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Assessment of 135 794 Pediatric Patients Tested for Severe Acute Respiratory Syndrome Coronavirus 2 Across the United States
2020
JAMA pediatrics
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In univariate analyses, nonmalignant chronic disease was associated with lower likelihood of testing, and preexisting respiratory conditions were associated with lower risk of positive test results (standardized ...
Data were from PEDSnet, a network of 7 US pediatric health systems, comprising 6.5 million patients primarily from 11 states. Data analysis was performed from September 8 to 24, 2020. ...
in networks such as PEDSnet offers opportunities to develop accurate computable phenotypes by integrating multiple factors, but this will require sustained effort. ...
doi:10.1001/jamapediatrics.2020.5052
pmid:33226415
pmcid:PMC7684518
fatcat:34hxfxb2ijaqzitl6wf2o6g3di
Validating a computable phenotype for nephrotic syndrome in children and adults using PCORnet® data
2021
Kidney360
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A computable phenotype may be powerful in identifying patients with these diseases for research across multiple institutions. ...
The classification accuracy (sensitivity, specificity, positive and negative predictive value, F1 score) of the computable phenotype was determined. ...
in pediatric patients utilizing PEDSnet is available, 17 a sensitivity analysis of the computable phenotype classification statistics solely in adults 20 years and older was performed. ...
doi:10.34067/kid.0002892021
pmid:35419531
pmcid:PMC8986057
fatcat:c7ssqsjrdjh4nnipslgexttslu
Clinical data for paediatric research: the Swiss approach
2021
BMC Proceedings
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The project "Harmonising the collection of health-related data and biospecimens in paediatric hospitals throughout Switzerland (SwissPedData)" was an infrastructure development project funded by the SPHN ...
in healthcare and the generation of necessary evidence to address those needs. ...
Acknowledgements The authors would like to thank the speakers of the symposium and all the people who helped with the organization and coordination: Katrin Crameri, Alex Leichtle, Katie Harron ...
doi:10.1186/s12919-021-00226-3
pmid:34538238
fatcat:kpjbqo56prac3iebkw7fkpwely
Disease associations depend on visit type: results from a visit-wide association study
2019
BioData Mining
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Some findings were expected (i.e., increase of neoplasm diagnoses among cancer visits), but others were surprising, including an increase in infectious disease conditions among those visiting the Ob/Gyn ...
In this study, we investigate the role of visit type on disease association results in the first Visit-Wide Association Study or 'VisitWAS'. ...
Acknowledgements The Clinical Informatics Core at the Institute for Biomedical Informatics, University of Pennsylvania, especially Sunil Thomas and Selah Lynch for helping with extracting the clinical ...
doi:10.1186/s13040-019-0203-2
pmid:31338127
pmcid:PMC6625053
fatcat:m6nks6ambncgve3m5lenoavhim
Leveraging a Neural-Symbolic Representation of Biomedical Knowledge to Improve Pediatric Subphenotyping
[article]
2021
Zenodo
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Unfortunately, molecular data are not currently available in most electronic health records (EHRs). ...
Methods: Med2Mech was evaluated using pediatric EHR data from a subset of rare disease and other similarly medically complex patients. First, patient-level clinical embeddings were generated. ...
In lieu of access to the wide range of data required to interrogate the full spectrum of phenotypic variance associated with human disease, the next best solution is to develop a proxy (i.e., "a placeholder ...
doi:10.5281/zenodo.5746187
fatcat:dldoh64wnfhetmd2g6jphtpemq
Leveraging a Neural-Symbolic Representation of Biomedical Knowledge to Improve Pediatric Subphenotyping
[article]
2021
Zenodo
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Unfortunately, molecular data are not currently available in most electronic health records (EHRs). ...
Methods: Med2Mech was evaluated using pediatric EHR data from a subset of rare disease and other similarly medically complex patients. First, patient-level clinical embeddings were generated. ...
In lieu of access to the wide range of data required to interrogate the full spectrum of phenotypic variance associated with human disease, the next best solution is to develop a proxy (i.e., "a placeholder ...
doi:10.5281/zenodo.5746174
fatcat:2f3glm27l5bv5frhrjc5pwom2y
Translating Medicine to Mechanism: Enhancing Clinical Phenotypes with Mechanistic Knowledge
[article]
2021
Zenodo
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Unfortunately, molecular data are not currently available in most electronic health records (EHRs). ...
Methods: Med2Mech was evaluated using pediatric EHR data from a subset of rare disease and other similarly medically complex patients. First, patient-level clinical embeddings were generated. ...
