory experiments, and Advanced Liquid Logic, Inc. for providing prototype chips for the experiments.  ... 
doi:10.1109/test.2008.4700635 dblp:conf/itc/ZhaoXC08 fatcat:4b7omwktpba35lzlpsjsczn4pe

Digital Microfluidic Logic Gates and Their Application to Built-in Self-Test of Lab-on-Chip

Yang Zhao, Krishnendu Chakrabarty
2010 IEEE Transactions on Biomedical Circuits and Systems  
This method utilizes digital microfluidic logic gates to implement the BIST architecture; AND, OR and NOT gates are used to compress multiple test-outcome droplets into a single droplet to facilitate detection  ...  We present a built-in self-test (BIST) method for digital microfluidic lab-on-chip.  ...  Fair from Duke University for help in carrying out the laboratory experiments, and Advanced Liquid Logic, Inc., for providing prototype chips for the experiments.  ... 
doi:10.1109/tbcas.2010.2048567 pmid:23853371 fatcat:ipzoohwjdrerdpixcukxjc7tay

Digital Signal Processing for Molecular Communication via Chemical Reactions-based Microfluidic Circuits [article]

Dadi Bi, Yansha Deng
2020 arXiv   pre-print
Logic Gates; and 5) Microfluidic Circuits.  ...  We then assemble basic modules to construct five types of logic gate for Level 4, including AND, NAND, OR, NOR, and XOR gates, which show advantages of microfluidic circuits in reusability and modularity  ...  Logic Gates -the digital logic gates assembled from the microfluidic modules designed for Level 3.  ... 
arXiv:2009.05009v2 fatcat:fywlc2cmrbc3fcm7jso4br5dti

On-Line Testing of Lab-on-Chip Using Digital Microfluidic Compactors

Yang Zhao, Krishnendu Chakrabarty
2008 2008 14th IEEE International On-Line Testing Symposium  
This method utilizes microfluidic compactors based on droplet-based AND gates, which are implemented using digital microfluidics.  ...  We present a built-in self-test (BIST) method for on-line testing of digital microfluidic lab-on-chip.  ...  The microfluidic compactor consists of a tree of logic AND operations implemented by 2-input microfluidic AND gates.  ... 
doi:10.1109/iolts.2008.45 dblp:conf/iolts/ZhaoC08 fatcat:rxd5wautr5grfmw44u7ey6jvey

Microfluidic pneumatic logic circuits and digital pneumatic microprocessors for integrated microfluidic systems

Minsoung Rhee, Mark A. Burns
2009 Lab on a Chip  
Schematics of universal pneumatic logic gates constructed by modifying the asymmetric pneumatic NOT gates. Figure S-3. NAND gate schematics and operations.  ...  Schematic concept of a pneumatic microprocessor embedded in a target microfluidic device. Figure S-2.  ...  Truth Table for Pneumatic NOR Logic Gate Table S-2. Truth Table for Pneumatic NAND Logic Gate Table S-3. Truth Table for Pneumatic XNOR Logic Gate Table S-4.  ... 
doi:10.1039/b904354c pmid:19823730 pmcid:PMC2917228 fatcat:zvdy6hlhcbd4nms5pqhr3nnrfq

Static control logic for microfluidic devices using pressure-gain valves

James A. Weaver, Jessica Melin, Don Stark, Stephen R. Quake, Mark A. Horowitz
2010 Nature Physics  
Outputs from this digital control logic can then be used to control traditional analyte flow valves.  ...  We show that this enables integration of fully static digital control logic and state storage directly on-chip, ultimately enabling microfluidic-state machines to be designed.  ...  ., co-founded a microfluidics company (Fluidigm).  ... 
doi:10.1038/nphys1513 fatcat:qrir3ydfcjgy7lo5yr6c7le6nu

A microfluidically controlled concave–convex membrane lens using an addressing operation system

Shouju Yao, Zhou Zhou, Gonghan He, Kunpeng Zhang, Xiang Huang, Bing Qiu, Daoheng Sun
2020 Microsystems & Nanoengineering  
An integrated digital microfluidic zoom actuating unit with a logic addressing unit for a built-in membrane lens array, e.g., a flexible bionic compound eye, is developed and studied in this article.  ...  A concave-convex membrane fluidic microvalve, which is the component element of the logic gate, actuator, and microlens, is proposed to replace the traditional solenoid valve.  ...  Results and discussion Microfluidic valves and logic gate A concave-convex membrane fluidic microvalve is the basic component of the logic gate, actuator, and microlens.  ... 
doi:10.1038/s41378-020-0148-0 pmid:34567648 pmcid:PMC8433168 fatcat:zmdth6mzfzavrk3wgwa3bh7g3u

Pressure‐Driven Two‐Input 3D Microfluidic Logic Gates

Nazek El‐Atab, Javier Chavarrio Canas, Muhammad M. Hussain
2019 Advanced Science  
Several Boolean logic functions are realized (AND, OR, and XOR) using different fluids in addition to a half adder digital microfluidic circuit.  ...  The demonstrated approach enables simple cascading of logic gates for large-scale microfluidic computing systems.  ...  In conclusion, a 3D multilevel microfluidic chip with dif ferent Boolean logic gates and a digital microfluidic circuit (AND, OR, XOR, and half adder) is demonstrated.  ... 
doi:10.1002/advs.201903027 pmid:31993297 pmcid:PMC6974944 fatcat:quhtqys75ffqnorkf2ni6tozce

