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Regional Cerebral Blood Flow Single Photon Emission Computed Tomography for detection of Frontotemporal dementia in people with suspected dementia

Hilary A Archer, Nadja Smailagic, Christeena John, Robin B Holmes, Yemisi Takwoingi, Elizabeth J Coulthard, Sarah Cullum
2015 The Cochrane library  
Eight of the 11 studies which used SPECT to differentiate FTD from Alzheimer's disease used multiple-headed camera SPECT.  ...  Background This review focused on one type of dementia, frontotemporal dementia (FTD).  ...  Reference standards We considered a diagnosis of FTD based on any of the following recognised diagnostic criteria as acceptable. Lund-Manchester (Lund and Manchester Groups 1994) 1.  ... 
doi:10.1002/14651858.cd010896.pub2 pmid:26102272 fatcat:ztvhdfvczffttmnqvrmuvpe2l4

Single-photon emission computed tomography perfusion imaging in the differential diagnosis of dementia: a retrospective regional audit

M. Doran, S. Vinjamuri, J. Collins, D. Parker, A. J. Larner
2005 International journal of clinical practice  
Application of easy Z score imaging system (eZIS) on brain perfusion SPECT images for quantitative evaluation of rCBF has attempted to explore the differential diagnosis of dementia with various degenerative  ...  diseases and to evaluate discrimination of early Alzheimer's disease (AD) from other types of dementia.  ...  Waragai et al. revealed that eZIS analysis of SPECT images could be convenient for the early and differential diagnosis of patients with neurodegenerative disease, including dementing diseases, AD, frontotemporal  ... 
doi:10.1111/j.1368-5031.2005.00499.x pmid:15853870 fatcat:gpy64iuggne5zfvuizriw2grla

Evaluation of brain perfusion in specific Brodmann areas in Frontotemporal dementia and Alzheimer disease using automated 3-D voxel based analysis

V Valotassiou, J Papatriantafyllou, N Sifakis, C Karageorgiou, I Tsougos, C Tzavara, C Zerva, P Georgoulias
2009 Journal of Instrumentation  
diagnosis of the dementia subtype is based on the postmortem examination of the brain [7] .  ...  Introduction Frontotemporal dementia (FTD) and Alzheimer's disease (AD) have been recognized as distinct clinical syndromes for a number of years, the former considered to be one of the most common neurodegenerative  ... 
doi:10.1088/1748-0221/4/05/p05020 fatcat:n3nwsodqyzfz5cofcibbu5j7om

Differential Diagnosis Between Neurodegenerative Dementia Disorders and Parkinson's Disease Using 99mTc-HMPAO SPECT

Barbara Palumbo, Donatella Siepi, Serena Amici, Helmut Sinzinger
2014 The Open Nuclear Medicine Journal  
Materials and Methods: We retrospectively evaluated 104 patients, 30 with Alzheimer's disease (AD), 26 with frontotemporal dementia (FTD), 25 with mild cognitive impairment (MCI), 23 with PD, undergoing  ...  Introduction and Objective: To investigate perfusion in dementia and Parkinson's disease (PD) we performed 99m Tc-HMPAO brain SPECT with semiquantitative analysis of Brodmann areas in different aged patients  ...  to the differential diagnosis.  ... 
doi:10.2174/1876388x01406010001 fatcat:erjagtze3rbhjhgbhecjsaxtti

Diagnostic imaging of dementia with Lewy bodies, frontotemporal lobar degeneration, and normal pressure hydrocephalus

Kazunari Ishii
2019 Japanese Journal of Radiology  
In DLB, medial temporal atrophy is milder than that of Alzheimer's disease. 2-fluoro-2-deoxy-D-glucose-positron emission tomography and brain perfusion single-photon emission computed tomography demonstrate  ...  Neuroimaging can provide important biomarkers and is very useful for supporting dementia diagnosis.  ...  (FP-CIT) single-photon emission computed tomography (SPECT) images of DLB and Alzheimer's disease.  ... 
doi:10.1007/s11604-019-00881-9 pmid:31549279 fatcat:dr4ao34npbdvtmasd74qnhxbbm

Behavioral variant frontotemporal dementia with dominant gait disturbances - case report
Wariant behawioralny otępienia czołowo-skroniowego z dominującymi zaburzeniami chodu w obrazie klinicznym – opis przypadku

