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Detailed somatotopy in primary motor and somatosensory cortex revealed by Gaussian population receptive fields

Wouter Schellekens, Natalia Petridou, Nick F. Ramsey
2018 NeuroImage  
In the current study we show that a detailed within-limb somatotopy can be obtained in M1 during finger movements using Gaussian population Receptive Field (pRF) models.  ...  The relevance of human primary motor cortex (M1) for motor actions has long been established.  ...  This work was additionally supported by the following grants: EU ERC-Advanced, 320708; STW NeuroCIMT, 14906.  ... 
doi:10.1016/j.neuroimage.2018.06.062 pmid:29940282 pmcid:PMC6413921 fatcat:kybrvjro7fh4vlnakysypjpew4

Preserved motor representations after paralysis [article]

Charles Guan, Tyson Aflalo, Carey Zhang, Emily R. Rosario, Nader Pouratian, Richard A. Andersen
2021 biorxiv/medrxiv   pre-print
To address this question, we analyzed intracortical population activity in a tetraplegic adult as she controlled a virtual hand through a brain-computer interface (BCI).  ...  Neural activity during finger movements exhibited robust representational structure and dynamics that matched the representational structure, previously identified in able-bodied individuals.  ...  Acknowledgments References Supplementary figures ACKNOWLEDGMENTS We thank participant X for her dedicated participation in the study.  ... 
doi:10.1101/2021.10.07.463105 fatcat:rwgccdnwsvh2fg4k24c7zky37q

Mapping quantal touch using 7 Tesla functional magnetic resonance imaging and single-unit intraneural microstimulation

Rosa Maria Sanchez Panchuelo, Rochelle Ackerley, Paul M Glover, Richard W Bowtell, Johan Wessberg, Susan T Francis, Francis McGlone
2016 eLife  
Additional brain regions in bilateral secondary somatosensory cortex, premotor cortex, primary motor cortex, insula and posterior parietal cortex, as well as in contralateral prefrontal cortex are also  ...  Activations are compared to those produced by applying vibrotactile stimulation to the unit's receptive field, and unit-type perceptual reports are analyzed.  ...  and secondary cortical areas, including contralateral S1, bilateral S2, primary motor cortex (M1), supplementary motor area (SMA), cingulate cortex, posterior parietal cortex (PPC), and insula cortex  ... 
doi:10.7554/elife.12812 pmid:27154626 pmcid:PMC4898929 fatcat:tqhuihnb2zesdlfbx4hk3t7vv4

Somatosensory cortical plasticity in carpal tunnel syndrome—a cross-sectional fMRI evaluation

Vitaly Napadow, Norman Kettner, Angela Ryan, Kenneth K. Kwong, Joseph Audette, Kathleen K.S. Hui
2006 NeuroImage  
Moreover, D3 fMRI activation in both the contralateral SI and motor cortex correlated positively with the D3 sensory conduction latency.  ...  Carpal tunnel syndrome (CTS) is a common entrapment neuropathy of the median nerve characterized by paresthesias and pain in the first, second, and third digits.  ...  Acknowledgments This research was supported by grants from the NIH: NCCAM (K01-AT002166-01, P01-AT002048-02, R21-AT001361-01), NCRR (P41RR14075), and the Mental Illness and Neuroscience Discovery (MIND  ... 
doi:10.1016/j.neuroimage.2005.12.017 pmid:16460960 fatcat:vfservie5jdn5o2gdxmuizfmbe

Bayesian population receptive field modeling in human somatosensory cortex [article]

Alexander M. Puckett, Saskia Bollmann, Keerat Junday, Markus Barth, Ross Cunnington
2019 bioRxiv   pre-print
Here we combined advanced imaging techniques at ultra-high field (7T) with a recently developed Bayesian population receptive field (pRF) modeling framework to examine pRF properties in primary somatosensory  ...  Our body is continuously sampling the environment using a variety of receptors tuned to different features, and this information is routed up to primary somatosensory cortex.  ...  Here we 29 combined advanced imaging techniques at ultra-high field (7T) with a recently 30 developed Bayesian population receptive field (pRF) modeling framework to examine 31 pRF properties in primary  ... 
doi:10.1101/577981 fatcat:aaub3aacyrhtxcsoddxzpb75ea

