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Arti Dhawal Shah, Nihar Vishnubhai Patel, Stani Francis Ajay, Rahul Ashok Pandya, Ajay George Aakkara, Dhawal Niranjan Shah, Vivek Thanga Durai, Niraj Nandakishore Murkey
2016 Journal of Evidence Based Medicine and Healthcare  
INTRODUCTION Spirometry is indicated to detect whether a pulmonary dysfunction is present or not, to rate the severity of a known pulmonary disease, to follow up the pulmonary function. Snoring is the vibration of respiratory structures and the resulting sound. Snoring during sleep may be the first sign of obstructive sleep apnoea (OSA). Common signs of OSA include unexplained daytime sleepiness, restless sleep, and loud snoring (with periods of silence followed by gasps). With this high
more » ... nce of OSA and the rising worldwide increase in morbidity and mortality in chronic obstructive pulmonary disease (COPD), more research required comparing nocturnal respiratory disturbances with attention directed on the effect of body composition, severity of OSA and severity of airway obstruction. MATERIAL & METHODS A cross-sectional observational study was carried out in snorers at Department of Respiratory Medicine. All patients underwent spirometry and PSG. RESULTS There was no significant correlation between severity of snoring and any spirometry parameter. CONCLUSION In our study, there was no correlation between snoring and spirometry nor between spirometry and AHI. It may be because of less number of subjects in our study, so study with large numbers of subjects are required to bring out the correlation.
doi:10.18410/jebmh/2016/545 fatcat:sbqtki4vk5egxnbdjznhpogavu

Ammonium Sulfate and Ultrafine Particles Affect Early Onset of Alzheimer's Disease

Samal Kaumbekova, Mehdi Amouei Torkmahalleh, Dhawal Shah
2021 Chemical Engineering Transactions  
Recent environmental studies have shown the impact of air quality on human health and in particular, toxicological effect of particulate matter (PM) and ultrafine particles (UFPs) on progression of neurodegenerative diseases. While in-vivo experiments reveal enhanced concentration of amyloid beta peptides in the brains of animals after the exposure to PM and UFPs, the molecular interactions between peptides and atmospheric pollutants remain obscure. In this study, molecular dynamics simulations
more » ... were performed to investigate the effect of UFPs on the aggregation of amyloid beta peptides, associated with the development of Alzheimer's Disease (AD) in human brain. In particular, the changes in the structure of eight Aß16-21 peptides, the segment of Aß1-42 peptide with the high propensity to aggregate were investigated. The aggregation kinetics of Aß16-21 peptides and amount of beta sheets in their secondary structures were studied in the presence of varying concentrations of NH4+ and SO4-2 ions, common secondary inorganic ions found in the environmental realm from the different sources of atmospheric pollution. Moreover, the effect of hydrophobic UFP, modelled by C60 molecule, on the structure of peptides was analysed. The aggregation kinetics was calculated by estimating the time necessary to reach Solvent Accessible Surface Area (SASA) of peptides of 60 nm2. The study demonstrated that, although, the inhibitory effect of hydrophobic UFP on the formation of beta sheets was revealed, there could be a synergistic effect of the concentration of (NH4)2SO4 salt and presence of UFP on the aggregation kinetics of peptides. Among three different salt concentrations of 0.15 M, 0.25 M and 0.35 M, the slowest aggregation of peptides in the absence of C60 molecule and the fastest aggregation in the presence of C60 were observed at 0.25 M of (NH4)2SO4.
doi:10.3303/cet2185032 doaj:d7c6e9494d014e6b8bba5bf20e02cffa fatcat:kcki65et3zcedlr3flc5z3e4gy

Thermogravimetric Study of Refuse Derived Fuel Produced from Municipal Solid Waste of Kazakhstan

