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Cerebral Blood Flow is an Earlier Indicator of Perfusion Abnormalities than Cerebral Blood Volume in Alzheimer's Disease

María Lacalle-Aurioles, José M Mateos-Pérez, Juan A Guzmán-De-Villoria, Javier Olazarán, Isabel Cruz-Orduña, Yasser Alemán-Gómez, María-Elena Martino, Manuel Desco
2014 Journal of Cerebral Blood Flow and Metabolism  
We compared measurements of CBV, CBF, and mean cortical thickness obtained from magnetic resonance images in a group of healthy controls, patients with mild cognitive impairment (MCI) who converted to  ...  The purpose of this study was to elucidate whether cerebral blood flow (CBF) can better characterize perfusion abnormalities in predementia stages of Alzheimer's disease (AD) than cerebral blood volume  ...  Sponsorship comes exclusively from public research funding, and there is no commercial or financial involvement that might present a conflict of interest in connection with this manuscript.  ... 
doi:10.1038/jcbfm.2013.241 pmid:24424381 pmcid:PMC3982085 fatcat:trawrpzikzedfbrezkglsnscya

Association of brain amyloid-β with cerebral perfusion and structure in Alzheimer's disease and mild cognitive impairment

Niklas Mattsson, Duygu Tosun, Philip S. Insel, Alix Simonson, Clifford R Jack, Laurel A. Beckett, Michael Donohue, William Jagust, Norbert Schuff, Michael W. Weiner
2014 Brain  
Patients with Alzheimer's disease have reduced cerebral blood flow measured by arterial spin labelling magnetic resonance imaging, but it is unclear how this is related to amyloid-b pathology.  ...  ), inferior parietal cortex (late mild cognitive impairment and dementia), and inferior temporal cortex (early and late mild cognitive impairment and dementia).  ...  Funding Data collection and sharing for this project was funded by the Alzheimer's Disease Neuroimaging Initiative (National Institutes of Health Grant U01 AG024904).  ... 
doi:10.1093/brain/awu043 pmid:24625697 pmcid:PMC3999717 fatcat:6w2izgshnrf4bm63ah6p7jhgva

Regional Cerebral Blood Flow in Mild Cognitive Impairment and Alzheimer's Disease Measured with Arterial Spin Labeling Magnetic Resonance Imaging

Alba Sierra-Marcos
2017 International Journal of Alzheimer's Disease  
Arterial spin labeling- (ASL-) based MRI methods have been applied for detecting regional cerebral blood flow (rCBF) perfusion changes in patients with AD and mild cognitive impairment (MCI).  ...  Alzheimer's disease (AD) depicts dynamic changes in regional brain function from early stages of the disease.  ...  Mild cognitive impairment (MCI) is considered the prodromal phase of AD, and it is characterized by early cognitive symptoms not severe enough to meet the criteria for dementia [2] .  ... 
doi:10.1155/2017/5479597 pmid:28573062 pmcid:PMC5442339 fatcat:kl4y5ve3yzc7xja4mizhd5fwva

Comparing Cerebral Perfusion in Alzheimer's Disease and Parkinson's Disease Dementia: An ASL-MRI Study

Campbell J Le Heron, Sarah L Wright, Tracy R Melzer, Daniel J Myall, Michael R MacAskill, Leslie Livingston, Ross J Keenan, Richard Watts, John C Dalrymple-Alford, Tim J Anderson
2014 Journal of Cerebral Blood Flow and Metabolism  
We sought to directly compare cerebral perfusion in these two conditions using arterial spin labeling magnetic resonance imaging (ASL-MRI).  ...  Alzheimer's disease and PDD perfusion was analyzed by whole-brain voxel-based analysis (to assess absolute blood flow), a priori specified region of interest analysis, and principal component analysis  ...  ACKNOWLEDGMENTS The authors would like to thank all subjects who gave their time to participate in this study. We would also like to thank Dr Matthew Croucher for assistance with AD data collection.  ... 
doi:10.1038/jcbfm.2014.40 pmid:24619276 pmcid:PMC4050238 fatcat:at73dzvgcndhpfupf4mn3ocq7q

