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Differences in biophysical properties of nucleus accumbens medium spiny neurons emerging from inactivation of inward rectifying potassium currents

John Steephen, Rohit Manchanda
2007 BMC Neuroscience  
Conclusion These results show that clear biophysical differences in the properties of medium spiny neurons can emerge owing to the presence of inactivation in K IR channels and indicate that these differences  ...  We describe a computational study comparing the biophysical properties of medium spiny neurons possessing these two types of currents.  ... 
doi:10.1186/1471-2202-8-s2-p116 fatcat:cjmf3jqlavcxfd4tyu5z6tublu

Differences in biophysical properties of nucleus accumbens medium spiny neurons emerging from inactivation of inward rectifying potassium currents

John Eric Steephen, Rohit Manchanda
2009 Journal of Computational Neuroscience  
Conclusion These results show that clear biophysical differences in the properties of medium spiny neurons can emerge owing to the presence of inactivation in K IR channels and indicate that these differences  ...  We describe a computational study comparing the biophysical properties of medium spiny neurons possessing these two types of currents.  ... 
doi:10.1007/s10827-009-0161-7 pmid:19488844 fatcat:cdxa3jfek5blvbqez447zrgfjm

Computational modeling of medium spiny projection neurons in nucleus accumbens: toward the cellular mechanisms of afferent stream integration

J.A. Wolf, L.F. Schroeder, L.H. Finkel
2001 Proceedings of the IEEE  
We describe simulations of a biophysical level model of a single medium spiny projection (MSP) neuron, the principle cell of the Nacc.  ...  We describe simulations of a biophysical level model of a single medium spiny projection (MSP) neuron, the principle cell of the Nacc.  ...  Wilson for providing the code for his potassium channel models as well as a number of insightful and helpful suggestions, and E. Menschik for guidance on the implementation.  ... 
doi:10.1109/5.939824 fatcat:ecag43pppfcztojakucyigr4b4

Intrinsic neuronal excitability: implications for health and disease

Rajiv Wijesinghe, Aaron J. Camp
2011 Biomolecular Concepts  
AbstractThe output of a single neuron depends on both synaptic connectivity and intrinsic membrane properties.  ...  The literature reviewed here shows that changes in intrinsic neuronal excitability (presumably in concert with synaptic plasticity) can fundamentally modify the output of neurons, and that these modifications  ...  Katie Dixon for useful comments on a previous version of this manuscript. We would also like to apologize for the fact that not all authors and studies could be included in this short review.  ... 
doi:10.1515/bmc.2011.026 pmid:25962033 fatcat:a36t3pgttzcljmwru6kvb3355m

Axon Physiology

Dominique Debanne, Emilie Campanac, Andrzej Bialowas, Edmond Carlier, Gisèle Alcaraz
2011 Physiological Reviews  
Giraud for providing confocal images of labeled neurons, and S. Binczak for helpful discussion. We thank J. J. Garrido, A. Marty, M. Seagar, and F.  ...  Tell for helpful comments on the manuscript and the members of D. Debanne's lab for positive feedback.  ...  Nav channels generate three different Na ϩ currents that can be distinguished by their biophysical properties, namely, 1) the fast-inactivating transient Na ϩ current (I NaT ), the persistent Na ϩ current  ... 
doi:10.1152/physrev.00048.2009 pmid:21527732 fatcat:ansqtculhngthjpefvbkgdspdu

Role of Dopamine Neurons in Reward and Aversion: A Synaptic Plasticity Perspective

Marco Pignatelli, Antonello Bonci
2015 Neuron  
This biophysical feature parallels a very unique inward rectifying current-voltage relationship that can be used to determine the presence or absence of GluA2-lacking AMPARs.  ...  Given the functional importance of GABAergic neurons located within the VTA, it is important to note that they receive inhibitory input from medium spiny neurons of the NAc (Bocklisch et al., 2013) ,  ... 
doi:10.1016/j.neuron.2015.04.015 pmid:26050034 fatcat:cshz3xi22nfvli46xyhawi6cpq

KIAA0209 [chapter]

2018 Encyclopedia of Signaling Molecules  
endogenous Kal-7 levels decreases spine density in medium spiny neurons in the rat nucleus accumbens (NAc), a brain region involved in drug addiction (Ma et al. 2012) .  ...  Medium levels of kalirin are found in amygdala, nucleus accumbens, caudate putamen, anterior olfactory nucleus, and thalamus.  ... 
doi:10.1007/978-3-319-67199-4_105424 fatcat:ulgmrsfczzhthfyi2cgsg3phvy

The Sigma-1 Receptor: When Adaptive Regulation of Cell Electrical Activity Contributes to Stimulant Addiction and Cancer

Olivier Soriani, Saïd Kourrich
2019 Frontiers in Neuroscience  
In this review, we present the current state of knowledge on σ1R's role in the regulation of cellular electrical activity, and how this seemingly adaptive function can shift cell homeostasis and contribute  ...  to the development of very distinct chronic pathologies such as psychostimulant abuse and tumor cell growth in cancers.  ...  These protein complexes undergo enduring cocaine-driven upregulation in NAc inhibitory medium spiny projection neurons (MSNs) and thereby lead to persistent decrease in neuronal intrinsic excitability  ... 
doi:10.3389/fnins.2019.01186 pmid:31780884 pmcid:PMC6861184 fatcat:d6z7zm4dzjfcbl7clg7wvesy5i

Stress-induced neuronal hypertrophy decreases the intrinsic excitability in stress habituation [article]

