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Development of a novel mobile application to detect urine protein for nephrotic syndrome disease monitoring

Chia-shi Wang, Richard Boyd, Russell Mitchell, W. Darryl Wright, Courtney McCracken, Cam Escoffery, Rachel E. Patzer, Larry A. Greenbaum
2019 BMC Medical Informatics and Decision Making  
We describe the development of a novel mobile application, UrApp - Nephrotic Syndrome Manager, to aid disease monitoring.  ...  Home monitoring of urine protein is a critical component of disease management in childhood nephrotic syndrome.  ...  We are also indebted to Pamela Winterberg and Bill Winterberg for their creation of the UrApp user instructional video.  ... 
doi:10.1186/s12911-019-0822-z pmid:31146731 pmcid:PMC6543567 fatcat:sx2aasmf3nge3j7cldpzfdotee

A dual efficacy-implementation trial of a novel mobile application for childhood nephrotic syndrome management: the UrApp for childhood nephrotic syndrome management pilot study protocol (UrApp pilot study)

Chia-shi Wang, Cam Escoffery, Rachel E. Patzer, Courtney McCracken, Diana Ross, Michelle N. Rheault, Amira Al-Uzri, Larry A. Greenbaum
2020 BMC Nephrology  
A novel, expert-designed, user-informed mobile application (app), UrApp©, was created to support management tasks, including home urine protein monitoring.  ...  The UrApp Pilot Study examines the efficacy of a novel app designed specifically for nephrotic syndrome.  ...  Recently, our team developed a novel mobile application (app) to support patients and their caregivers with NS disease management, UrApp©.  ... 
doi:10.1186/s12882-020-01778-w pmid:32272901 fatcat:vxuelxyyibd6tkd6vizxrwqfhu

Screening for Kidney Diseases: Older Measures versus Novel Biomarkers

I. Wu, C. R. Parikh
2008 American Society of Nephrology. Clinical Journal  
The measurement of serum creatinine as a screening test for kidney disease falls short, however, because serum creatinine is not particularly sensitive for the diagnosis of kidney disease.  ...  Biomarkers have been used to screen for kidney disease since creatinine was recognized to be correlated with renal function.  ...  The amount of protein excretion signifies the severity of nephrotic syndrome and creatinine clearance screens for a loss in GFR.  ... 
doi:10.2215/cjn.02030408 pmid:18922990 fatcat:4dmifpywcjdnfdkcmbatu72nki

Shotgun proteomics identifies proteins specific for acute renal transplant rejection

Tara K. Sigdel, Amit Kaushal, Marina Gritsenko, Angela D. Norbeck, Wei-Jun Qian, Wenzhong Xiao, David G. Camp, Richard D. Smith, Minnie M. Sarwal
2010 PROTEOMICS - Clinical Applications  
This label-free, semi-quantitative approach for sampling the urinary proteome in normal and disease states provides a robust and sensitive method for detection of urinary proteins for serial, non-invasive  ...  A subset of proteins (UMOD, SERPINF1 and CD44), have been further cross-validated by ELISA in an independent set of urine samples, for significant differences in the abundance of these urinary proteins  ...  Acknowledgments The authors thank the NIH (grant RR018522 to R.D.S.) for support of portions of this research and the Environmental Molecular Sciences Laboratory (EMSL) for use of the instrumentation applied  ... 
doi:10.1002/prca.200900124 pmid:20543976 pmcid:PMC2883247 fatcat:t4e3l6q5zvfhroujmkq3lenq5a

Biomarkers in Rare Genetic Diseases [chapter]

Chiara Scotton, Alessandra Ferlini
2016 Role of Biomarkers in Medicine  
Biomarkers also pave the way to personalised medicine, a rapidly developing field that is of particular interest in rare diseases (RDs), i.e. those with a prevalence of less than 5/10,000, which are often  ...  Biomarkers offer a way to speed up medical research by shedding light on the physiopathological mechanisms of disease.  ...  The ultimate aim of such research is the development of innovative methods of using imaging tools for the detection and monitoring of the signs and symptoms of RDs.  ... 
doi:10.5772/63354 fatcat:pyhrqcfpqzcmfnhje77jhm42pa

Disentangling the effects of climate, topography, soil and vegetation on stand-scale species richness in temperate forests

