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Detecting microstructural properties of white matter based on compartmentalization of magnetic susceptibility

Way Cherng Chen, Sean Foxley, Karla L. Miller
2013 NeuroImage  
There is increasing evidence that these microstructural properties alter signal in magnetic resonance imaging (MRI) driven by magnetic susceptibility of different compartments (e.g., myelin sheaths and  ...  To explain these observations, we have developed a multi-compartmental geometric model of whitematter microstructure.  ...  Introduction White matter (WM) in the brain is composed of a highly complex cellular microstructure, consisting primarily of myelinated axons, glia, vasculature and interstitial space.  ... 
doi:10.1016/j.neuroimage.2012.12.032 pmid:23268785 pmcid:PMC3591254 fatcat:qqkc5wbnsndq3az46elhp4b4ri

MR susceptibility imaging

Jeff Duyn
2013 Journal of magnetic resonance (San Diego, Calif. 1997 : Print)  
This work reviews recent developments in the use of magnetic susceptibility contrast for human MRI, with a focus on the study of brain anatomy.  ...  In white matter, the myelin sheath introduces an anisotropic susceptibility that has distinct effects on the water compartments inside the axons, between the myelin sheath, and the axonal space, and renders  ...  Introduction One area of MRI that has seen rapid development in recent years is that of contrast based on magnetic susceptibility, which relates to the tendency of tissue to become magnetized by a magnetic  ... 
doi:10.1016/j.jmr.2012.11.013 pmid:23273840 pmcid:PMC3602381 fatcat:wldbhsew2zcfxadv25hs7yjo6e

Studying magnetic susceptibility, microstructural compartmentalisation and chemical exchange in a formalin-fixed ex vivo human brain specimen [article]

Kwok-Shing Chan, Renaud Hedouin, Jeroen Mollink, Anne-Marie van Cappellen van Walsum, Jose P Marques
2021 bioRxiv   pre-print
We, therefore, study the impacts of formalin fixation on magnetic susceptibility, microstructural compartmentalisation and chemical exchange measurement on human brain tissue.  ...  Homogeneous white matter tissues were subsequently excised from the whole-brain specimen and scanned in multiple rotations on an MRI scanner to measure the anisotropic magnetic susceptibility and microstructure-related  ...  One major QSM research challenge is to understand the mechanism of phase evolution in white matter (WM) (4, 5) .  ... 
doi:10.1101/2021.07.30.454493 fatcat:pg2dlskj6nesfcoedkll66wx44

Susceptibility-weighted imaging and quantitative susceptibility mapping in the brain

Chunlei Liu, Wei Li, Karen A. Tong, Kristen W. Yeom, Samuel Kuzminski
2014 Journal of Magnetic Resonance Imaging  
Susceptibility-weighted imaging (SWI) is one such technique that takes advantage of the magnetic property to create useful image contrast (1-3).  ...  While SWI generates contrast based on phase images, QSM further computes the underlying susceptibility of each voxel as a scalar quantity.  ...  In an analysis of gray-white matter phase contrast, He and Yablonskiy (71) predicted a dependence of white matter phase on the relative angle between axons and magnetic field due to the elongated shape  ... 
doi:10.1002/jmri.24768 pmid:25270052 pmcid:PMC4406874 fatcat:gyq5hcecdrf4dnujswgqtgmicm

Assessing White Matter Microstructure in Brain Regions with Different Myelin Architecture Using MRI

Samuel Groeschel, Gisela E. Hagberg, Thomas Schultz, Dávid Z. Balla, Uwe Klose, Till-Karsten Hauser, Thomas Nägele, Oliver Bieri, Thomas Prasloski, Alex L. MacKay, Ingeborg Krägeloh-Mann, Klaus Scheffler (+1 others)
2016 PLoS ONE  
Assessing White Matter Microstructure in Brain Regions with Different Myelin Architecture PLOS ONE | 11. Stikov N, Campbell JSW, Stroh T, Lavelée M, Frey S, Novek J, et al.  ...  In vivo histology of the myelin gratio with magnetic resonance imaging.  ...  Acknowledgments This study was funded by the Medical Faculty of the University of Tübingen, Germany. We also acknowledge support by Deutsche Forschungsgemeinschaft (DFG) and Open Access  ... 
doi:10.1371/journal.pone.0167274 pmid:27898701 pmcid:PMC5127571 fatcat:fjdfaevmxzdh5jgtf26kskaeoe

