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Detection of lobular structures in normal breast tissue

Grégory Apou, Nadine S. Schaadt, Benoît Naegel, Germain Forestier, Ralf Schönmeyer, Friedrich Feuerhake, Cédric Wemmert, Anne Grote
2016 Computers in Biology and Medicine  
Herein, we compare different approaches to automatically detect lobular structures in human normal breast tissue in digitized whole slide images (WSIs).  ...  Additionally, detected ROIs could be used as a basis for quantification of immune infiltration in lobular structures.  ...  RS applied the nuclei detection used in MBU and established exchange of image analysis data. FF provided the expert annotations and pathological input.  ... 
doi:10.1016/j.compbiomed.2016.05.004 pmid:27209271 fatcat:v63poyqhyjh7ngi374hxx3x4jm

The Expression of the Zonula Adhaerens Protein PLEKHA7 Is Strongly Decreased in High Grade Ductal and Lobular Breast Carcinomas

Jean-Christophe Tille, Liza Ho, Jimit Shah, Olivia Seyde, Thomas A. McKee, Sandra Citi, Fernando Schmitt
2015 PLoS ONE  
In summary, PLEKHA7 is a junctional marker of epithelial cells within tubular structures both in normal breast tissue and ductal carcinomas, and since PLEKHA7 protein but not mRNA expression is strongly  ...  PLEKHA7 was detected at epithelial junctions of normal mammary ducts and lobules, and of tubular and micropapillary structures within G1 and G2 ductal carcinomas.  ...  In normal breast tissue, PLEKHA7 was detected at apical zonular junctions of epithelial cells facing the lumen of glands (Fig 2A' , arrow in magnified inset).  ... 
doi:10.1371/journal.pone.0135442 pmid:26270346 pmcid:PMC4535953 fatcat:ppjtymka7beztlezkzqcojcbwe

Modelling and Validating Three-Dimensional Human Breast and Cancerous Human Breast Tissues In Vitro

Anna Karolina Zuk, Anna Karolina Zuk, Beata Burczynska, Dong Li, Lucy Ghali, Stephen Dilworth, Xuesong Wen
2020 Clinical Oncology and Research  
to the ducto-lobular structures observed in normal 3-D model of the breast but the former cells were more loosely connected, irregular and largely disorganized.  ...  The established 3-D in vitro model of normal breast showed the development of ducto-lobular structures composed of an inner cell layer which was stained positive with α mucin 1 antibody, a biomarker that  ...  Acknowledgements This work was supported by the Middlesex University, particularly in the award of a Postgraduate Research Studentship that provided the necessary financial support for this research.  ... 
doi:10.31487/j.cor.2020.04.05 fatcat:gyvdciucpjc7lnahsvpjsp4x7u

Image analysis of immune cell patterns in the human mammary gland during the menstrual cycle refines lymphocytic lobulitis

Nadine S. Schaadt, Juan Carlos López Alfonso, Ralf Schönmeyer, Anne Grote, Germain Forestier, Cédric Wemmert, Nicole Krönke, Mechthild Stoeckelhuber, Hans H. Kreipe, Haralampos Hatzikirou, Friedrich Feuerhake
2017 Breast Cancer Research and Treatment  
Purpose: To improve microscopic evaluation of immune cells relevant in breast cancer oncoimmunology, we aim at distinguishing normal infiltration patterns from lymphocytic lobulitis by advanced image analysis  ...  an article published in Breast Cancer Research and Treatment.  ...  Welsch, Department for Cell Biology, Biomedical Center Munich, for his kind permission to use materials from previous studies that were collected during his term as Head of the Department for Microscopic  ... 
doi:10.1007/s10549-017-4239-z pmid:28444535 fatcat:wftsiq72ebghdmcpvikcsqdzuq

Exploring the spatial dimension of estrogen and progesterone signaling: detection of nuclear labeling in lobular epithelial cells in normal mammary glands adjacent to breast cancer