Detection of severity in Alzheimer's disease (AD) using computational modeling

Hyunjo Kim
2018 Bioinformation  
Detection of changed regional cerebral blood flow in mild cognitive impairment and early AD by perfusion-weighted magnetic resonance imaging has been a challenge.  ...  The utility of perfusion-weighted magnetic resonance imaging (PW-MRI) for detecting changes in regional cerebral blood flow (rCBF) in patients with mild cognitive impairment (MCI) and early AD was evaluated  ...  Acknowledgement: The author thanks the Department of Life Sciences, Gachon University, Gyeonggido, Korea for support.  ... 
doi:10.6026/97320630014259 pmid:30108425 pmcid:PMC6077821 fatcat:4jkrrn2l55hc7dlqbjtmgi34fq

Potential neuroimaging biomarkers of pathologic brain changes in Mild Cognitive Impairment and Alzheimer's disease: a systematic review

Qingwei Ruan, Grazia D'Onofrio, Daniele Sancarlo, Zhijun Bao, Antonio Greco, Zhuowei Yu
2016 BMC Geriatrics  
Neuroimaging-biomarkers of Mild Cognitive Impairment (MCI) allow an early diagnosis in preclinical stages of Alzheimer's disease (AD).  ...  The goal in this paper was to review of biomarkers for Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD), with emphasis on neuroimaging biomarkers.  ...  Regional cerebral blood flow measured by [11C]dihydrotetrabenazine (DTBZ)-PET also provided similar information in assessment of regional cerebral metabolic deficits in mild dementia and MCI with FDG-PET  ... 
doi:10.1186/s12877-016-0281-7 pmid:27184250 pmcid:PMC4869390 fatcat:spci42k24rarvkagqslsivbfd4

Pattern of cerebral hyperperfusion in Alzheimer's disease and amnestic mild cognitive impairment using voxel-based analysis of 3D arterial spin-labeling imaging: initial experience

Bei Ding, Hua Wei Ling, Juan Huang, Huan Zhang, Tao Wang, Fu Hua Yan, Yong Zhang
2014 Clinical Interventions in Aging  
amnestic mild cognitive impairment (aMCI), and age-and sex-matched healthy controls.  ... Purpose: A three-dimensional (3D) continuous pulse arterial spin labeling (ASL) technique was used to investigate cerebral blood flow (CBF) changes in patients with Alzheimer's disease (AD),  ...  research found decreased regional cerebral blood flow (CBF) in AD. 4 Indeed, perfusion deficiencies are present from very early preclinical phases of AD (ie, during mild cognitive impairment [MCI]  ... 
doi:10.2147/cia.s58879 pmid:24707173 pmcid:PMC3971940 fatcat:5r2bpgrcq5hsbedoobkk65rr5y

Basic principles of spectroscopy, and perfusion weighted imaging

Norbert W. Schuff
2005 Alzheimer's & Dementia  
In this course, the physical principles of magnetic resonance (MR) spectroscopy, which detects cerebral metabolites and arterial spin labeling (ALS) magnetic resonance imaging (MRI), which can measure  ...  Moreover, ASL-MRI showed regional hypoperfusion already in mild cognitively impaired subjects, who are at increased risk for AD, suggesting that early signs of AD before clinical symptoms develop may be  ... 
doi:10.1016/j.jalz.2005.06.042 fatcat:bhsfemey6re6jitwc7kej6emvm

Disorders of cerebrovascular angioarchitectonics and microcirculation in the etiology and pathogenesis of Alzheimer's disease

Ivan V. Maksimovich
2013 Advances in Alzheimer s Disease  
All patients underwent: assessment of cognitive function (MMSE), severity of dementia (CDR) and AD stages (TDR), laboratory examination, computed tomography (CT), magnetic resonance imaging (MRI), brain  ...  lesions with manifestations of dementia and cognitive impairment but without AD.  ...  SG) [42] , single-photon emission computed tomography (SPECT), positron emission tomography (PET) [27, 43] , perfusion weighted magnetic resonance imaging (Perfusion MRI or PWI) [27] .  ... 
doi:10.4236/aad.2013.24022 fatcat:d4r3bhr6wbeftocphjdtbeafum

Paradoxical hippocampus perfusion in mild-to-moderate Alzheimer's disease

K Ishii, M Sasaki, S Yamaji, S Sakamoto, H Kitagaki, E Mori
1998 Journal of Nuclear Medicine  
The purpose of this study was to clarify the changes in hippocampal perfusion in mild-to-moderate Alzheimer's disease using PET and (15)O-labeled water.  ...  Lateralization of epileptic foci by magnetic resonance imaging in temporal lobe epilepsy. J Neuroimag 1991:1:163-167. 8. Spencer SS.  ...  lobe in the early stage of Alzheimer's disease and contribute to early memory impair ment (2) .  ... 
pmid:9476938 fatcat:7g6gmbiwcbcdzid3gdmwcy7tmi

