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Dependence of paracentric inversion rate on tract length

Thomas L York, Rick Durrett, Rasmus Nielsen
2007 BMC Bioinformatics  
We develop a Bayesian method based on MCMC for estimating the relative rates of pericentric and paracentric inversions from marker data from two species.  ...  We find that pericentric inversions occur at a much lower rate compared to paracentric inversions.  ...  Inversion tract lengths We are interested in investigating how the rate at which inversions occur depends on the inversion tract length, i.e., the distance between inversion breakpoints.  ... 
doi:10.1186/1471-2105-8-115 pmid:17407601 pmcid:PMC1858705 fatcat:qpcxtbuvsfe7ne4yboddk5khyu

Recombination and gene flux caused by gene conversion and crossing over in inversion heterokaryotypes

A Navarro, E Betrán, A Barbadilla, A Ruiz
1997 Genetics  
depends strongly on the position of the markers along the inverted segment.  ...  Because inversions are ubiquitous in the evolutionary history of many Drosophila species, the effects of inversions on recombination are expected to influence DNA variation patterns.  ...  For neutral variation, the rate of decay of the locus-inversion disequilibria depends only on gene flux.  ... 
pmid:9178017 pmcid:PMC1208008 fatcat:4hssq5bkungnzhprkyjpdgmfqu

Recombination and Gene Flux Caused by Gene Conversion and Crossing Over in Inversion Heterokaryotypes

Arcadio Navarro, Esther Betrán, Antonio Barbadilla, Alfredo Ruiz
1997 Genetics  
depends strongly on the position of the markers along the inverted segment.  ...  Because inversions are ubiquitous in the evolutionary history of many Drosophila species, the effects of inversions on recombination are expected to influence DNA variation patterns.  ...  For neutral variation, the rate of decay of the locus-inversion disequilibria depends only on gene flux.  ... 
doi:10.1093/genetics/146.2.695 fatcat:bs4zjty6izagzodd2g7igzg3aq

CANPMR Syndrome and Chromosome 1p32-p31 Deletion Syndrome Coexist in Two Related Individuals Affected by Simultaneous Haplo-insufficiency of CAMTA1 and NIFA Genes

E. Coci, U. Koehler, T. Liehr, A. Stelzner, C. Fink, H. Langen, J. Riedel
2016 Neuropediatrics  
Genetic investigations revealed a paracentric inversion in the short arm of one chromosome 1 with breakpoints within CAMTA1 and NFIA coding sequences.  ...  Conclusions: To the best of our knowledge, this is the first report of two patients harboring the simultaneous mono-allelic disruptions and consequent haplo-insufficiencies of two genes due to an inversion  ...  Although an inversion-dependent imbalance on the expression of neighboring genes, located nearby to inversion breakpoints, cannot be theoretically excluded as co-factor responsible for the clinical phenotype  ... 
doi:10.1055/s-0036-1583695 fatcat:2jbnhgvttvcvvivc2eweauaz5e

CANPMR syndrome and chromosome 1p32-p31 deletion syndrome coexist in two related individuals affected by simultaneous haplo-insufficiency of CAMTA1 and NIFA genes

Emanuele G. Coci, Udo Koehler, Thomas Liehr, Armin Stelzner, Christian Fink, Hendrik Langen, Joachim Riedel
2016 Molecular Cytogenetics  
Genetic investigations revealed a paracentric inversion in the short arm of one chromosome 1 with breakpoints within CAMTA1 and NFIA coding sequences.  ...  Conclusions: To the best of our knowledge, this is the first report of two patients harboring the simultaneous mono-allelic disruptions and consequent haplo-insufficiencies of two genes due to an inversion  ...  Although an inversion-dependent imbalance on the expression of neighboring genes, located nearby to inversion breakpoints, cannot be theoretically excluded as co-factor responsible for the clinical phenotype  ... 
doi:10.1186/s13039-016-0219-y pmid:26848311 pmcid:PMC4741010 fatcat:dxnsknxpizgkxair7nzmuh2ydm

Mechanisms of Genetic Exchange Within the Chromosomal Inversions of Drosophila pseudoobscura

S. W. Schaeffer
2005 Genetics  
We estimate that the average gene conversion tract length is 205 bp and that the average conversion rate is 3.4 3 10 ÿ6 , which is 2 orders of magnitude greater than the mutation rate.  ...  At least one case where selection rather than proximity to an inversion breakpoint is responsible for reduction in polymorphism was identified.  ...  Any opinions, findings, conclusions, or recommendations expressed in this article are those of the authors and do not necessarily reflect the views of the National Science Foundation.  ... 
doi:10.1534/genetics.105.041947 pmid:16143625 pmcid:PMC1456099 fatcat:xx4l2gtsuzbjbkpx6zjgdbxdpm

Page 1730 of Genetics Vol. 171, Issue 4 [page]

2005 Genetics  
We use the BETRAN ef al. (1997) method to identify gene conversion tracts and estimate the rate of gene conversion per base.  ...  We find that gene conversion rates are 2 orders of magnitude greater than the mutation rate, that gene conversion events were not detected between all pairs of gene arrangements, and that at least one  ... 