Wojciech Guenter, Ewa Betscher, Paweł Bochniak, Robert Bonek
2016 Psychiatria Polska  
It is the second most common neurodegenerative cause of dementia after Alzheimer's type dementia.  ...  However, it is not a predominant symptom of behavioural variant frontotemporal dementia excluding terminal stage of the disease. Conclusions.  ...  SCEPT image of the brain: A -axial SPECT/CT fused image; B -sagittal SPECT image state that gait is not an automatic motor activity independent of cognitive processes.  ... 
doi:10.12740/pp/58937 pmid:27288678 fatcat:vl4dh7z2mvblfoh6mh6lzt6fra

Alzheimer's disease and frontotemporal dementia are differentiated by discriminant analysis applied to 99mTc HmPAO SPECT data

P Charpentier
2000 Journal of Neurology, Neurosurgery and Psychiatry  
Objective-Alzheimer's disease (AD) and frontotemporal dementia (FTD) are the most frequent neurodegenerative cognitive disorders. However, FTD remains poorly recognised clinically.  ...  value of SPECT in diVerential diagnosis between AD and FTD.  ...  The frontotemporal dementia (FTD) concept still needs clinical and non-clinical tools to enable better discrimination. The main diVerential diagnosis remains Alzheimer's disease (AD).  ... 
doi:10.1136/jnnp.69.5.661 pmid:11032624 pmcid:PMC1763418 fatcat:4tepghmssfhfzg6jehyuw3gsyq

Neuroimaging characteristics of dementia with Lewy bodies

Elijah Mak, Li Su, Guy B Williams, John T O'Brien
2014 Alzheimer's Research & Therapy  
DLB shares common clinical, neuropsychological and pathological features with Parkinson's disease dementia and other dementia subtypes, such as Alzheimer's disease.  ...  We also discuss the increasingly important role of imaging biomarkers in differential diagnosis and outline promising areas for future research in DLB.  ...  Acknowledgements This work was supported by the NIHR Biomedical Research Unit in Dementia and the Biomedical Research Centre awarded to Cambridge University Hospitals NHS Foundation Trust and the University  ... 
doi:10.1186/alzrt248 pmid:25031634 pmcid:PMC4055038 fatcat:c7tko6q7tjafjkb7dtmjz2mfn4

Application of Artificial Neural Networks to Identify Alzheimer's Disease Using Cerebral Perfusion SPECT Data

Dariusz Świetlik, Jacek Białowąs
2019 International Journal of Environmental Research and Public Health  
The aim of this study was to demonstrate the usefulness of artificial neural networks in Alzheimer disease diagnosis (AD) using data of brain single photon emission computed tomography (SPECT).  ...  The sensitivity of Alzheimer disease diagnosis detection by artificial neural network and discriminant analysis were 93.8% and 86.1%, respectively, and the corresponding specificity was 100% and 95%.  ...  Dougall et al. suggested that perfusion SPECT is unable to draw a clear line between AD and other dementias [35] .  ... 
doi:10.3390/ijerph16071303 pmid:30979022 pmcid:PMC6479441 fatcat:k5x74wl5sncujnga2xmalcffky

Neuronuclear Imaging in the Evaluation of Dementia and Mild Decline in Cognition

Nare Torosyan, Daniel H.S. Silverman
2012 Seminars in nuclear medicine  
in the human brain --especially, processes that herald impending dementia due to Alzheimer's disease (AD), in its prodromal form.  ...  Recently, the National Institute on Aging (NIA) and the Alzheimer's Association (AA), identified specific structural and functional neuroimaging findings as valuable markers of biological processes occurring  ...  Levels of specific proteins in CSF, and scans obtained with MRI, SPECT, and PET, serve as biomarkers with varying degrees of utility for predicting subsequent cognitive decline, as discussed in detail  ... 
doi:10.1053/j.semnuclmed.2012.06.004 pmid:23026363 pmcid:PMC4309799 fatcat:npndyl4arvgz5ni47qbm7wzwqq

Neuroimaging in Lewy body dementia

Tayyabah Yousaf, George Dervenoulas, Polytimi-Eleni Valkimadi, Marios Politis
2018 Journal of Neurology  
Early diagnosis of DLB has been challenging; particularly in the context of differentiation with Parkinson's disease dementia and other forms of dementias, such as Alzheimer's disease and rapidly progressive  ...  Structural imaging techniques have an essential role for excluding structural causes, which could lead to a DLBlike phenotype, as well as aiding differential diagnosis through illustrating disease-specific  ...  , AD Alzheimer's disease, HC healthy controls, PD Parkinson's disease, PDD Parkinson's disease dementia, FTD frontotemporal dementia, MCI mild cognitive impairment, VaD vascular dementia,  ... 
doi:10.1007/s00415-018-8892-x pmid:29761296 fatcat:4aaplvy7bjcitcsigarc5rswhi