Finger somatotopy is preserved after tetraplegia but deteriorates over time

Sanne Kikkert, Dario Pfyffer, Michaela Verling, Patrick Freund, Nicole Wenderoth
2021 eLife  
In this observational study we used functional MRI and an (attempted) finger movement task in tetraplegic patients to characterise the somatotopic hand layout in primary somatosensory cortex.  ...  Previous studies showed reorganised and/or altered activity in the primary sensorimotor cortex after a spinal cord injury (SCI), suggested to reflect abnormal processing.  ...  Bayesian population receptive field modeling in human somatosensory cortex. Neuroimage 208:116465. doi:10.1016/j.neuroimage.2019.116465 Sanders Z-B, Wesselink DB, Dempsey-Jones H, Makin TR. 2019.  ... 
doi:10.7554/elife.67713 pmid:34665133 pmcid:PMC8575460 fatcat:6cjqli56m5bitntvsmrxtvqu7y

Intact finger representation within primary sensorimotor cortex of Musicians Dystonia [article]

Anna Sadnicka, Tobias Wiestler, Katherine Butler, Eckart Altenmueller, Mark John Edwards, Naveed Ejaz, Joern Diedrichsen
2021 medRxiv   pre-print
Here, we tested this hypothesis by investigating the finger-specific activity patterns in the primary somatosensory and motor cortex using functional magnetic resonance (fMRI) in nine musicians with dystonia  ...  A predominant hypothesis has been that this is underpinned by maladaptive neural changes to the somatotopic organisation of finger representations within primary somatosensory cortex.  ...  Acknowledgements We thank the musicians with and without dystonia that generously gave their time for these experiments.  ... 
doi:10.1101/2021.12.01.21266860 fatcat:x2q3uvjb7faqhlsnaahkkchoui

Multiple Somatotopic Representations of Heat and Mechanical Pain in the Operculo-Insular Cortex: A High-Resolution fMRI Study

Ulf Baumgärtner, Gian Domenico Iannetti, Laura Zambreanu, Peter Stoeter, Rolf-Detlef Treede, Irene Tracey
2010 Journal of Neurophysiology  
Receptive field properties of the macaque second somatosensory cortex: evidence for multiple functional representations.  ...  Whereas studies of somatotopic representation of touch have been useful to distinguish multiple somatosensory areas within primary (SI) and secondary (SII) somatosensory cortex regions, no such analysis  ...  Detailed electrophysiological studies of receptive field somatotopies revealed multiple representations of the body within the primary (SI) and secondary (SII) somatosensory cortex in monkeys (Fitzgerald  ... 
doi:10.1152/jn.00253.2010 pmid:20739597 pmcid:PMC2997041 fatcat:7dbyyv6ecjhtvatnohixl4rx7y

Population Receptive Field Characteristics in the between- and Within-Digit Dimensions of the Undominant Hand in the Primary Somatosensory Cortex

Luyao Wang, Zhilin Zhang, Tomohisa Okada, Chunlin Li, Duanduan Chen, Shintaro Funahashi, Jinglong Wu, Tianyi Yan
2021 Cerebral Cortex  
Somatotopy is an important guiding principle for sensory fiber organization in the primary somatosensory cortex (S1), which reflects tactile information processing and is associated with disease-related  ...  Here, we investigated the somatotopic map of the undominant hand using a Bayesian population receptive field (pRF) model.  ...  Abbreviations population receptive field (pRF), primary somatosensory cortex (S1), difference of Gaussian (DoG), region of interest (ROI). Figure 1 . 1 Phase encoding experimental design.  ... 
doi:10.1093/cercor/bhab097 pmid:33973012 pmcid:PMC8408438 fatcat:hsfgnxerandkxmxjcvksdmp4wu

Whisker-Mediated Touch System in Rodents: From Neuron to Behavior

Mehdi Adibi
2019 Frontiers in Systems Neuroscience  
A key question in systems neuroscience is to identify how sensory stimuli are represented in neuronal activity, and how the activity of sensory neurons in turn is "read out" by downstream neurons and give  ...  cortex.  ...  In turn, primary somatosensory cortex receives inputs from the secondary somatosensory cortex and motor cortex (Carvell and Simons, 1987; Kim and Ebner, 1999) .  ... 
doi:10.3389/fnsys.2019.00040 pmid:31496942 pmcid:PMC6712080 fatcat:ndthvrmpn5e2zimv5p74fmpwly

