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Depth-dependent intracortical myelin organization in the living human brain determined by in vivo ultra-high field magnetic resonance imaging

Emma Sprooten, Rafael O'Halloran, Juliane Dinse, Won Hee Lee, Dominik Andreas Moser, Gaelle Eve Doucet, Morgan Goodman, Hannah Krinsky, Alejandro Paulino, Alexander Rasgon, Evan Leibu, Priti Balchandani (+2 others)
2019 NeuroImage  
Here we describe a whole-brain approach for the in vivo investigation of intracortical myelin in the human brain using ultra-high field MRI.  ...  Magnetic resonance imaging (MRI) facilitates the examination of intracortical myelin but presents with methodological challenges.  ...  Discussion We used quantitative ultra-high field MR imaging to examine intracortical myelin organization in the living human brain in relation to cortical thickness and subcortical FA values.  ... 
doi:10.1016/j.neuroimage.2018.10.023 pmid:30312809 pmcid:PMC6289812 fatcat:yj3q27evwbairnw6gyz3bclmeu

Myelin and Modeling: Bootstrapping Cortical Microcircuits

Robert Turner
2019 Frontiers in Neural Circuits  
Histological studies of myelin-stained sectioned cadaver brain and in vivo myelin-weighted magnetic resonance imaging (MRI) show that the cerebral cortex is organized into cortical areas with generally  ...  The process of myelination is largely driven by neural experience, in which the axonal passage of action potentials stimulates neighboring oligodendrocytes to perform their task.  ...  ACKNOWLEDGMENTS We would like to thank Rudolf Nieuwenhuys for his advice and encouragement in the preparation of this article.  ... 
doi:10.3389/fncir.2019.00034 pmid:31133821 pmcid:PMC6517540 fatcat:di6mutjoyzeahajaexswl3essa

Layer-Specific Intracortical Connectivity Revealed with Diffusion MRI

C. W. U. Leuze, A. Anwander, P.-L. Bazin, B. Dhital, C. Stuber, K. Reimann, S. Geyer, R. Turner
2012 Cerebral Cortex  
Using diffusion magnetic resonance imaging (dMRI), we have succeeded in tracking intracortical fiber pathways running tangentially within the cortex.  ...  In contrast with histological methods, which reveal little regarding 3-dimensional organization in the human brain, dMRI delivers additional understanding of the layer dependence of the fiber orientation  ...  of Radiological Sciences Chiba in Japan for proofreading and helpful comments, and Miriam Wähnert, Marcel Weiß and Robert Trampel at the Max Planck Institute for Human Cognitive and Brain Sciences for  ... 
doi:10.1093/cercor/bhs311 pmid:23099298 pmcid:PMC3888365 fatcat:okxzjczxn5awzap7pa6zkxzjmm

Dissociations between microstructural and functional hierarchies within regions of transmodal cortex [article]

Casey Paquola, Reinder Vos de Wael, Konrad Wagstyl, Richard Bethlehem, Jakob Seidlitz, Seok-Jun Hong, Ed Bullmore, Alan Evans, Bratislav Misic, Daniel Margulies, Jonathon Smallwood, Boris Bernhardt
2018 bioRxiv   pre-print
Our approach was initially formulated based on an ultra-high-resolution 3D histological reconstruction of an entire human brain and then translated to myelin-sensitive MRI data in a large cohort of healthy  ...  While non-human primate research has demonstrated a close structure-function correspondence, the relationship between microstructure and function remains poorly understood in humans, in part because of  ...  With the advent of high-field magnetic resonance imaging (MRI), it has become possible to probe microstructural properties of different cortical regions in the living human brain.  ... 
doi:10.1101/488700 fatcat:qtr2xloqxrclvhojtpn6cokb7m

Mapping remodeling of thalamocortical projections in the living reeler mouse brain by diffusion tractography

L.-A. Harsan, C. David, M. Reisert, S. Schnell, J. Hennig, D. von Elverfeldt, J. F. Staiger
2013 Proceedings of the National Academy of Sciences of the United States of America  
A major challenge in neuroscience is to accurately decipher in vivo the entire brain circuitry (connectome) at a microscopic level.  ...  Through a unique combination of approaches, we designed and evaluated herein a framework for reliable fiber tracking and mapping of the living mouse brain connectome.  ...  Matthew Budde for kindly providing the ImageJ plug-in used for registration of histological and MRI images and Dr.  ... 
doi:10.1073/pnas.1218330110 pmid:23610438 pmcid:PMC3651497 fatcat:ewcfpopx3vgfbgss5ltvz4dlja

