Filters








26,436 Hits in 5.0 sec

Differential Gene Expression in the Auditory System [chapter]

Irene S. Gabashvili, Richard J. Carter, Peter Markstein, Anne B. S. Giersch
2005 Lecture Notes in Computer Science  
Development of appropriate therapeutic approaches requires understanding of the auditory system, which remains largely incomplete.  ...  We have identified hearing-specific genes and pathways by mapping over 15000 cochlear expressed sequence tags (ESTs) to the human genome (NCBI Build 35) and comparing it to other EST clusters (Unigene  ...  We have mapped and analyzed genes predominantly expressed in the inner ear and their pathways. We have also studied cochlear genes expressed in low numbers.  ... 
doi:10.1007/11532323_1 fatcat:tt3bbbabu5bhbdcwwrztd3t2lu

Differential gene expression during compensatory sprouting of dendrites in the auditory system of the cricketGryllus bimaculatus

H. W. Horch, S. S. McCarthy, S. L. Johansen, J. M. Harris
2009 Insect molecular biology (Print)  
Several candidates identified in this study are known to influence the translation and degradation of proteins in other systems.  ...  The potential role of these factors in the compensatory sprouting of cricket auditory interneurons in response to denervation is discussed.  ...  Given the robust nature of the compensatory growth of dendrites in the cricket auditory system, we have used suppression subtractive hybridization to ask which genes are differentially expressed after  ... 
doi:10.1111/j.1365-2583.2009.00891.x pmid:19453768 pmcid:PMC3551613 fatcat:xg2djhmivfelzc2ms2s4le3t34

Gene expression underlying enhanced, steroid-dependent auditory sensitivity of hair cell epithelium in a vocal fish

Daniel J. Fergus, Ni Y. Feng, Andrew H. Bass
2015 BMC Genomics  
Gene ontology (GO) term enrichment analyses of the differentially expressed transcripts showed that the reproductive saccular epithelium was transcriptionally, translationally, and metabolically more active  ...  Conclusions: We identified a suite of differentially expressed genes belonging to neurotransmission and steroid-signaling pathways, consistent with previous work showing the importance of these characters  ...  We are grateful to the Broad Institute, particularly Brian Haas, for providing and assisting with the Trinity software package.  ... 
doi:10.1186/s12864-015-1940-3 pmid:26466782 pmcid:PMC4607102 fatcat:55dnaf5ngjecld6ivhho6fkebq

Intrinsically Self-renewing Neuroprogenitors From the A/J Mouse Spiral Ganglion as Virtually Unlimited Source of Mature Auditory Neurons

Francis Rousset, Vivianne B. C. Kokje, Rebecca Sipione, Dominik Schmidbauer, German Nacher-Soler, Sten Ilmjärv, Marta Coelho, Stefan Fink, François Voruz, Antoun El Chemaly, Antoine Marteyn, Hubert Löwenheim (+4 others)
2020 Frontiers in Cellular Neuroscience  
The differentiated cells express both neuronal and glial cell phenotypic markers and exhibit similar functional properties as mouse spiral ganglion primary explants and human sphere-derived spiral ganglion  ...  In contrast to other rodent models aiming at sustained production of auditory neurons, no genetic transformation of the progenitors is needed.  ...  FIGURE 4 | 4 Changes in gene expression upon differentiation.  ... 
doi:10.3389/fncel.2020.599152 pmid:33362466 pmcid:PMC7761749 fatcat:z2i7zzte5zdsfk5zpwzaiawxlu

Neural stem/progenitor cell properties of glial cells in the adult mouse auditory nerve

Hainan Lang, Yazhi Xing, LaShardai N. Brown, Devadoss J. Samuvel, Clarisse H. Panganiban, Luke T. Havens, Sundaravadivel Balasubramanian, Michael Wegner, Edward L. Krug, Jeremy L. Barth
2015 Scientific Reports  
NSPs have been characterized in several locations in the adult nervous system, including the subgranular zone (SGZ) of the dentate gyrus, the subventricular zone (SVZ) of the lateral ventricle, and the  ...  We examined the regenerative potential of the auditory nerve in a mouse model of auditory neuropathy.  ...  Of the 506 adult stemness genes Figure 5. Validation of differential gene expression in ouabain-injured auditory nerve.  ... 
doi:10.1038/srep13383 pmid:26307538 pmcid:PMC4549618 fatcat:2rgwudu5hnbfxdvrfxzicwazoq