Towards Detailed Cortical Maps of the Human Back with Representational Similarity Analysis [article]

Alexandros Guekos, David M Cole, Monika A Doerig, Philipp Staempfli, Louis Schibli, Philipp A Schuetz, Michael Lukas Meier
2022 bioRxiv   pre-print
the primary (S1) and secondary somatosensory (S2) cortices.  ...  Cortical reorganization and its potential pathological significance is increasingly studied in chronic low back pain (CLBP) patients.  ...  patterns primarily located in the primary and secondary somatosensory cortices (S , S ) and the motor cortex (M ), providing novel and detailed information about the cortical organization of the healthy  ... 
doi:10.1101/2022.08.05.502912 fatcat:prgz7nbgizcrji4yqosevirc2e

Optical imaging reveals functional domains in primate sensorimotor cortex

Robert M. Friedman, Nicholas G. Chehade, Anna Wang Roe, Omar A. Gharbawie
2020 NeuroImage  
Motor cortex (M1) and somatosensory cortex (S1) are central to arm and hand control.  ...  ISOI revealed spatial domains that were active in M1 and S1 in response to instructed reaching and grasping.  ...  Acknowledgments Funding The project was supported by NIH R01 NS105697 (OAG), NIH K99/R00 NS079471 (OAG), Whitehall Foundation Inc. research grant 2017-12-94 (OAG), NIH R01 NS044375 (AWR, RMF), and NIH  ... 
doi:10.1016/j.neuroimage.2020.117188 pmid:32711067 pmcid:PMC7841645 fatcat:cfqmhrkxybgrrewiw5c3uj7ngm

The Cutaneous Rabbit Illusion Affects Human Primary Sensory Cortex Somatotopically

Felix Blankenburg, Christian C Ruff, Ralf Deichmann, Geraint Rees, Jon Driver, James Ashe
2006 PLoS Biology  
These results provide direct evidence that illusory somatosensory percepts can affect primary somatosensory cortex in a manner that corresponds somatotopically to the illusory percept.  ...  The illusion additionally activated areas of premotor and prefrontal cortex.  ...  FB, CCR, GR, and JD wrote the paper. Funding. This research was funded by the Wellcome Trust and Medical Research Council (UK). JD holds a Royal Society Wolfson Research Merit Award.  ... 
doi:10.1371/journal.pbio.0040069 pmid:16494530 pmcid:PMC1382015 fatcat:tw5wdom3t5b6tap3bwcxslt6fq

Coding of Tactile Response Properties in the Rat Deep Cerebellar Nuclei

Nathan C. Rowland, Dieter Jaeger
2005 Journal of Neurophysiology  
In the lateral hemispheres of the cerebellar cortex, somatosensory responses are represented in a finely grained fractured somatotopy.  ...  In fact, the receptive field of most neurons covered the ipsi-and contralateral face as well as forepaws.  ...  G R A N T S This work was supported by National Institutes of Health Grants RO1 MH-065634 and F31 GM-020685.  ... 
doi:10.1152/jn.00285.2005 pmid:16061491 fatcat:mdzwcl2vkjefhnojt5bpwmq5ne

Receptive Field Properties of the Macaque Second Somatosensory Cortex: Evidence for Multiple Functional Representations

P. J. Fitzgerald
2004 Journal of Neuroscience  
The detailed functional organization of the macaque second somatosensory cortex (SII) is not well understood.  ...  Data from the motorized stimulator indicate that neurons in the central field are more responsive to oriented bars, more frequently exhibit orientation tuning, and have larger receptive fields than neurons  ...  Distributions A, B, D, and F were fit well by Gaussians ( p Ͻ 0.001). Figure 12 . 12 Summary map of the SII hand region and surrounding cortex.  ... 
doi:10.1523/jneurosci.3481-04.2004 pmid:15590936 pmcid:PMC1800879 fatcat:bvdy2muhmvgnhjj4oiersndfzy
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