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Developing a Molecular Roadmap of Drug-Food Interactions

Kasper Jensen, Yueqiong Ni, Gianni Panagiotou, Irene Kouskoumvekaki, Kai Tan
2015 PLoS Computational Biology  
Although the importance of drug-food interactions has long been known, a systematic approach to identify, predict and prevent potential interactions between food and drugs has not yet been established.  ...  A well-known example of a drug-food interaction, the inhibitory effect of grapefruit juice on cytochrome P450, results in increased bioavailability of drugs such as felodipine, cyclosporine and saquinavir  ...  Acknowledgments GP would like to thank the University of Hong Kong (e-SRT on Integrative Biology) for support.  ... 
doi:10.1371/journal.pcbi.1004048 pmid:25668218 pmcid:PMC4323218 fatcat:b4dndvaasjc4dcaayylw3xxava

Roadmap of Agricultural Production and Food Safety Science and Technology Development [chapter]

Qiguo Zhao, Jikun Huang
2011 Agricultural Science & Technology in China: A Roadmap to 2050  
Address the Basic Needs of Food Safety Food safety is the basic needs for the development of human society.  ...  The Demand and Significance of Development "The people take food as their prime want", food is not only the most basic human survival needs, but also the eternal theme for the national stability and social  ...  in China: A Roadmap to 2050 · 114 · 114 Agricultural Science & Technology in China: A Roadmap to 2050 · 121 · 121 Roadmap 2050 Roadmap of Agricultural Production and Food Safety Science and Technology  ... 
doi:10.1007/978-3-642-19128-2_7 fatcat:w4ix4pzlazh67eykyswyzv57oy

Nanoherbals in Human Healthcare: A Proposed Research and Development Roadmap II

S Ahmad, U Hashim
2012 ASEAN Journal on Science and Technology for Development  
molecule drug developments.  ...  Using the principles of nanoscience and technology in association with genomics and proteomics, an attempt has been made to decipher whether a suitable form of drug discovery and targeted drug delivery  ...  Hamid are acknowledged for their kind support to the authors for conducting this kind of futuristic study in the University. Date of submission: May 2012 Date of acceptance: June 2012  ... 
doi:10.29037/ajstd.51 fatcat:7zkkgtkmrjay7fwm7zfeopvwui

Fostering Scientific Innovation to Impact AKI: A Roadmap from ASN's AKINow Basic Science Workgroup

Samir M. Parikh, Anupam Agarwal, Amandeep Bajwa, Sanjeev Kumar, Sherry G. Mansour, Mark D. Okusa, Jorge Cerda
2022 Kidney360  
ACKNOWLEDGMENTS This work is published on hebalf of the AKINow Initiative of the American Society of Nephrology.  ...  Finally, a key transition from discovery to drug development is how to apply animal models of AKI in the study of human AKI [5, 6] .  ...  Whereas clinical trial design is crucial in establishing the efficacy of a drug in the prevention or treatment of AKI, identifying meaningful molecular targets is of paramount importance.  ... 
doi:10.34067/kid.0007472021 pmid:36176660 pmcid:PMC9416831 fatcat:g3r3acdalfcihdfa3snl7tqwhq

A physiome interoperability roadmap for personalized drug development

Simon Thomas, Katherine Wolstencroft, Bernard de Bono, Peter J. Hunter
2016 Interface Focus  
One contribution of 12 to a theme issue 'The Human Physiome: a necessary key to the creative destruction of medicine'.  ...  Identifying the key steps along a roadmap to this kind of interoperability depends on the collection of requirements from a wide range of industry experts along the life cycle of drug discovery and development  ...  The Food and Drug Administration (FDA) lists (3 August 2015) approximately 125 combinations of drug treatments and biomarkers (approx. 110 treatments and 25 biomarkers) for which drug labelling information-warnings  ... 
doi:10.1098/rsfs.2015.0094 pmid:27051513 pmcid:PMC4759752 fatcat:i3hyu56qhbbmhlgodz62pcq5ay

Directed Assembly Network - A Roadmap to Innovation, 2017 Edition

Julian Rose, Paul Raithby, Jenny Woods, Harris Makatsoris, Sally Price, Chick Wilson, George Jackson, Mike Ward, Lee Brammer, Matt Rosseinsky, Sophia Yaliraki, Neil Champness (+3 others)
2016 Figshare  
physicists, chemical engineers, mathematicians, and computer scientists, to name but a few.This Roadmap has been constructed by the Network community over years of consultations and continuous engagement  ...  The vision of the Network is to be able to control the assembly of matter with sufficient certainty and precision to allow the preparation of materials and molecular assemblies, with far more sophisticated  ...  Note: The molecular assembly picture used as the Directed Assembly Network logo is generated from a crystal structure reported by Jean-Marie Lehn and coworkers in Angew. Chem., Int. Ed.  ... 
doi:10.6084/m9.figshare.4483502 fatcat:yzfwjokfyffcxnluy4fv36gqwe

Exploring the Landscape of Protein-Ligand Interaction Energy Using Probabilistic Approach

Marcin Pacholczyk, Marek Kimmel
2011 Journal of Computational Biology  
Using computer simulations instead of sophisticated laboratory procedures may significantly reduce cost of some stages of drug development.  ...  Analysis of protein/small molecule interactions is crucial in the discovery of new drug candidates and lead structure optimization.  ...  Molecular graphics images were produced using the UCSF Chimera package from the Resource for Biocomputing, Visualization, and Informatics at the University of California, San Francisco (supported by NIH  ... 
doi:10.1089/cmb.2010.0017 pmid:21091064 pmcid:PMC3117400 fatcat:6urtwuwecvaafixeqkrpla3g4q

