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Detecting hippocampal shape changes in Alzheimer's disease using statistical shape models
2011
Medical Imaging 2011: Image Processing
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Statistical shape models (SSM) are usually used to describe and model the hippocampal shape variations among the population. ...
The hippocampus is affected at an early stage in the development of Alzheimer's disease (AD). ...
Description of purpose Early detection and diagnosis of Alzheimer's disease (AD) is a challenging task. ...
doi:10.1117/12.877869
dblp:conf/miip/ShenBFMS11
fatcat:zbonq5sfenf7posu3myazjqz5e
A Model of Volumetric Shape for the Analysis of Longitudinal Alzheimer's Disease Data
[chapter]
2010
Lecture Notes in Computer Science
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A signed energy function (SEF) derived from the model is designed to quantify the magnitude of regional shape changes that correlate well with local shrinkage and expansion. ...
We develop a multi-scale model of shape based on a volumetric representation of solids in 3D space. ...
We use the model to quantify and compare regional and global shape changes in the hippocampus (HC) due to normal aging, tissue loss caused by conversion to Alzheimer's disease (AD) and progression of the ...
doi:10.1007/978-3-642-15558-1_43
fatcat:t2lzc6jzgbahhoezzdbwjvcrti
Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla
2008
Brain
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The first attempt to detect local atrophic changes within the hippocampus in Alzheimer's disease that we are aware of dates back to the year 2000, when on 1.5T images Laakso and colleagues divided the ...
[2806^5270]
50.0005
Table 2 2 Synopsis of local hippocampal changes in normal ageing and Alzheimer's disease Normal ageing
ß The Author (2008). ...
doi:10.1093/brain/awn280
pmid:18988639
fatcat:mvzhrxf4vvaarpk2pn42zws6cy
Whole-brain analysis reveals increased neuroanatomical asymmetries in dementia for hippocampus and amygdala
2016
Brain
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We demonstrate that neurodegeneration of subcortical structures in Alzheimer's disease is not symmetric. ...
are associated with disease progression and can yield a powerful imaging biomarker for the early presymptomatic classification and prediction of Alzheimer's disease. ...
Due to an increase in sensitivity to local shape changes, our shape asymmetry analysis can detect these subtle effects earlier than volumetry. ...
doi:10.1093/brain/aww243
pmid:27913407
pmcid:PMC5840883
fatcat:ug3lsuyx5fb2jnvrt7tfiqcrme
Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals
2016
European Journal of Neuroscience
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Hence, localized shape measures and cortical thickness may be potential biomarkers of presymptomatic Alzheimer's disease. ...
Hence, localized shape measures and cortical thickness may be potential biomarkers of presymptomatic Alzheimer's disease. ...
Introduction Sporadic Alzheimer's disease (AD) is a major global health burden with no cure available at the moment. ...
doi:10.1111/ejn.13408
pmid:27646656
fatcat:kzem4wz5gbdyxayo7pkrhms5iy
Age effects on hippocampal structural changes in old men: The HAAS
2008
NeuroImage
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Statistical analyses reveal that the loss of hippocampal volume and changes in shape are more significantly related to aging in the control group than in AD/VaD. ...
Then statistical methods, including regression, and permutation tests, are applied to detect the differences in hippocampal distance maps and volumes under the effect of age in each group. ...
Additional support was provided by the NIH research grant R01 MH071940 and P01 EB001955, the NIH/NCRR resource grant P41 RR013642. ...
doi:10.1016/j.neuroimage.2007.12.034
pmid:18280181
pmcid:PMC3785795
fatcat:nlb3szaaivfa3mfphcfskmihoy
Efficient Morphometric Techniques in Alzheimer's Disease Detection: Survey and Tools
2016
Neuroscience International
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The development of advance techniques in the multiple fields such as image processing, data mining and machine learning are required for the early detection of Alzheimer's Disease (AD) and to prevent the ...
The different types of morphometry techniques used are Voxel Based Morphometry (VBM), Deformation Based Morphometry (DBM), Shape Based Morphometry (SBM) and Feature Based Morphometry (FBM). ...
Author's Contributions All authors were involved in the manuscript preparation.
Ethics This article is original and contains unpublished material. ...
doi:10.3844/amjnsp.2016.19.44
fatcat:3zeb2s5pjzfv7mptqi7cy2a3au
QC-SPHRAM: Quasi-conformal Spherical Harmonics Based Geometric Distortions on Hippocampal Surfaces for Early Detection of the Alzheimer's Disease
[article]
2020
arXiv
pre-print
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We propose a disease classification model, called the QC-SPHARM, for the early detection of the Alzheimer's Disease (AD). ...
Local geometric distortions of the deformation from the template surface to each subject are quantified in terms of conformality distortions and curvatures distortions. ...