Sara Matovic, Aoi Ichiyama, Hiroyuki Igarashi, Eric W Salter, Xie-Fan Wang, Mathilde Henry, Nathalie Vernoux, Marie-Eve Tremblay, Wataru Inoue
2019 bioRxiv   pre-print
neurons of the HPA axis.  ...  We found that the intrinsic excitability of these neurons substantially decreased after daily repeated restraint stress in a time course that coincided with their loss of stress responsiveness in vivo.  ...  Interestingly, Francis et al. (2017) recently reported a complementary finding that chronic social defeat stress causes dendritic atrophy of dopamine D1 containing medium spiny neurons in the nucleus  ... 
doi:10.1101/593665 fatcat:uu6lg32acvhvxh6tdbnqxyzxii

30th Annual Computational Neuroscience Meeting: CNS*2021–Meeting Abstracts

2021 Journal of Computational Neuroscience  
Currently, most functional models of neural activity are based on firing rates, while the most relevant signals for inter-neuron communication are spikes.  ...  One of the goals of neuroscience is to understand the computational principles that describe the formation of behaviorally relevant signals in the brain, as well as how these computations are realized  ...  O14 On the role of arkypallidal and prototypical neurons for neural synchronization in the basal ganglia Acknowledgements This work was supported by NIH-NIBIB (R01-EB027584).  ... 
doi:10.1007/s10827-021-00801-9 pmid:34931275 pmcid:PMC8687879 fatcat:evpmmfpaivgpxdqpive5xdgmwu

Deficiency of aldose reductase attenuates inner retinal neuronal changes in a mouse model of retinopathy of prematurity

Zhongjie Fu, Shen Nian, Suk-Yee Li, David Wong, Sookja K. Chung, Amy C. Y. Lo
2015 Graefe's Archives for Clinical and Experimental Ophthalmology  
Results: Previously, we find that 50 Hz electromagnetic field can hardly make any influence on potassium current of rat cerebellar granule neurons.  ...  But in this research, results showed that chlorine current of rat cerebellar granule neurons induced by GABA increased after 1 hour exposed by 1 mT 50 Hz electromagnetic field.  ...  current (I Kur ) and transient outward potassium current (I to ) in human atrial myocytes, and also acetylcholine-activated potassium current (I K.ACh ).  ... 
doi:10.1007/s00417-015-3024-0 pmid:25921391 fatcat:unct52ay2bbsdi3dwydcwlx4vy

Extraction of spatio-temporal primitives of emotional body expressions

Lars Omlor, Martin A. Giese
2007 Neurocomputing  
) was adapted and extended by the Hodgkin-Huxley formalisms of the inward rectifying current IKIR and the leak potassium current ITASK (carried by TASK channels, TWIKrelated acid-sensitive K+ channels)  ...  potassium currents.  ... 
doi:10.1016/j.neucom.2006.10.100 fatcat:esivhljzsbcihdl5qbp756josu

25th Annual Computational Neuroscience Meeting: CNS-2016

Tatyana O. Sharpee, Alain Destexhe, Mitsuo Kawato, Vladislav Sekulić, Frances K. Skinner, Daniel K. Wójcik, Chaitanya Chintaluri, Dorottya Cserpán, Zoltán Somogyvári, Jae Kyoung Kim, Zachary P. Kilpatrick, Matthew R. Bennett (+597 others)
2016 BMC Neuroscience  
Part of this complexity is related to the number of different cell types that work together to encode stimuli.  ...  These results outline a framework for categorizing neuronal types based on their functional properties.  ...  Acknowledgements: The work of JB, RG, and SMC was supported in part by R01MH1006674 from the National Institutes of Health.  ... 
doi:10.1186/s12868-016-0283-6 pmid:27534393 pmcid:PMC5001212 fatcat:bt45etzj2bbolfcxlxo7hlv6ju

EMG-based Simultaneous and Proportional Estimation of Wrist Kinematics and its Application in Intuitive Myoelectric Control for Unilateral transradial Amputees

Farina Dario
2011 Frontiers in Computational Neuroscience  
[T 67] Developmental changes of activity in simple biological neuronal networks Steffen Kandler 1,2,3* , Samora Okujeni 1,2,3 , Sebastian Reinartz 2 and Ulrich Egert 1,3 *steffen.kandler@bcf.uni-freiburg.de  ...  Rose (Institute for Neurobiology, Heinrich-Heine-University Düsseldorf) for her inspiring advices on neurobiological aspects of the potassium spatial buffering.  ...  When analyzing medium spiny neuron calcium imaging data, we again find that the results of the two methods are not in line.  ... 
doi:10.3389/conf.fncom.2011.53.00081 fatcat:nkq5wesfpbcjnikbxqh3v3gtqi

Abstracts of the Tenth Annual Meeting of the Israel Society for Neurosciences

2001 Neural Plasticity  
In line with the literature, there was no difference in the mean execution time in the two conditions (Logan and Zbrodoff, Journal of Experimental Psychology: HPP 24(3_): 978-992 199.8]).  ...  According to the model, the conflicting intirmatign arriving from the intended processing of color and the (unintended) automatic reading finds, its expression.either in an incorrect response or in an  ...  Thus, this current belongs to the delayed rectifier family. The properties of these currents were incorporated into a model cell using the Neuron modeling simulator.  ... 
doi:10.1155/np.2001.157 pmid:11783444 pmcid:PMC2565376 fatcat:ybrait32srfhbaddpozdxlwvcu
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