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Detection of statistically significant differences between process variants through declarative rules [article]

Alessio Cecconi, Adriano Augusto, Claudio Di Ciccio
2021 arXiv   pre-print
The contribution to the research area is two-pronged: the use of declarative rules for the explanation of the process variants and the statistical significance analysis of the outcome.  ...  In this paper, we aim at describing the distinctive behavioural characteristics between variants expressed in the form of declarative process rules.  ...  The work of C.  ... 
arXiv:2104.07926v2 fatcat:f4agr2uljzckpd4qc6ic4sinwu

Process Variance Analysis and Configuration in the Public Administration Sector

Flavio Corradini, Caterina Luciani, Andrea Morichetta, Andrea Polini
2021 International Conference on Recent Trends and Applications in Computer Science and Information Technology  
This paper presents a three-layered methodology to contrast variants of services offered by Municipalities with the main aim of improving their business processes re-engineering as well as other significant  ...  The methodology makes it possible to detect discrepancies or alignments among services' variants.  ...  The logs are represented as annotated transition systems, and statistical tests are then performed to identify significant differences between the two models.  ... 
dblp:conf/rtacsit/CorradiniL0P21 fatcat:wyzpxnju65e2phiwohnaia3n44

Automated Simulation P2P Botnets Signature Detection by Rule-based Approach

Raihana Syahirah, Faizal M.A., Zul Azri, Nurulhuda Ahmad
2016 International Journal of Advanced Computer Science and Applications  
In this paper, we proposed an automated P2P botnets through rule-based detection approach which currently focuses on P2P signature illumination.  ...  The rule-based approach have high detection accuracy and low false positive.  ...  The tabulated of false negative that indicates undetectable P2P botnets has been proves can be successfully detected through the statistical approach.  ... 
doi:10.14569/ijacsa.2016.070819 fatcat:n2e5rubjm5arxhmtdhkc6dnhiy

How do multiple testing correction and spatial autocorrelation affect areal boundary analysis?

Pierre Goovaerts
2010 Spatial and Spatio-temporal Epidemiology  
between target and detected edges according to van Rijsbergen's F-measure.  ...  This paper presents alternative implementations of boundary analysis to: 1) quantify rate changes across boundaries both in an absolute (rate difference) and relative (rate ratio) ways, 2) detect changes  ...  The views stated in this publication are those of the author and do not necessarily represent the official views of the NCI.  ... 
doi:10.1016/j.sste.2010.09.004 pmid:21151834 pmcid:PMC2998766 fatcat:unqea36sdzgmjjsuopgk7asc7m

Genetic association studies in cardiovascular diseases: Do we have enough power?

Paul L. Auer, Nathan O. Stitziel
2017 Trends in cardiovascular medicine  
We provide an overview of the component parts that determine statistical power and preview the future of CVD genetic association studies through this lens.  ...  As these studies continue to expand, the issue of statistical power plays an important role in study design as well as the interpretation of results.  ...  5 percent cutoff for declaring "statistical significance"), the cutoff for declaring statistical significance should be p=0.05/n.  ... 
doi:10.1016/j.tcm.2017.03.005 pmid:28456354 pmcid:PMC5642948 fatcat:qfsipbrnnjevjbt5syisgns4va

Decoding expectation and surprise in dementia: the paradigm of music Musical surprise processing in dementia

Elia Benhamou, Sijia Zhao, Harri Sivasathiaseelan, Jeremy C S Johnson, Maï-Carmen Requena-Komuro, Rebecca L Bond, Janneke E P van Leeuwen, Lucy L Russell, Caroline V Greaves, Annabel Nelson, Jennifer M Nicholas, Chris J D Hardy (+2 others)
2021 Brain Communications  
We studied 62 patients (24 female; aged 53–88) representing major syndromes of frontotemporal dementia (behavioural variant, semantic variant primary progressive aphasia, nonfluent-agrammatic variant primary  ...  Whereas Alzheimer's disease was associated with normal deviant detection accuracy, behavioural and semantic variant frontotemporal dementia syndromes were associated with strikingly similar profiles of  ...  No significant AUC differences were found between deviant conditions.  ... 
doi:10.1093/braincomms/fcab173 pmid:34423301 pmcid:PMC8376684 fatcat:vtagqfegtrfojndcjzgcwu45vm

Anomaly detection

Varun Chandola, Arindam Banerjee, Vipin Kumar
2009 ACM Computing Surveys  
For each category, we provide a basic anomaly detection technique, and then show how the different existing techniques in that category are variants of the basic technique.  ...  This survey tries to provide a structured and comprehensive overview of the research on anomaly detection.  ...  ACKNOWLEDGMENTS The authors thank Shyam Boriah and Gang Fang for extensive comments on the final draft of the article.  ... 
doi:10.1145/1541880.1541882 fatcat:bdimpqcz5bbyhjqatvpw45cmja

The harmonic mean p-value for combining dependent tests [article]

Daniel John Wilson
2017 bioRxiv   pre-print
Analysis of 'big data' frequently involves statistical comparison of millions of competing hypotheses to discover hidden processes underlying observed patterns of data, for example in the search for genetic  ...  I show that the HMP easily combines information to detect statistically significant signals among groups of individually nonsignificant hypotheses in examples of a human GWAS for neuroticism and a joint  ...  Since human GWAS began routinely testing millions of variants by statistically imputing untyped variants, a new convention was adopted in which a p-value is deemed significant if p  5 ⇥ 10 8 , a rule  ... 
doi:10.1101/171751 fatcat:4wxafdpuhrghtpt5zwri3234ky