Florian Zellweger, Veronika Braunisch, Felix Morsdorf, Andri Baltensweiler, Meinrad Abegg, Tobias Roth, Harald Bugmann, Kurt Bollmann
2015 Forest Ecology and Management  
Application of this derived 5 peak model to all urine specimens collected at <20 weeks gestation, yielded a sensitivity of 87% and specificity of 82% for the detection of pre-eclampsia.  ...  findings in a novel cohort and characterisation of the peptides in the panel will allow development of a simple and accurate point-of-care test to identify women at greatest risk of developing the disease  ...  I give permission for these individuals to have access to my records. 7.  ... 
doi:10.1016/j.foreco.2015.04.008 fatcat:mgh2bp24dzg2bfxra4xm7szubm

Podocytes, proteinuria, nephrotic syndrome, miscellaneous

2005 Nephrology, Dialysis and Transplantation  
For this purpose we design a study to evaluate the influence of colchicine therapy on the development of IF in 25 FMF patients (Group 1).  ...  Connective tissue growth factor (CTGF) is up-regulated in fibrotic kidney diseases. It is one of the key factors contributing to excess synthesis of extracellular matrix proteins.  ...  LOSARTAN AND SIMVASTATIN REGIMES IN EXPERIMENTAL NEPHROTIC SYNDROME MODEL MP031 SIGNE: A GIS FOR END-STAGE RENAL DISEASE MP032 PRE-ECLAMPSIA LIKE SYNDROME IN PREGNANT RATS TREATED WITH A SEROTONIN  ... 
doi:10.1093/ndt/20.suppl_5.v209 fatcat:gy4jf2efcbe5xhumy4ba37wwbi

Biomarkers to Monitor Adherence to Gluten-Free Diet by Celiac Disease Patients: Gluten Immunogenic Peptides and Urinary miRNAs

Alessandro Paolini, Meysam Sarshar, Cristina Felli, Stefania Paola Bruno, Mohammad Rostami-Nejad, Francesca Ferretti, Andrea Masotti, Antonella Baldassarre
2022 Foods  
Celiac disease (CD) is a multifactorial autoimmune enteropathy with a prevalence greater than 1% in the pediatric population. The only therapy for CD patients is a strict gluten-free diet (GFD).  ...  To this aim, small gluten immunogenic peptides (GIPs) obtained by the hydrolysis of gluten and present in urine and feces have been studied as biomarkers of gluten intake and to monitor adherence to GFD  ...  Acknowledgments: The authors thank Tiziana Franchin for having provided the license to access to the BioRender program for image creation.  ... 
doi:10.3390/foods11101380 pmid:35626950 pmcid:PMC9140451 fatcat:64huqlxryvhylfxlxaqk2w25ki

The Identification of Novel Potential Injury Mechanisms and Candidate Biomarkers in Renal Allograft Rejection by Quantitative Proteomics

Tara K. Sigdel, Nathan Salomonis, Carrie D. Nicora, Soyoung Ryu, Jintang He, Van Dinh, Daniel J. Orton, Ronald J. Moore, Szu-Chuan Hsieh, Hong Dai, Minh Thien-Vu, Wenzhong Xiao (+4 others)
2013 Molecular & Cellular Proteomics  
The fibrinogen proteins further segregated AR from BK virus nephritis (FGB p ‫؍‬ 0.03, FGG p ‫؍‬ 0.02), a finding that supports the utility of monitoring these urinary proteins for the specific and sensitive  ...  2) was identified as a "hub" protein for graft injury irrespective of causation.  ...  on the CNIT score (19) ); BK (n ϭ 38), patients with nonspecific proteinuria from native renal disease because of nephrotic syndrome (NS; to control for nonspecific renal injury) (n ϭ 8), and healthy  ... 
doi:10.1074/mcp.m113.030577 pmid:24335474 pmcid:PMC3916658 fatcat:ltmx3pn5kbflfkjja2cijrtdgi

mHealth Dipstick Analyzer for Monitoring of Pregnancy Complications

Karthik Raj Konnaiyan, Surya Cheemalapati, Michael Gubanov, Anna Pyayt
2017 IEEE Sensors Journal  
Here we present a novel smartphone-based colorimeter and demonstrate its application to the measurements of glucose and protein concentrations in biological samples.  ...  The key innovations of our approach was to combine powerful image processing encoded into a mobile phone application with a low cost 3D printed sample holder that allowed to control lighting conditions  ...  ACKNOWLEDGEMENTS THIS WORK WAS SUPPORTED BY A GRANT FROM  ... 
doi:10.1109/jsen.2017.2752722 fatcat:ez4vzcw2dncfxflbclldu5l3da

