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Detecting hippocampal shape changes in Alzheimer's disease using statistical shape models

Kaikai Shen, Pierrick Bourgeat, Jurgen Fripp, Fabrice Meriaudeau, Olivier Salvado, Benoit M. Dawant, David R. Haynor
2011 Medical Imaging 2011: Image Processing  
Statistical shape models (SSM) are usually used to describe and model the hippocampal shape variations among the population.  ...  The hippocampus is affected at an early stage in the development of Alzheimer's disease (AD).  ...  Description of purpose Early detection and diagnosis of Alzheimer's disease (AD) is a challenging task.  ... 
doi:10.1117/12.877869 dblp:conf/miip/ShenBFMS11 fatcat:zbonq5sfenf7posu3myazjqz5e

A Model of Volumetric Shape for the Analysis of Longitudinal Alzheimer's Disease Data [chapter]

Xinyang Liu, Xiuwen Liu, Yonggang Shi, Paul Thompson, Washington Mio
2010 Lecture Notes in Computer Science  
A signed energy function (SEF) derived from the model is designed to quantify the magnitude of regional shape changes that correlate well with local shrinkage and expansion.  ...  We develop a multi-scale model of shape based on a volumetric representation of solids in 3D space.  ...  We use the model to quantify and compare regional and global shape changes in the hippocampus (HC) due to normal aging, tissue loss caused by conversion to Alzheimer's disease (AD) and progression of the  ... 
doi:10.1007/978-3-642-15558-1_43 fatcat:t2lzc6jzgbahhoezzdbwjvcrti

Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla

G. B. Frisoni, R. Ganzola, E. Canu, U. Rub, F. B. Pizzini, F. Alessandrini, G. Zoccatelli, A. Beltramello, C. Caltagirone, P. M. Thompson
2008 Brain  
The first attempt to detect local atrophic changes within the hippocampus in Alzheimer's disease that we are aware of dates back to the year 2000, when on 1.5T images Laakso and colleagues divided the  ...  [2806^5270] 50.0005 Table 2 2 Synopsis of local hippocampal changes in normal ageing and Alzheimer's disease Normal ageing ß The Author (2008).  ... 
doi:10.1093/brain/awn280 pmid:18988639 fatcat:mvzhrxf4vvaarpk2pn42zws6cy

Whole-brain analysis reveals increased neuroanatomical asymmetries in dementia for hippocampus and amygdala

Christian Wachinger, David H. Salat, Michael Weiner, Martin Reuter
2016 Brain  
We demonstrate that neurodegeneration of subcortical structures in Alzheimer's disease is not symmetric.  ...  are associated with disease progression and can yield a powerful imaging biomarker for the early presymptomatic classification and prediction of Alzheimer's disease.  ...  Due to an increase in sensitivity to local shape changes, our shape asymmetry analysis can detect these subtle effects earlier than volumetry.  ... 
doi:10.1093/brain/aww243 pmid:27913407 pmcid:PMC5840883 fatcat:ug3lsuyx5fb2jnvrt7tfiqcrme

Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals

Clemens Schroeder, Min Tae M. Park, Jürgen Germann, M. Mallar Chakravarty, Lars Michels, Spyros Kollias, Sara L. Kroll, Alfred Buck, Valerie Treyer, Egemen Savaskan, Paul G. Unschuld, Roger M. Nitsch (+5 others)
2016 European Journal of Neuroscience  
Hence, localized shape measures and cortical thickness may be potential biomarkers of presymptomatic Alzheimer's disease.  ...  Hence, localized shape measures and cortical thickness may be potential biomarkers of presymptomatic Alzheimer's disease.  ...  Introduction Sporadic Alzheimer's disease (AD) is a major global health burden with no cure available at the moment.  ... 
doi:10.1111/ejn.13408 pmid:27646656 fatcat:kzem4wz5gbdyxayo7pkrhms5iy

