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Understanding Neurological Disease Mechanisms in the Era of Epigenetics
2013
JAMA Neurology
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and chromatin remodeling, noncoding RNA (ncRNA) expression, and RNA editing. ...
Such noncoding regions give rise to numerous classes of noncoding RNAs (ncRNAs)-a previously unexplored layer within the genome-that are interlaced with each other and with proteincoding messenger RNAs ...
doi:10.1001/jamaneurol.2013.1443
pmid:23571666
pmcid:PMC4465100
fatcat:dfelhxykavchrcqrah2tsw2xki
Altered Long Noncoding RNA and Messenger RNA Expression in Experimental Intracerebral Hemorrhage - a Preliminary Study
2018
Cellular Physiology and Biochemistry
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Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission. ...
Author Contributions: WY, TT and CHJ designed the experiments. CHJ, LT, LPF, YAL and ZHJ performed the experiments. WY, TT, CHJ and LJK analyzed the data. ...
LT, LPF, YAL, ZHJ and LJK provided insight into the interpretation of the results. CHJ wrote the manuscript. WY and TT supervised the whole experimental process and the preparation of the manuscript. ...
doi:10.1159/000487464
pmid:29448258
fatcat:tkp42p7kvvbllnd7jklkgwnpvm
Functions of Noncoding RNAs in Neural Development and Neurological Diseases
2011
Molecular Neurobiology
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In this review, we have highlighted discoveries of functions of noncoding RNAs, in particular microRNAs and long noncoding RNAs, in neural development and neurological diseases. ...
In addition, long noncoding RNAs are found to play a role in neural development by regulating expression of protein coding genes. ...
Dolores Malaspina, Rajiv Ratan and Quanhong Ma for critical reading of the manuscript and providing thoughtful comments. ...
doi:10.1007/s12035-011-8211-3
pmid:21969146
pmcid:PMC3246283
fatcat:fpcs3wcd5rcgtoqwe5tuidsxdi
Non-coding RNAs and neuroprotection after acute CNS injuries
2017
Neurochemistry International
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Interestingly, ncRNAs have been shown to interact with messenger RNA, DNA and proteins, and these interactions could induce epigenetic modifications and control transcription and translation, thereby adding ...
The ncRNA expression profiles are known to be altered after acute CNS injuries including stroke, traumatic brain injury and spinal cord injury that are major contributors of morbidity and mortality worldwide ...
Acknowledgements The authors are supported by grants from American Heart Association, National Institute of Health and Veterans Administration. ...
doi:10.1016/j.neuint.2017.01.015
pmid:28131900
pmcid:PMC5529259
fatcat:sragv3sp6rcrvd742ctz3nbwgi
Study on the Relationship between the miRNA-centered ceRNA Regulatory Network and Fatigue
2021
Journal of Molecular Neuroscience
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Transcriptome-level regulation is the key link in the gene regulatory network. The transcriptome includes messenger RNAs (mRNAs) and noncoding RNAs (ncRNAs). ...
MRNAs are common research targets in gene expression profiling. Noncoding RNAs, including miRNAs, lncRNAs, circRNAs and so on, have been developed rapidly. ...
syndrome; CNS: Central nervous system; DNA: Deoxyribonucleic acid; lncRNAs: Long noncoding RNAs; mRNAs: Messenger RNAs; mtDNA: Mitochondrial DNA; ncR-NAs: Noncoding RNAs; PBMC: Peripheral blood mononuclear ...
doi:10.1007/s12031-021-01845-3
pmid:33993410
pmcid:PMC8500871
fatcat:ehcah54tpff6totsz5lmzeybdy
The Emerging Role of Epigenetics in Stroke
2011
Archives of Neurology
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maintenance, neurogenesis and gliogenesis, neural subtype specification, and synaptic and neural network connectivity and plasticity. ...
for targeted reprogramming of endogenous pools of NSPCs, neural cells at risk, and dysfunctional neural networks to rescue and restore neurologic function in the ischemic brain. ...
RNA processing (eg, RNA modification, quality control, and intracellular and intercellular transport), and the structure and function of these complex and highly flexible RNA-based networks in the CNS ...
doi:10.1001/archneurol.2011.6
pmid:21403016
pmcid:PMC3671373
fatcat:u74e7hrowjghbbjajowsddugiy
Noncoding RNAs and RNA Editing in Brain Development, Functional Diversification, and Neurological Disease
2007
Physiological Reviews
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Therefore, nonsanc-tioned alterations in the profiles of expression of miRNAs may induce dedifferentiation and cellular transformation. ...
A number of very long ncRNA species, termed "macroRNAs" or long expressed noncoding regions (ENORs), have recently been identified in mice (88) . ...
doi:10.1152/physrev.00036.2006
pmid:17615389
fatcat:ihcler6mrzb2rce4vpff4igizi
Reconstruction of circRNA-miRNA-mRNA associated ceRNA networks reveal functional circRNAs in intracerebral hemorrhage
2021
Scientific Reports
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Here, we described sequencing-based transcriptome profiling, providing comprehensive analysis of cerebral circRNA, messenger RNA (mRNA) and microRNA (miRNA) expression in ICH rats. ...
These analyses revealed different expression profiles of circRNAs, mRNAs and miRNAs in day-7 and day-28 ICH groups, respectively, compared with the Sham. ...
