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Developing a Framework for Studying Brain Networks in Neonatal Hypoxic-Ischemic Encephalopathy [chapter]

Finn Lennartsson, Angela Darekar, Koushik Maharatna, Daniel Konn, David Allen, J-Donald Tournier, John Broulidakis, Brigitte Vollmer
2018 Communications in Computer and Information Science  
Here, an analysis pipeline to study the structural and functional brain networks from neonatal MRI in newborns with HIE is presented.  ...  Newborns with hypoxic-ischemic encephalopathy (HIE) are at high risk of brain injury, with subsequent developmental problems including severe neuromotor, cognitive and behavioral impairment.  ...  Introduction Neonatal hypoxic-ischaemic encephalopathy (HIE) as a consequence of perinatal asphyxia is associated with a high risk for brain injury and subsequent neurological and cognitive impairment  ... 
doi:10.1007/978-3-319-95921-4_20 fatcat:4764fut665aybe5v6yku5rsbi4

Commentary on "The long-term effect of perinatal asphyxia on hippocampal volumes"

Dalit Cayam-Rand, Steven P. Miller
2018 Pediatric Research  
Neonatal hypoxic ischemic encephalopathy (HIE), occurring in 1-6/1000 live births, is a leading cause of neurological impairment among children.  ...  mild neonatal encephalopathy. 23 Even among mild HIE infants who have undergone therapeutic hypothermia, studies show hypoxic ischemic injury in a significant number of cases.  ... 
doi:10.1038/s41390-018-0209-3 fatcat:lx6x35jl6jgd3opksie3uti2qq

A pictorial review of the pathophysiology and classification of the magnetic resonance imaging patterns of perinatal term hypoxic ischemic brain injury – What the radiologist needs to know…

Shalendra K. Misser, Anthony J. Barkovich, Jan W. Lotz, Moherndran Archary
2020 South African Journal of Radiology  
This article provides a correlation of the pathophysiology and magnetic resonance imaging (MRI) patterns identified on imaging of children with hypoxic ischemic brain injury (HIBI).  ...  In addition, a database of MRI studies accumulated over a decade (including a total of 314 studies) was analysed and subclassified into the various patterns of cerebral injury.  ...  Acknowledgements The authors would like to thank Dr Usha Chhagan for reviewing the manuscript.  ... 
doi:10.4102/sajr.v24i1.1915 pmid:33240541 pmcid:PMC7670012 fatcat:u2msbu5vivc7pbpviop5afe43a

Therapeutic Hypothermia in Asphyxiated Neonates with Hypoxic-ischemic Encephalopathy: A single-center Experience from its First Application in Saudi Arabia

Najia Al Hojaili
2016 Journal of Medical Science And clinical Research  
study period for moderate and severe hypoxic-ischemic encephalopathy.  ...  Background/ Objective: Therapeutic hypothermia has become an accepted therapy in asphyxiated newborns with evidence of moderate to severe hypoxic-ischemic encephalopathy.  ...  Introduction Hypoxic-ischemic encephalopathy (HIE) is a risk manifestation of perinatal asphyxia.  ... 
doi:10.18535/jmscr/v4i4.63 fatcat:2fst4xpycnatnfohwfksfnqdvi

Effect of Depth and Duration of Cooling on Deaths in the NICU Among Neonates With Hypoxic Ischemic Encephalopathy

Seetha Shankaran, Abbot R. Laptook, Athina Pappas, Scott. A. McDonald, Abhik Das, Jon E. Tyson, Brenda B. Poindexter, Kurt Schibler, Edward F. Bell, Roy J. Heyne, Claudia Pedroza, Rebecca Bara (+17 others)
2014 Journal of the American Medical Association (JAMA)  
IMPORTANCE Hypothermia at 33.5°C for 72 hours for neonatal hypoxic ischemic encephalopathy reduces death or disability to 44% to 55%; longer cooling and deeper cooling are neuroprotective in animal models  ...  ischemic encephalopathy.  ...  hypoxic ischemic encephalopathy.  ... 
doi:10.1001/jama.2014.16058 pmid:25536254 pmcid:PMC4335311 fatcat:x2qyz7lp7bgqrcrvrjekgktn54

Effect of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-Ischemic Encephalopathy