Botagoz Kuspangaliyeva, Botakoz Suleimenova, Dhawal Shah, Yerbol Sarbassov
2021 Applied Sciences  
Efficient waste management, including proper utilization of municipal solid waste (MSW), is imperative for a sustainable future. Among several management options, pyrolysis and combustion of MSW has regained interest because of improved combustion techniques. This work aims to investigate the thermal conversion and combustion characteristics of refuse derived solid fuel (RDF) samples and its individual compounds collected from Nur-Sultan's MSW landfills. The waste-derived solid RDF samples
more » ... nally consist of textile, mixed paper, and mixed plastic. In particular, the samples, including RDF and its three constituent components, were analyzed in the temperature range of 25 to 900 °C, at three different heating rates, by thermogravimetric method. The gross calorific value for RDF derived from Nur-Sultan's MSW was determined to be 23.4 MJ/kg. The weight loss rates of the samples, differential thermogravimetry (DTG), and kinetic analysis were compared between individual RDF components and for the mixed RDF. Combustion kinetics models were calculated using Flynn–Wall–Ozawa (FWO), Kissinger–Akahira–Sunose (KAS), and Friedman methods. The results revealed that first decomposition of RDF samples was observed at the range of 180–370 °C. Moreover, the activation energy for conversion of RDF was observed to be the highest among the constituent components and gradually decreased from 370 to 140 kJ/kmol.
doi:10.3390/app11031219 fatcat:x24eq3qsvjd6rkcgzwjkz3bvra

Evaluation of disulfiram in the treatment of alcoholism

V N Bagadia, K M Dhawale, L P Shah, P V Pradhan
1982 Indian Journal of Psychiatry  
Seventy five male patients with the diagnosis of alcohol dependence syndrome were given disulfiram and an alcohol challenge was administered to all of them. They were kept on maintenance dose of the drug and followed up for six months, note being made of their improvement on several parameters, viz. the number of drinking episodes, the sevarity of reaction suffered, the side effects experienced etc. Twenty one patients were considered as drop outs and four were abstainent without the aid of the
more » ... drug. 54 % of the fifty patients who continued taking the drug showed good to moderate improvement. 42% had one or more drinking episode while consuming the tablets. Older patients, and those brought by relatives and friends did better than the others. Results are discussed.
pmid:21965919 pmcid:PMC3012813 fatcat:lu2emeifufctfnmcseq3dytyhu

Skeletal Fluorosis With Thoracic Myelopathy: A Report of 2 Cases

Darshil Shah, Arjun Dhawale, Kshitij Chaudhary, Ajinkya Achalare
2021 The International Journal of Spine Surgery  
To report 2 different presentations of thoracic myelopathy with ossification of ligamantum flavum (OLF) due to fluorosis. Two females presented with thoracic myelopathy secondary to spinal stenosis with OLF due to fluorosis. On examination, the first patient had a grade 4 power in both lower limbs with altered sensation below L1 dermatome. She had segmental OLF on magnetic resonance imaging and computed tomography and was treated with posterior thoracic laminectomy and recovered well. The
more » ... patient had a history of a prior thoracic laminectomy at another institution and presented with paraplegia with bladder involvement. Radiological investigations revealed a 3-column injury at the level of D8/D9. This patient was treated with decompression and stabilization. The first patient recovered neurologically and regained independent ambulation while the second patient had a reduction in spasticity but no recovery of power or bladder function. Different presentations and causes of myelopathy due to OLF should be recognized and treated. An unstable injury is very rare and should not be missed.
doi:10.14444/7170 pmid:33900950 pmcid:PMC7888201 fatcat:bmsuoggjznb27i4uflexem7ndm

Enhanced arsenate uptake in Saccharomyces cerevisiae overexpressing the Pho84 phosphate transporter

