1,032 Hits in 4.3 sec

Short-Term Learning Induces White Matter Plasticity in the Fornix

S. Hofstetter, I. Tavor, S. Tzur Moryosef, Y. Assaf
2013 Journal of Neuroscience  
A recent diffusion tensor imaging (DTI) study showed that training in a car racing game for 2 h induces changes in the hippocampus and parahippocampal gyri.  ...  Here we investigated the influence of short learning tasks on structural plasticity in the white matter, and specifically in the fornix, in humans and rats.  ...  . • MRI Study of White Matter Plasticity  ... 
doi:10.1523/jneurosci.4520-12.2013 pmid:23904619 pmcid:PMC6618548 fatcat:hbyvcrnmzncaznmpzpronz6i2u

Axonal tract tracing for delineating interacting brain regions: implications for Alzheimer's disease-associated memory

Thomas van Groen, Pasi Miettinen, Inga Kadish
2014 Future Neurology  
Furthermore, MRI-diffusion tensor imaging analysis indicates a decrease in the quality of the white matter tracts connecting the hippocampus to the brain; in other words, the fimbria/fornix and perforant  ...  area or lamina of the hippocampus.  ...  Acknowledgments The authors thank E von Schnier for his excellent comments on an earlier version of this manuscript.  ... 
doi:10.2217/fnl.13.67 pmid:24678267 pmcid:PMC3963157 fatcat:ve7rvyhbuzdmrerwxedvt2rfq4

Diffusion MRI of Structural Brain Plasticity Induced by a Learning and Memory Task

Tamar Blumenfeld-Katzir, Ofer Pasternak, Michael Dagan, Yaniv Assaf, Ya-Ping Tang
2011 PLoS ONE  
Methodology/Principal Finding: Here we used diffusion tensor imaging (DTI) to examine the microstructural manifestations of neuroplasticity in rats that performed a spatial navigation task.  ...  Conclusion/Significance: We relate the observed DTI changes to the structural plasticity that occurs in astrocytes and discuss the potential of MRI for probing structural neuroplasticity and hence indirectly  ...  The main finding of this MRI study is that diffusion MRI can be used to assess structural plasticity, which occurs to a significant extent in the adult brain and extends from the region of the hippocampus  ... 
doi:10.1371/journal.pone.0020678 pmid:21701690 pmcid:PMC3119075 fatcat:6qskluopnngnlp6cwy4bnabe54

White matter changes in microstructure associated with a maladaptive response to stress in rats

R Magalhães, J Bourgin, F Boumezbeur, P Marques, M Bottlaender, C Poupon, B Djemaï, E Duchesnay, S Mériaux, N Sousa, T M Jay, A Cachia
2017 Translational Psychiatry  
In the current work, we employed ex vivo high field diffusion magnetic resonance imaging (MRI) to uncover the differences in white matter properties in the entire brain between Fisher 344 (F344) and Sprague-Dawley  ...  The strain-by-stress interaction revealed an effect on SD rats in MD, RD and axial diffusivity (AD), with lower diffusion metric levels on stressed animals.  ...  This work was performed on a platform of France Life Imaging (FLI) network partly funded by the grant ANR-11-INBS-0006.  ... 
doi:10.1038/tp.2016.283 pmid:28117841 pmcid:PMC5545740 fatcat:mp3xs3a5mjeyzkag3p6n5rce4e

Differential microstructural alterations in rat cerebral cortex in a model of chronic mild stress depression

Ahmad Raza Khan, Christopher D. Kroenke, Ove Wiborg, Andrey Chuhutin, Jens R. Nyengaard, Brian Hansen, Sune Nørhøj Jespersen, Hao Huang
2018 PLoS ONE  
The study employs ex-vivo diffusion MRI (d-MRI) to assess cortical microstructure in stressed (anhedonic and resilient) and control animals.  ...  We find significantly lower extracellular diffusivity in auditory cortex (AC) of stress groups and a significantly higher fractional anisotropy in the resilient group.  ...  Biophysical modeling of high field diffusion MRI demonstrates micro-structural aberration in chronic mild stress rat brain.  ... 
doi:10.1371/journal.pone.0192329 pmid:29432490 pmcid:PMC5809082 fatcat:glrlso5lsbhflirhizab3c7yhm

Diffusion tensor-MRI detects exercise-induced neuroplasticity in the hippocampal microstructure in mice

