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Alternative to animal experimentation in pharmacology teaching: Development and validation of an equivalent digital learning tool

Roland Lawson, Sophie Leymarie, Claire Nikitopoulos, Antoine Humeau, Hichem Bouchenaki, Jean‐Luc Duroux, Laurent Fourcade, Sandrine Karam, Nicolas Picard, Claire Demiot
2022 Pharmacology Research & Perspectives  
The participants were randomly assigned to groups of traditional or digital teaching methods, with the common theme of the class being the effect of a diuretic agent (furosemide) in rats.  ...  It found the two teaching methods (digital and traditional) to be equivalent in terms of motivation and knowledge acquisition.  ...  Know how to use experimental data and present it in the form of a graph Existing knowledge Renal physiology Pharmacology and therapeutic effect of diuretic agents Ethic of animal experimentation Regulation  ... 
doi:10.1002/prp2.908 pmid:35147294 pmcid:PMC8929359 fatcat:honydrv2mbegpj5m26cj3wlocq

A Review of Treatment of Coronavirus Disease 2019 (COVID-19): Therapeutic Repurposing and Unmet Clinical Needs

Po-Lin Chen, Nan-Yao Lee, Cong-Tat Cia, Wen-Chien Ko, Po-Ren Hsueh
2020 Frontiers in Pharmacology  
However, a trend could be observed based on current clinical evidence.  ...  Combination therapy of traditional Chinese medicine with antiviral agents (ex. interferon, lopinavir, or arbidol) may alleviate inflammation in severe COVID-19 patients based on small sample-sized observational  ...  Many drugs in emergency use are based on in vitro evidence or expert opinions.  ... 
doi:10.3389/fphar.2020.584956 pmid:33364959 pmcid:PMC7751753 fatcat:vk2orkjojza2hanekb4eufqzfq

A Case-Based Toxicology Elective Course to Enhance Student Learning in Pharmacotherapy

Stacy D. Brown, Brooks B. Pond, Kathryn A. Creekmore
2011 American Journal of Pharmaceutical Education  
A case-based clinical toxicology elective course that contained topics from 2 required courses, Pharmacology III and Pharmacotherapy II, was offered in the spring 2009 to second-and third-year pharmacy  ...  To assess the impact of a case-based toxicology elective course on student learning in related required courses and student performance on the Pharmacy Curriculum Outcomes Assessment (PCOA) examination  ...  Wendy Williams of the Office of Admissions and Records for graciously providing data in support of this project.  ... 
doi:10.5688/ajpe756118 pmid:21931456 pmcid:PMC3175670 fatcat:alvyvs3qcreyldiwbsdbp44s3e

How to Valorize Biodiversity? Let's Go Hashing, Extracting, Filtering, Mining, Fishing

Quoc Do, José Medina-Franco, Thomas Scior, Philippe Bernard
2015 Planta Medica  
Karina Martinez-Mayorga for her insightful discussions, stimulating ideas, and fruitful conversations. Conflict of Interest ! The authors declare that they do not have any conflict of interest.  ...  A total of eight satiety agents were identified in the literature, which were used as reference compounds for similarity searching.  ...  In actual applications of similarity searching, and molecular similarity analysis in general, a number of different types of representations are used.  ... 
doi:10.1055/s-0034-1396314 pmid:25714727 fatcat:ytrehxb7q5f77cxceajmr3mgri

Paramedics Australasia International Conference abstracts and poster presentations

Jamie Nathan Rhodes
2020 Australasian Journal of Paramedicine  
This online competency tool should be considered across any workplace that requires the use of competency based clinical assessment and used in place of traditional paper-based portfolios.  ...  Within the preceptor results, 63 ± 2% of preceptors felt the CompTracker© was preferred over the traditional paper-based methods.  ... 
doi:10.33151/ajp.16.773 fatcat:fcu7xrkdpzfi3b37mjr3t6zc4q

Medical students' personal knowledge, searching proficiency, and database use in problem solving