Michael W.Y. Shen, Dhawal Shah, Wilfred Chen, Nancy Da Silva
2012 Biotechnology progress (Print)  
in Wiley Online Library ( Arsenate is a major toxic constituent in arsenic-contaminated water supplies. Saccharomyces cerevisiae was engineered as a potential biosorbent for enhanced arsenate accumulation. The phosphate transporter, Pho84p, known to import arsenate, was overexpressed using a 2l-based vector carrying PHO84 under the control of the late-phase ADH2 promoter. Arsenate uptake was then evaluated using a resting cell system. In buffer solutions containing high
more » ... rsenate concentrations (12,000 and 30,000 ppb), the engineered strains internalized up to 750 lg of arsenate per gram of cells, a 50% improvement over control strains. Increasing the cell mass 2.5-fold yielded a proportional increase in the volumetric arsenate uptake, while maintaining the same level of specific uptake. At high levels of arsenate, loss from the intact cells to the medium was observed with time; knockouts of two known arsenic extrusion genes, ACR3 and FPS1, did not prevent this loss. At trace level concentrations (120 ppb), rapid and total arsenate removal was observed. The presence of 50 lM phosphate reduced uptake by approximately 15% in buffer containing 80 lM (6,000 ppb) arsenate. At trace levels of arsenate (70 ppb), the phosphate reduced the initial rate of uptake, but not the total amount removed. PHO84 mRNA levels were nearly 30 times higher in the engineered strains relative to the control strains. Uptake may no longer be a limiting factor in the engineered system and further increases should be possible by upregulating the downstream reduction and sequestration pathways.
doi:10.1002/btpr.1531 pmid:22628173 fatcat:bcadggfxgrbhph4knyxjutabii

Enhanced arsenic accumulation in Saccharomyces cerevisiae overexpressing transporters Fps1p or Hxt7p

Dhawal Shah, Michael W.Y. Shen, Wilfred Chen, Nancy A. Da Silva
2010 Journal of Biotechnology  
Arsenic contamination of ground water affects the health of millions of people worldwide. Bioremediation has the potential to lower contaminant levels in cases where physical methods are either ineffective or cost prohibitive. The yeast Saccharomyces cerevisiae was engineered for enhanced arsenite accumulation by overexpression of transporters responsible for the influx of the contaminant. The transporter genes FPS1 and HXT7 were cloned under the control of the late-phase ADH2-promoter. This
more » ... owed for protein production at high biomass levels without the addition of inducer. Following the transfer of stationary phase cells to buffer, the engineered strains were capable of 3-4-fold greater arsenic uptake as compared to control cells. Further, at trace levels of the metalloid, the cells overexpressing the Fps1p transporter removed ca. 40% more arsenite from the extracellular medium than the controls. Arsenic uptake was also evaluated in cells overexpressing the transporters coupled with high-level production of cytosolic As sequestors (phytochelatins or bacterial ArsRp) to act as an intracellular sink. This led to an up to 4-fold increase in As accumulation in the resting cell culture as compared to native cells. The results demonstrate important steps needed to engineer a yeast biosorbent with enhanced accumulation capabilities for this metalloid.
doi:10.1016/j.jbiotec.2010.07.012 pmid:20638426 fatcat:whi5eenpufa3zn33mjqhfsjp7q

Impact of volatile organic compounds on chromium containing atmospheric particulate: insights from molecular dynamics simulations

Dhawal Shah, Mirat Karibayev, Enoch Kwasi Adotey, Mehdi Amouei Torkmahalleh
2020 Scientific Reports  
Shah et al. 27 initially studied the molecular dynamic simulation of atmospheric chromium (III) compound in the presence of additives such as ozone, formaldehyde, and benzene.  ... 
doi:10.1038/s41598-020-74522-x pmid:33060789 fatcat:4n3vhw33v5hsrj63waze34ikxi


Harin Tailor, Firdaus A Dekhaiya, Smit Mehta, Samir M Shah, Dhawal Panchal
2020 International Journal of Medical and Biomedical Studies  
Bezoars are concretions of foreign material in the gastrointestinal tract, mainly the stomach. In humans, the most common type of bezoar is the trichobezoar, is more often found in children and teenage girls. . The most frequent type of bezoar in adults is phytobezoar. A rare manifestation of trichobezoar is Rapunzel syndrome (RS) which occurs when the bezoar extends into the small intestine. An 11 years old girl from low socio economic social status presented to emergency department. . She had
more » ... a complain of abdominal pain and vomiting before 3 month which was relieved itself after vomiting which contains hair, threads and cloths. Abdominal examination revealed a generalised abdominal distension. Ultrasonography (USG) of abdomen was done. . Trichobezoar was removed by open surgery with longitudinal enterotomy. The mass was occupying 30cm part of terminal ileum up to iliocecal junction with a putrid smell which was removed from enterotomy. Trichobezoars are a bizarre medical problem, and Rapunzel syndrome is an extremely uncommon variety of trichobezoar which occurs when the bezoar extends into the small intestine. The diagnosis of trichobezoar is possible on imaging in a proper clinical setting. Keywords: Trichobezoar, Rapunzel Syndrome, Enterotomy.
doi:10.32553/ijmbs.v4i1.847 fatcat:6vkoouvfbvgedhafvdqoxvhahu