Taming of the wild: a new tool for cross study RNA-seq analysis applied to behavioural traits in dogs and tame foxes

Diana Lobo, Raquel Godinho, John Archer
2022 Zenodo  
The expression analysis revealed 21 over expressed and 3 under expressed gene families in common in the brain of dogs and tame foxes. Among those, seven [...]  ...  By applying our method, the distribution of the gene-wise dispersion estimates improved and the number of outliers detected in differential expression analysis decreased.  ...  Over Expressed -21 gene families: -Total = 50 genes genes in common Under Expressed -3 gene families: -Total = 4 genes Target given the need that domestic animals had to face new conditions and pathogens  ... 
doi:10.5281/zenodo.6107386 fatcat:2ajsspdldjep5pewj73vnwbwce

Preliminary studies on differential expression of auditory functional genes in the brain after repeated blast exposures

Manojkumar Valiyaveettil, Yonas Alamneh, Stacy-Ann Miller, Rasha Hammamieh, Ying Wang, Peethambaran Arun, Yanling Wei, Samuel Oguntayo, Madhusoodana P Nambiar
2012 Journal of rehabilitation research and development  
Differential expression of cadherin and protocadherin genes, which are involved in hearing impairment, was observed in the hippocampus, cerebellum, frontal cortex, and midbrain after repeated blasts.  ...  We analyzed the expression of hearing-related genes in different regions of the brain 6 h after repeated blast exposures in mice.  ...  The gene expression profile showed differential pattern in various regions of the brain of mice exposed to repeated blasts.  ... 
pmid:23341286 fatcat:6txcawe2b5f4nke5xlgoz5ufse

Preliminary studies on differential expression of auditory functional genes in the brain after repeated blast exposures

Manojkumar Valiyaveettil, Yonas Alamneh, Stacy-Ann Miller, Rasha Hammamieh, Ying Wang, Peethambaran Arun, Yanling Wei, Samuel Oguntayo; Madhusoodana P. Nambiar, Madhusoodana P. Nambiar
2012 Journal of rehabilitation research and development  
Differential expression of cadherin and protocadherin genes, which are involved in hearing impairment, was observed in the hippocampus, cerebellum, frontal cortex, and midbrain after repeated blasts.  ...  We analyzed the expression of hearingrelated genes in different regions of the brain 6 h after repeated blast exposures in mice.  ...  The gene expression profile showed differential pattern in various regions of the brain of mice exposed to repeated blasts.  ... 
doi:10.1682/jrrd.2011.09.0182 fatcat:w245cby7obct3hafkicarhpcoa

Lhx3, a LIM domain transcription factor, is regulated by Pou4f3 in the auditory but not in the vestibular system

Ronna Hertzano, Amiel A. Dror, Mireille Montcouquiol, Zubair M. Ahmed, Buffy Ellsworth, Sally Camper, Thomas B. Friedman, Matthew W. Kelley, Karen B. Avraham
2007 European Journal of Neuroscience  
This is the first example of a hair cell-specific gene expressed both in auditory and in vestibular hair cells, with differential regulation of expression in these two closely related systems.  ...  Lhx3 is a hair cell-specific gene expressed in all hair cells of the auditory and vestibular system as early as embryonic day 16.  ...  Acknowledgements We would like to thank Leonid Mittleman for confocal microscopy, Darcy Butts for animal care and Rani Elkon for the bioinformatic analysis of the microarrays.  ... 
doi:10.1111/j.1460-9568.2007.05332.x pmid:17331196 fatcat:vltchonimrf2jmnjmrdbneaexi

Cell Type–Specific Transcriptome Analysis Reveals a Major Role for Zeb1 and miR-200b in Mouse Inner Ear Morphogenesis

Ronna Hertzano, Ran Elkon, Kiyoto Kurima, Annie Morrisson, Siaw-Lin Chan, Michelle Sallin, Andrew Biedlingmaier, Douglas S. Darling, Andrew J. Griffith, David J. Eisenman, Scott E. Strome, Wayne N. Frankel
2011 PLoS Genetics  
The mammalian inner ear consists of the auditory and vestibular systems that are each composed of hair cells, supporting cells, neurons, mesenchymal cells, other epithelial cells, and blood vessels.  ...  Furthermore, we detected a misregulation of the ZEB1 pathway in the inner ear of Twirler mice, which manifest, among other phenotypes, malformations of the auditory and vestibular labyrinth.  ...  Dror for in situ hybridization advice; Dr. Guy P. Richardson and Dr. Christine Petit for antibodies; Dr. Thomas B. Friedman, Dr. Doris K. Wu, and Dr.  ... 
doi:10.1371/journal.pgen.1002309 pmid:21980309 pmcid:PMC3183091 fatcat:a7xyxis4ojggrfkufpsl34avdq

