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Understanding Neurological Disease Mechanisms in the Era of Epigenetics

Irfan A. Qureshi, Mark F. Mehler
2013 JAMA Neurology  
and chromatin remodeling, noncoding RNA (ncRNA) expression, and RNA editing.  ...  Such noncoding regions give rise to numerous classes of noncoding RNAs (ncRNAs)-a previously unexplored layer within the genome-that are interlaced with each other and with proteincoding messenger RNAs  ... 
doi:10.1001/jamaneurol.2013.1443 pmid:23571666 pmcid:PMC4465100 fatcat:dfelhxykavchrcqrah2tsw2xki

Altered Long Noncoding RNA and Messenger RNA Expression in Experimental Intracerebral Hemorrhage - a Preliminary Study

Cui Hanjin, Liu Tao, Li Pengfei, Yang Ali, Zhou Huajun, Luo Jiekun, Wang Yang, Tang Tao
2018 Cellular Physiology and Biochemistry  
Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission.  ...  Author Contributions: WY, TT and CHJ designed the experiments. CHJ, LT, LPF, YAL and ZHJ performed the experiments. WY, TT, CHJ and LJK analyzed the data.  ...  LT, LPF, YAL, ZHJ and LJK provided insight into the interpretation of the results. CHJ wrote the manuscript. WY and TT supervised the whole experimental process and the preparation of the manuscript.  ... 
doi:10.1159/000487464 pmid:29448258 fatcat:tkp42p7kvvbllnd7jklkgwnpvm

Functions of Noncoding RNAs in Neural Development and Neurological Diseases

Shan Bian, Tao Sun
2011 Molecular Neurobiology  
In this review, we have highlighted discoveries of functions of noncoding RNAs, in particular microRNAs and long noncoding RNAs, in neural development and neurological diseases.  ...  In addition, long noncoding RNAs are found to play a role in neural development by regulating expression of protein coding genes.  ...  Dolores Malaspina, Rajiv Ratan and Quanhong Ma for critical reading of the manuscript and providing thoughtful comments.  ... 
doi:10.1007/s12035-011-8211-3 pmid:21969146 pmcid:PMC3246283 fatcat:fpcs3wcd5rcgtoqwe5tuidsxdi

Non-coding RNAs and neuroprotection after acute CNS injuries

Raghavendar Chandran, Suresh L. Mehta, Raghu Vemuganti
2017 Neurochemistry International  
Interestingly, ncRNAs have been shown to interact with messenger RNA, DNA and proteins, and these interactions could induce epigenetic modifications and control transcription and translation, thereby adding  ...  The ncRNA expression profiles are known to be altered after acute CNS injuries including stroke, traumatic brain injury and spinal cord injury that are major contributors of morbidity and mortality worldwide  ...  Acknowledgements The authors are supported by grants from American Heart Association, National Institute of Health and Veterans Administration.  ... 
doi:10.1016/j.neuint.2017.01.015 pmid:28131900 pmcid:PMC5529259 fatcat:sragv3sp6rcrvd742ctz3nbwgi

Study on the Relationship between the miRNA-centered ceRNA Regulatory Network and Fatigue

Xingzhe Yang, Feng Li, Jie Ma, Yan Liu, Xuejiao Wang, Ruochong Wang, Yifei Zhang, Wei Zhang, Qingyun He, Dandan Song, Jiaojiao Yu
2021 Journal of Molecular Neuroscience  
Transcriptome-level regulation is the key link in the gene regulatory network. The transcriptome includes messenger RNAs (mRNAs) and noncoding RNAs (ncRNAs).  ...  MRNAs are common research targets in gene expression profiling. Noncoding RNAs, including miRNAs, lncRNAs, circRNAs and so on, have been developed rapidly.  ...  syndrome; CNS: Central nervous system; DNA: Deoxyribonucleic acid; lncRNAs: Long noncoding RNAs; mRNAs: Messenger RNAs; mtDNA: Mitochondrial DNA; ncR-NAs: Noncoding RNAs; PBMC: Peripheral blood mononuclear  ... 
doi:10.1007/s12031-021-01845-3 pmid:33993410 pmcid:PMC8500871 fatcat:ehcah54tpff6totsz5lmzeybdy