Gene conversion homogenizes the CMT1A paralogous repeats

M E Hurles
2001 BMC Genomics  
Bounds are placed on the rate of these conversion processes, with central values of 1.3 x 10(-4) and 5.1 x 10(-5) per generation for the alternative models.  ...  The rates of these processes are such that it is probable that homogenized CMT1A-REPs are polymorphic within modern populations.  ...  There are a number of polymorphic inversions known to be mediated by inverted paralogous repeats, including paracentric inversions of Yp [8] , Xq [9] and 8p [10] .  ... 
pmid:11801183 pmcid:PMC64552 fatcat:46ibwyc4mvch5cftssnizzerfa

Gene conversion homogenizes the CMT1A paralogous repeats

Matthew E Hurles
2001 BMC Genomics  
Bounds are placed on the rate of these conversion processes, with central values of 1.3 × 10 -4 and 5.1 × 10 -5 per generation for the alternative models.  ...  The rates of these processes are such that it is probable that homogenized CMT1A-REPs are polymorphic within modern populations.  ...  There are a number of polymorphic inversions known to be mediated by inverted paralogous repeats, including paracentric inversions of Yp [8] , Xq [9] and 8p [10] .  ... 
doi:10.1186/1471-2164-2-11 fatcat:e4f7gobpjjc4zd277olcjan5pa

Local Inversion Heterozygosity Alters Recombination throughout the Genome

K. Nicole Crown, Danny E. Miller, Jeff Sekelsky, R. Scott Hawley
2018 Current Biology  
In Drosophila species, the local suppression of COs by heterozygous inversions triggers an increase in crossing over on freely recombining chromosomes termed the interchromosomal (IC) effect [1, 2] .  ...  Centromeric suppression of COs is much weaker on the X chromosome due to a large block Crown et al.  ...  Scripts used in this study can be found on GitHub at https://github.com/danrdanny/interChromosomalEffect.  ... 
doi:10.1016/j.cub.2018.07.004 pmid:30174188 pmcid:PMC6156927 fatcat:iwb7aelfgfa2jfywsthqnp4a34

Quantification of structural changes in the corpus callosumin children with profound hypoxic–ischaemic brain injury

Stavros M. Stivaros, Mark R. Radon, Reneta Mileva, Daniel J. A. Connolly, Patricia E. Cowell, Nigel Hoggard, Neville B. Wright, Vivian Tang, Ann Gledson, Ruth Batty, John A. Keane, Paul D. Griffiths
2015 Pediatric Radiology  
Birth-related acute profound hypoxic-ischaemic brain injury has specific patterns of damage including the paracentral lobules.  ...  Conclusion Focal volume loss is seen in the corpus callosum of children with hypoxic-ischaemic brain injury secondary to loss of commissural fibres arising in the paracentral lobules.  ...  Conflicts of interest None Open AccessThis article is distributed under the terms of the Creative Comm ons Attribution 4.0 International License (http:// creativecommons.org/licenses/by/4.0/), which permits  ... 
doi:10.1007/s00247-015-3444-3 pmid:26403618 pmcid:PMC4706576 fatcat:ukk6i6czqvavnin6t7zgermxqa

Reduced structural connectivity within a prefrontal-motor-subcortical network in amyotrophic lateral sclerosis

Colin R. Buchanan, Lewis D. Pettit, Amos J. Storkey, Sharon Abrahams, Mark E. Bastin
2014 Journal of Magnetic Resonance Imaging  
of local connectivity) and the network efficiency (the average of the inverse shortest path length).  ...  Note that the absolute values of these properties are dependent on the choice of nodes and thresholding.  ... 
doi:10.1002/jmri.24695 pmid:25044733 fatcat:sjbn64dy5bfhzh4zg44vzjo4jm

Genetic Exchange versus Genetic Differentiation in a Medium-Sized Inversion of Drosophila: The A2/Ast Arrangements of Drosophila subobscura

C. Nobrega, M. Khadem, M. Aguade, C. Segarra
2008 Molecular biology and evolution  
A 2 can be considered a typical successful inversion of D. subobscura according to its relative length.  ...  , and P125) located along the A 2 inversion was analyzed in A st and A 2 chromosomes of D. subobscura.  ...  The evolutionary success of an inversion partly depends on its length.  ... 
doi:10.1093/molbev/msn100 pmid:18436552 fatcat:5q545qicnrbwlipyiuvzil3ika

Aberrant Default-Mode Functional and Structural Connectivity in Heroin-Dependent Individuals

Xiaofen Ma, Yingwei Qiu, Junzhang Tian, Jinhui Wang, Shumei Li, Wenfeng Zhan, Tianyue Wang, Shaoqing Zeng, Guihua Jiang, Yikai Xu, Giuseppe Biagini
2015 PLoS ONE  
FA values for the tract connecting PCC/PCUN to the right PHG and connecting PCC/PCUN to the MPFC were negatively correlated to the duration of heroin use.  ...  Structural (path length, tracts count, (fractional anisotropy) FA and (mean diffusivity) MD derived from DTI tractography) and functional (temporal correlation coefficient derived from rs-fMRI) DMN connectivity  ...  Group maps were obtained using one-sample t-tests using a threshold of P<0.01 false discovery rate (FDR)-corrected for multiple comparisons.  ... 
doi:10.1371/journal.pone.0120861 pmid:25859661 pmcid:PMC4393019 fatcat:ll4tfelfg5bbtmame2d42t3ytu

Genome mapping in capsicum and the evolution of genome structure in the solanaceae

K D Livingstone, V K Lackney, J R Blauth, R van Wijk, M K Jahn
1999 Genetics  
We conclude there have been 30 breaks as part of 5 translocations, 10 paracentric inversions, 2 pericentric inversions, and 4 disassociations or associations of genomic regions that differentiate tomato  ...  Many of the markers are tomato probes that were chosen to cover the tomato genome, allowing comparison of this pepper map to the genetic map of tomato.  ...  A10: The potato/pepper and tomato homeologs differ by one paracentric inversion, indicating the paracentric inversion and break has occurred in the tomato lineage.  ... 
pmid:10388833 pmcid:PMC1460652 fatcat:yi3mrrdrknctxhflo7ncylaw64
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