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Detecting resting-state brain activity by spontaneous cerebral blood volume fluctuations using whole brain vascular space occupancy imaging

Xinyuan Miao, Hong Gu, Lirong Yan, Hanzhang Lu, Danny J.J. Wang, Xiaohong Joe Zhou, Yan Zhuo, Yihong Yang
2014 NeuroImage  
In this study, we demonstrate that resting-state brain activity can be reliably detected by spontaneous fluctuations of CBV-weighted signal using whole-brain gradient and spin echo (GRASE) based vascular  ...  Resting-state brain activity has been investigated extensively using BOLD contrast.  ...  Research Program of the National Institute on Drug Abuse (NIDA), and R01 NS067015/NS/NINDS NIH HHS/United States.  ... 
doi:10.1016/j.neuroimage.2013.09.019 pmid:24055705 fatcat:xampgjydong6zmrwom4yuup36y

Comparison of Resting-State Brain Activation Detected by BOLD, Blood Volume and Blood Flow

Ke Zhang, Dengfeng Huang, N Jon Shah
2018 Frontiers in Human Neuroscience  
Resting-state brain activity has been widely investigated using blood oxygenation level dependent (BOLD) contrast techniques.  ...  In this study, resting-state brain activation was detected and compared using the following techniques: (a) BOLD, using a gradient-echo echo planar imaging (GE-EPI) sequence; (b) CBV-weighted signal, acquired  ...  The use of the spontaneous fluctuation of the CBV-weighted signal using whole-brain gradient and spin echo (GRASE) based vascular space occupancy (VASO) to detect resting-state networks has also been demonstrated  ... 
doi:10.3389/fnhum.2018.00443 pmid:30467468 pmcid:PMC6235966 fatcat:4jznjwuesbfodix6xhi5qm57oa

Using Magnetic Resonance Imaging in the Early Detection of Alzheimer's Disease [chapter]

Emily J., Manus J., Brandon A.
2013 Understanding Alzheimer's Disease  
Novel approach to the measurement of absolute cerebral blood volume using vascular-space-occupancy magnetic resonance imaging. Magn Reson Med.  ...  Cerebral blood volume Cerebral blood volume measures the amount of blood per mL brain tissue.  ...  Regional cerebral perfusion in patients with "lzheimer's disease and mild cognitive impairment effect of "POE Epsilon allele. Neuroradiology. Jul. .  ... 
doi:10.5772/54445 fatcat:lyc7fm7kfnh3njaadtflsgctte

Anxiety, respiration, and cerebral blood flow: implications for functional brain imaging

Nicholas D. Giardino, Seth D. Friedman, Stephen R. Dager
2007 Comprehensive Psychiatry  
Brain functional imaging methods, such as fMRI, are sensitive to changes in cerebral blood flow (CBF) that are normally associated with changes in regional neural activation.  ...  However, other endogenous and exogenous factors can alter CBF independently of brain neural activity, thus complicating the interpretation of functional imaging data.  ...  blood flow [11] (fMRI based on changes in vascular space occupancy [12] , for example).  ... 
doi:10.1016/j.comppsych.2006.11.001 pmid:17292699 pmcid:PMC1820771 fatcat:bpomyxfu3bfplewldlbf7aqu4m

Alterations in resting-state network dynamics along the Alzheimer's disease continuum: a combined MEG-PET/MR approach [article]

Delphine Puttaert, Nicolas Coquelet, Vincent Wens, Philippe Peigneux, Patrick Fery, Antonin Rovai, Nicola Trotta, Jean-Christophe Bier, Serge Goldman, Xavier De Tiege
2020 bioRxiv   pre-print
The fast activation/deactivation state dynamics of RSNs were assessed using hidden Markov modeling (HMM) of power envelope fluctuations at rest measured with MEG.  ...  Human brain activity is intrinsically organized into resting-state networks (RSNs) that transiently activate or deactivate at the sub-second timescale.  ...  Among those, resting-state functional magnetic resonance imaging (rsfMRI), which measures the spontaneous fluctuations of blood oxygenation level-dependent (BOLD) signals in brain regions at rest (i.e.  ... 
doi:10.1101/2020.05.18.101683 fatcat:5ns6ifchhvatpj6h6335hfgqse

Alterations in resting-state network dynamics along the Alzheimer's disease continuum