The harmonic mean p-value for combining dependent tests

Daniel J. Wilson
2019 Proceedings of the National Academy of Sciences of the United States of America  
Analysis of "big data" frequently involves statistical comparison of millions of competing hypotheses to discover hidden processes underlying observed patterns of data, for example, in the search for genetic  ...  I show that the HMP effortlessly combines information to detect statistically significant signals among groups of individually nonsignificant hypotheses in examples of a human GWAS for neuroticism and  ...  Since human GWAS began routinely testing millions of variants by statistically imputing untyped variants, a new convention was adopted in which a p-value is deemed significant if p ≤ 5 × 10 −8 , a rule  ... 
doi:10.1073/pnas.1814092116 pmid:30610179 pmcid:PMC6347718 fatcat:xwucv2mkofb3ne5lsl34zn2q7e

GATK hard filtering: tunable parameters to improve variant calling for next generation sequencing targeted gene panel data

Simona De Summa, Giovanni Malerba, Rosamaria Pinto, Antonio Mori, Vladan Mijatovic, Stefania Tommasi
2017 BMC Bioinformatics  
Conclusions: Our results showed that GATK hard filtering parameter values can be tailored through a simulation study based-on the DNA region of interest to ameliorate the accuracy of the variant calling  ...  The proprietary software that are generally used for variant calling often depend on preset parameters that may not fit in a satisfactory manner for different genes.  ...  Competing interests The authors declare that they have no competing interests.  ... 
doi:10.1186/s12859-017-1537-8 pmid:28361668 pmcid:PMC5374681 fatcat:5bqj62utbfelvlaro3eo3cyboe

The PTPN22 C1858T (R620W) functional polymorphism in inflammatory bowel disease

Younes Zaid, Nezha Senhaji, Fatima Zahra Bakhtaoui, Aurora Serrano, Nadia Serbati, Mehdi Karkouri, Wafaa Badre, Mounia Oudghiri, Javier Martin, Sellama Nadifi
2018 BMC Research Notes  
No evidence of statistically significant differences was observed when the PTPN22 (R620W) allele and genotype distribution among IBD, Crohn's disease (CD), ulcerative colitis (UC) patients and healthy  ...  Furthermore, the frequency of this allele was increased in UC patients compared to controls (4.17% vs. 1.77%, OR = 2.42, 95% CI 0.82-7.08; P = 0.09), but the difference was not statistically significant  ...  When comparing patients Similarly, no statistically significant differences were observed when the 1858C>T SNP genotype distribution between CD patients, UC patients, and healthy controls was compared.  ... 
doi:10.1186/s13104-018-3875-7 fatcat:escjmlpzzzhjvbyaaxejidhutq

Dynamic Memory for Interpretable Sequential Optimisation [article]

Srivas Chennu, Andrew Maher, Jamie Martin, Subash Prabanantham
2022 arXiv   pre-print
It enables interpretability through statistical hypothesis testing, by targeting a set point of statistical power when comparing rewards and adjusting its memory dynamically to achieve this power.  ...  By design, the agent is agnostic to different kinds of non-stationarity.  ...  Alongside, the business operator is shown statistical confidence in significant differences between the variants, for the purposes of interpretation and decision making.  ... 
arXiv:2206.13960v1 fatcat:nkoguvspbzf2vhthv3qqfz6tbe

Search and discovery in an uncertain networked world

E.B. Ermis, M. Alanyali, V. Saligrama
2006 IEEE Signal Processing Magazine  
While significant effort over the last decade has produced the necessary infrastructure for deployment, efficient monitoring requires development of new distributed signal processing and decision making  ...  We consider the example of a sensor network for  ...  Figure 7 illustrates the tradeoff between communication bits and number of detections generated using 100 observations, 30 of which were significant.  ... 
doi:10.1109/msp.2006.1657821 fatcat:ld4l5vrno5h6vpuqcjyijndvjm

The common non-synonymous variant G38S of the KCNE1-(minK)-gene is not associated to QT interval in Central European Caucasians: results from the KORA study

M. Akyol, S. Jalilzadeh, M. F. Sinner, S. Perz, B. M. Beckmann, C. Gieger, T. Illig, H.-E. Wichmann, T. Meitinger, S. Kaab, A. Pfeufer
2007 European Heart Journal  
We did not detect any significant association between the genotypes of the G38S variant and the QT interval in the entire population or in any gender.  ...  A recent family-based study found an association between QT interval and the common non-synonymous Glycin 38 Serine variant (G38S, rs1805127) of the KCNE1 gene coding for the minK-potassium channel subunit  ...  Acknowledgements Conflict of interest: none declared.  ... 
doi:10.1093/eurheartj/ehl460 pmid:17227789 fatcat:d36u4hrqm5hvtcjpzqmspjldry

Identification of recurrent genetic patterns from targeted sequencing panels with advanced data science: a case-study on sporadic and genetic neurodegenerative diseases

M. Tarozzi, A. Bartoletti-Stella, D. Dall'Olio, T. Matteuzzi, S. Baiardi, P. Parchi, G. Castellani, S. Capellari
2022 BMC Medical Genomics  
Pathway enrichment and protein–protein interaction network revealed different altered pathways between the two PRNP mutations.  ...  patterns in different types of dementia.  ...  Table 2 2 Summary of results of statistical analysis on each variant detected in our target sequencing panelRows identify pathologic groups with their numerosity reported between brackets.  ... 
doi:10.1186/s12920-022-01173-4 pmid:35144616 pmcid:PMC8830183 fatcat:6sjxum55enc4lcvlm6wqjjo6ku
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