Predicting Very Early Stage Mild Cognitive Impairment Based on a Voxel-wise Arterial Spin Labeling Analysis [chapter]

Gloria Díaz, Pablo García-Polo, Virginia Mato, Eva Alfayate, Juan Antonio Hernández-Tamames, Norberto Malpica
2014 Lecture Notes in Computer Science  
Most previous studies have been based on structural or functional magnetic resonance imaging. However, the results are not yet sufficient to identify early stages of dementia.  ...  In this paper, we present an image processing and pattern recognition strategy that allows to predict short-term conversion to Mild Cognitive Impairment (MCI) based on the analysis of Arterial Spin Labeling  ...  For cerebral blood flow (CBF) in the brain, this is attained by tagging a small bolus of arterial blood in the carotid arteries.  ... 
doi:10.1007/978-3-319-12568-8_87 fatcat:ybiyvcv3dbhzfo37vlzotgifj4

Using Magnetic Resonance Imaging in the Early Detection of Alzheimer's Disease [chapter]

Emily J., Manus J., Brandon A.
2013 Understanding Alzheimer's Disease  
Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia. "rch Neurol.  ...  Understanding Alzheimer's Disease 244 Using Magnetic Resonance Imaging in the Early Detection of Alzheimer's Disease  ...  Regional cerebral perfusion in patients with "lzheimer's disease and mild cognitive impairment effect of "POE Epsilon allele. Neuroradiology. Jul. .  ... 
doi:10.5772/54445 fatcat:lyc7fm7kfnh3njaadtflsgctte

Divergent regional patterns of cerebral hypoperfusion and gray matter atrophy in mild cognitive impairment patients

Miranka Wirth, Alexa Pichet Binette, Peter Brunecker, Theresa Köbe, A Veronica Witte, Agnes Flöel
2016 Journal of Cerebral Blood Flow and Metabolism  
The findings support applicability of cerebral perfusion and gray matter structure as complementary magnetic resonance imaging-based biomarkers in early Alzheimer's disease detection, a hypothesis to be  ...  In each participant, cerebral perfusion and gray matter structure were extracted within selected brain regions vulnerable to Alzheimer's disease using magnetic resonance imaging.  ...  Sylvia Villeneuve (Centre for Studies on Prevention of Alzheimer's Disease, Douglas Mental Health University Institute, Montreal, Canada) for help in data collection, analysis or manuscript drafting, respectively  ... 
doi:10.1177/0271678x16641128 pmid:27037094 pmcid:PMC5363461 fatcat:ciga7mm2zzddhlfrqaytep47hu

Electroencephalography-driven approach to prodromal Alzheimer's disease diagnosis: from biomarker integration to network-level comprehension

Moretti DV
2016 Clinical Interventions in Aging  
Neuropsychological evaluation, EEG recording, and magnetic resonance imaging were conducted in 74 patients with mild cognitive impairment (MCI).  ...  In view of α3/α2 power ratio, the patients were divided into three groups. The connections among cortical decay, cerebral perfusion, and memory loss were evaluated by Pearson's r coefficient.  ...  Neuropsychological evaluation, EEG recording, and magnetic resonance imaging were conducted in 74 patients with mild cognitive impairment (MCI).  ... 
doaj:fa78da26fabd4897b1c6e9c97773b312 fatcat:nouewespbbazrkbxlanbx4bau4

Three-dimensional pseudocontinuous arterial spin labeling and susceptibility-weighted imaging associated with clinical progression in amnestic mild cognitive impairment and Alzheimer's disease

Qingling Huang, Xuan Cao, Xue Chai, Xiao Wang, Ligang Xu, Chaoyong Xiao
2019 Medicine  
We assessed the cerebral blood flow (CBF) in 11 different regions of interest, and counted number of microhemorrhages (MB) in 3 regions of brain lobes, bilateral basal ganglia/thalamus, and brain stem/  ...  This study aimed to evaluate the value of 3-dimensional pseudocontinuous arterial spin labeling (3D-pcASL) and susceptibility-weighted imaging (SWI) for the early disease-sensitive markers of conversion  ...  Its symptoms usually begin with a subtle decrease in memory of mild cognitive impairment (MCI), especially in the subtype of amnestic mild cognitive impairment (aMCI).  ... 
doi:10.1097/md.0000000000015972 pmid:31169728 pmcid:PMC6571427 fatcat:zc42j3j4orb5rnyj5udbyhasr4
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