The Emerging Role of Epigenetics in Stroke

Irfan A. Qureshi, Mark F. Mehler
2011 Archives of Neurology  
maintenance, neurogenesis and gliogenesis, neural subtype specification, and synaptic and neural network connectivity and plasticity.  ...  for targeted reprogramming of endogenous pools of NSPCs, neural cells at risk, and dysfunctional neural networks to rescue and restore neurologic function in the ischemic brain.  ...  RNA processing (eg, RNA modification, quality control, and intracellular and intercellular transport), and the structure and function of these complex and highly flexible RNA-based networks in the CNS  ... 
doi:10.1001/archneurol.2011.6 pmid:21403016 pmcid:PMC3671373 fatcat:u74e7hrowjghbbjajowsddugiy

Noncoding RNAs and RNA Editing in Brain Development, Functional Diversification, and Neurological Disease

Mark F. Mehler, John S. Mattick
2007 Physiological Reviews  
Therefore, nonsanc-tioned alterations in the profiles of expression of miRNAs may induce dedifferentiation and cellular transformation.  ...  A number of very long ncRNA species, termed "macroRNAs" or long expressed noncoding regions (ENORs), have recently been identified in mice (88) .  ... 
doi:10.1152/physrev.00036.2006 pmid:17615389 fatcat:ihcler6mrzb2rce4vpff4igizi

Reconstruction of circRNA-miRNA-mRNA associated ceRNA networks reveal functional circRNAs in intracerebral hemorrhage

Zhen Liu, Xinran Wu, Zihan Yu, Xiaobo Tang
2021 Scientific Reports  
Here, we described sequencing-based transcriptome profiling, providing comprehensive analysis of cerebral circRNA, messenger RNA (mRNA) and microRNA (miRNA) expression in ICH rats.  ...  These analyses revealed different expression profiles of circRNAs, mRNAs and miRNAs in day-7 and day-28 ICH groups, respectively, compared with the Sham.  ...  It revealed that both the expression profile of differentially expressed circRNAs and that of mRNAs provided adequate power to distinguish hemorrhagic from non-hemorrhagic stroke as well as hemorrhage-inducing  ... 
doi:10.1038/s41598-021-91059-9 pmid:34078991 fatcat:lrcqglmyx5hzjn6atigd3p22gm

Identification of miRNAs as the Crosstalk in the Interaction between Neural Stem/Progenitor Cells and Endothelial Cells

Xin Wang, Simin Li, Yihong Ma, Yuzhen Xu, Anthony Chukwunonso Ogbuehi, Xianda Hu, Aneesha Acharya, Rainer Haak, Dirk Ziebolz, Gerhard Schmalz, Hanluo Li, Sebastian Gaus (+4 others)
2020 Disease Markers  
Differential expression analysis (DEA) was applied to identify NSPC-induced EC alterations by comparing the expression profiles between monoculture of ECs and ECs grown in EC/NSPC cocultures.  ...  Materials and Methods. Datasets pertaining to reciprocal mRNA and noncoding RNA changes induced by the interaction between NSPCs and ECs were obtained from the GEO database.  ...  Furthermore, miRNA crosstalk analysis and functional enrichment analysis were performed, and the relationship between DEmiRNAs and small molecular drug targets/environment chemical compounds was investigated  ... 
doi:10.1155/2020/6630659 pmid:33381243 pmcid:PMC7758130 fatcat:nwlf3jjefrendjcc4czictkeyq

Role of Non-Coding RNAs in Stroke

Steffen Tiedt, Martin Dichgans
2018 Stroke  
By convention, ncRNAs are divided into long noncoding RNAs (lncRNAs) ≥200 nucleotides in length and small non-coding RNAs (<200 nucleotides), which include microRNAs (miRNAs), PIWI (P-element-induced wimpy  ...  Conformational rearrangements within the RNA-induced silencing complex allow the 6 to 8 nucleotides long miRNA seed region to scan for target messenger RNAs (mRNA; Figure 1A ). 3 Binding of complementary  ... 
doi:10.1161/strokeaha.118.021010 fatcat:ef3ayzx2wnf2znuc6ctpzy6tcm

