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Postnatal Guinea Pig Brain Development, as Revealed by Magnetic Resonance and Diffusion Kurtosis Imaging

Roger J. Mullins, Su Xu, Jiachen Zhuo, Steve Roys, Edna F.R. Pereira, Edson X. Albuquerque, Rao P. Gullapalli
2020 Brain Sciences  
The regional data analysis revealed that between-age changes of diffusion kurtosis metrics were more pronounced than those observed in diffusion tensor metrics.  ...  Anatomical T2-weighted images, diffusion kurtosis (DKI) imaging, and T2 relaxometry measures were acquired from a cohort of male guinea pigs from postnatal day (PND) 18–25 (juvenile) to PND 46–51 (adolescent  ...  A common conclusion to these studies was that DKI shows far more sensitivity to microstructural alterations in gray matter than standard DTI metrics.  ... 
doi:10.3390/brainsci10060365 pmid:32545593 pmcid:PMC7349860 fatcat:olyrw2grv5dspcfkgiaftj7ine

Delineation of early brain development from fetuses to infants with diffusion MRI and beyond

Minhui Ouyang, Jessica Dubois, Qinlin Yu, Pratik Mukherjee, Hao Huang
2018 NeuroImage  
Specifically, we review studies that delineate the emergence and microstructural maturation of white matter tracts, as well as dynamic mapping of inhomogeneous cortical microstructural organization unique  ...  Collectively, this review summarizes findings that contribute to charting spatiotemporally heterogeneous gray and white matter structural development, offering MRI-based biomarkers of typical brain development  ...  Jeffrey Neil for the comments and suggestions. We thank the lab member, Michelle Slinger, for contribution to writing.  ... 
doi:10.1016/j.neuroimage.2018.04.017 pmid:29655938 pmcid:PMC6185831 fatcat:h2qkou7sxjhe5hw4fksh6luqum

Novel Diffusion-Kurtosis-Informed Template Reduces Distortions due to Partial Volume Effects and Improves Statistical between-Group Comparisons

Farida Grinberg, Ezequiel Farrher, Xiang Gao, Kerstin Konrad, Irene Neuner, Jon Shah N
2017 Journal of Alzheimer's Disease & Parkinsonism  
Maximov for his contribution in post-processing of diffusion data.  ...  The application is demonstrated in a DKI study of a group of children versus a group of adults.  ...  fibres in the group of adults and the group of children.  ... 
doi:10.4172/2161-0460.1000393 fatcat:d6i276vjird7rgucpovikyunsa

Axonal deficits in young adults with High Functioning Autism and their impact on processing speed

Mariana Lazar, Laura M. Miles, James S. Babb, Jeffrey B. Donaldson
2014 NeuroImage: Clinical  
In this study, we sought to further characterize white matter deficits in ASD by employing an advanced diffusion imaging method, the Diffusional Kurtosis Imaging (DKI), and a two-compartment diffusion  ...  Comparative studies were conducted in 16 young male adults with High Functioning Autism (HFA) and 17 typically developing control participants (TDC).  ...  advertising the study and recruiting participants.  ... 
doi:10.1016/j.nicl.2014.01.014 pmid:24624327 pmcid:PMC3950557 fatcat:g3mehadmpfb5rnbdulj2unetiy

Recent advancements in diffusion MRI for investigating cortical development after preterm birth—potential and pitfalls

J. Dudink, K. Pieterman, A. Leemans, M. Kleinnijenhuis, A. M. van Cappellen van Walsum, F. E. Hoebeek
2015 Frontiers in Human Neuroscience  
alongside a disturbed development of neuronal connectivity as measured using diffusion magnetic resonance imaging (dMRI).  ...  Preterm infants are born during a critical period of brain maturation, in which even subtle events can result in substantial behavioral, motor and cognitive deficits, as well as psychiatric diseases.  ...  Hoebeek is supported by ZON-MW TOP-GO (10.066) and NWO-VIDI 864.11.016. The research of K. Pieterman is supported by a KNAW Ter Meulen Grant.  ... 
doi:10.3389/fnhum.2014.01066 pmid:25653607 pmcid:PMC4301014 fatcat:g4j7tr3f7naytfqdjuo2hanp4m

Brain Development From Newborn to Adolescence: Evaluation by Neurite Orientation Dispersion and Density Imaging