Inducible podocyte-specific deletion of CTCF drives progressive kidney disease and bone abnormalities

Marta Christov, Abbe R. Clark, Braden Corbin, Samy Hakroush, Eugene P. Rhee, Hiroaki Saito, Dan Brooks, Eric Hesse, Mary Bouxsein, Niels Galjart, Ji Yong Jung, Peter Mundel (+3 others)
2018 JCI Insight  
We are grateful to Frederick Schoen of Brigham and Women's Hospital Cardiac Pathology for the histological examination of cardiac sections.  ...  We wish to also thank Marcus Moeller (University of Aachen, Germany) for providing podocyte-specific Cre deleter mice. M.  ...  First, induction of podocyte loss is sufficient for the development of nephrotic syndrome and progressive CKD.  ... 
doi:10.1172/jci.insight.95091 pmid:29467330 pmcid:PMC5916242 fatcat:w7zwgrzkpffr7cai66zflhmefy

The 13th International Podocyte Conference

Silke R. Brix, Durga A.K. Kanigicherla, Dean Wallace, Tejas Desai, Rachel Lennon
2022 Glomerular Diseases  
In the long term, hybrid models will likely remain a significant component for many events as we learn and benefit from innovations being developed during the ongoing COVID-19 pandemic.  ...  The podocyte community adapted rapidly to this novel meeting format and as such reflected the adaptive and versatile nature of the glomerular podocyte.  ...  Acknowledgements The authors thank the International Organising Committee for the Podocyte Conference and the organisers of the Patient Day for their valuable contributions to the meeting organisation.  ... 
doi:10.1159/000525410 doaj:e9679bf2babd49ef96532d7420cbcd97 fatcat:yltzcfedyvf3tgj4dghkeomvdq

Screening for Potential Active Components of Fangji Huangqi Tang on the Treatment of Nephrotic Syndrome by Using Integrated Metabolomics Based on "Correlations Between Chemical and Metabolic Profiles"

Xiao Liu, Qi-Gang Zhou, Xiao-Chai Zhu, Li Xie, Bao-Chang Cai
2019 Frontiers in Pharmacology  
Firstly, a metabolomics study was carried out to select representative biomarkers of nephrotic syndrome.  ...  In this paper, an integrated metabolomic method was presented for a systematic discovery of potential active components in Fangji Huangqi Tang (FHT), a well-known TCM prescription for nephrotic syndrome  ...  This work was financially supported by the National Natural Science Foundation of China (no. 81503207), Major Projects of Natural Science Foundation of Jiangsu Higher Education Institutions (no. 17KJA360006  ... 
doi:10.3389/fphar.2019.01261 pmid:31695617 pmcid:PMC6817620 fatcat:qgj4b5isevau7agesrd6eyo2pq

Can microRNA profiles predict corticosteroid responsiveness in childhood nephrotic syndrome? A study protocol

Saroj Kumar Patnaik, Pradeep Kumar, Priya Yadav, Anubha Mittal, Sakshi Patel, Mahendra Pal Yadav, Tathagata Bose, Madhuri Kanitkar
2018 BMJ Paediatrics Open  
Since miRNA in urinary sediment is relatively stable and easily quantified, it has the potential to be developed as a biomarker for disease diagnosis and monitoring.  ...  Identification of serum and urinary levels of certain miRNAs may assist in the diagnosis and assessment of disease activity in patients with nephrotic syndrome (NS).  ...  Acknowledgements We acknowledge our sincere thanks to Defence Research and Development Organization, Government of India, New Delhi, India, for funding support and Dr Santosh K Patnaik, Assistant Professor  ... 
doi:10.1136/bmjpo-2018-000319 pmid:30555935 pmcid:PMC6267312 fatcat:yf4hbmfyurbl3f5gyht2h2n3sa

Update on the clinical management of Wilson's disease

Peter Hedera
2017 The Application of Clinical Genetics  
It is a great imitator and requires a high index of suspicion for correct and timely diagnosis.  ...  Wilson's disease (WD), albeit relatively rare, is an important genetic metabolic disease because of highly effective therapies that can be lifesaving.  ...  Application of this scoring system in a cohort of 142 children with liver disease only yielded a sensitivity of 98.14%, a specificity of 96.59%, a positive predictive value of 94.64% and a negative predictive  ... 
doi:10.2147/tacg.s79121 pmid:28144156 pmcid:PMC5245916 fatcat:cs74hdruknamzhsqcc6uhndymm
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