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Describing multiple levels of abstraction in the metabolism

M L Mavrovouniotis
1994 Proceedings. International Conference on Intelligent Systems for Molecular Biology  
A simple reaction mechanism serves as an illustration and shows the emergence of the concept of a catalyst from metabolic abstraction levels.  ...  We discuss some central issues that arise in the computer representation of the metabolism and its subsystems.  ...  The thrust of this paper is the modeling of multi-level abstraction in the metabolism.  ... 
pmid:7584404 fatcat:unssj6ttxrgv7kegpq5h5avslu

Pathways Database System

Z. Meral Ozsoyoglu, Joseph H. Nadeau, G. Ozsoyoglu
2003 Omics  
To facilitate the use of genomic information in such studies, a new modeling perspective is needed to examine and study genome sequences in the context of many kinds of biological information.  ...  levels of genetic, molecular, biochemical and organismal detail.  ...  pathways at multiple abstraction levels of detail.  ... 
doi:10.1089/153623103322006779 pmid:12831573 fatcat:gj7kxd6brfc53jv2sjzf3dedny

AB018. OP18 Malnutrition due to transit bipartition: reversal to sleeve gastrectomy

Mehmet Mahir Özmen, Emre Gündoğdu, Emir Güldoğan
2020 Annals of Laparoscopic and Endoscopic Surgery  
This case describes the clinical course and unfortunate outcome of a morbidly obese patient who underwent TBSG and developed malnutrition in the seventh postoperative month.  ...  Multiple factors can contribute to postoperative malnutrition and liver dysfunction after TBSG, including the presence of baseline liver disease, inadequate diet supplementation, leaving a too-short common  ...  This case describes the clinical course and unfortunate outcome of a morbidly obese patient who underwent TBSG and developed malnutrition in the seventh postoperative month.  ... 
doi:10.21037/ales-2019-bms-29 fatcat:k3hilnshczgm3curigrcdaujni

The Central Role of Multiple P450 Genes and Their Co-factor CPR in the Development of Permethrin Resistance in the Mosquito Culex quinquefasciatus

Youhui Gong, Ting Li, Qi Li, Shikai Liu, Nannan Liu
2022 Frontiers in Physiology  
system, boosting the metabolism of permethrin and hence the development of permethrin resistance in Cx. quinquefasciatus.  ...  showed their capability in metabolism of permethrin.  ...  Metabolites PBOH and PBCHO Metabolism When PBOH was used as a substrate (elution time descried in Figure 1), in the presence of NADPH no decrease in the level of PBOH (measured in terms of peak area) was  ... 
doi:10.3389/fphys.2021.802584 pmid:35095564 pmcid:PMC8792746 fatcat:q4xr3tf7tfhwlbftmun2k6hmh4

Anopheles gambiae Actively Metabolizes Uric Acid Following Plasmodium Infection to Limit Malaria Parasite Survival

Hyeogsun Kwon, Ryan Smith
2022 Frontiers in Physiology  
Targeting the essential first step in uric acid metabolism by silencing UO resulted in elevated levels of uric acid, enhancing malaria parasite survival.  ...  In this study, we examine the role of uric acid metabolism in the mosquito, Anopheles gambiae, following malaria parasite infection.  ...  Targeting the essential first step in uric acid metabolism by silencing UO resulted in elevated levels of uric acid, enhancing malaria parasite survival.  ... 
doi:10.3389/fphys.2021.821869 pmid:35140633 pmcid:PMC8818946 fatcat:5kch23weirhmley562j5v2s7ny

Page 13 of International Pharmaceutical Abstracts Vol. 21, Issue 18 [page]

1984 International Pharmaceutical Abstracts  
APPL. 276:463-470 (Sep 9) 1983 English An LC assay for determining thiacetazone (amithiozone) plasma and urine levels in vitro and in humans was described.  ...  WEBSTER International Pharmaceutical Abstracts Drug Metabolism and Body Distribution 2110165 HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF THIACETAZONE IN BODY FLUIDS Jenner, P. J. (Natl.  ... 

Multiple acyl-CoA Dehydrogenase Deficiency: a rare cause of hypoglycaemia

Ross Cairns, Laura Connell
2018 Endocrine Abstracts  
We describe an unusual cause of hypoglycaemia caused by a late presentation of an in born error of metabolism: Multiple acyl-CoA Dehydrogenase Deficiency (MADD).  ...  A metabolic disorder was suspected owing to the combination of intermittent and variable symptoms in association with hypoglycaemia, raised Creatine Kinase level , deranged liver function tests and metabolic  ...  Discussion ◼ Multiple acyl-CoA dehydrogenation deficiency (MADD) is a autosomal recessive disorder of fatty acid and amino acid oxidation. ◼ Mutations in ETFA, ETFB and ETFDH genes, which encode subunits  ... 
doi:10.1530/endoabs.59.ep43 fatcat:fg7kjvmqdzcibjba4b63deypla

Diagnostic Challenges in Late Onset Multiple Acyl-CoA Dehydrogenase Deficiency: Clinical, Morphological, and Genetic Aspects

Antonino Lupica, Rosaria Oteri, Sara Volta, Daniele Ghezzi, Daniele Ghezzi, Selene Francesca Anna Drago, Carmelo Rodolico, Olimpia Musumeci, Antonio Toscano
2022 Frontiers in Neurology  
in our neuromuscular unit in the last 20 years.  ...  Laboratory blood tests revealed a variable increase in serum CK (266–6,500) and LDH levels (500–2,000). Plasma acylcarnitine profile evidenced increased levels of different chains intermediates.  ...  Peripheral neuropathy has been described in other few metabolic myopathies due to the alteration of lipid metabolism, such as the mitochondrial trifunctional protein deficiency (MTPD) and long-chain 3-  ... 
doi:10.3389/fneur.2022.815523 pmid:35309592 pmcid:PMC8929684 doaj:a53109d9d3e04fc69abc5d5b15630425 fatcat:kvxpvv6md5baflsb33p4xckqei

