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Developing a Framework for Studying Brain Networks in Neonatal Hypoxic-Ischemic Encephalopathy
[chapter]
2018
Communications in Computer and Information Science
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Here, an analysis pipeline to study the structural and functional brain networks from neonatal MRI in newborns with HIE is presented. ...
Newborns with hypoxic-ischemic encephalopathy (HIE) are at high risk of brain injury, with subsequent developmental problems including severe neuromotor, cognitive and behavioral impairment. ...
Introduction Neonatal hypoxic-ischaemic encephalopathy (HIE) as a consequence of perinatal asphyxia is associated with a high risk for brain injury and subsequent neurological and cognitive impairment ...
doi:10.1007/978-3-319-95921-4_20
fatcat:4764fut665aybe5v6yku5rsbi4
Commentary on "The long-term effect of perinatal asphyxia on hippocampal volumes"
2018
Pediatric Research
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Neonatal hypoxic ischemic encephalopathy (HIE), occurring in 1-6/1000 live births, is a leading cause of neurological impairment among children. ...
mild neonatal encephalopathy. 23 Even among mild HIE infants who have undergone therapeutic hypothermia, studies show hypoxic ischemic injury in a significant number of cases. ...
doi:10.1038/s41390-018-0209-3
fatcat:lx6x35jl6jgd3opksie3uti2qq
A pictorial review of the pathophysiology and classification of the magnetic resonance imaging patterns of perinatal term hypoxic ischemic brain injury – What the radiologist needs to know…
2020
South African Journal of Radiology
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This article provides a correlation of the pathophysiology and magnetic resonance imaging (MRI) patterns identified on imaging of children with hypoxic ischemic brain injury (HIBI). ...
In addition, a database of MRI studies accumulated over a decade (including a total of 314 studies) was analysed and subclassified into the various patterns of cerebral injury. ...
Acknowledgements The authors would like to thank Dr Usha Chhagan for reviewing the manuscript. ...
doi:10.4102/sajr.v24i1.1915
pmid:33240541
pmcid:PMC7670012
fatcat:u2msbu5vivc7pbpviop5afe43a
Therapeutic Hypothermia in Asphyxiated Neonates with Hypoxic-ischemic Encephalopathy: A single-center Experience from its First Application in Saudi Arabia
2016
Journal of Medical Science And clinical Research
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study period for moderate and severe hypoxic-ischemic encephalopathy. ...
Background/ Objective: Therapeutic hypothermia has become an accepted therapy in asphyxiated newborns with evidence of moderate to severe hypoxic-ischemic encephalopathy. ...
Introduction Hypoxic-ischemic encephalopathy (HIE) is a risk manifestation of perinatal asphyxia. ...
doi:10.18535/jmscr/v4i4.63
fatcat:2fst4xpycnatnfohwfksfnqdvi
Effect of Depth and Duration of Cooling on Deaths in the NICU Among Neonates With Hypoxic Ischemic Encephalopathy
2014
Journal of the American Medical Association (JAMA)
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IMPORTANCE Hypothermia at 33.5°C for 72 hours for neonatal hypoxic ischemic encephalopathy reduces death or disability to 44% to 55%; longer cooling and deeper cooling are neuroprotective in animal models ...
ischemic encephalopathy. ...
hypoxic ischemic encephalopathy. ...
doi:10.1001/jama.2014.16058
pmid:25536254
pmcid:PMC4335311
fatcat:x2qyz7lp7bgqrcrvrjekgktn54
Effect of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-Ischemic Encephalopathy
2017
Journal of the American Medical Association (JAMA)
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and Human Development Neonatal Research Network located across the United States. ...
TRIAL REGISTRATION-clinicaltrials.gov Identifier: NCT00614744 Hypoxic-ischemic encephalopathy represents a subset of neonatal encephalopathy, occurring in approximately 1.5 per 1000 live births. 1 It ...
Meaning Hypothermia treatment initiated at 6 to 24 hours for newborns with hypoxic-ischemic encephalopathy may reduce death or disability but there is uncertainty in its effectiveness. ...
doi:10.1001/jama.2017.14972
pmid:29067428
pmcid:PMC5783566
fatcat:dk3p662ihrh53nsnwxjauopsca
Hypoxic-Ischemic Encephalopathy and Serum Magnesium Monitoring and Maintenance
2016
Neonatal Network
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There is some evidence to suggest a role for magnesium sulfate as a therapeutic neuroprotective agent along with therapeutic hypothermia in infants with hypoxic-ischemic encephalopathy, but studies are ...
Ischemic insult and hypothermia may both play a role in altered magnesium levels in this population. ...
hypothermia in infants with hypoxic-ischemic encephalopathy, but studies are inconclusive. ischemic insult and hypothermia may both play a role in altered magnesium levels in this population. ...
doi:10.1891/0730-0832.35.3.159
pmid:27194611
fatcat:jfgfzazixrer7lqxsnd5ophmge
Mining multi-site clinical data to develop machine learning MRI biomarkers: application to neonatal hypoxic ischemic encephalopathy
2019
Journal of Translational Medicine
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This study aims to create a retrospective clinical dataset of Magnetic Resonance Images (MRI) and clinical records of neonatal hypoxic ischemic encephalopathy (HIE), from which clinically-relevant analytic ...
Secondary and retrospective use of hospital-hosted clinical data provides a time- and cost-efficient alternative to prospective clinical trials for biomarker development. ...