Micro-compartment specific T2⁎ relaxation in the brain

Pascal Sati, Peter van Gelderen, Afonso C. Silva, Daniel S. Reich, Hellmut Merkle, Jacco A. de Zwart, Jeff H. Duyn
2013 NeuroImage  
MRI at high field can be sensitized to the magnetic properties of tissues, which introduces a signal dependence on the orientation of white matter (WM) fiber bundles relative to the magnetic field.  ...  Here we further investigated the effects of water compartmentalization on the MRI signal with the goal of extracting compartment-specific information.  ...  We acknowledge the Intramural Research Program of the National Institute of Neurological Disorders and Stroke (NINDS) for support.  ... 
doi:10.1016/j.neuroimage.2013.03.005 pmid:23528924 pmcid:PMC3816634 fatcat:io6otyy5drhlljujwtk6sa5pue

Studying neuroanatomy using MRI

Jason P Lerch, André J W van der Kouwe, Armin Raznahan, Tomáš Paus, Heidi Johansen-Berg, Karla L Miller, Stephen M Smith, Bruce Fischl, Stamatios N Sotiropoulos
2017 Nature Neuroscience  
In this review we provide an overview of the methods for measuring macro-and mesoscopic structure and inferring microstructural properties; we also describe key artefacts and confounds that can lead to  ...  However, MRI provides an indirect measurement of the biological signals we aim to investigate.  ...  properties of hydrogen or which can be detected through manipulation of magnetic fields.  ... 
doi:10.1038/nn.4501 pmid:28230838 fatcat:coxs7fvuxneifo5sh2yoos2nf4

Quantitative Susceptibility Mapping: Contrast Mechanisms and Clinical Applications

2015 Tomography  
Consequently, by quantifying magnetic susceptibility, QSM is becoming a quantitative imaging approach for characterizing normal and pathological tissue properties.  ...  More importantly, magnetic susceptibility directly reflects the molecular composition and cellular architecture of the tissue.  ...  Thus, nonrotational methods for investigating microstructure based on MRI-measured susceptibility are of great interest.  ... 
doi:10.18383/j.tom.2015.00136 pmid:26844301 pmcid:PMC4734903 fatcat:asrfxxhhcrbpnobdc3hjkhnlfq

Model-free analysis in the spectral domain of postmortem mouse brain EPSI reveals inconsistencies with model-based analyses of the free induction decay [article]

Scott Trinkle, Gregg Wildenberg, Narayanan Kasthuri, Patrick La Riviere, Sean Foxley
2022 bioRxiv   pre-print
To estimate the voxel-wise proportion of myelin, data are typically fit to compartmental models in the time domain.  ...  new model-based approaches.  ...  to recover microstructural properties with a combination of GRE and dMRI data.  ... 
doi:10.1101/2022.02.24.481824 fatcat:5fhpcpy2dvfrtaygu5bp5nmlym

Microscopic susceptibility anisotropy imaging

Enrico Kaden, Noemi G. Gyori, S. Umesh Rudrapatna, Irina Y. Barskaya, Iulius Dragonu, Mark D. Does, Derek K. Jones, Chris A. Clark, Daniel C. Alexander
2020 Magnetic Resonance in Medicine  
The gradient-echo MR signal in brain white matter depends on the orientation of the fibers with respect to the external magnetic field.  ...  properties of tissue microenvironments, especially the myelin microstructure, and (b) the axon orientation distribution relative to the magnetic field.  ...  on the susceptibility properties of the material under investigation.  ... 
doi:10.1002/mrm.28303 pmid:32378746 fatcat:apptu4wlxvgd5i6xaidrfsclmm

Magnetic susceptibility anisotropy of human brain in vivo and its molecular underpinnings