Translational medicine in orthopaedics

Ling Qin
2013 Journal of Orthopaedic Translation  
the Food and Drug Administration in the United States or China Food and Drug Administration (CFDA) in China.  ...  bioinformatics, applied immunology, molecular imaging, drug discovery and development, and last but not least, the regulation and health policies.  ... 
doi:10.1016/j.jot.2013.07.005 fatcat:g7tlp3jrkjdjvaxzrmc4sszcze

Nutrition and cancer: Essential elements for a roadmap

J.A. Milner
2008 Cancer Letters  
or direction of a response to bioactive food components.  ...  This nutritional preemption roadmap must begin with accurately assessing intakes/exposures of which bioactive food component(s) is needed to bring about a desired response in critical cellular processes  ...  to developing a realistic preemptive roadmap for cancer prevention.  ... 
doi:10.1016/j.canlet.2008.05.030 pmid:18599198 fatcat:4ay7cekznrainarxfs7trwseli

The directed assembly grand challenge network

J. A. R. Rose, P. R. Raithby, C. Makatsoris
2017 Chemistry Central Journal  
for the purification and reclamation of water. • The development of new agrochemicals and agricultural processes that will safely enhance food production and provide world food security.  ...  The grand challenge In the modern world the design, development and use of new materials is having a major economic and societal impact in areas as diverse as: healthcare, energy, food production, transport  ...  for the purification and reclamation of water. • The development of new agrochemicals and agricultural processes that will safely enhance food production and provide world food security.  ... 
doi:10.1186/s13065-017-0303-3 pmid:29086861 pmcid:PMC5539067 fatcat:vfd6m6pw7zawngmmfympjo7m2u

The case for strategic international alliances to harness nutritional genomics for public and personal health

Jim Kaput, Jose M. Ordovas, Lynnette Ferguson, Ben van Ommen, Raymond L. Rodriguez, Lindsay Allen, Bruce N. Ames, Kevin Dawson, Bruce German, Ronald Krauss, Wasyl Malyj, Michael C. Archer (+75 others)
2005 British Journal of Nutrition  
Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene-nutrient interactions in ways that increase the risk of developing chronic disease.  ...  reducing health disparities in developed and developing countries.  ...  Acknowledgements Many of the authors of the present paper have already contributed significantly to the field of nutrigenomics, our current understanding of nutrient -gene interactions, and/or the effects  ... 
doi:10.1079/bjn20051585 pmid:16277761 fatcat:5hqk46dnlbfwfabhvfmyfzugvi

Open Access High Throughput Drug Discovery in the Public Domain: A Mount Everest in the Making

Anuradha Roy, Peter R. McDonald, Sitta Sittampalam, Rathnam Chaguturu
2010 Current Pharmaceutical Biotechnology  
The various facets of academic HTS centers as well as their implications on technology transfer and drug discovery are discussed, and a roadmap for successful drug discovery in the public domain is presented  ...  In recent years, a significant number of drugs in clinical trails originated from HTS campaigns, validating HTS as a bona fide mechanism for hit finding.  ...  KU-HTSL is a KU Cancer Center Shared Resource, and is funded in part by NIH/ NCRR COBRE grant P20 RR015563.  ... 
doi:10.2174/138920110792927757 pmid:20809896 pmcid:PMC3716285 fatcat:opo2pcknojgwzcqi5xkvmqiql4

The Role of Quantitative Pharmacology in an Academic Translational Research Environment

Jeffrey S. Barrett
2008 AAPS Journal  
KEY WORDS: Model-based drug development; NIH Roadmap; Quantitative pharmacology; Translational research.  ...  A key component of the CTSA and an element of both the NIH Roadmap and the FDA Critical Path is the bridging of bench and bedside science via quantitative pharmacologic relationships.  ...  At the same time, their governing regulatory counterparts crafted the critical path (7) and roadmap (8) initiatives from the Food and Drug Administration (FDA) and National Institute of Health (NIH  ... 
doi:10.1208/s12248-007-9002-7 pmid:18446501 pmcid:PMC2751447 fatcat:blpdhncu2jbvrlw2m44z4fy4iy

Insights of Pharmaceutical Co crystals

F Preshita P Desai
2018 Biomedical Journal of Scientific & Technical Research  
required to enable the API and co former interaction to form the co crystal; co crystal recovery and scalability [2] .  ...  A detailed scientific understanding of co former properties, interactions between API and co former, and its impact on properties of co crystal lattice are the key steps in this development.  ...  Introduction Active pharmaceutical ingredients (API) and API drug products developments are facing impending challenges as approximately 60-70% of newly discovered APIs belong to biopharmaceutical classification  ... 
doi:10.26717/bjstr.2018.03.000899 fatcat:xc3j6yqrgzgcljwqqak7ay2ekq

Nanorobotics : A Newer Platform for Molecular Diagnose

Vijayakumar R, Jagannathan S, Rahul Gandhi P, Chaansha S
2011 Nano Biomedicine and Engineering  
The present era of nanotechnology has reached to a stage where scientist are able to develop and programme complex machines that are built at molecular level which can work inside the patient body.  ...  This study of nanorobot serves as a lead to the field of nanomedicine. There are many applications for nanorobotic systems and its biggest impact would be in the area of medicine.  ...  The roadmap of nanorobotics A roadmap is proposed which details the main steps towards the design and development of bio-nanorobots (Fig. 3 ). The roadmap progresses through the following steps.  ... 
doi:10.5101/nbe.v3i3.p192-201 fatcat:hyboiyqb2fgxvkasroiq7op4li
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