Age effects on hippocampal structural changes in old men: The HAAS

Yuan Xu, Daniel J. Valentino, Ann I. Scher, Ivo Dinov, Lon R. White, Paul M. Thompson, Lenore J. Launer, Arthur W. Toga
2008 NeuroImage  
Statistical analyses reveal that the loss of hippocampal volume and changes in shape are more significantly related to aging in the control group than in AD/VaD.  ...  Then statistical methods, including regression, and permutation tests, are applied to detect the differences in hippocampal distance maps and volumes under the effect of age in each group.  ...  Additional support was provided by the NIH research grant R01 MH071940 and P01 EB001955, the NIH/NCRR resource grant P41 RR013642.  ... 
doi:10.1016/j.neuroimage.2007.12.034 pmid:18280181 pmcid:PMC3785795 fatcat:nlb3szaaivfa3mfphcfskmihoy

Efficient Morphometric Techniques in Alzheimer's Disease Detection: Survey and Tools

Vinutha N., P. Deepa Shenoy, P. Deepa Shenoy, K.R. Venugopal
2016 Neuroscience International  
The development of advance techniques in the multiple fields such as image processing, data mining and machine learning are required for the early detection of Alzheimer's Disease (AD) and to prevent the  ...  The different types of morphometry techniques used are Voxel Based Morphometry (VBM), Deformation Based Morphometry (DBM), Shape Based Morphometry (SBM) and Feature Based Morphometry (FBM).  ...  Author's Contributions All authors were involved in the manuscript preparation. Ethics This article is original and contains unpublished material.  ... 
doi:10.3844/amjnsp.2016.19.44 fatcat:3zeb2s5pjzfv7mptqi7cy2a3au

QC-SPHRAM: Quasi-conformal Spherical Harmonics Based Geometric Distortions on Hippocampal Surfaces for Early Detection of the Alzheimer's Disease [article]

Anthony Hei-Long Chan, Yishan Luo, Lin Shi, Ronald Lok-Ming Lui
2020 arXiv   pre-print
We propose a disease classification model, called the QC-SPHARM, for the early detection of the Alzheimer's Disease (AD).  ...  Local geometric distortions of the deformation from the template surface to each subject are quantified in terms of conformality distortions and curvatures distortions.  ...  Figure 1 : 1 Examples of segmented hippocampal surfaces in the database Data used in the preparation of this article were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database  ... 
arXiv:2003.10229v1 fatcat:mbdd4awbg5em3glaffoign6cie

Automatic Morphological Analysis of Medial Temporal Lobe

Andrea Chincarini, Mirko Corosu, Gianluca Gemme, Piero Calvini, Roberta Monge, Maria Antonietta Penco, Luca Rei, Sandro Squarcia, Patrizia Boccacci, Guido Rodriguez
2010 The Open Nuclear Medicine Journal  
Research in Alzheimer's disease (AD) has seen a tremendous growth of candidate biomarkers in the last decade.  ...  The role of such established or putative biomarkers is to allow an accurate diagnosis of AD, to infer about its prognosis, to monitor disease progression and evaluate changes induced by disease-modifying  ...  Shape analysis and/or classification methods using both local and global information may give complementary information and improve classification reliability.  ... 
doi:10.2174/1876388x01002010031 fatcat:qix37g6d4ngoper5be7kzlwuky

An Overview of Quantitative Magnetic Resonance Imaging Analysis Studies in the Assessment of Alzheimer's Disease [chapter]

Stephanos Leandrou, Styliani Petroudi, Panicos A. Kyriacou, Constantino Carlos Reyes-Aldasoro, Constantinos S. Pattichis
2016 International Federation for Medical and Biological Engineering Proceedings  
and metabolic changes detected rom PET.  ...  Shape analysis methods can be used to reveal atrophy on local and non-global areas of the hippocampus, and according to the authors, the classification accuracy was superior to studies that used volume  ... 
doi:10.1007/978-3-319-32703-7_56 fatcat:ryyepcaberbxhhxgjutojtnae4

Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease

Marianne Chapleau, Christophe Bedetti, Gabriel A. Devenyi, Signy Sheldon, Howie Rosen, Bruce Miller, Marilu Gorno-Tempini, M. Mallar Chakravarty, Simona M. Brambati
2020 NeuroImage: Clinical  
The goal of the present study is to conduct a detailed characterization of the impact of svPPA on global hippocampus volume and morphology compared with control subjects and patients with Alzheimer's disease  ...  However, less is known about disease-related morphological hippocampal changes.  ...  This manuscript was prepared using a Memory and Aging Center data set and does not necessarily reflect the opinions or views of the Memory and Aging Center investigators, the NIH or the private funding  ... 
doi:10.1016/j.nicl.2020.102305 pmid:32544853 pmcid:PMC7298722 fatcat:lrxwbf3g3vg5nc5z3gozqx5chm

Tracking Alzheimer's Disease

P. M THOMPSON, K. M HAYASHI, R. A DUTTON, M.-C. CHIANG, A. D LEOW, E. R SOWELL, G. DE ZUBICARAY, J. T BECKER, O. L LOPEZ, H. J AIZENSTEIN, A. W TOGA
2007 Annals of the New York Academy of Sciences  
A third technique, hippocampal surface modeling, plots the profile of shape alterations across the hippocampal surface.  ...  drug trials, and shed light on the neuroscience of brain degeneration in Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI).  ...  , and the National Institute for Child Health and Development (AG016570, LM05639, EB01651, RR019771 and HD050735 to P.M.T.).  ... 
doi:10.1196/annals.1379.017 pmid:17413023 pmcid:PMC3197831 fatcat:ztx5gpereze5fiujthiwuktr5q

Detecting Spatially Consistent Structural Differences in Alzheimer's and Fronto Temporal Dementia Using Deformation Morphometry [chapter]

C. Studholme, V. Cardenas, N. Schuff, H. Rosen, B. Miller, M. Weiner
2001 Lecture Notes in Computer Science  
Atrophy is known to occur at specific sites around the brain in both Alzheimer's disease (AD) and Fronto-Temporal Lobe Dementia (FTLD), inducing characteristic shape changes in brain anatomy.  ...  Statistical measures were then applied to locate points where voxel level differences in the Jacobian occur between a control group and each of the disease groups, indicating spatially consistent shape  ...  Rogers for advice on the statistical analysis and Dr J. Gee and Dr D. Pettey for discussions on the Jacobian shape analysis.  ... 
doi:10.1007/3-540-45468-3_6 fatcat:t4fh67hgafcenehzjhrk4nprh4

Shape versus Size: Improved Understanding of the Morphology of Brain Structures [chapter]

Guido Gerig, Martin Styner, Martha E. Shenton, Jeffrey A. Lieberman
2001 Lecture Notes in Computer Science  
Driving applications are the detection of group differences of amhygdala-hippocampal shapes in schizophrenia and the analysis of ventricular shape similarity in a mono/dizygotic twin study.  ...  Improved global and local structure characterization as proposed herein might help to explain pathological changes in neurodevelopment/neurodegeneration in terms of their biological meaning.  ...  Weinberger and W. Douglas, NIMH Neuroscience at St. Elizabeth, Washington for providing the twin datasets.  ... 
doi:10.1007/3-540-45468-3_4 fatcat:7h52wdzabfbqfinangtzlifpx4

Comparing 3T and 1.5T MRI for Mapping Hippocampal Atrophy in the Alzheimer's Disease Neuroimaging Initiative

N. Chow, K.S. Hwang, S. Hurtz, A.E. Green, J.H. Somme, P.M. Thompson, D.A. Elashoff, C.R. Jack, M. Weiner, L.G. Apostolova
2015 American Journal of Neuroradiology  
MATERIALS AND METHODS: We analyzed baseline MR imaging data from 166 subjects from the Alzheimer's Disease Neuroimaging Initiative-1 (37 with Alzheimer disease, 76 with mild cognitive impairment, and 53  ...  We applied our automated hippocampal segmentation technique to 1.5T and 3T MR imaging data, to determine whether hippocampal atrophy detection was enhanced at 3T.  ...  National Center for Research Resources RR019771 and National Institutes of Health RR021813, and the ADNI National Imaging Associates U01AG024904.  ... 
doi:10.3174/ajnr.a4228 pmid:25614473 pmcid:PMC5832348 fatcat:rvkfxjcxqzayjm76fowddah2mu
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