In lieu of access to the wide range of data required to interrogate the full spectrum of phenotypic variance associated with human disease, the next best solution is to develop a proxy (i.e., "a placeholder ...
doi:10.5281/zenodo.6503192
fatcat:ieeur4b4ybbuvk2i3y3nub7e44
Translating Medicine to Mechanism: Enhancing Clinical Phenotypes with Mechanistic Knowledge
[article]
2021
Zenodo
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Unfortunately, molecular data are not currently available in most electronic health records (EHRs). ...
Methods: Med2Mech was evaluated using pediatric EHR data from a subset of rare disease and other similarly medically complex patients. First, patient-level clinical embeddings were generated. ...
In lieu of access to the wide range of data required to interrogate the full spectrum of phenotypic variance associated with human disease, the next best solution is to develop a proxy (i.e., "a placeholder ...
doi:10.5281/zenodo.6503189
fatcat:w23g6vrh4bhjhgo2c6bempy5ym
Transgenic Expression of IL15 Improves Antiglioma Activity of IL13Rα2-CAR T Cells but Results in Antigen Loss Variants
2017
Cancer immunology research
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We describe our experience developing a CP for pediatric leukemia and lymphoma from EHRderived data standardized in the PEDSnet Common Data Model to support translation of results across datasets. ...
COMPUTABLE PHENOTYPE FOR PEDIATRIC LEUKEMIA AND LYMPHOMACharles Phillips, Hanieh Razzaghi, Taylor Aglio, Charles BaileyThe Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States ...
Our patient displayed symptoms consistent with this phenotype including development of malignancy and extreme chemosenstivity. ...
doi:10.1158/2326-6066.cir-16-0376
pmid:28550091
pmcid:PMC5746871
fatcat:pptxshofvjepzoo2f7qgm4zk5y
2020 Pediatric Endocrine Society (PES) Annual Meeting
2020
Hormone Research in Paediatrics
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Therefore, PES is thrilled to bring a portion of the scientific essence of the PES 2020 annual meeting to you through publication of the meeting abstracts online in collaboration with Hormone Research ...
in Paediatrics. ...
Poster 172: Lifetime impact of achondroplasia on health-related quality of life (HR-QoL) and healthcare resource use: interim results from a multinational study Wayne Pan, MD PhD MBA, BioMarin Pharmaceutical ...
doi:10.1159/000509576
pmid:32604090
fatcat:nhpmnanojnhpxjine7ss7hcmni
Learning deep translational patient representations: systematic integration of clinical records and biomedical knowledge
[article]
2022
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Traditional computational phenotypes (CPs) identify patient cohorts without consideration of underlying pathophysiological mechanisms. ...
First, 36 strategies to align five eMERGE CPs to standard clinical terminologies were examined and revealed lower false negative and positive counts in adults than in pediatric patient populations. ...
A variety of computational methods have been developed to generate deep phenotypes [151] [152] [153] . ...
doi:10.25677/se22-we57
fatcat:sjoxgbfatvdvha7w6kgi2izape
SwissPedData: Standardising hospital records for the benefit of paediatric research
2021
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In this project, we aimed to assess the way routine clinical data are currently recorded in large paediatric clinics in Switzerland and to develop a national EHR-based set of common data elements (CDEs ...
) that covers all processes of routine paediatric care in hospitals. ...
Acknowledgments We thank all the experts who participated in the Delphi process, Swis-sPedNet, College A, the Swiss Personalized Health Network (SPHN), and ISPM Bern staff: Alexander Laemmle, Alexander ...
doi:10.5167/uzh-212946
fatcat:ylgdu3kjw5dkzcuzvb4pltclmq
SwissPedData: Standardising hospital records for the benefit of paediatric research
2021
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In this project, we aimed to assess the way routine clinical data are currently recorded in large paediatric clinics in Switzerland and to develop a national EHR-based set of common data elements (CDEs ...
) that covers all processes of routine paediatric care in hospitals. ...
Acknowledgments We thank all the experts who participated in the Delphi process, Swis-sPedNet, College A, the Swiss Personalized Health Network (SPHN), and ISPM Bern staff: Alexander Laemmle, Alexander ...
doi:10.48350/163898
fatcat:l43d2mg3xng6rjcir5e6sgsjhu
Towards a Learning Health System: a SOA based platform for data re-use in chronic infectious diseases
[article]
2018
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to improve activity and processes in the medical field [8] . in Minnesota [14] and the "Pediatric Learning Health System" (PEDSnet) in Pennsylvania [15] , both started in 2015 with an expected duration ...
The development of computer interpretable guidelines is facilitated by the use of a guideline editor. ...
doi:10.15167/giannini-barbara_phd2018-02-13
fatcat:s2wypthvxfg45mktn4eh55bfv4