Medial temporal cortices in ex vivo magnetic resonance imaging

Jean C. Augustinack, André J.W. van der Kouwe, Bruce Fischl
2013 Journal of Comparative Neurology  
This review focuses on the ex vivo magnetic resonance imaging (MRI) modeling of medial temporal cortices and associated structures, the entorhinal verrucae and the perforant pathway.  ...  The two pathological hallmarks in Alzheimer's disease, neurofibrillary tangles and amyloid plaques, manifest differently spatially and temporally in the human brain (Braak and Braak, 1991) .  ...  Acknowledgments The authors thank those who generously donated the brain and made this research possible.  ... 
doi:10.1002/cne.23432 pmid:23881818 pmcid:PMC6014627 fatcat:tq263igezfbr5ks2zqjwzjrdpa

Linking cortical circuit models to human cognition with laminar fMRI

Jiajia Yang, Laurentius Huber, Yinghua Yu, Peter A. Bandettini
2021 Neuroscience and Biobehavioral Reviews  
The use of functional magnetic resonance imaging (fMRI) in conjunction with neural models provides new opportunities to gain important insights from current knowledge.  ...  During the last five years, human studies have demonstrated the value of high-resolution fMRI to study laminar-specific activity in the human brain.  ...  in the human brain. 2) How can the structural laminar organization in the living human brain be estimated?  ... 
doi:10.1016/j.neubiorev.2021.07.005 pmid:34245758 fatcat:vxiltrg3s5fk5ilkq7ekvqhnqe

Advancing Cardiovascular, Neurovascular, and Renal Magnetic Resonance Imaging in Small Rodents Using Cryogenic Radiofrequency Coil Technology

Thoralf Niendorf, Andreas Pohlmann, Henning M. Reimann, Helmar Waiczies, Eva Peper, Till Huelnhagen, Erdmann Seeliger, Adrian Schreiber, Ralph Kettritz, Klaus Strobel, Min-Chi Ku, Sonia Waiczies
2015 Frontiers in Pharmacology  
Research in pathologies of the brain, heart and kidney have gained immensely from the plethora of studies that have helped shape new methods in magnetic resonance (MR) for characterizing preclinical disease  ...  In this review we will focus on the applications of cryogenic radiofrequency (RF) coils in small animal MR as a means of boosting image quality (e.g., by supporting MR microscopy) and making data acquisition  ...  ACKNOWLEDGMENTS The authors wish to thank Leili Riazy (B.U.F.F., MDC) as well as Tim Wokrina and Daniel Marek (Bruker BioSpin).  ... 
doi:10.3389/fphar.2015.00255 pmid:26617515 pmcid:PMC4642111 fatcat:fejxorfcyzbivhwv6jndp5n36a

2020 Index IEEE Transactions on Biomedical Engineering Vol. 67

2020 IEEE Transactions on Biomedical Engineering  
., Hearables: Automatic Overnight Sleep Monitoring With Standardized In-Ear EEG Sensor; TBME Jan. 2020 203-212 Nakanishi, M., Wang, Y., Wei, C., Chiang, K., and Jung, T., Facilitating Calibration in High-Speed  ...  S.K., TBME Sept. 2020 2646-2658 Nguyen, K., see Abiri, P., TBME Dec. 2020 3307-3316 Nie, D., Trullo, R., Lian, J., Wang, L., Petitjean, C., Ruan, S., Wang, Q., and Shen, D., Corrections to "Medical Image  ...  ., +, TBME May 2020 1321-1327 Evaluation of Hand Tendon Movement by Using High-Frequency Ultra- sound Vector Doppler Imaging.  ... 
doi:10.1109/tbme.2020.3048339 fatcat:y7zxxew27fgerapsnrhh54tm7y

Molecular and microstructural biomarkers of neuroplasticity in neurodegenerative disorders through preclinical and diffusion magnetic resonance imaging studies

Rodolfo Gabriel Gatto
2020 Journal of Integrative Neuroscience  
in animal models that contribute to our knowledge of neuroplasticity; and (iii) illustrate the capabilities and limitations of current diffusion magnetic resonance imaging techniques to study cortical  ...  Advances in the understanding of genetic and molecular mechanisms and imaging technologies have opened a new window of research possibilities to address dynamic processes associated with neuroplasticity  ...  With further development and applications of ultra-high field dMRI systems (Gatto et al., 2020a) , DTI has been the upfront imaging technique to study microstructural changes associated with NP mechanisms  ... 
doi:10.31083/j.jin.2020.03.165 pmid:33070535 fatcat:ql64dr7n4jhu7n6ymsgjsd7xge