MicroRNAs as Effectors of Brain Function with Roles in Ischemia and Injury, Neuroprotection, and Neurodegeneration

Julie A Saugstad
2010 Journal of Cerebral Blood Flow and Metabolism  
Owing to constraints, many of these central studies are cited in reviews, and exclusion of any particular article was not  ...  Peripheral blood examined in ischemic stroke patients revealed differential expression of microRNAs implicated in endothelial cell and vascular function, erythropoiesis, angiogenesis, neural function,  ...  for inducing neurogenesis during CNS development (Visvanathan et al, 2007) .  ... 
doi:10.1038/jcbfm.2010.101 pmid:20606686 pmcid:PMC2932764 fatcat:eti4mtqhm5eozc3mobhfoehlcu

Non-coding RNAs as Emerging Regulators of Neural Injury Responses and Regeneration

Songlin Zhou, Fei Ding, Xiaosong Gu
2016 Neuroscience Bulletin  
It has been shown that numerous ncRNAs, especially microRNAs and long non-coding RNAs, are differentially expressed after insults such as acquired brain injury, spinal cord injury, and peripheral nerve  ...  Non-coding RNAs (ncRNAs) are a large cluster of RNAs that do not encode proteins, but have multiple functions in diverse cellular processes.  ...  (miRNAs, miRs), small interfering RNAs (siRNAs), Piwi-interacting RNAs (piRNAs), and long chain noncoding RNAs (long non-coding RNAs, lncRNAs).  ... 
doi:10.1007/s12264-016-0028-7 pmid:27037691 pmcid:PMC5563772 fatcat:b54chtnlwzhr7aq6cl7m366o5e

Analysis of Long Non-Coding RNA expression profiles in neonatal rats with hypoxic-ischemic brain damage

Han Zhou, Xuan Wang, Rui Cheng, Xuewen Hou, Ying Chen, Yun Feng, Jie Qiu
2019 Journal of Neurochemistry  
To give a foundation for subsequent functional studies of lncRNAs in HIBD, we investigated the profiling of lncRNAs and messenger RNAs (mRNAs) using neonatal HIBD rat model.  ...  Long non-coding RNAs (lncRNAs) were demonstrated to play a crucial role in many diseases.  ...  Acknowledgments and conflict of interest disclosure All experiments were conducted in compliance with the ARRIVE guidelines.  ... 
doi:10.1111/jnc.14689 pmid:30802942 fatcat:w5vpcyhoejgqbofbs3vmk5daji

Epitranscriptomic regulation of transcriptome plasticity in development and diseases of the brain

Chan-Woo Park, Sung-Min Lee, Ki-Jun Yoon
2020 BMB Reports  
Proper development of the nervous system is critical for its function, and deficits in neural development have been implicated in many brain disorders.  ...  Here, we review recent advances in our understanding of molecular regulation on transcriptome plasticity by RNA modifications in neurodevelopment and how alterations in these RNA regulatory programs lead  ...  ACKNOWLEDGEMENTS We thank for wonderful illustrations by Jaewook Lee, and for careful reading and suggestions by Huiseon Hwang. This work was supported by the National Research Foundation of Korea  ... 
doi:10.5483/bmbrep.2020.53.11.204 fatcat:htdnnrafqzbfhnwi4vjcmmzf7i

The functional role of long non-coding RNAs and epigenetics

Jinneng Cao
2014 Biological Procedures Online  
This review will focus on the functional roles of lncRNAs in epigenetics and related research progress will be summarized. Figure 2 Long non-coding RNA-mediated transcription regulation. A.  ...  Recent recognition that lncRNAs make effects in many biological and pathological processes such as stem cell pluripotency, neurogenesis, oncogenesis and etc.  ...  Epigenetic role for lncRNAs in gene activation The dynamics of miRNA regulatory network mediated by RNA editing is implicated in stroke.  ... 
doi:10.1186/1480-9222-16-11 pmid:25276098 pmcid:PMC4177375 fatcat:46fz4ee7xnhwzfxtt5u2evayoq
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