Abbot R. Laptook, Seetha Shankaran, Jon E. Tyson, Breda Munoz, Edward F. Bell, Ronald N. Goldberg, Nehal A. Parikh, Namasivayam Ambalavanan, Claudia Pedroza, Athina Pappas, Abhik Das, Aasma S. Chaudhary (+25 others)
2017 Journal of the American Medical Association (JAMA)  
and Human Development Neonatal Research Network located across the United States.  ...  TRIAL REGISTRATION-clinicaltrials.gov Identifier: NCT00614744 Hypoxic-ischemic encephalopathy represents a subset of neonatal encephalopathy, occurring in approximately 1.5 per 1000 live births. 1 It  ...  Meaning Hypothermia treatment initiated at 6 to 24 hours for newborns with hypoxic-ischemic encephalopathy may reduce death or disability but there is uncertainty in its effectiveness.  ... 
doi:10.1001/jama.2017.14972 pmid:29067428 pmcid:PMC5783566 fatcat:dk3p662ihrh53nsnwxjauopsca

Hypoxic-Ischemic Encephalopathy and Serum Magnesium Monitoring and Maintenance

Susan Givens Bell
2016 Neonatal Network  
There is some evidence to suggest a role for magnesium sulfate as a therapeutic neuroprotective agent along with therapeutic hypothermia in infants with hypoxic-ischemic encephalopathy, but studies are  ...  Ischemic insult and hypothermia may both play a role in altered magnesium levels in this population.  ...  hypothermia in infants with hypoxic-ischemic encephalopathy, but studies are inconclusive. ischemic insult and hypothermia may both play a role in altered magnesium levels in this population.  ... 
doi:10.1891/0730-0832.35.3.159 pmid:27194611 fatcat:jfgfzazixrer7lqxsnd5ophmge

Mining multi-site clinical data to develop machine learning MRI biomarkers: application to neonatal hypoxic ischemic encephalopathy

Rebecca J. Weiss, Sara V. Bates, Ya'nan Song, Yue Zhang, Emily M. Herzberg, Yih-Chieh Chen, Maryann Gong, Isabel Chien, Lily Zhang, Shawn N. Murphy, Randy L. Gollub, P. Ellen Grant (+1 others)
2019 Journal of Translational Medicine  
This study aims to create a retrospective clinical dataset of Magnetic Resonance Images (MRI) and clinical records of neonatal hypoxic ischemic encephalopathy (HIE), from which clinically-relevant analytic  ...  Secondary and retrospective use of hospital-hosted clinical data provides a time- and cost-efficient alternative to prospective clinical trials for biomarker development.  ...  We would like to extend our sincere thanks to them for their significant contributions to the study and future collaborations.  ... 
doi:10.1186/s12967-019-2119-5 pmid:31752923 pmcid:PMC6873573 fatcat:ahqtaxndffdtpf3spsqttb6qea

Current and Future Uses of Continuous EEG in the NICU

Amanda G. Sandoval Karamian, Courtney J. Wusthoff
2021 Frontiers in Pediatrics  
activity, plays a role in predicting which neonates are at risk for seizures when combined with clinical factors, and allows for accurate diagnosis and management of neonatal seizures.  ...  Continuous EEG (cEEG) is a fundamental neurodiagnostic tool in the care of critically ill neonates and is increasingly recommended. cEEG enhances prognostication via assessment of the background brain  ...  For all these reasons, clinical diagnosis of neonatal seizures is challenging and often inaccurate; in a study in a large NICU network in Ireland, only 9% of true electrographic seizures were clinically  ... 
doi:10.3389/fped.2021.768670 pmid:34805053 pmcid:PMC8595393 fatcat:ocvsqtb55nf57er6b3jg7vw4va

Neonatal brain injury and aberrant connectivity

Christopher D. Smyser, Muriah D. Wheelock, David D. Limbrick, Jeffrey J. Neil
2018 NeuroImage  
Brain injury sustained during the neonatal period may disrupt development of critical structural and functional connectivity networks leading to subsequent neurodevelopmental impairment in affected children  ...  We conclude by reviewing technical challenges associated with neonatal neuroimaging, highlighting those most relevant to studying infants with brain injury and emphasizing the need for further targeted  ...  Hypoxic-Ischemic Encephalopathy: Studies reporting changes in the structural connectome in association with brain injury in the context of neonatal encephalopathy are also limited (Table 2 ).  ... 
doi:10.1016/j.neuroimage.2018.07.057 pmid:30059733 pmcid:PMC6289815 fatcat:w43hj74n7ra3jnbxytsn4cvuwi

Off-Label Use of Therapeutic Hypothermia for Infants with Hypoxic-Ischemic Encephalopathy