Xueying Zhao, Jingjing Shi, Fei Dai, Lei Wei, Boyu Zhang, Xuchen Yu, Chengyan Wang, Wenzhen Zhu, He Wang
2021 Frontiers in Human Neuroscience  
Despite recent studies suggesting that NODDI modeling might be more sensitive to brain development than diffusion tensor imaging (DTI), these studies were limited to a relatively small age range and mainly  ...  To summarize, this study verified the high sensitivity of NODDI to age over a crucial developmental period from newborn to adolescence.  ...  Both Paydar et al. (2014) and Shi et al. (2019) pointed out that except DTI, Diffusion Kurtosis Imaging (DKI) has also been applied to normal brain development by capturing the diffusion kurtosis of  ... 
doi:10.3389/fnhum.2021.616132 pmid:33790750 pmcid:PMC8005551 fatcat:wflufr5exjgynmg7mcfamwjcci

Spatially selective 2D RF inner field of view (iFOV) diffusion kurtosis imaging (DKI) of the pediatric spinal cord

Chris J. Conklin, Devon M. Middleton, Mahdi Alizadeh, Jürgen Finsterbusch, David L. Raunig, Scott H. Faro, Pallav Shah, Laura Krisa, Rebecca Sinko, Joan Z. Delalic, M.J. Mulcahey, Feroze B. Mohamed
2016 NeuroImage: Clinical  
A novel DKI imaging sequence based on a tilted 2D spatially selective radio frequency pulse providing reduced field of view (FOV) imaging was developed, implemented, and optimized on a 3 Tesla MRI scanner  ...  Software was developed and validated for post processing of the DKI images and estimation of the tensor parameters.  ...  Acknowledgments This work was funded by the National Institute of Health [Grant number RO1 NS079635-01A1].  ... 
doi:10.1016/j.nicl.2016.01.009 pmid:26909329 pmcid:PMC4735660 fatcat:wtpsmcwzuvdxzoyys2ypjjncqm

Evidence of altered age-related brain cytoarchitecture in mouse models of down syndrome: a diffusional kurtosis imaging study

Xingju Nie, Eric D. Hamlett, Ann-Charlotte Granholm, Edward S. Hui, Joseph A. Helpern, Jens H. Jensen, Heather A. Boger, Heather R. Collins, Maria F. Falangola
2015 Magnetic Resonance Imaging  
In this study we investigated the ability of diffusional kurtosis imaging (DKI) to detect the progressive developmental and neurodegenerative changes in the Ts65Dn (TS) DS mouse model.  ...  TS mice displayed higher diffusional kurtosis (DK) in the frontal cortex (FC) compared to normal mice at 2 months of age.  ...  Acknowledgments The authors wish to acknowledge and thank Ms. Claudia Umphlet and Mr. Alfred Moore for technical assistance.  ... 
doi:10.1016/j.mri.2014.12.008 pmid:25527393 pmcid:PMC4747671 fatcat:ucmv6qt6efhjdkk5nhtf6acqxi

Predicting Outcome In Childhood Diffuse Midline Gliomas Using Magnetic Resonance Imaging Based Texture Analysis

Elwira Szychot, Adam Youssef, Balaji Ganeshan, Raymond Endozo, Harpreet Hyare, Jenny Gains, Kshitij Mankad, Ananth Shankar
2020 Journal of neuroradiology  
MRTA comprised filtration-histogram technique using statistical and histogram metrics for quantification of texture.  ...  Diffuse midline gliomas (DMG) are aggressive brain tumours, previously known as diffuse intrinsic pontine gliomas (DIPG), with 10% overall survival (OS) at 18 months.  ...  Median survival of children with homogenous tumour texture (medium texture, MPP), i.e. poor prognostic group was 7.5 months compared to children with more heterogenous tumour texture, i.e. good prognostic  ... 
doi:10.1016/j.neurad.2020.02.005 pmid:32184119 fatcat:ywznwd5mprau7dcgncznyd2k4i

Investigating Brain Microstructural Alterations in Type 1 and Type 2 Diabetes Using Diffusion Tensor Imaging: A Systematic Review

Abdulmajeed Alotaibi, Christopher Tench, Rebecca Stevenson, Ghadah Felmban, Amjad Altokhis, Ali Aldhebaib, Rob A. Dineen, Cris S. Constantinescu
2021 Brain Sciences  
Diffusion Tensor Imaging (DTI) has been used as a sensitive MRI-based technique for quantifying and assessing brain microstructural abnormalities in patients with diabetes.  ...  A total of thirty-eight published studies that demonstrate the impact of diabetes mellitus on brain microstructure using DTI are included, and these demonstrate that both type 1 diabetes mellitus and type  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/brainsci11020140 pmid:33499073 fatcat:jxcl763nw5ejvav3gxap4m63iu

Diffusion Kurtosis Imaging of the neonatal Spinal Cord: design and application of the first processing pipeline implemented in Spinal Cord Toolbox [article]