Barbara M. Wildemuth, Ruth de Bliek, Charles P. Friedman, Dean D. File
1995 Journal of the American Society for Information Science  
The relationship between personal knowledge in a domain and searching proficiency in that domain, and the relationship between searching proficiency and database-assisted problem-solving performance were  ...  On four assessment occasions over a 2-year period, 36 medical students solved problems in three biomedical domains (bacteriology, pharmacology, and toxicology) with and without assistance from a factual  ...  Personal Knowledge Score Bacteriology Fall 90 vs. Spr 9 1 Spr 91 vs. Fall 91 ** ** Pharmacology Fall 91 vs. Spr 92 n.s. Toxicology Spr 91 vs. Spr 92 n.s.  ... 
doi:10.1002/(sici)1097-4571(199509)46:8<590::aid-asi7>;2-# fatcat:4xud4kreerfpxp6luvq3hy6bna

Novel Natural Products for Healthy Ageing from the Mediterranean Diet and Food Plants of Other Global Sources—The MediHealth Project

Birgit Waltenberger, Maria Halabalaki, Stefan Schwaiger, Nicolas Adamopoulos, Noureddine Allouche, Bernd Fiebich, Nina Hermans, Pidder Jansen-Dürr, Victor Kesternich, Luc Pieters, Stefan Schönbichler, Alexios-Leandros Skaltsounis (+7 others)
2018 Molecules  
To achieve this goal, a series of plants from the Mediterranean diet and food plants from other origins are carefully selected and subjected to in silico, cell-based, in vivo (fly and mouse models), and  ...  There is a rapid increase in the percentage of elderly people in Europe. Consequently, the prevalence of age-related diseases will also significantly increase.  ...  To our knowledge, these methods have so far not been used in NPs research.  ... 
doi:10.3390/molecules23051097 pmid:29734769 fatcat:enho2taurnag5evb6322kc6kl4

Evolving Roles of Spontaneous Reporting Systems to Assess and Monitor Drug Safety [chapter]

Emanuel Raschi, Ugo Moretti, Francesco Salvo, Antoine Pariente, Ippazio Cosimo Antonazzo, Fabrizio De Ponti, Elisabetta Poluzzi
2018 Pharmacovigilance [Working Title]  
Many sources of data and relevant methods of analysis are used in PhV: from disproportionality analyses (DAs) in spontaneous reporting systems (SRSs) to analytical studies (cohort or case-control designs  ...  Clinical pharmacology knowledge is requested to design and interpret results from DMAs and to decide if further examination is needed (either within the same source of data or by other types of data) or  ...  In a recent study, a web-based search query method called "query log reaction score" was developed to detect whether adverse events associated with certain drugs could be found from search engine query  ... 
doi:10.5772/intechopen.79986 fatcat:bguoxablmzbqxhqilyfxeltbwi

Mining external RD

Alan L. Porter, Nils C. Newman
2011 Technovation  
., Rindflesch T.C. (2007) : Using the literature-based discovery paradigm to investigate drug mechanisms.  ...  Ultimately, one can even discover new knowledge by screening research databases. Once one determines the value in mining external R&D, tough issues remain to be overcome.  ...  A research team in China searches a US maintained database to isolate research results from over 1,000 addiction articles from around 30 different countries.  ... 
doi:10.1016/j.technovation.2011.01.001 fatcat:6akfe7ljuzhydovoilw6yxv2oa

Mobile health applications for managing atrial fibrillation for healthcare professionals and patients: a systematic review

Deirdre A Lane, Naoimh McMahon, Josephine Gibson, Jo C Weldon, Michal M Farkowski, Radoslaw Lenarczyk, Caroline L Watkins, Polychronis Dilaveris, Enrico G Caiani, Tatjana S Potpara
2020 Europace  
Mobile health apps ranged widely in design, features, and method of delivery.  ...  Methods and results MEDLINE, EMBASE, CINAHL, and PsychInfo were searched from 1 January 2005 to 5 September 2019, with hand-searching of clinical trial registers and grey literature.  ...  P.D. has been a speaker for Abbott, Boehringer Ingelheim, Biotronik, and Medtronic; and served in the advisory board for Boehringer Ingelheim.  ... 
doi:10.1093/europace/euaa269 pmid:32853369 fatcat:zekrl53jangv3hno74dtnikshu