2012 Virtual Mentor  
infants with hypoxic ischemic encephalopathy.  ...  In the 1940s, neonatologists learned that supplemental oxygen, delivered abundantly to premature babies with respiratory distress syndrome, was toxic to the developing retina and associated with thousands  ...  Background Perinatal-neonatal hypoxic ischemic encephalopathy (HIE) is a serious condition caused by acute and unexpected disruption of blood flow and oxygen delivery to the fetus around the time of birth  ... 
doi:10.1001/virtualmentor.2012.14.10.stas1-1210 pmid:23351857 fatcat:2vecg5rjiffxfkpiji7dvq3bfi

Long-Term Outcomes after Neonatal Hypoxic-Ischemic Encephalopathy in the Era of Therapeutic Hypothermia: A Longitudinal, Prospective, Multicenter Case-Control Study in Children without Overt Brain Damage

Elisa Cainelli, Luca Vedovelli, Emmanuele Mastretta, Dario Gregori, Agnese Suppiej, Patrizia Silvia Bisiacchi
2021 Children  
Our sample population consisted of 40 children with a history of hypoxic-ischemic encephalopathy (HIE) treated with TH, with an average age of 6.25 years (range 5.5, 7.33), 24 (60%) males; and 33 peers  ...  Our study supports previous findings on a higher incidence of neuropsychological, cognitive, and psychopathological sequelae after HIE treated with TH.  ...  Introduction Great improvements in outcomes have been reported in children who experience neonatal hypoxic-ischemic encephalopathy (HIE) since the introduction of therapeutic hypothermia (TH).  ... 
doi:10.3390/children8111076 pmid:34828791 pmcid:PMC8625352 fatcat:3nxmzt3bdjc4voaiukyyzn3kmq

Hypothermia and Other Treatment Options for Neonatal Encephalopathy: An Executive Summary of the Eunice Kennedy Shriver NICHD Workshop

Rosemary D. Higgins, Tonse Raju, A. David Edwards, Denis V. Azzopardi, Carl L. Bose, Reese H. Clark, Donna M. Ferriero, Ronnie Guillet, Alistair J. Gunn, Henrik Hagberg, Deborah Hirtz, Terrie E. Inder (+16 others)
2011 Journal of Pediatrics  
P erinatal hypoxic-ischemic encephalopathy (HIE), a subset of neonatal encephalopathy, is associated with high neonatal mortality and severe long-term neurologic morbidity.  ...  A review of animal studies found that brain cooling to approximately 32-34 C starting within 5.5 hours after hypoxic ischemic injury and contining for 12-72 hours reduced secondary energy failure and cell  ... 
doi:10.1016/j.jpeds.2011.08.004 pmid:21875719 pmcid:PMC3263823 fatcat:evaemndlsraa7c5gslsmzz6fn4

Single cell sequencing technology and its application in Hypoxic ischemic encephalopathy research

Ting‐Bao Chen, Hong‐Su Zhou, Liu‐Lin Xiong
2021 Ibrain  
Hypoxic ischemic encephalopathy (HIE) is the common etiology of neonatal morbidity and mortality, which exerts a negative seriously inluence for the growth and development of children, and even threatens  ...  It also plays an extremely signiicant role in the basic research and precision medicine. Some studies have suggested that SCS serves a vital function in the study of HIE.  ...  Introduction Neonatal hypoxic ischemic encephalopathy (NHIE) is a destructive neurological event , and is one of the most severe disease and can trigger a series of complications caused by neonatal asphyxia  ... 
doi:10.1002/j.2769-2795.2021.tb00086.x fatcat:hrbu4ullpjaohf2afhvwbjpvwm

Neonatal Seizures—Are We there Yet?

Georgia Ramantani, Bernhard Schmitt, Barbara Plecko, Ronit M. Pressler, Gabriele Wohlrab, Katrin Klebermass-Schrehof, Cornelia Hagmann, Francesco Pisani, Geraldine B. Boylan
2019 Neuropediatrics  
While the majority of neonatal seizures are caused by hypoxic-ischemic events, stroke, hemorrhage, or infection, approximately 15% of patients will require more sophisticated algorithms for diagnostic  ...  These recent developments have led to renew interest in the classification of neonatal seizures, which aim to help identify etiology and guide appropriate therapeutic and prognostic decisions.  ...  Hypoxic-ischemic encephalopathy (HIE) in term neonates and intraventricular hemorrhage (IVH) in premature neonates are the most prevalent etiology.  ... 
doi:10.1055/s-0039-1693149 pmid:31340400 fatcat:tsxjzcurg5ejhgp7khpacb6nzi
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