Anne Grote, Mahmoud Abbas, Nina Linder, Hans H Kreipe, Johan Lundin, Friedrich Feuerhake
2014 Diagnostic Pathology  
Herein, we propose a combination of automated region labeling at low resolution and subsequent detailed tissue evaluation of subcellular structures in lobular structures adjacent to breast cancer, as a  ...  Presence of disrupted lobular structures, either by brisk inflammatory infiltrate, or diffuse tumor infiltration, was common in cases with lower detection accuracy.  ...  We show that object-oriented evaluation of ER/PR expression in the spatial context of surrounding tissue is feasible and propose an approach of automated detection of lobular structures based on texture  ... 
doi:10.1186/1746-1596-9-s1-s11 pmid:25565114 pmcid:PMC4305969 fatcat:izlwcgfw25d7zopm4anh7birim

The Myoepithelial Cell Layer May Serve As a Potential Trigger Factor for Different Outcomes of Stage-Matched Invasive Lobular and Ductal Breast Cancers

Yi-Hsuan Hsiao, Horng-Der Tsai, Ming-Chih Chou, Yan-gao Man
2011 International Journal of Biological Sciences  
In the lobular system, elevated cell proliferation or malignancy-associated changes are often simultaneously present at the entire lobular structures of morphologically normal appearing lobules, in which  ...  Hidden malignant cells within leukocyte aggregates in normal or hyperplastic tissues of pregnancy-associated breast cancer. Cancer Epid, in press 24. Hsiao YH, Chou MC, Fowler C, Mason JT, Man YG.  ...  Conflict of Interests The authors have declared that no conflict of interest exists.  ... 
doi:10.7150/ijbs.7.147 pmid:21326853 pmcid:PMC3039295 fatcat:hhhmpmbffzbaro2m5tfclvc7f4

Influence of the antioestrogen tamoxifen on normal breast tissue

KJ Walker, JM Price-Thomas, W Candlish, RI Nicholson
1991 British Journal of Cancer  
Ki67 expression was observed in < 10% of all normal cells and was suppressed by the menopause in lobular tissue.  ...  Immunohistochemical assays have been employed to study the expression of ER, PgR, EGFR and Ki67 immunostaining in normal breast tissue (n = 76).  ...  in the lobular component of normal breast tissue in comparison to postmenopausal controls (median values 30 and 20 respec-tively).  ... 
doi:10.1038/bjc.1991.395 pmid:1911227 pmcid:PMC1977690 fatcat:zbv57i3q7bdy5ovmrdyal4cibi

The Shrinking Breast: An Unusual Mammographic Finding of Invasive Lobular Carcinoma

Nazia Jafri
2007 Radiology Case Reports  
The abnormality in the cases manifested as an apparent decrease in breast glandular tissue volume when compared with the patients' previous mammograms, observed as "shrinking" of the breast on mammography  ...  Although magnetic resonance imaging and computer-aided detection have somewhat improved the detection of invasive lobular carcinoma, radiologic and clinical detection remains a challenge.  ...  The normal, scalloped appearance of breast tissue may take on a tented appearance [6] .  ... 
doi:10.2484/rcr.2007.v2i3.94 fatcat:txo6pjw7ezad3be2nexpv2icua

The Shrinking Breast: An Unusual Mammographic Finding of Invasive Lobular Carcinoma

Nazia F. Jafri, Priscilla J. Slanetz
2007 Radiology Case Reports  
The abnormality in the cases manifested as an apparent decrease in breast glandular tissue volume when compared with the patients' previous mammograms, observed as "shrinking" of the breast on mammography  ...  Although magnetic resonance imaging and computer-aided detection have somewhat improved the detection of invasive lobular carcinoma, radiologic and clinical detection remains a challenge.  ...  The normal, scalloped appearance of breast tissue may take on a tented appearance [6] .  ... 
doi:10.2484/rcr.v2i3.94 pmid:27303480 pmcid:PMC4895069 fatcat:rjnsrqhhajai7itibz4mqs7uua