Rosella Denise Tro', Monica Roascio, Domenico Tortora, Mariasavina Severino, Andrea Rossi, Julien Cohen-Adad, Marco Massimo Fato, Gabriele Arnulfo
2021 medRxiv   pre-print
Diffusion Kurtosis Imaging (DKI) has undisputed advantages over more classical diffusion Magnetic Resonance Imaging (dMRI), as witnessed by a fast-increasing number of clinical applications and software  ...  stage of development, and not identifiable with only DTI.  ...  ), University of Genoa, Italy) and the LIFT (Laboratorio di Imaging Funzionale 3 Tesla).  ... 
doi:10.1101/2021.03.12.21253413 fatcat:yaytyxwblnfvzht5shsqjaxcey

The potential role of novel diffusion imaging techniques in the understanding and treatment of epilepsy

Gavin P Winston
2015 Quantitative Imaging in Medicine and Surgery  
DTI assumes a single diffusion process following a Gaussian distribution within each voxel and is thus an overly simplistic representation of tissue microstructure.  ...  Diffusion kurtosis imaging (DKI) characterises the degree to which diffusion deviates from Gaussian behaviour and gives an idea of the underlying tissue complexity.  ...  Diffusional kurtosis imaging (DKI) Principle of method As stated above, DTI assumes that diffusion follows a Gaussian profile and is thus unrestricted.  ... 
doi:10.3978/j.issn.2223-4292.2015.02.03 pmid:25853085 pmcid:PMC4379320 fatcat:5w4tsngy3zafjo3qlnphvec6ym

Rapid microstructural plasticity in the cortical semantic network following a short language learning session

Nikola Vukovic, Brian Hansen, Torben Ellegaard Lund, Sune Jespersen, Yury Shtyrov, Timothy D. Griffiths
2021 PLoS Biology  
Learning-induced microstructural changes, as measured by diffusion kurtosis imaging (DKI) and machine learning-based analysis, were evident in prefrontal, temporal, and parietal neocortical sites, likely  ...  Even though behavioural manifestations of learning are evident near instantly, previous neuroimaging work across a range of semantic categories has largely studied neural changes associated with months  ...  Acknowledgments We would like to thank Andreas Nielsen and Jan Detlefsen for help with stimuli selection and paradigm implementation, and Camilla Andersen and Caroline Børsting for their help with MRI  ... 
doi:10.1371/journal.pbio.3001290 pmid:34125828 fatcat:ulq62c27lzagpitqgahj6iqw7u

Neurite orientation dispersion and density imaging reveals white matter microstructural alterations in adults with autism

Christina Andica, Koji Kamagata, Eiji Kirino, Wataru Uchida, Ryusuke Irie, Syo Murata, Shigeki Aoki
2021 Molecular Autism  
diffusivity [RD]) measures were compared between autism (N = 26; 19 males and 7 females; 32.93 ± 9.24 years old) and age- and sex-matched typically developing (TD; N = 25; 17 males and 8 females; 34.43  ...  Herein, we applied neurite orientation dispersion and density imaging (NODDI) to quantify and define more specific causes of WM microstructural changes associated with autism in adults.  ...  Acknowledgements The authors would like to thank all the study participants. CA is an overseas researcher under Postdoctoral Fellowship of JSPS.  ... 
doi:10.1186/s13229-021-00456-4 pmid:34193257 pmcid:PMC8247240 doaj:2460983fae9e47789eb8bc60e30df5e0 fatcat:52yh4yg5drcnhdflvfuhakn7fu

Stress-Induced Microstructural Alterations Correlate With the Cognitive Performance of Rats: A Longitudinal in vivo Diffusion Tensor Imaging Study

Szilvia Anett Nagy, Anett Vranesics, Zsófia Varga, Dávid Csabai, Nóra Bruszt, Zsolt Kristóf Bali, Gábor Perlaki, István Hernádi, Zoltán Berente, Attila Miseta, Tamás Dóczi, Boldizsár Czéh
2020 Frontiers in Neuroscience  
In vivo detection of these microstructural changes may help us to develop objective biomarkers for psychiatric disorders.  ...  We used a 4.7T small-animal MRI system and examined 18 gray and white matter structures calculating the following parameters: fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD),  ...  ACKNOWLEDGMENTS The authors would like to thank Klára Lencse for her assistance in animal care and Sai Ambika Tadepalli for her assistance in behavioral testing.  ... 
doi:10.3389/fnins.2020.00474 pmid:32581670 pmcid:PMC7283577 fatcat:uw5tttbemncqxgagbwsplrgoxy
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