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Diffusion-Weighted Imaging of the Spinal Cord
[chapter]
2014
Quantitative MRI of the Spinal Cord
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Kurtosis imaging contains quantitative information about the non-Gaussian diffusion profile (especially useful at high b-values, where restricted diffusion is better depicted). ...
Despite differences in pulse sequences, if signal attenuation is plotted versus the degree of diffusion weighting (i.e., b-value) for the human studies, it produces a mean ADC in the human cervical spinal ...
doi:10.1016/b978-0-12-396973-6.00009-5
fatcat:2pzz7ydv2rcvhmn7zuhsows7si
Double diffusion encoding and applications for biomedical imaging
2020
Journal of Neuroscience Methods
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2020 pre-print arXiv:2011.02913v1 fatcat:w7jjqtzsxndmxnfat3qq6jpaba
Diffusion Magnetic Resonance Imaging (dMRI) is one of the most important contemporary non-invasive modalities for probing tissue structure at the microscopic scale. ...
These enhanced contrasts can play important roles in characterizing biological tissues, for instance upon diseases (e.g. neurodegenerative, cancer, stroke), aging, learning, and development. ...
Acknowledgements The authors would like to acknowledge the following sources of financial support. ...
doi:10.1016/j.jneumeth.2020.108989
pmid:33144100
fatcat:qqjbwghlmngbzctpi2cs37gz4m
In vivo observation and biophysical interpretation of time-dependent diffusion in human white matter
2016
NeuroImage
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The presence of micrometer-level restrictions leads to a decrease of diffusion coefficient with diffusion time. Here we investigate this effect in human white matter in vivo. ...
We perform stimulated echo diffusion tensor imaging on 5 healthy volunteers and observe a relatively weak time-dependence in diffusion transverse to major fiber tracts. ...
Acknowledgments We would like to thank Kecheng Liu, Christopher Glielmi and Thorsten Feiweier from Siemens Healthcare for providing support and guidance related to the STEAM acquisition. ...
doi:10.1016/j.neuroimage.2016.01.018
pmid:26804782
pmcid:PMC4803645
fatcat:vqqvs2dcmzayde4qwaaxdx2czu
Diffusion-Exchange Weighted Imaging
2009
Magnetic Resonance Insights
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A method has been developed whereby diffusion and exchange in micro cellular structures in the human brain are correlated to produce a new type of image contrast leading to determination of water exchange ...
The diffusion method relies on differential apparent diffusion coefficients as detectable nuclei exchange between adjacent compartments marked with different apparent diffusion coefficient values (e.g. ...
The financial support of S.R. by an Australian Research Council Discovery Project Grant (DP0663987) is acknowledged.
Disclosure The author reports no conflicts of interest. ...
doi:10.4137/mri.s3504
fatcat:d7uxyns57jhzlfdbdy3jgynl2m
Combined diffusion‐relaxometry microstructure imaging: Current status and future prospects
2021
Magnetic Resonance in Medicine
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Combined diffusion-relaxometry acquisitions vary multiple MR contrast encodings-such as b-value, gradient direction, inversion time, and echo time-in a multidimensional acquisition space. ...
This article reviews an emerging paradigm that has the potential to provide a more detailed assessment of tissue microstructure-combined diffusion-relaxometry imaging. ...
ACKNOWLEDGEMENTS The authors thank the ISMRM for supporting their combined diffusion-relaxometry microstructure imaging memberinitiated symposium at the ISMRM 2019 Annual Meeting & Exhibition. ...
doi:10.1002/mrm.28963
pmid:34411331
pmcid:PMC8568657
fatcat:b7rdybwwdbgppkdrbxqbiayjxq
Towards microstructure fingerprinting: Estimation of tissue properties from a dictionary of Monte Carlo diffusion MRI simulations
2019
NeuroImage
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In an in vivo rat model of spinal cord injury, our approach provided microstructural parameters that showed better correspondence with histology than five closed-form models of the diffusion signal: MMWMD ...
On whole-brain in vivo data from the human connectome project (HCP), our method exhibited spatial distributions of apparent axonal radius and axonal density indices in keeping with ex vivo studies. ...
Acknowledgments The authors thank Damien Jacobs for providing the in vivo data set of the rat model of Wallerian degeneration in the spinal cord, including DW-MRI acquisitions and histological analyses ...
doi:10.1016/j.neuroimage.2018.09.076
pmid:30282007
pmcid:PMC6230496
fatcat:uvi6ed7nrzdbrfj46jjljsknhy
Ex vivo diffusion MRI of the human brain: Technical challenges and recent advances
2018
NMR in Biomedicine
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This review discusses ex vivo diffusion magnetic resonance imaging (dMRI) as an important research tool for neuroanatomical investigations and the validation of in vivo dMRI techniques, with a focus on ...
and microstructure of human brain tissue in vivo. ...
In post-mortem human high angular resolution diffusion imaging (HARDI) studies (see also Section 3.2), data with high angular resolution (≥30 directions) and relatively high b values (>3000-4000 s/mm 2 ...
doi:10.1002/nbm.3941
pmid:29863793
fatcat:kfyxizpnjvec7lprpkatnha4eu
Small animal neuroimaging using magnetic resonance microscopy
2002
Progress in nuclear magnetic resonance spectroscopy
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[378] have employed the q-space imaging approach to analyze diffusion-weighted images of excised spinal cord of stroke prone spontaneously hypertensive rats using large b values, where b g 2 g 2 d 2 ...