It revealed that both the expression profile of differentially expressed circRNAs and that of mRNAs provided adequate power to distinguish hemorrhagic from non-hemorrhagic stroke as well as hemorrhage-inducing ...
doi:10.1038/s41598-021-91059-9
pmid:34078991
fatcat:lrcqglmyx5hzjn6atigd3p22gm
Identification of miRNAs as the Crosstalk in the Interaction between Neural Stem/Progenitor Cells and Endothelial Cells
2020
Disease Markers
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Differential expression analysis (DEA) was applied to identify NSPC-induced EC alterations by comparing the expression profiles between monoculture of ECs and ECs grown in EC/NSPC cocultures. ...
Materials and Methods. Datasets pertaining to reciprocal mRNA and noncoding RNA changes induced by the interaction between NSPCs and ECs were obtained from the GEO database. ...
Furthermore, miRNA crosstalk analysis and functional enrichment analysis were performed, and the relationship between DEmiRNAs and small molecular drug targets/environment chemical compounds was investigated ...
doi:10.1155/2020/6630659
pmid:33381243
pmcid:PMC7758130
fatcat:nwlf3jjefrendjcc4czictkeyq
Role of Non-Coding RNAs in Stroke
2018
Stroke
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By convention, ncRNAs are divided into long noncoding RNAs (lncRNAs) ≥200 nucleotides in length and small non-coding RNAs (<200 nucleotides), which include microRNAs (miRNAs), PIWI (P-element-induced wimpy ...
Conformational rearrangements within the RNA-induced silencing complex allow the 6 to 8 nucleotides long miRNA seed region to scan for target messenger RNAs (mRNA; Figure 1A ). 3 Binding of complementary ...
doi:10.1161/strokeaha.118.021010
fatcat:ef3ayzx2wnf2znuc6ctpzy6tcm
MicroRNAs as Effectors of Brain Function with Roles in Ischemia and Injury, Neuroprotection, and Neurodegeneration
2010
Journal of Cerebral Blood Flow and Metabolism
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Owing to constraints, many of these central studies are cited in reviews, and exclusion of any particular article was not ...
Peripheral blood examined in ischemic stroke patients revealed differential expression of microRNAs implicated in endothelial cell and vascular function, erythropoiesis, angiogenesis, neural function, ...
for inducing neurogenesis during CNS development (Visvanathan et al, 2007) . ...
doi:10.1038/jcbfm.2010.101
pmid:20606686
pmcid:PMC2932764
fatcat:eti4mtqhm5eozc3mobhfoehlcu
Non-coding RNAs as Emerging Regulators of Neural Injury Responses and Regeneration
2016
Neuroscience Bulletin
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It has been shown that numerous ncRNAs, especially microRNAs and long non-coding RNAs, are differentially expressed after insults such as acquired brain injury, spinal cord injury, and peripheral nerve ...
Non-coding RNAs (ncRNAs) are a large cluster of RNAs that do not encode proteins, but have multiple functions in diverse cellular processes. ...
(miRNAs, miRs), small interfering RNAs (siRNAs), Piwi-interacting RNAs (piRNAs), and long chain noncoding RNAs (long non-coding RNAs, lncRNAs). ...
doi:10.1007/s12264-016-0028-7
pmid:27037691
pmcid:PMC5563772
fatcat:b54chtnlwzhr7aq6cl7m366o5e
Analysis of Long Non-Coding RNA expression profiles in neonatal rats with hypoxic-ischemic brain damage
2019
Journal of Neurochemistry
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To give a foundation for subsequent functional studies of lncRNAs in HIBD, we investigated the profiling of lncRNAs and messenger RNAs (mRNAs) using neonatal HIBD rat model. ...
Long non-coding RNAs (lncRNAs) were demonstrated to play a crucial role in many diseases. ...
Acknowledgments and conflict of interest disclosure All experiments were conducted in compliance with the ARRIVE guidelines. ...
doi:10.1111/jnc.14689
pmid:30802942
fatcat:w5vpcyhoejgqbofbs3vmk5daji
Epitranscriptomic regulation of transcriptome plasticity in development and diseases of the brain
2020
BMB Reports
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Proper development of the nervous system is critical for its function, and deficits in neural development have been implicated in many brain disorders. ...
Here, we review recent advances in our understanding of molecular regulation on transcriptome plasticity by RNA modifications in neurodevelopment and how alterations in these RNA regulatory programs lead ...
ACKNOWLEDGEMENTS We thank for wonderful illustrations by Jaewook Lee, and for careful reading and suggestions by Huiseon Hwang. This work was supported by the National Research Foundation of Korea ...
doi:10.5483/bmbrep.2020.53.11.204
fatcat:htdnnrafqzbfhnwi4vjcmmzf7i
The functional role of long non-coding RNAs and epigenetics
2014
Biological Procedures Online
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This review will focus on the functional roles of lncRNAs in epigenetics and related research progress will be summarized. Figure 2 Long non-coding RNA-mediated transcription regulation. A. ...
Recent recognition that lncRNAs make effects in many biological and pathological processes such as stem cell pluripotency, neurogenesis, oncogenesis and etc. ...
Epigenetic role for lncRNAs in gene activation The dynamics of miRNA regulatory network mediated by RNA editing is implicated in stroke. ...
doi:10.1186/1480-9222-16-11
pmid:25276098
pmcid:PMC4177375
fatcat:46fz4ee7xnhwzfxtt5u2evayoq
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