Multi-scale optoacoustic molecular imaging of brain diseases

Daniel Razansky, Jan Klohs, Ruiqing Ni
2021 European Journal of Nuclear Medicine and Molecular Imaging  
In this review, we describe the principles of optoacoustic imaging and showcase recent technical advances that enable high-resolution real-time brain observations in preclinical models.  ...  The ability to non-invasively visualize endogenous chromophores and exogenous probes and sensors across the entire rodent brain with the high spatial and temporal resolution has empowered optoacoustic  ...  Imaging methods that can visualize and quantify several processes over prolonged durations in vivo are highly desired, but pose high demands on the sensitivity, field-of-view (FOV), depth of penetration  ... 
doi:10.1007/s00259-021-05207-4 pmid:33594473 pmcid:PMC8566397 fatcat:djy2fspznnaylpqe4wrjd2jvlu

The BigBrainWarp toolbox for integration of BigBrain 3D histology with multimodal neuroimaging

Casey Paquola, Jessica Royer, Lindsay B Lewis, Claude Lepage, Tristan Glatard, Konrad Wagstyl, Jordan DeKraker, Paule-Joanne Toussaint, Sofie Louise Valk, D Louis Collins, Ali Khan, Katrin Amunts (+3 others)
2021 eLife  
Neuroimaging stands to benefit from emerging ultrahigh-resolution 3D histological atlases of the human brain; the first of which is 'BigBrain'.  ...  Finally, we demonstrate the utility of BigBrainWarp with three tutorials and discuss the potential of the toolbox to support multi-scale investigations of brain organisation.  ...  Brains for Healthy Lives.  ... 
doi:10.7554/elife.70119 pmid:34431476 pmcid:PMC8445620 fatcat:hdw4lzyayjcvfnp6ayx6plpkca

An Update on Graphene-Based Nanomaterials for Neural Growth and Central Nervous System Regeneration

Maria Grazia Tupone, Gloria Panella, Michele d'Angelo, Vanessa Castelli, Giulia Caioni, Mariano Catanesi, Elisabetta Benedetti, Annamaria Cimini
2021 International Journal of Molecular Sciences  
In this review, we will focus on the recent applications of graphene-based nanomaterials in vitro and in vivo, also combining graphene with other smart materials to achieve the best benefits in the fields  ...  We will then highlight the potential use of these graphene-based materials to construct graphene 3D scaffolds able to stimulate neural growth and regeneration in vivo for clinical applications.  ...  Data Availability Statement: No new data were created or analyzed in this study. Data sharing is not applicable to this article. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/ijms222313047 pmid:34884851 pmcid:PMC8657785 fatcat:ws4jxqj4ajchpj2oklkmuzmmya

Graphene-Based Electrode Materials for Neural Activity Detection

Weichen Wei, Xuejiao Wang
2021 Materials  
Constructing a high-performance electrode–nerve interface is required for the long-term stable detection of neural signals by electrodes.  ...  The neural electrode technique is a powerful tool for monitoring and regulating neural activity, which has a wide range of applications in basic neuroscience and the treatment of neurological diseases.  ...  The fabricated electrodes can be used to record local field potentials and single-cell action potentials in the rat brain without producing image artifacts in the magnetic resonance imaging (MRI) scanner  ... 
doi:10.3390/ma14206170 pmid:34683762 fatcat:qfcfawryk5apdmdlvj67qgbdjm

2014 Joint ACTRIMS-ECTRIMS Meeting (MSBoston 2014): Oral Presentations

2014 Multiple Sclerosis  
ELISA was used to determine expression of IL-26 in serum and cerebrospinal fluid (CSF) of MS patients and controls, and to analyze supernatant of human blood brain barrier endothelial cells (BBB-ECs) after  ...  We acquired whole-brain 3D T2-FLAIR and T1-weighted magnetization-prepared rapid gradient echo (T1-MPRAGE) scans, as well as high-resolution multislice gradient-echo scans providing T2* contrast (voxel  ...  Ultra-high field MRI has markedly improved sensitivity in detecting tissue susceptibility differences.  ... 
doi:10.1177/1352458514546076 pmid:25205047 pmcid:PMC4518813 fatcat:5giyc6lpwrdhzgjat3fhfcfcmi
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