We would like to extend our sincere thanks to them for their significant contributions to the study and future collaborations. ...
doi:10.1186/s12967-019-2119-5
pmid:31752923
pmcid:PMC6873573
fatcat:ahqtaxndffdtpf3spsqttb6qea
Current and Future Uses of Continuous EEG in the NICU
2021
Frontiers in Pediatrics
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activity, plays a role in predicting which neonates are at risk for seizures when combined with clinical factors, and allows for accurate diagnosis and management of neonatal seizures. ...
Continuous EEG (cEEG) is a fundamental neurodiagnostic tool in the care of critically ill neonates and is increasingly recommended. cEEG enhances prognostication via assessment of the background brain ...
For all these reasons, clinical diagnosis of neonatal seizures is challenging and often inaccurate; in a study in a large NICU network in Ireland, only 9% of true electrographic seizures were clinically ...
doi:10.3389/fped.2021.768670
pmid:34805053
pmcid:PMC8595393
fatcat:ocvsqtb55nf57er6b3jg7vw4va
Neonatal brain injury and aberrant connectivity
2018
NeuroImage
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Brain injury sustained during the neonatal period may disrupt development of critical structural and functional connectivity networks leading to subsequent neurodevelopmental impairment in affected children ...
We conclude by reviewing technical challenges associated with neonatal neuroimaging, highlighting those most relevant to studying infants with brain injury and emphasizing the need for further targeted ...
Hypoxic-Ischemic Encephalopathy: Studies reporting changes in the structural connectome in association with brain injury in the context of neonatal encephalopathy are also limited (Table 2 ). ...
doi:10.1016/j.neuroimage.2018.07.057
pmid:30059733
pmcid:PMC6289815
fatcat:w43hj74n7ra3jnbxytsn4cvuwi
Off-Label Use of Therapeutic Hypothermia for Infants with Hypoxic-Ischemic Encephalopathy
2012
Virtual Mentor
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infants with hypoxic ischemic encephalopathy. ...
In the 1940s, neonatologists learned that supplemental oxygen, delivered abundantly to premature babies with respiratory distress syndrome, was toxic to the developing retina and associated with thousands ...
Background Perinatal-neonatal hypoxic ischemic encephalopathy (HIE) is a serious condition caused by acute and unexpected disruption of blood flow and oxygen delivery to the fetus around the time of birth ...
doi:10.1001/virtualmentor.2012.14.10.stas1-1210
pmid:23351857
fatcat:2vecg5rjiffxfkpiji7dvq3bfi
Long-Term Outcomes after Neonatal Hypoxic-Ischemic Encephalopathy in the Era of Therapeutic Hypothermia: A Longitudinal, Prospective, Multicenter Case-Control Study in Children without Overt Brain Damage
2021
Children
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Our sample population consisted of 40 children with a history of hypoxic-ischemic encephalopathy (HIE) treated with TH, with an average age of 6.25 years (range 5.5, 7.33), 24 (60%) males; and 33 peers ...
Our study supports previous findings on a higher incidence of neuropsychological, cognitive, and psychopathological sequelae after HIE treated with TH. ...
Introduction Great improvements in outcomes have been reported in children who experience neonatal hypoxic-ischemic encephalopathy (HIE) since the introduction of therapeutic hypothermia (TH). ...
doi:10.3390/children8111076
pmid:34828791
pmcid:PMC8625352
fatcat:3nxmzt3bdjc4voaiukyyzn3kmq
Hypothermia and Other Treatment Options for Neonatal Encephalopathy: An Executive Summary of the Eunice Kennedy Shriver NICHD Workshop
2011
Journal of Pediatrics
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P erinatal hypoxic-ischemic encephalopathy (HIE), a subset of neonatal encephalopathy, is associated with high neonatal mortality and severe long-term neurologic morbidity. ...
A review of animal studies found that brain cooling to approximately 32-34 C starting within 5.5 hours after hypoxic ischemic injury and contining for 12-72 hours reduced secondary energy failure and cell ...
doi:10.1016/j.jpeds.2011.08.004
pmid:21875719
pmcid:PMC3263823
fatcat:evaemndlsraa7c5gslsmzz6fn4
Single cell sequencing technology and its application in Hypoxic ischemic encephalopathy research
2021
Ibrain
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Hypoxic ischemic encephalopathy (HIE) is the common etiology of neonatal morbidity and mortality, which exerts a negative seriously inluence for the growth and development of children, and even threatens ...
It also plays an extremely signiicant role in the basic research and precision medicine. Some studies have suggested that SCS serves a vital function in the study of HIE. ...
Introduction Neonatal hypoxic ischemic encephalopathy (NHIE) is a destructive neurological event , and is one of the most severe disease and can trigger a series of complications caused by neonatal asphyxia ...
doi:10.1002/j.2769-2795.2021.tb00086.x
fatcat:hrbu4ullpjaohf2afhvwbjpvwm
Neonatal Seizures—Are We there Yet?
2019
Neuropediatrics
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While the majority of neonatal seizures are caused by hypoxic-ischemic events, stroke, hemorrhage, or infection, approximately 15% of patients will require more sophisticated algorithms for diagnostic ...
These recent developments have led to renew interest in the classification of neonatal seizures, which aim to help identify etiology and guide appropriate therapeutic and prognostic decisions. ...
Hypoxic-ischemic encephalopathy (HIE) in term neonates and intraventricular hemorrhage (IVH) in premature neonates are the most prevalent etiology. ...
doi:10.1055/s-0039-1693149
pmid:31340400
fatcat:tsxjzcurg5ejhgp7khpacb6nzi
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