Page 87 of International Pharmaceutical Abstracts Vol. 24, Issue 9 [page]

1987 International Pharmaceutical Abstracts  
are described. The drug rapidly reached high levels in the renal tissue and provided an effective therapeutic action against sensitive pathogenic microorganisms, and was still detectable after 12 hr.  ...  A positive tropism was observed in the medullary part of the renal parenchyma. (16 references) VicTOR ORIGONI IN VIVO METABOLISM AND DISPOSITION OF DRUGS BY AQUATIC SPECIES Guarino, A. M. (FDA, P.O.  ... 

An ontology for collaborative construction and analysis of cellular pathways

E. Demir, O. Babur, U. Dogrusoz, A. Gursoy, A. Ayaz, G. Gulesir, G. Nisanci, R. Cetin-Atalay
2004 Bioinformatics  
Furthermore, novel structures for representation of multiple levels of abstraction for pathways and homologies is provided. Lastly, our ontology supports efficient querying of large amounts of data.  ...  Motivation: As the scientific curiosity in genome studies shifts toward identification of functions of the genomes in large scale, data produced about cellular processes at molecular level has been accumulating  ...  of mechanism is unknown at the metabolic level.  ... 
doi:10.1093/bioinformatics/btg416 pmid:14960461 fatcat:qz57tj6xaja37emtpykzj62vn4

Inductively-Coupled Plasma Mass Spectrometry–Novel Insights From an Old Technology Into Stressed Red Blood Cell Physiology

Daniel Stephenson, Travis Nemkov, Syed M. Qadri, William P. Sheffield, Angelo D'Alessandro
2022 Frontiers in Physiology  
Iron efflux was observed as a function of temperatures, with ionic and heat stress at 40°C causing the maximum decrease in intracellular iron pools and increases in the supernatants.  ...  In particular, ionomycin treatment or hypertonic stress significantly impacted intracellular sodium and extracellular potassium and magnesium levels.  ...  Of note, increases in the intracellular levels of Na and extracellular levels of K showed positive and negative correlations, respectively, to multiple glycolytic metabolites—suggestive of altered glycolysis  ... 
doi:10.3389/fphys.2022.828087 pmid:35197866 pmcid:PMC8859330 fatcat:verwhgjuzzh55bx6kdctfthro4

Pseudoglandular disturbances

1948 Journal of Clinical Endocrinology and Metabolism  
THE ASSOCIATION FOR THE STUDY OF INTERNAL SECRETIONS ABSTRACTS OF PAPERS PRESENTED AT THE THIRTIETH ANNUAL MEETING FRIDAY AND SATURDAY, JUNE 18 AND 19, 1948 Palmer House, Chicago, Illinois ABSTRACTS ARRANGED  ...  Normal variations in skeletal growth, mammary develop- ment, amount of body hair, basal metabolic rate, etc., are probably due to variations in end-organ sensitiveness rather than to variations in the  ... 
pmid:18869604 fatcat:kgwnrzbaobg5lmkcyf24pvdh4m

Page 17 of International Pharmaceutical Abstracts Vol. 19, Issue 7 [page]

1982 International Pharmaceutical Abstracts  
CONTRACEPTION 19:39-45 (Jan) 1979 English The rate of metabolism of orally administered norethisterone (norethindrone) was compared in 14 centers in different countries by measuring plasma levels of the  ...  Pharmaceutical Abstracts Pharmacognosy 19 1609 CAPACITY LIMITED GUT WALL METABOLISM OF 5- AMINOSALICYLIC ACID, A THERAPEUTICALLY ACTIVE METABOLITE OF SULFASALAZINE, IN RATS Pieniaszek, H.  ... 

Stable Isotopes for Tracing Cardiac Metabolism in Diseases

Anja Karlstaedt
2021 Frontiers in Cardiovascular Medicine  
The goal of this review is to summarize techniques and concepts for in vivo or ex vivo stable isotope labeling in cardiovascular research, to highlight mathematical concepts and their limitations, to describe  ...  Stable-isotope tracer measurements are a powerful tool for measuring flux distributions at the whole organism level and assessing metabolic changes at a systems level in vivo.  ...  A reaction rate describes the velocity of a given biochemical reaction in response to a substrate and enzyme in isolation, while metabolic fluxes describe the same reaction in the context of a biological  ... 
doi:10.3389/fcvm.2021.734364 pmid:34859064 pmcid:PMC8631909 fatcat:ao425ijwv5fplaqrlvesd3c7hu

Improvement in blood pressure control through interdisciplinary medication assistance efforts in hypertensive patients with multiple metabolic syndrome

D King
2000 American Journal of Hypertension  
for multiple metabolic syndrome.  ...  The University of Mississippi Medical Center; Division of Hypertension; Jackson, MS Key Words: Medication adherence/compliance; cost hypertension; multiple metabolic syndrome; barriers to care POOR HYPERTENSION  ...  In order to identify the most likely reasons for the low levels of hypertension control found in NHANES III, we compared demographic characteristics, health care access and utilization, and mean blood  ... 
doi:10.1016/s0895-7061(00)00345-9 fatcat:g26s65zsb5aendtrbccrosid3q
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