Joint Assessment of Structural, Perfusion, and Diffusion MRI in Alzheimer's Disease and Frontotemporal Dementia

Yu Zhang, Norbert Schuff, Christopher Ching, Duygu Tosun, Wang Zhan, Marzieh Nezamzadeh, Howard J. Rosen, Joel H. Kramer, Maria Luisa Gorno-Tempini, Bruce L. Miller, Michael W. Weiner
2011 International Journal of Alzheimer's Disease  
Most MRI studies of Alzheimer's disease (AD) and frontotemporal dementia (FTD) have assessed structural, perfusion and diffusion abnormalities separately while ignoring the relationships across imaging  ...  Joint assessments of multimodal MRI have potential value to provide new imaging markers for improved differential diagnoses between FTD and AD.  ...  Shannon Buckley and Mr. Pouria Mojabi for assistance with image processing, Mr. Philip Insel for the help with statistics, and Dr. Susanne Mueller for the advice in data analysis.  ... 
doi:10.4061/2011/546871 pmid:21760989 pmcid:PMC3132541 fatcat:kesbbet2yzdhxjz52lejs2di2a

Pulsed Arterial Spin Labeling and Segmented Brain Volumetry in the Diagnostic Evaluation of Frontotemporal Dementia, Alzheimer's Disease and Mild Cognitive Impairment

Dominique Cornelius Marterstock, Michael Franz Xaver Knott, Philip Hoelter, Stefan Lang, Timo Oberstein, Johannes Kornhuber, Arnd Doerfler, Manuel A. Schmidt
2022 Tomography  
Methods: Our study comprised 17 patients with diagnosed cognitive impairment (five Alzheimer's disease = AD, five frontotemporal dementia = FTD, seven mild cognitive impairment = MCI) and 19 healthy control  ...  between brain maps with atrophy and this non-contrast-enhanced brain-perfusion method.  ...  In particular, Alzheimer's disease (AD)-the most common cause of dementia (~70%)-and frontotemporal dementia (FTD) are well-examined conditions.  ... 
doi:10.3390/tomography8010018 pmid:35076603 pmcid:PMC8788517 fatcat:flq2dgj6e5dq3dashv5sudv4oq

Regional Cerebral Blood Flow in Alzheimer's Disease: Classification and Analysis of Heterogeneity

Siegbert Warkentin, Mattias Ohlsson, Per Wollmer, Lars Edenbrandt, Lennart Minthon
2004 Dementia and Geriatric Cognitive Disorders  
The study population consisted of one group of 92 normal healthy subjects and one group of 132 patients with mild-tomoderate Alzheimer's disease.  ...  Neural networks have been successfully applied to brain perfusion images to classify patients with Alzheimer's disease from normal or other patient populations.  ...  The diagnosis of AD was made by exclusion of other dementias, in accordance with the National Institute of Neurological and Communication Disorders and Stroke-Alzheimer's Disease and Related Disorders  ... 
doi:10.1159/000076358 pmid:14739546 fatcat:ytpvaljqprbp3j43e5qpvuycfi

Combining SPECT and Quantitative EEG Analysis for the Automated Differential Diagnosis of Disorders with Amnestic Symptoms

Yvonne Höller, Arne C. Bathke, Andreas Uhl, Nicolas Strobl, Adelheid Lang, Jürgen Bergmann, Raffaele Nardone, Fabio Rossini, Harald Zauner, Margarita Kirschner, Amirhossein Jahanbekam, Eugen Trinka (+1 others)
2017 Frontiers in Aging Neuroscience  
We aimed to increase the diagnostic power by combining quantitative markers from SPECT and EEG for differential diagnosis of disorders with amnestic symptoms.  ...  We suggest that quantitative analysis of EEG and machine-learning techniques can support differentiating AD, aMCI, aSCC, and DCC, especially when being combined with imaging methods such as SPECT.  ...  ACKNOWLEDGMENTS We thank the memory clinic and the EEG-staff for their routine work in collecting the data, Andreas Westiner for help in organizing the data, and Gert Dehnen for helpful suggestions for  ... 
doi:10.3389/fnagi.2017.00290 pmid:28936173 pmcid:PMC5594223 fatcat:biimatqr7benvod3undj3wj4ea
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