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Neurobiological underpinnings of rapid white matter plasticity during intensive reading instruction [article]

Elizabeth Huber, Aviv Mezer, Jason Yeatman
2020 bioRxiv   pre-print
Here we capitalize on metrics derived from diffusion kurtosis imaging (DKI) to interpret previously reported changes in mean diffusivity throughout the white matter during an 8-week, intensive reading  ...  about white matter microstructure.  ...  "Diffusion kurtosis imaging probes cortical 544 alterations and white matter pathology following cuprizone induced demyelination 545 and spontaneous remyelination."  ... 
doi:10.1101/2020.05.28.122499 fatcat:qmy232lvivgirdlkqjs4kzekye

Magnetic Resonance Image of Neonatal Acute Bilirubin Encephalopathy: A Diffusion Kurtosis Imaging Study

Hongyi Zheng, Jiefen Lin, Qihuan Lin, Wenbin Zheng
2021 Frontiers in Neurology  
The values of mean diffusivity (MD), axial kurtosis (AK), radial kurtosis (RK), and mean kurtosis (MK), and fractional anisotropy (FA), radial diffusivity (RD), and axis diffusivity (AD) of the ROIs were  ...  This study aims to assess the value of diffusion kurtosis imaging (DKI) in detecting ABE and understanding its pathogenesis.Method: Seventy-six newborns with hyperbilirubinemia were grouped into three  ...  Diffusion kurtosis imaging probes cortical alterations and white matter pathology following cuprizone induced demyelination and spontaneous remyelination. Neuroimage.  ... 
doi:10.3389/fneur.2021.645534 pmid:34512498 pmcid:PMC8425508 fatcat:5v2tkf32xrdjdlzyuyulauwogi

ACTRIMS-ECTRIMS MSBoston 2014: Poster Sessions 2

2014 Multiple Sclerosis  
Advanced MRI techniques such as diffusion tensor (DTI) and diffusional kurtosis imaging (DKI) provide information about tissue microstructure.  ...  P493 White matter and long-tract lesions play a marginal role in determining cortical atrophy Background: To what extent retrograde axonal degeneration induces cortical atrophy in white matter diseases  ...  NMO patients show absence of demyelination and lack of cortical lesions, but presence of cortical thinning in the visual and motor cortices, suggesting that imaging measures related to grey matter (GM)  ... 
doi:10.1177/1352458514547846 pmid:25205049 pmcid:PMC4244175 fatcat:gj757y4jlvejpnrfw22guoit7m

ISNI 2012 Abstracts

2012 Journal of Neuroimmunology  
changes in the normal-appearing white matter of multiple sclerosis (MS) patients precede appearance of gadolinium-enhancing lesions.  ...  immune cell infiltration and demyelination.  ...  We propose to use Diffusional kurtosis imaging (DKI) a novel clinically feasible DWI method to probe non-Gaussian diffusion tissue properties.  ... 
doi:10.1016/j.jneuroim.2012.10.001 fatcat:bih44opaxndnxi3e7ursnupioe

The cells of the oligodendrocyte lineage are differentially altered by tau accumulation and amyloidosis

SCA Ferreira
2020
Highly myelinated white matter regions are amongst the first to be damaged in Alzheimer's disease (AD), and early oligodendrocyte damage has been detected in transgenic mice carrying human genetic variants  ...  The OPC response to glutamate and GABA was unchanged in pre-symptomatic MAPT mice; however, OPC responded more robustly to GABA in early amyloid pathology.  ...  Additionally, Benitez et al. (2014) characterized white matter tract metrics using diffusional kurtosis imaging and showed a correlation between the decrease in late-myelinating tracts integrity (superior  ... 
doi:10.25959/100.00034892 fatcat:olbtqd47pbhplchum3lc5gagc4

5th International Symposium on Focused Ultrasound

Menashe Zaaroor, Alon Sinai, Dorit Goldsher, Ayelet Eran, Maria Nassar, Ilana Schlesinger, Jonathon Parker, Vinod Ravikumar, Pejman Ghanouni, Sherman Stein, Casey Halpern, Vibhor Krishna (+1008 others)
2016 Journal of Therapeutic Ultrasound  
Contrast T1 and T2* images allowed semi-real time confirmation of BBB disruption and safety, respectively.  ...  Efficacy was assessed using an ELISA for GDNF, tyrosine hydroxylase (TH) and VMAT2 immunolabeling for neural degeneration, HPLC for dopamine, and behavioral analysis (i.e. apomorphine-induced rotational  ...  Fractional anisotropic (FA) changes in white matter fiber structure-and gray matter-abnormalities on DTI MRI were detected in regions with the T2* abnormalities suggestive of increased astrogliosis and  ... 
doi:10.1186/s40349-016-0076-5 fatcat:4vm7i5mt6vheni3hflxd3pwl2i

Quantifying brain microstructure with diffusion MRI: Theory and parameter estimation [article]

Dmitry S. Novikov, Els Fieremans, Sune N. Jespersen, Valerij G. Kiselev
2018 arXiv   pre-print
We review, systematize and discuss models of diffusion in neuronal tissue, by putting them into an overarching physical context of coarse-graining over an increasing diffusion length scale.  ...  We conclude with our outlook on the future directions which can open exciting possibilities for designing quantitative markers of tissue physiology and pathology, based on methods of studying mesoscopic  ...  Jones, and white matter modeling metrics in cuprizone-induced corpus 12 pher D Kroenke, Jens R Nyengaard, Brian Hansen, and 76 76 Yaniv Assaf, "Resolving relaxometry and diffusion proper-callosum demyelination  ... 
arXiv:1612.02059v2 fatcat:bqzc7kibe5gg5pkkioponedkq4