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Synchrony Dynamics Across Brain Structures in Limbic Epilepsy Vary Between Initiation and Termination Phases of Seizures

T. Sobayo, A. S. Fine, E. Gunnar, C. Kazlauskas, D. Nicholls, D. J. Mogul
2013 IEEE Transactions on Biomedical Engineering  
In this study, we sought to develop a more in-depth understanding of multisite dynamics underlying seizure evolution in limbic epilepsy by analyzing oscillators in recordings of local field potentials  ...  from three brain structures (bilateral hippocampi and anteromedial thalamus) in a kainic acid in vivo rat model of temporal lobe epilepsy extracted using the empirical mode decomposition (EMD) technique  ...  To our knowledge, this is the first evidence of clear interregional synchrony between these structures at well-defined frequencies and seizure states in an in vivo animal model of limbic epilepsy.  ... 
doi:10.1109/tbme.2012.2189113 pmid:22389141 fatcat:aszlukk2xbevhli3h7hhbromq4

Expanding Brain–Computer Interfaces for Controlling Epilepsy Networks: Novel Thalamic Responsive Neurostimulation in Refractory Epilepsy

Abhijeet Gummadavelli, Hitten P. Zaveri, Dennis D. Spencer, Jason L. Gerrard
2018 Frontiers in Neuroscience  
We highlight the network theory of epilepsy, potential targets for neuromodulation in epilepsy and the first reported use of RNS as a first generation brain-computer interface to detect and stimulate the  ...  centromedian intralaminar thalamic nucleus in a patient with bilateral cortical onset of seizures.  ...  With all detections, the CM nucleus receives a short burst of high-frequency stimulation (Figure 5) .  ... 
doi:10.3389/fnins.2018.00474 pmid:30108472 pmcid:PMC6079216 fatcat:76o4tl72crdlnp367rvptqhrgy

Control of in vivo ictogenesis via endogenous synaptic pathways

Hiram Luna-Munguia, Phillip Starski, Wu Chen, Stephen Gliske, William C. Stacey
2017 Scientific Reports  
In this work, we present a novel method of controlling ictogenesis in an in vivo model of temporal lobe epilepsy in rats.  ...  Building upon previous theoretical and in vitro work showing that synaptic noise can induce seizures, we developed a novel in vivo model of ictogenesis.  ...  This effect was shown previously in normal signal detection 22 , high frequency oscillations 17 , and seizures 24 .  ... 
doi:10.1038/s41598-017-01450-8 pmid:28465556 pmcid:PMC5431002 fatcat:nod2bkkypjaqjkd4rvov4igsve

Effects of Transcranial Direct-Current Stimulation on Gait Initiation in People with Parkinson's Disease [article]

Jonathan Lyon Jacob Lommen, University, My, University, My
Statistical Analyses/Results: Two-way repeated measures ANOVAs with Bonferroni corrections and a post-hoc analyses when appropriate, revealed a significant reduction in the magnitude of center of pressure  ...  in PD.  ...  Calculations for RT also incorporated a Teager-Kaiser Energy Operator to increase the accuracy of EMG onset detection .  ... 
doi:10.20381/ruor-24198 fatcat:q6yzhrlenzdkjdc2t4fyjkdy5i