Ultrasonic analysis of breast tissue for pathology classification

Kristina M. Sorensen, Timothy E. Doyle
2011 Journal of the Acoustical Society of America  
Ultrasonic results from breast specimens were used to construct a multivariate analysis of the parameters that permitted differentiation of normal, adipose, benign, and malignant breast pathologies.  ...  Previous findings show that highfrequency ultrasound can differentiate between a range of breast pathologies in surgical specimens.  ...  Tissues with lower slopes in 2 nd -order spectra exhibit normal microscopic ductal structures, such as shown between normal breast glands and renal medulla.  ... 
doi:10.1121/1.3654728 fatcat:vh23w3jt4vedjkz5i7ylz6mr3q

Hamartoma of the breast in two patients: A case report

FATMA CAVIDE SONMEZ, ZUHAL GUCIN, PELIN YILDIZ, ZEYNEP TOSUNER
2013 Oncology Letters  
The hamartoma was first described in 1971 as a lipofibroadenoma, fibroadenolipoma or adenolipoma, based on the predominant component of the breast tissue.  ...  Breast hamartomas are rare, benign, tumor-like nodules composed of glandular, adipose and fibrous tissue.  ...  Microscopic observations were also characteristic of a lipoma; the tumor was surrounded by a fibrous pseudocapsule and consisted of mature fat and islands of structurally normal glandular tissue with lobular  ... 
doi:10.3892/ol.2013.1366 pmid:24137343 pmcid:PMC3789047 fatcat:d2q7ljqjczbetndxulgvumhpti

A Technique for Detection and Analysis of Human Breast Cancer

Samir Kumar Bandyopadhyay, Indra Kanta Maitra
2010 International Journal of Computer Applications  
Imaging techniques can play an important role in helping perform breast biopsies, especially of abnormal areas.  ...  Here an attempt is made to analyze the biopsy slides for identification and detection of the area of affected cancer.  ...  Identification and Detection We have to understand the structure of normal breast and identify the abnormality due to propagation of cancer.  ... 
doi:10.5120/1068-1396 fatcat:uiovg2yw5vhtxbinklzbx24zha

Detecting Breast Cancer Not Visible by Mammography

D. B. Kopans
1992 Journal of the National Cancer Institute  
One of the goals of high-quality mammography is to enhance the relatively low contrast differences between the normal attenuating tissues of the breast and pathologically significant structures.  ...  A second reason why breast cancers may be obscured on mammography is that the mammogram is a two-dimensional projection of three-dimensional tissues and the shadows of normal structures superimposed on  ... 
doi:10.1093/jnci/84.10.745 pmid:1573658 fatcat:v2wpg74xrrd6dkjugb5alhhntm

Lobular breast cancer series: imaging

Karen Johnson, Deba Sarma, E Shelley Hwang
2015 Breast Cancer Research  
The limitations of mammography in the detection and evaluation of invasive lobular carcinoma (ILC) have long been recognized, presenting real clinical challenges in treatment planning for these tumors.  ...  Further, we will discuss emerging technologies that may be employed to enhance the detection rate and ultimately result in more effective screening and staging of ILC.  ...  Acknowledgements The authors thank Dr Rachel Brem MD of George Washington Medical Faculty Associates of Washington DC for her contribution of molecular breast imaging radiographs.  ... 
doi:10.1186/s13058-015-0605-0 pmid:26163296 pmcid:PMC4499185 fatcat:k3rr25wn75a6titco734m4s23e

In-silico insights on the prognostic potential of immune cell infiltration patterns in the breast lobular epithelium

J. C. L. Alfonso, N. S. Schaadt, R. Schönmeyer, N. Brieu, G. Forestier, C. Wemmert, F. Feuerhake, H. Hatzikirou
2016 Scientific Reports  
Scattered inflammatory cells are commonly observed in mammary gland tissue, most likely in response to normal cell turnover by proliferation and apoptosis, or as part of immunosurveillance.  ...  In contrast, lymphocytic lobulitis (LLO) is a recurrent inflammation pattern, characterized by lymphoid cells infiltrating lobular structures, that has been associated with increased familial breast cancer  ...  Welsch (Ludwig-Maximilians University of Munich, Germany) for kindly allowing the use of normal breast tissue samples from a previous study [43] .  ... 
doi:10.1038/srep33322 pmid:27659691 pmcid:PMC5034260 fatcat:cd66lviesjahfpu5kerzds66qu
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