Effect of water on the thermo-physical properties of Reline: An experimental and molecular simulation based approach

Dhawal Shah, Farouq S. Mjalli
2014 Physical Chemistry, Chemical Physics - PCCP  
doi:10.1039/c4cp02600d pmid:25277220 fatcat:x4opyp2k4fca3cb4etwyh27z2q

Silver Nanoparticles Impregnated Zeolites Derived from Coal Fly Ash: Effect of the Silver Loading on Adsorption of Mercury (II)

Zhandos Tauanov, Dhawal Shah, Vassilis Inglezakis
2018 Proceedings (MDPI)  
Removal of mercury (II) from aqueous phase is of utmost importance, as it is highly toxic and hazardous to the environment and human health. A promising method for the removal of mercury (II) ions from aqueous solutions is by using adsorbents derived from coal fly ash (CFA), such as synthetic zeolites. In this work we present the hydrothermal production of synthetic zeolites from CFA followed by a modification for impregnation of silver nanoparticles, in solid concentrations from 0.15 to 4.71
more » ... .%. All produced zeolites and parent materials are characterized by XRD, XRF, BET and PSA to obtain morphological and microstructural data. Moreover, mercury (II) ions removal from aqueous solutions with initial concentration of 10 ppm is studied. According to results, zeolites and Ag-nanocomposites demonstrate much higher removal than parent CFA (up to 98%). In addition to this, we could observe a distinct adsorption behavior depending on the loading of Ag NPs in nanocomposites. A possible removal mechanism for both zeolites and Ag-nanocomposites is discussed.
doi:10.3390/proceedings2110647 fatcat:5fmudfqnyjcpljqk5c5vdrsidm

Sternal Osteomylitis due to Arrow-head Injury: A Rare Case Report

Dhawal Sharma, Snehal Dixit, Himanshu Shah, R.P. Bharaney, B.M. Halvadia, Rahul Patel, Kamlesh Tharwani, Bhaskar LNU
2022 Indian journal of chest diseases & allied sciences  
Sternal osteomyelitis secondary to penetrating trauma is an uncommon entity and only few cases have been reported. We report a case of sternal osteomyelitis in a patient with sickle-cell anaemia with a unique past history of arrow-head injury who presented with signs and symptoms of sternal infection. Imaging studies suggested osteomyelitis and the patient underwent sternal debridement, with a successful outcome.
doi:10.5005/ijcdas-54-4-255 fatcat:6recnk2z7bcybnyzwloujewl2a

Changes in the Secondary Structure and Assembly of Proteins on Fluoride Ceramic (CeF3) Nanoparticle Surfaces

Naoya Sakaguchi, Samal Kaumbekova, Ryodai Itano, Mehdi Amouei Torkmahalleh, Dhawal Shah, Masakazu Umezawa
2022 ACS Applied Bio Materials  
Fluoride nanoparticles (NPs) are materials utilized in the biomedical field for applications including imaging of the brain. Their interactions with biological systems and molecules are being investigated, but the mechanism underlying these interactions remains unclear. We focused on possible changes in the secondary structure and aggregation state of proteins on the surface of NPs and investigated the principle underlying the changes using the amyloid β peptide (Aβ16-20) based on infrared
more » ... rometry. CeF3 NPs (diameter 80 nm) were synthesized via thermal decomposition. Infrared spectrometry showed that the presence of CeF3 NPs promotes the formation of the β-sheet structure of Aβ16-20. This phenomenon was attributed to the hydrophobic interaction between NPs and Aβ peptides in aqueous environments, which causes the Aβ peptides to approach each other on the NP surface and form ordered hydrogen bonds. Because of the coexisting salts on the secondary structure and assembly of Aβ peptides, the formation of the β-sheet structure of Aβ peptides on the NP surface was suppressed in the presence of NH4+ and NO3- ions, suggesting the possibility that Aβ peptides were adsorbed and bound to the NP surface. The formation of the β-sheet structure of Aβ peptides was promoted in the presence of NH4+, whereas it was suppressed in the presence of NO3- because of the electrostatic interaction between the lysine residue of the Aβ peptide and the ions. Our findings will contribute to comparative studies on the effect of different NPs with different physicochemical properties on the molecular state of proteins.
doi:10.1021/acsabm.2c00239 pmid:35653551 pmcid:PMC9214759 fatcat:kmsn23jopbcjvbnud4g7rgbxyq