Mohammad R. Islam, Renhao Luo, Sophia Valaris, Erin B. Haley, Hajime Takase, Yinching Iris Chen, Bradford C. Dickerson, Karin Schon, Ken Arai, Christopher T. Nguyen, Christiane D. Wrann
2020 Brain Plasticity  
Here we aim to bridge this divide by using diffusion tensor imaging MRI (DTI), an advanced imaging technique commonly applied in human studies, in a longitudinal exercise study with mice.  ...  These results provide compelling in vivo support for the concept that similar adaptive changes occur in the brains of mice and humans in response to exercise.  ...  315 or radial diffusivity in the hippocampus 316 MD is calculated as the mean of the diffusion 317 tensor's three eigenvalues.  ... 
doi:10.3233/bpl-190090 pmid:33282678 pmcid:PMC7685674 fatcat:wcy6uihyfncdxgaurxn2tmdrvi

Long-Term Monitoring of Post-Stroke Plasticity After Transient Cerebral Ischemia in Mice Using In Vivo and Ex Vivo Diffusion Tensor MRI

C Granziera, H D'Arceuil, L Zai, P.J Magistretti, A.G Sorensen, A.J de Crespigny
2007 The Open Neuroimaging Journal  
WE USED A MURINE MODEL OF TRANSIENT FOCAL CEREBRAL ISCHEMIA TO STUDY: 1) in vivo DTI long-term temporal evolution of the apparent diffusion coefficient (ADC) and diffusion fractional anisotropy (FA) at  ...  In the stroke group, GAP-43 expression and FA values were significantly higher in the ipsilateral (IL) striatum and contralateral (CL) hippocampus compared to the shams.  ...  ACKNOWLEDGEMENT This work was supported in part by the Swiss Heart Foundation (CG), an Established Investigator Award from the American Heart Association (AdC), and the Athinoula A.  ... 
doi:10.2174/1874440000701010010 pmid:19018310 pmcid:PMC2577937 fatcat:spz36wsh45dm5nuqolq3nfin2q

Plasticity in gray and white: neuroimaging changes in brain structure during learning

Robert J Zatorre, R Douglas Fields, Heidi Johansen-Berg
2012 Nature Neuroscience  
Here we review human neuroimaging findings of structural plasticity and then discuss cellular and molecular level changes that could underlie observed imaging effects.  ...  Greater dialog between researchers in these different fields would help to facilitate cross-talk between cellular and systems level explanations of how learning sculpts brain structure. npg  ...  npg The authors declare no competing financial interests. Published online at  ... 
doi:10.1038/nn.3045 pmid:22426254 pmcid:PMC3660656 fatcat:vfggkd5v2zfm5n2p7gncsn4uky

Diffusion tensor imaging reveals adolescent binge ethanol-induced brain structural integrity alterations in adult rats that correlate with behavioral dysfunction

Ryan P. Vetreno, Richard Yaxley, Beatriz Paniagua, Fulton T. Crews
2015 Addiction Biology  
Radial diffusivity (RD) was reduced in the hippocampus and neocortex of AIE-treated animals.  ...  While we did not observe a long-term effect of AIE on structural volumes, AIE did reduce axial diffusivity (AD) in the cerebellum, hippocampus, and neocortex.  ...  Acknowledgments This work was supported in part by the National Institutes of Health, National Institute on Alcoholism and Alcohol Abuse (AA019767, AA11605, AA007573, and AA021040), the Neurobiology of  ... 
doi:10.1111/adb.12232 pmid:25678360 pmcid:PMC4532660 fatcat:tcamo2sy5vddbgc3ddsfyz2e4y

MRI Characterization of Progressive Brain Alterations After Experimental Traumatic Brain Injury: Region Specific Tissue Damage, Hemodynamic Changes and Axonal Injury [chapter]

Riikka Immonen, Nick Haywar
2012 Brain Injury - Pathogenesis, Monitoring, Recovery and Management  
and diffusion tensor imaging, respectively) are used to estimate the myelin loss and axonal injury.  ...  One MRI technique that provides information about diffuse axonal injury (in addition to diffusion tensor imaging and magnetization transfer imaging that are not discussed here) is susceptibility weighted  ... 
doi:10.5772/29829 fatcat:iubxv6khmbbrzb4rkncfovwsbe

Molecular and microstructural biomarkers of neuroplasticity in neurodegenerative disorders through preclinical and diffusion magnetic resonance imaging studies