2014 CSHP National Awards Program Winners Programme national des prix 2014 de la SCPH : lauréats et lauréates

The Canadian Journal Of Hospital Pharmacy
2014 The Canadian Journal of Hospital Pharmacy  
a difference in 30 day postdischarge patient hospital visits.  ...  Inherent toxicity vs. occupational exposure NIOSH defines hazard based on inherent drug toxicity.  ...  Methods: Information was retrieved via a MEDLINE search for English language human studies and case reports for the years 2011present.  ... 
doi:10.4212/cjhp.v67i1.1326 fatcat:ui4cy5q2sfh55eieaaoz3zio64

A Machine Learning Approach to Identify Clinical Trials Involving Nanodrugs and Nanodevices from

Diana de la Iglesia, Miguel García-Remesal, Alberto Anguita, Miguel Muñoz-Mármol, Casimir Kulikowski, Víctor Maojo, Vasilis J. Promponas
2014 PLoS ONE  
Our method involves several stages: i) extraction and manual annotation of CTs as nano vs. non-nano, ii) pre-processing and automatic classification, and iii) performance evaluation using several state-of-the-art  ...  Finding out whether nanodrugs and nanodevices were involved in a study from CT summaries alone is a challenging task.  ...  Julián Dorado, from the University of A Coruñ a (Spain), who provided invaluable insight and expertise for assessing and curating the extensive body of material used in this research.  ... 
doi:10.1371/journal.pone.0110331 pmid:25347075 pmcid:PMC4210133 fatcat:sagbusgf2bdlvbncvqbv46qwsm

Intra-Target Microdosing (ITM): A Novel Drug Development Approach Aimed at Enabling Safer and Earlier Translation of Biological Insights Into Human Testing

T Burt, RJ Noveck, DB MacLeod, AT Layton, M Rowland, G Lappin
2017 Clinical and Translational Science  
with the advantage of using human-based data to inform the models.  ...  interest enables detection of changes in biomarkers indicative of drug efficacy or toxicity, such as displacement of PET ligands at pharmacologically active concentrations (an advantage vs. traditional  ... 
doi:10.1111/cts.12464 pmid:28419765 pmcid:PMC5593170 fatcat:2aaky6ogebfy3eskcjvuw756rm

Drug Discovery for Mycobacterium tuberculosis Using Structure-Based Computer-Aided Drug Design Approach

Murtala A. Ejalonibu, Segun A. Ogundare, Ahmed A. Elrashedy, Morufat A. Ejalonibu, Monsurat M. Lawal, Ndumiso N. Mhlongo, Hezekiel M. Kumalo
2021 International Journal of Molecular Sciences  
In recent times, new techniques, which involve computational and analytical methods, enhanced the chances of drug development, as opposed to traditional drug design methods, which are laborious and time-consuming  ...  The computational techniques in drug design have been improved with a new generation of software used to develop and optimize active compounds that can be used in future chemotherapeutic development to  ...  acknowledge the College of Health Science, University of KwaZulu-Natal, South Africa, and the Centre of High-Performance Computing (CHPC), Cape Town, RSA, for computational resources (, last access  ... 
doi:10.3390/ijms222413259 pmid:34948055 pmcid:PMC8703488 fatcat:wyw2ukfdwrf6rp76agwifbat6a

The Pharmacology of Buprenorphine Microinduction for Opioid Use Disorder

Joao P De Aquino, Suprit Parida, Mehmet Sofuoglu
2021 Clinical drug investigation  
Although expanding the availability of buprenorphine-a first-line pharmacotherapy for opioid-use disorder (OUD)-has increased the capacity of healthcare systems to offer treatment, starting this medication  ...  In this review, we examine the pharmacological basis for microinduction and appraise the evidence of this approach to improve clinical outcomes among persons with OUD.  ...  Importantly, the potency of a pharmacological agent depends on both its affinity and efficacy.  ... 
doi:10.1007/s40261-021-01032-7 pmid:33818748 pmcid:PMC8020374 fatcat:3n2moamadrhsved65x3qovyyju
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