The columns show four different slices with spinal cord evident in the top center of the left most three columns. ...
doi:10.1016/s0079-6565(02)00003-1
fatcat:twvecdhoyjbyvec4mfc5k4lt24
Microstructural imaging of the human brain with a 'super-scanner': 10 key advantages of ultra-strong gradients for diffusion MRI
2018
NeuroImage
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This review, written from the perspective of the National Facility for In Vivo MR Imaging of Human Tissue Microstructure, an initiative to establish a shared 300 mT/m-gradient facility amongst the microstructural ...
experiments, e.g. diffusionrelaxometry; 5) tractography and high-resolution imaging in vivo and 6) post mortem; 7) diffusion-weighted spectroscopy of metabolites other than water; 8) tumour characterisation ...
ACKNOWLEDGEMENTS: The UK National Facility for In Vivo MR Imaging of Human Tissue Microstructure was generously funded by the Engineering and Physical Sciences Research Council (EPSRC) (grant EP/M029778 ...
doi:10.1016/j.neuroimage.2018.05.047
pmid:29793061
fatcat:ozzxbxhol5em3cvnsgsjpzbc5i
In vivo observation and biophysical interpretation of time-dependent diffusion in human cortical gray matter
2020
NeuroImage
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neurites in human gray matter in vivo. ...
The estimated power-law dynamical exponent ϑ≃1/2 in both D(t) and K(t) is consistent with one-dimensional diffusion in the presence of randomly positioned restrictions along neurites. ...
vitro (Yang et al., 2018) , much shorter exchange time range τ ex ≃ 10-30 ms was recently found in human gray matter on a human Connectome scanner in the high-b regime, at b 25 ms/µm 2 . ...
doi:10.1016/j.neuroimage.2020.117054
pmid:32585341
pmcid:PMC7736473
fatcat:cbdg5vax6veqzhsdw2baj7l7j4
In vivo observation and biophysical interpretation of time-dependent diffusion in human cortical gray matter
[article]
2020
arXiv
pre-print
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neurites in human gray matter in vivo. ...
The estimated power-law dynamical exponent ϑ≃1/2 in both D(t) and K(t) is consistent with one-dimensional diffusion in the presence of randomly positioned restrictions along neurites. ...
vitro (Yang et al., 2018) , much shorter exchange time range τ ex 10-30 ms was recently found in human gray matter on a human Connectome scanner in the high-b regime, at b 25 ms/µm 2 . ...
arXiv:2001.06529v1
fatcat:fdnikcm45nadnmtkdr6oeqpr3a
Clinical Proton MR Spectroscopy in Central Nervous System Disorders
2014
Radiology
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Herein, the authors present a summary of brain disorders in which MR spectroscopy has an impact on patient management, together with a critical consideration of common data acquisition and processing procedures ...
The article documents the impact of 1 H MR spectroscopy in the clinical evaluation of disorders of the central nervous system. ...
Acknowledgments: The initiative for the MRS ...
doi:10.1148/radiol.13130531
pmid:24568703
pmcid:PMC4263653
fatcat:u2eawafyfvcethnzkft62cog7q
Proton Magnetic Resonance Spectroscopy in Multiple Sclerosis
2009
Neuroimaging clinics of North America
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This article reviews the role of MRS-determined metabolic alterations in lesions, normal appearing white matter, gray matter, and spinal cord in advancing our knowledge of pathological changes in multiple ...
Synopsis Proton magnetic resonance spectroscopy ( 1 H-MRS) provides tissue metabolic information in vivo. ...
Acknowledgements This work was supported in part by NIH/NIBIB Grant No. EB02095 ...
doi:10.1016/j.nic.2008.08.002
pmid:19064199
pmcid:PMC2615006
fatcat:2dbu2ksz5vdwbloc7k343qlpqq
Stem Cell in Neurological Disorders
[chapter]
2011
Stem Cells in Clinic and Research
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Throughout the entire spinal cord, human NSC F3.CD cells were found to distribute diffusely to metastatic medulloblastoma cells after injection in the cisterna magna, and the CD gene in NSCs functioned ...
Its clinical value remains to be validated in controlled trials.(b) MS types characterized by neurodegenerative pathogenic components are unlikely to benefit from ASCT. ...
doi:10.5772/21408
fatcat:l67yljidrjezpgpeskjsfdsrf4
A Study of N-Acetyl aspartic acid/Creatine Ratio in the White Matter of HIV Positive Patients and Its Application
[article]
2015
arXiv
pre-print
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In all three groups the values of the mean NAA to Cr ratio ratio was significantly (p-value less than 0.05) reduced in comparison to controls. ...
A total of 50 patients were enrolled in the study, and MRI brain with MR spectroscopy was done. ...
The central caseous material however has a High ADC, with no diffusion restriction seen on the DW images. ...
arXiv:1502.07848v1
fatcat:emjhgrfwazfapjjpe4ydyxmeem
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