Travelogue: A Travel Application using MERN and Augmented Reality

Sahil Shah, Maheshsing Rajput, Zaman Mumbrawala, Abhishek Ghodke, Prof. Sagar Shinde, Prof. Anand Dhawale
2022 International Journal for Research in Applied Science and Engineering Technology  
Abstract: Now a days web application plays a vital role from ordering food from a restaurant, ordering any electronic stuff or anything from web apps, watching movies, book a seat for a movie theatre, for study, download pictures from the internet, etc. and MERN stack is one of the most popular JavaScript stacks used for easier and faster deployment of full-stack web application comprising backend, frontend and database components. Travel enthusiasts have always desired for traveling
more » ... places and archiving their memorable experiences. Currently, there are a wide range of travel based web applications. This paper aims at exploring features that could be integrated with travel applications for offering customizable user experience. Further, the paper discusses the prevailing drawbacks of the existing travel applications and looks forward for embracing modern features to make travel applications accessible. Currently there's no simple standalone platform where people can share their travel experiences, receive suggestions for places to travel and recommend travel places to their dear ones. So we came up with an idea to build a full stack web application where folks can share their journey through images and location. That way it won't be a tedious process anymore to surf the web and head on to travel. Keywords: Augmented Reality, Chatbot, MERN Stack, Web Application
doi:10.22214/ijraset.2022.42703 fatcat:3ukhoxm3nbhhlnq2zhl2uw55qm

Co-Firing of Refuse-Derived Fuel with Ekibastuz Coal in a Bubbling Fluidized Bed Reactor: Analysis of Emissions and Ash Characteristics

Botakoz Suleimenova, Berik Aimbetov, Daulet Zhakupov, Dhawal Shah, Yerbol Sarbassov
2022 Energies  
Converting municipal solid waste (MSW) into valuable feedstocks, such as refuse-derived fuel (RDF), is a sustainable method according to the concept of waste management hierarchy. A heterogeneous composition with a good calorific value and lower emissions allows RDF to be used for energy recovery purposes. We have earlier analyzed the generation and thermochemical characteristics of the MSW produced in Kazakhstan. This work aims to study the combustion characteristics in terms of emissions and
more » ... sh composition to evaluate the possibility of RDF co-firing with Ekibastuz coal. In particular, RDF is blended with high ash bituminous coal (Ekibastuz coal) and co-fired in the laboratory scale bubbling fluidized bed reactor (BFB) at a bed temperature of 850 °C. The co-firing tests of RDF to coal samples were conducted under various proportions to analyze flue gas compositions. Experiments were carried in the presence of bed material (sand), and the fuel particles were fed in batch mode into the hot riser. The BFB reactor had a height of 760 mm and internal diameter of 48 mm. The gaseous products in the flue gas were analyzed by FTIR spectrometry (Gasmet Dx4000). Ash composition was examined by XRD, XRF, SEM, and PSD. The results showed that a high RDF content decreased SO2 emissions to 28 ppm, while it negatively affected NOx release to 1400 ppm, owing to excess air. The emissions of gases from different blended samples and mineral transformations were investigated and discussed in this study.
doi:10.3390/en15165785 fatcat:jxnxf3t4fzfthe74xen2jygw4y
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