Rodolfo Gabriel Gatto
2020 Journal of Integrative Neuroscience  
plasticity, as well as the use of alternative diffusion models.  ...  in animal models that contribute to our knowledge of neuroplasticity; and (iii) illustrate the capabilities and limitations of current diffusion magnetic resonance imaging techniques to study cortical  ...  One of the first diffusion-weighted MRI (DW-MRI) studies in the neurobiological field was intended to explore the ex vivo microstructure of the unmyelinated giant axons of the squid, where diffusivity  ... 
doi:10.31083/j.jin.2020.03.165 pmid:33070535 fatcat:ql64dr7n4jhu7n6ymsgjsd7xge

Neuroimaging biomarkers of epileptogenesis

Asht Mangal Mishra, Harrison Bai, Alexandra Gribizis, Hal Blumenfeld
2011 Neuroscience Letters  
Much progress has been made in the field studying the process of epileptogenesis via neuroimaging techniques.  ...  This review provides a brief summary of the major human and animal studies in both partial and generalized epilepsies that demonstrate the potential of these imaging modalities to serve as biomarkers of  ...  Multiparametric quantitative MRI changes (such as T2, T1 ρ, diffusion tensor trace, the extent of hyperintense lesion and intracerebral hemorrhage) acquired shortly after TBI in the LFPI rat model were  ... 
doi:10.1016/j.neulet.2011.01.076 pmid:21303682 pmcid:PMC3432283 fatcat:lviogqzi3nbydijv4jk36sz2lq

MR Diffusion Tensor Imaging Detects Rapid Microstructural Changes in Amygdala and Hippocampus Following Fear Conditioning in Mice

Abby Y. Ding, Qi Li, Iris Y. Zhou, Samantha J. Ma, Gehua Tong, Grainne M. McAlonan, Ed X. Wu, David R. Borchelt
2013 PLoS ONE  
Methods: We hypothesized that in vivo magnetic resonance diffusion tensor imaging (DTI) would be sensitive to rapid microstructural changes elicited by FC in an experimental mouse PTSD model.  ...  Consistent with this, neuroimaging studies of individuals with established PTSD in the months after trauma have revealed changes in brain regions responsible for processing fear.  ...  Diffusion tensor imaging (DTI) is an MRI technique that can characterize tissue microstructure quantitatively [43, 44, 45, 46] .  ... 
doi:10.1371/journal.pone.0051704 pmid:23382811 pmcid:PMC3559642 fatcat:aeryqxvjxrgcjjlnuovbl27z6i

Diffusion-Weighted MRI and Quantitative Biophysical Modeling of Hippocampal Neurite Loss in Chronic Stress

Peter Vestergaard-Poulsen, Gregers Wegener, Brian Hansen, Carsten R. Bjarkam, Stephen J. Blackband, Niels C. Nielsen, Sune N. Jespersen, Joseph Najbauer
2011 PLoS ONE  
Here we show that high field diffusion-weighted MRI combined with quantitative biophysical modeling of the hippocampal dendritic loss in 21 day restraint stressed rats highly correlates with former histological  ...  Our study strongly indicates that diffusion-weighted MRI is sensitive to regional dendritic loss and thus a promising candidate for non-invasive studies of dendritic plasticity in chronic stress and stress-related  ...  Shepherd for their support with the design of this study. We thank C. Frith, Kim Mouridsen, and J. Flint for their valuable comments on this manuscript.  ... 
doi:10.1371/journal.pone.0020653 pmid:21747929 pmcid:PMC3128590 fatcat:3w624h54m5ci7cjwgaw43i5mrq

Stress-Induced Morphological, Cellular and Molecular Changes in the Brain—Lessons Learned from the Chronic Mild Stress Model of Depression

Ahmad Raza Khan, Lili Geiger, Ove Wiborg, Boldizsár Czéh
2020 Cells  
Future studies examining the neurobiological changes in the CMS model in combination with clinically effective antidepressant drug intervention will likely deliver further valuable information on the pathophysiology  ...  Here, we summarize current knowledge on the structural and molecular alterations in the brain that have been described using the CMS model.  ...  Jespersen to provide a Matlab Script for 3D Visualization of the brain. Conflicts of Interest: The authors declare no conflict of interest. The funders had no role in the writing of the manuscript.  ... 
doi:10.3390/cells9041026 pmid:32326205 pmcid:PMC7226496 fatcat:yviu4dzhm5bszpjw5qrvnmdre4
« Previous Showing results 1 — 15 out of 1,032 results