Figure 1 : 1 Examples of segmented hippocampal surfaces in the database
Data used in the preparation of this article were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database ...
arXiv:2003.10229v1
fatcat:mbdd4awbg5em3glaffoign6cie
Automatic Morphological Analysis of Medial Temporal Lobe
2010
The Open Nuclear Medicine Journal
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Research in Alzheimer's disease (AD) has seen a tremendous growth of candidate biomarkers in the last decade. ...
The role of such established or putative biomarkers is to allow an accurate diagnosis of AD, to infer about its prognosis, to monitor disease progression and evaluate changes induced by disease-modifying ...
Shape analysis and/or classification methods using both local and global information may give complementary information and improve classification reliability. ...
doi:10.2174/1876388x01002010031
fatcat:qix37g6d4ngoper5be7kzlwuky
An Overview of Quantitative Magnetic Resonance Imaging Analysis Studies in the Assessment of Alzheimer's Disease
[chapter]
2016
International Federation for Medical and Biological Engineering Proceedings
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and metabolic changes detected rom PET. ...
Shape analysis methods can be used to reveal atrophy on local and non-global areas of the hippocampus, and according to the authors, the classification accuracy was superior to studies that used volume ...
doi:10.1007/978-3-319-32703-7_56
fatcat:ryyepcaberbxhhxgjutojtnae4
Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease
2020
NeuroImage: Clinical
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The goal of the present study is to conduct a detailed characterization of the impact of svPPA on global hippocampus volume and morphology compared with control subjects and patients with Alzheimer's disease ...
However, less is known about disease-related morphological hippocampal changes. ...
This manuscript was prepared using a Memory and Aging Center data set and does not necessarily reflect the opinions or views of the Memory and Aging Center investigators, the NIH or the private funding ...
doi:10.1016/j.nicl.2020.102305
pmid:32544853
pmcid:PMC7298722
fatcat:lrxwbf3g3vg5nc5z3gozqx5chm
Tracking Alzheimer's Disease
2007
Annals of the New York Academy of Sciences
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A third technique, hippocampal surface modeling, plots the profile of shape alterations across the hippocampal surface. ...
drug trials, and shed light on the neuroscience of brain degeneration in Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI). ...
, and the National Institute for Child Health and Development (AG016570, LM05639, EB01651, RR019771 and HD050735 to P.M.T.). ...
doi:10.1196/annals.1379.017
pmid:17413023
pmcid:PMC3197831
fatcat:ztx5gpereze5fiujthiwuktr5q
Detecting Spatially Consistent Structural Differences in Alzheimer's and Fronto Temporal Dementia Using Deformation Morphometry
[chapter]
2001
Lecture Notes in Computer Science
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Atrophy is known to occur at specific sites around the brain in both Alzheimer's disease (AD) and Fronto-Temporal Lobe Dementia (FTLD), inducing characteristic shape changes in brain anatomy. ...
Statistical measures were then applied to locate points where voxel level differences in the Jacobian occur between a control group and each of the disease groups, indicating spatially consistent shape ...
Rogers for advice on the statistical analysis and Dr J. Gee and Dr D. Pettey for discussions on the Jacobian shape analysis. ...
doi:10.1007/3-540-45468-3_6
fatcat:t4fh67hgafcenehzjhrk4nprh4
Shape versus Size: Improved Understanding of the Morphology of Brain Structures
[chapter]
2001
Lecture Notes in Computer Science
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Driving applications are the detection of group differences of amhygdala-hippocampal shapes in schizophrenia and the analysis of ventricular shape similarity in a mono/dizygotic twin study. ...
Improved global and local structure characterization as proposed herein might help to explain pathological changes in neurodevelopment/neurodegeneration in terms of their biological meaning. ...
Weinberger and W. Douglas, NIMH Neuroscience at St. Elizabeth, Washington for providing the twin datasets. ...
doi:10.1007/3-540-45468-3_4
fatcat:7h52wdzabfbqfinangtzlifpx4
Comparing 3T and 1.5T MRI for Mapping Hippocampal Atrophy in the Alzheimer's Disease Neuroimaging Initiative
2015
American Journal of Neuroradiology
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MATERIALS AND METHODS: We analyzed baseline MR imaging data from 166 subjects from the Alzheimer's Disease Neuroimaging Initiative-1 (37 with Alzheimer disease, 76 with mild cognitive impairment, and 53 ...
We applied our automated hippocampal segmentation technique to 1.5T and 3T MR imaging data, to determine whether hippocampal atrophy detection was enhanced at 3T. ...
National Center for Research Resources RR019771 and National Institutes of Health RR021813, and the ADNI National Imaging Associates U01AG024904. ...
doi:10.3174/ajnr.a4228
pmid:25614473
pmcid:PMC5832348
fatcat:rvkfxjcxqzayjm76fowddah2mu
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