D Puttaert, N Coquelet, V Wens, P Peigneux, P Fery, A Rovai, N Trotta, N Sadeghi, T Coolen, J-C Bier, S Goldman, X De Tiège
2020 Scientific Reports  
The fast activation/deactivation state dynamics of RSNs were assessed using hidden Markov modeling (HMM) of power envelope fluctuations at rest measured with MEG.  ...  The time spent by participants in the activated posterior DMN state did not correlate significantly with cognitive scores, nor with the whole hippocampal volume.  ...  Nicolas Coquelet is supported by the « Excellence of Science -MEMODYN » from the Fonds de la Recherche Scientifique (FRS-FNRS, Brussels, Belgium).  ... 
doi:10.1038/s41598-020-76201-3 pmid:33319785 fatcat:xiu44ub26renvdjcrc3uaywyba

Vascular autorescaling of fMRI (VasA fMRI) improves sensitivity of population studies: A pilot study

Samira M. Kazan, Siawoosh Mohammadi, Martina F. Callaghan, Guillaume Flandin, Laurentius Huber, Robert Leech, Aneurin Kennerley, Christian Windischberger, Nikolaus Weiskopf
2016 NeuroImage  
The VasA maps compared well to cerebrovascular reactivity (CVR) maps and cerebral blood volume maps based on vascular space occupancy (VASO) measurements in four volunteers, speaking to the physiological  ...  The blood oxygenation level-dependent (BOLD) signal is widely used for functional magnetic resonance imaging (fMRI) of brain function in health and disease.  ...  Materials and methods Theory The BOLD fMRI signal depends on the complex coupling between neuronal activity, changes in cerebral blood flow, blood volume, and oxygenation in the activated brain regions  ... 
doi:10.1016/j.neuroimage.2015.09.033 pmid:26416648 pmcid:PMC4655941 fatcat:uixhpixh2vcnnmfem5i22jzvke

Spontaneous activity changes in large-scale cortical networks in older adults couple to distinct hemodynamic morphology [article]

Tatiana Sitnikova, Jeremy W Hughes, Casey M Howard, Kimberly A Stephens, Mark W Woolrich, David H Salat
2020 bioRxiv   pre-print
Therefore, even spontaneous changes in neural activity not linked directly to goal-directed behavior are expected to evoke a vascular hemodynamic response (HDR).  ...  functional magnetic resonance imaging (fMRI).  ...  designs 98-101 and across spontaneous fluctuations during resting-state recordings 57 .  ... 
doi:10.1101/2020.05.05.079749 fatcat:3af4lpkngngwlhawcswjxq47bi

Biophysical and Physiological Origins of Blood Oxygenation Level-Dependent fMRI Signals

Seong-Gi Kim, Seiji Ogawa
2012 Journal of Cerebral Blood Flow and Metabolism  
After its discovery in 1990, blood oxygenation level-dependent (BOLD) contrast in functional magnetic resonance imaging (fMRI) has been widely used to map brain activation in humans and animals.  ...  and intrinsic hemodynamic responses, (4) BOLD signal contributions from functional changes in cerebral blood flow (CBF), cerebral blood volume (CBV), and cerebral metabolic rate of O 2 utilization (CMRO  ...  Acknowledgements The authors thank colleagues at the University of Pittsburgh, especially Alberto Vazquez for providing unpublished images and Kristy Hendrich for proofreading and providing critical comments  ... 
doi:10.1038/jcbfm.2012.23 pmid:22395207 pmcid:PMC3390806 fatcat:ysnuzc5tjrbkhn34p2ar22flda

Selected Topics Relating to Functional MRI Study of the Brain

Seiji Ogawa, Yul-Wan Sung
2019 The Keio Journal of Medicine  
The topics are (I) Detectable MRI signals in response to functional activity of the brain, including the current status of neurocurrent MRI; (II) Vascular-dependent and vascular-independent MRI signals  ...  , leading to the distinction of functional and structural MRI; (III) Functional specificity and functional connectivity of local sites, including differences between task-fMRI and resting state fMRI; (  ...  Changes in the cerebral blood volume (CBV) are known to be well linked to neural activation.  ... 
doi:10.2302/kjm.2018-0011-oa pmid:30971631 fatcat:4m7jaghm4jgs7o7gqzfp6uzgd4