Wei Li, Bing Wu, Alexandru V. Avram, Chunlei Liu
2012 NeuroImage  
Recent studies suggest that the frequency and susceptibility contrast depend on white matter fiber orientation. However, the molecular underpinning of the orientation dependence is unclear.  ...  It is predicted by the theoretical model and illustrated by the experimental data that the magnetic susceptibility of the white matter is least diamagnetic along the fiber direction.  ...  The imaging of mouse brains was carried out at the Center of In Vivo Microscopy of Duke University. In vivo human imaging was conducted at the Brain Imaging and Analysis Center of Duke University.  ... 
doi:10.1016/j.neuroimage.2011.10.038 pmid:22036681 pmcid:PMC3254777 fatcat:ga6ittd2pzhgfo26imjpythvxa

Decoding the microstructural properties of white matter using realistic models

Renaud Hédouin, Riccardo Metere, Kwok-Shing Chan, Christian Licht, Jeroen Mollink, Anne-Marievan Cappellen van Walsum, José P. Marques
2021 NeuroImage  
Multi-echo gradient echo (ME-GRE) magnetic resonance signal evolution in white matter has a strong dependence on the orientation of myelinated axons with respect to the main static field.  ...  In this work, we present a pipeline to (i) generate realistic 2D WM models with their microstructure based on real axon morphology with adjustable fiber volume fraction (FVF) and g-ratio.  ...  Presentation of the model In this appendix, we compare three distinct infinite cylinder white matter models to address the question of how to better model the compartmentalization of water in the myelin  ... 
doi:10.1016/j.neuroimage.2021.118138 pmid:33964461 fatcat:nbjiw5a3gze5hau43dqks23mka

Imaging whole-brain cytoarchitecture of mouse with MRI-based quantitative susceptibility mapping

Hongjiang Wei, Luke Xie, Russell Dibb, Wei Li, Kyle Decker, Yuyao Zhang, G. Allan Johnson, Chunlei Liu
2016 NeuroImage  
We demonstrate magnetic susceptibility maps at a nominal resolution of 10-µm isotropic, approaching the average cell size of a mouse brain.  ...  We present an MRI method to resolve tissue microstructure and infer brain cytoarchitecture by mapping the magnetic susceptibility in the brain at high resolution.  ...  Acknowledgments This study was supported in part by the National Institutes of Health through grants NIBIB P41EB015897, NIBIB T32EB001040, NIMH R01MH096979, NINDS R01-NS079653, NIMH R24MH106096 and NHLBI  ... 
doi:10.1016/j.neuroimage.2016.05.033 pmid:27181764 pmcid:PMC5201162 fatcat:24mkcl2sfrhpbpc7ije3jvqhwi

Advanced Diffusion MR Imaging for Multiple Sclerosis in the Brain and Spinal Cord

Masaaki Hori, Tomoko Maekawa, Kouhei Kamiya, Akifumi Hagiwara, Masami Goto, Mariko Yoshida Takemura, Shohei Fujita, Christina Andica, Koji Kamagata, Julien Cohen-Adad, Shigeki Aoki
2022 Magnetic Resonance in Medical Sciences  
advanced diffusion MRI for assessing MS in vivo as part of an issue celebrating two decades of magnetic resonance in medical sciences (MRMS), an official journal of the Japanese Society of Magnetic Resonance  ...  dispersion and density imaging, white matter tract integrity, and multiple diffusion encoding, referred to as advanced diffusion MRI, have been proposed.  ...  on the microstructure of the body.  ... 
doi:10.2463/mrms.rev.2021-0091 pmid:35173096 pmcid:PMC9199983 fatcat:wuwlhbqo3zdorojj6gfb43w7hi

Correlation tensor magnetic resonance imaging

Rafael Neto Henriques, Sune N. Jespersen, Noam Shemesh
2020 NeuroImage  
Our intra-compartmental kurtosis index exhibited positive values in both white and grey matter tissues.  ...  Diffusional Kurtosis Magnetic Resonance Imaging (DKI) quantifies the extent of non-Gaussian water diffusion, which has been shown to be a sensitive biomarker for microstructure in health and disease.  ...  All these reinforce the need for in vivo accurate mapping of microstructural properties 13 (Le Bihan and Johansen-Berg, 2012). 14 Diffusion MRI (dMRI), mainly based on variants of the Single Diffusion  ... 
doi:10.1016/j.neuroimage.2020.116605 pmid:32044435 fatcat:s7xfwkdnxjb6jpwnhfmbpe3xle
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