Microdroplet-based universal logic gates by electrorheological fluid

Mengying Zhang, Limu Wang, Xiang Wang, Jinbo Wu, Jiaxing Li, Xiuqing Gong, Jianhua Qin, Weihua Li, Weijia Wen
2011 Soft Matter  
We demonstrate a uniquely designed microfluid logic gate with universal functionality, which is capable of conducting all 16 logic operations in one chip, with different input voltage combinations.  ...  The universal logic gate reveals the possibilities of achieving a large-scale microfluidic processor with more complexity for on-chip processing for biological, chemical as well as computational experiments  ...  Since the universal logic gate is the most basic component of digitalized computing, this invention promises to become the building block of microfluidic processors.  ... 
doi:10.1039/c1sm05687e fatcat:m4lkdh73z5fqrgnj7maidtqkl4

Universal logic gates via liquid-electronic hybrid divider

Bingpu Zhou, Limu Wang, Shunbo Li, Xiang Wang, Yu Sanna Hui, Weijia Wen
2012 Lab on a Chip  
We demonstrated two-input microdroplet-based universal logic gates using a liquid-electronic hybrid divider. All 16 Boolean logic functions have been realized by manipulating the applied voltages.  ...  The microfluidic chip can be scaled up to construct large-scale microfluidic logic computation.  ...  The concept and operation of microfluidic logic functions are in analogy to digital electronics.  ... 
doi:10.1039/c2lc40840f pmid:23111629 fatcat:wnl24gusfffsnhtoikj7da2tly

Pneumatic Computers for Embedded Control of Microfluidics [article]

Siavash Ahrar, Manasi Raje, Irene C. Lee, Elliot E. Hui
2022 arXiv   pre-print
We demonstrate finite state machines implemented as pneumatic circuits of microfluidic valves, and we employ these controllers to direct microfluidic liquid handling procedures such as serial dilution  ...  State machines with up to four bits of state memory are demonstrated, and next-state combinational logic can be fully reprogrammed by changing the hole-punch pattern on a membrane in the chip.  ...  Results The finite state machine (FSM) is a widely employed abstraction in digital control systems and can be implemented efficiently with a limited number of logic gates.  ... 
arXiv:2201.09755v1 fatcat:qkzfvngmlvfxllhqczmorurjlu

Digital logic for soft devices

Daniel J. Preston, Philipp Rothemund, Haihui Joy Jiang, Markus P. Nemitz, Jeff Rawson, Zhigang Suo, George M. Whitesides
2019 Proceedings of the National Academy of Sciences of the United States of America  
Soft, pneumatic NOT, AND, and OR digital logic gates—which generate known pneumatic outputs as a function of one, or multiple, pneumatic inputs—allow fabrication of digital logic circuits for a set–reset  ...  This paper describes completely soft pneumatic digital logic gates having a physical scale appropriate for use with current (macroscopic) soft actuators.  ...  Digital Logic Gates.  ... 
doi:10.1073/pnas.1820672116 pmid:30923120 pmcid:PMC6475414 fatcat:piqhy43uzvdkleineo6rhqif5e

Integrated Control of Microfluidics – Application in Fluid Routing, Sensor Synchronization, and Real-Time Feedback Control [chapter]

Elishai Ezra, Danny Bavli, Yaakov Nahmias
2016 Advances in Microfluidics - New Applications in Biology, Energy, and Materials Sciences  
Microfluidic applications range from combinatorial chemical synthesis to high-throughput screening, with platforms integrating analog perfusion components, digitally controlled microvalves, and a range  ...  of unspecialized microfluidics users.  ...  A more recent development is the development of logical gates with microfluidic valves.  ... 
doi:10.5772/64429 fatcat:h76k7dal6naj7lbj74xsw2ncse

Logic control of microfluidics with smart colloid

Limu Wang, Mengying Zhang, Jiaxing Li, Xiuqing Gong, Weijia Wen
2010 Lab on a Chip  
Our results show that such a logic switch is also a logic IF gate, while its inverter functions as a NOT gate.  ...  We report the successful realization of a microfluidic chip with switching and corresponding inverting functionalities.  ...  Here we demonstrate two basic logic functions, a switcher (IF gate) and invertor (NOT gate).  ... 
doi:10.1039/c0lc00003e pmid:20882229 fatcat:hly433te65ew3n76rsktlgorlq

Next-generation integrated microfluidic circuits

Bobak Mosadegh, Tommaso Bersano-Begey, Joong Yull Park, Mark A. Burns, Shuichi Takayama
2011 Lab on a Chip  
of control lines, or by the microfluidic circuitembedded encoding of instructions to eliminate control lines altogether.  ...  This mini-review provides a brief overview of recent devices that use networks of elastomeric valves to minimize or eliminate the need for interconnections between microfluidic chips and external instruction  ...  Fig. 4 4 Microfluidic logic-gates made by normally open gain-valves.  ... 
doi:10.1039/c1lc20387h pmid:21799977 fatcat:gvjbrni4encj7pr6z3j5aqxt7e
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