Magnetic Resonance Imaging technology — bridging the gap between noninvasive human imaging and optical microscopy

Jonathan R Polimeni, Lawrence L Wald
2018 Current Opinion in Neurobiology  
These new sampling strategies improve image acquisition efficiency and enable increased image encoding in the time-frame needed to follow hemodynamic changes associated with brain activation.  ...  This has motivated a push toward novel, high-resolution MR imaging strategies that can match this biological resolution limit while recording from the entire human brain.  ...  This work was supported in part was supported in part by the NIH NIBIB (grants P41-EB015896, R01-EB023281, and R01-EB019437), by the NEI  ... 
doi:10.1016/j.conb.2018.04.026 pmid:29753942 pmcid:PMC6015259 fatcat:7msf5i7k5ja3tpavexhuzlw7wu

Resting State BOLD Functional Connectivity at 3T: Spin Echo versus Gradient Echo EPI

Piero Chiacchiaretta, Antonio Ferretti, Emmanuel Andreas Stamatakis
2015 PLoS ONE  
These characteristics suggest that, despite the reduced sensitivity, SE fMRI might also provide a potential benefit when investigating spontaneous fluctuations of brain activity.  ...  In this study we compared resting state functional connectivity as measured with GE and SE EPI sequences at 3T.  ...  of spontaneous fluctuations of cerebral blood volume (CBV) weighted signal reported in a recent study using the vascular space occupancy (VASO) technique [42] .  ... 
doi:10.1371/journal.pone.0120398 pmid:25749359 pmcid:PMC4352074 fatcat:vopt7p43bnb5tav6fiaw277o5e

Magnetic Resonance Imaging to Visualize Stroke and Characterize Stroke Recovery: A Review

Bradley J. MacIntosh, Simon J. Graham
2013 Frontiers in Neurology  
In the last decade, however, the future outlook for such patients has been tempered by movement toward the view that the brain is capable of reorganizing after injury.  ...  As a probe of brain anatomy, function and physiology, magnetic resonance imaging (MRI) is a non-invasive and highly versatile modality that promises to play a particularly important role in such research  ...  (see below) or vascular space occupancy (VASO) CBV-fMRI (Kleim et al., 2002) .  ... 
doi:10.3389/fneur.2013.00060 pmid:23750149 pmcid:PMC3664317 fatcat:jigs3qhoiff7ris57wfl5setl4

Biomarkers, designs, and interpretations of resting-state fMRI in translational pharmacological research: A review of state-of-the-Art, challenges, and opportunities for studying brain chemistry

Najmeh Khalili-Mahani, Serge A.R.B. Rombouts, Matthias J.P. van Osch, Eugene P. Duff, Felix Carbonell, Lisa D. Nickerson, Lino Becerra, Albert Dahan, Alan C Evans, Jean-Paul Soucy, Richard Wise, Alex P. Zijdenbos (+1 others)
2017 Human Brain Mapping  
Common biomarkers in these studies include functional connectivity, graph metrics, cerebral blood flow and the amplitude and spectrum of BOLD fluctuations.  ...  in Wiley Online Library (wileyonlinelibrary.com). r Human Brain Mapping 38:2276-2325 (2017) r V C 2017 Wiley Periodicals, Inc. r r Abstract: A decade of research and development in resting-state functional  ...  Subtracting this labeled image from a second image acquired without labeling the inflowing blood, results in a perfusion-weighted image that can be used to calculate cerebral blood flow in units of mL/  ... 
doi:10.1002/hbm.23516 pmid:28145075 fatcat:o6h7ahdzerbbngzx6vcfsvbn3q

Characterizing Resting-State Brain Function Using Arterial Spin Labeling

J. Jean Chen, Kay Jann, Danny J.J. Wang
2015 Brain Connectivity  
surrogate of the metabolic activity within corresponding networks; and (3) the study of resting-state dynamic CBF-BOLD coupling and cerebral metabolism: the use of dynamic CBF information obtained using  ...  This review addresses the use of ASL to assess brain function in the resting state.  ...  K.J. has a fellowship funded by SNSF/SSMBS (grant no. 142743). Author Disclosure Statement No competing financial interests exist.  ... 
doi:10.1089/brain.2015.0344 pmid:26106930 pmcid:PMC4652156 fatcat:bcp4otgrcnabfn3iqkf72mlriq
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