A Review of Gene Delivery and Stem Cell Based Therapies for Regenerating Inner Ear Hair Cells

Keerthana Devarajan, Hinrich Staecker, Michael S. Detamore
2011 Journal of Functional Biomaterials  
In this review article, we evaluate the use of several genes involved in hair cell regeneration, the advantages and disadvantages of the different viral vectors employed in inner ear gene delivery and  ...  Understanding the role of genes, vectors and stem cells in therapeutic strategies led us to explore potential solutions to overcome the limitations associated with their use in hair cell regeneration.  ...  Expressed in supporting cells of auditory and vestibular system.  ... 
doi:10.3390/jfb2030249 pmid:24956306 pmcid:PMC4030941 fatcat:nk25u3l5wra3jbw4h3zbrnhkq4

Filling the Silent Void: Genetic Therapies for Hearing Impairment

Joel Sng, Thomas Lufkin
2012 Genetics Research International  
This paper provides a brief introduction into the key role of genes regulating inner ear development and function.  ...  Owing to the inability of the mammalian cochlea to regenerate sensory hair cells, the loss of hair cells is a leading cause of deafness in humans.  ...  The inner ear is comprised of two main components, the auditory system which receives the amplified mechanical vibrations transmitted from the middle ear and the vestibular system which is responsible  ... 
doi:10.1155/2012/748698 pmid:23304527 pmcid:PMC3529436 fatcat:dyyk4titbrfkfaaail6wbc5ima

RNA Microarray Analysis in Prenatal Mouse Cochlea Reveals Novel IGF-I Target Genes: Implication of MEF2 and FOXM1 Transcription Factors

Hortensia Sanchez-Calderon, Lourdes Rodriguez-de la Rosa, Marta Milo, Jose G. Pichel, Matthew Holley, Isabel Varela-Nieto, Rafael Linden
2010 PLoS ONE  
In the mouse, deficits in IGF-I result in profound hearing loss associated with reduced survival, differentiation and maturation of auditory neurons.  ...  Parallel, in silico promoter analysis of the genes modulated in conjunction with the loss of IGF-I revealed the possible involvement of MEF2 in cochlear development.  ...  Acknowledgments We appreciate the critical reading and useful comments done by Drs. J. A.  ... 
doi:10.1371/journal.pone.0008699 pmid:20111592 pmcid:PMC2810322 fatcat:x2czhaie75dznelx6btanf627e

A Critical E-box in Barhl1 3′ Enhancer Is Essential for Auditory Hair Cell Differentiation

Kun Hou, Hui Jiang, Md. Rezaul Karim, Chao Zhong, Zhouwen Xu, Lin Liu, Minxin Guan, Jianzhong Shao, Xiao Huang
2019 Cells  
In brief, our findings delineate the detail molecular mechanism of Barhl1 expression regulation in auditory hair cell differentiation.  ...  Barhl1, a mouse homologous gene of Drosophila BarH class homeobox genes, is highly expressed within the inner ear and crucial for the long-term maintenance of auditory hair cells that mediate hearing and  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/cells8050458 fatcat:br2iq3nwenhexldmwxh5gwfrue

Genome-wide identification and expression profiling of long non-coding RNAs in auditory and vestibular systems

Kathy Ushakov, Tal Koffler-Brill, Aviv Rom, Kobi Perl, Igor Ulitsky, Karen B. Avraham
2017 Scientific Reports  
However, little is known about lncRNA function in the auditory and vestibular systems, or how they play a role in deafness and vestibular dysfunction.  ...  The spatial and temporal patterns of three lncRNAs, two of which are in proximity to genes associated with hearing and deafness, were explored further.  ...  The four RNA-seq datasets were deposited in NCBI and are available in the Gene Expression Omnibus (GEO) repository under accession no. GSE97270 (E16.5) and no.  ... 
doi:10.1038/s41598-017-08320-3 pmid:28819115 pmcid:PMC5561060 fatcat:qgoo7iedsfbnde67nolcjenj6e
« Previous Showing results 1 — 15 out of 26,436 results