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Product design is often intended to change the user's behavior and attitude, especially for products that carry educational functions. Digital technology works to enrich products with more interactive experiences while placing increased emphasis on the influence of user behavior. Using products aimed at facilitating children's learning as examples, this paper will explore an approach that may employ interaction design in transforming persuasive intentions into actual products for educationaldoi:10.5281/zenodo.2619790 fatcat:5bah4fwjwrfspn7auisak5csea
more »... motivational purposes. The research begins with the study of persuasive technology, educational technology, and learning motivation. Then it will seek to analyze the design strategies of ten related examples based on the framework of persuasive technology. The relevance between these persuasive strategies and the aim of enhancing learning motivations will be further examined to provide an insight into how to target learners' motivation. Then as a conclusion, this paper will propose some design principles based on human-computer interaction to transform persuasive intentions into real products that may motivate children to learn. In addition to providing the user with more experiences and emotional attachments, interaction design can influence users even more persuasively. The study proposes an approach to enhance the persuasive power of products via interaction design for the purpose of motivating children's learning. The approach may provide designers with a new tool as they proceed to design related products for children. It'll further suggest a new thinking in both industrial and interaction designs.
Recently, Wu et al. ... IEEE Transactions on Pattern Analysis and Machine Intelligence, 2005, 27(8): 1327∼1333 6 Wu Y, Li Y, Hu Z. Easy calibration for para-catadioptric-like camera. ...doi:10.1360/aas-007-0801 fatcat:bzrz44jmuzdyzliioui2fquf5y
Wu: None. H. Xiao: None. C. Yang: None. Z. Yi: None. P. Deng: None. H. Wang: None. N. Zeng: None. Y. Wu: None. K. Celie: None. Y. Toyoda: None. J.S. Buro: None. A.J. Lin: None. J. Xu: None. A. ...doi:10.1097/01.gox.0000534038.36318.eb fatcat:il5t6gx7jjgudhrltwy6zsvjfi
Special thanks to Jianjun Sun and other former and current members of the Deng lab for developing protocols on this topic; W.-M.D. is supported by NIH grant R01GM072562. ...doi:10.1007/978-1-4939-2851-4_15 pmid:26324440 pmcid:PMC5455776 fatcat:hv5hffubkzaztpmbobr7zdiadm
As baculoviruses usually have a narrow insecticidal spectrum, knowing the mechanisms by which they control the host-range is prerequisite for improvement of their applications as pesticides. In this study, from supernatant of culture cells transfected with DNAs of an Autographa californica multiple nucleopolyhedrovirus (AcMNPV) mutant lacking the antiapoptotic gene p35 (vAc ∆P35 ) and a cosmid representing a fragment of Spodoptera exigua nucleopolyhedrovirus (SeMNPV), a viral strain wasdoi:10.1038/srep28072 pmid:27321273 pmcid:PMC4913269 fatcat:mqc3qoxfc5ezvknncjkqckk3zy
more »... urified and named vAcRev. vAcRev had a broader host range than either vAc ∆P35 or SeMNPV parental virus, being able to infect not only the permissive hosts of its parental viruses but also a nonpermissive host (Spodoptera litura). Genome sequencing indicated that vAcRev comprises a mixture of two viruses with different circular dsDNA genomes. One virus contains a genome similar to vAc ∆P35 , while in the other viral genome, a 24.4 kbp-fragment containing 10 essential genesis replaced with a 4 kbp-fragment containing three SeMNPV genes including a truncated Se-iap3 gene. RNA interference and ectopic expression assays found that Se-iap3 is responsible for the host range expansion of vAcRev, suggesting that Se-iap3 inhibits the progression of apoptosis initiated by viral infection and promotes viral propagation in hosts both permissive and non-permissive for AcMNPV and SeMNPV.
Deng, X.-F. Ma,  Y. Chen, H. T. Yi, X. Wu, R. Haroldson, Y. N. Gartstein, Z.-Q. Li, and Z.-W. Wang, Energy resonance transfer Y. I. Rodionov, K. S. Tikhonov, A. Zakhidov, X.-Y. ... Liu,1 Xu-Fei Ma,1 Jia-Pei Deng,1 Yi-Yan Liu,1 Zhi-Qing Li,1 and Zi-Wu Wang*1, ∗ 1 ...arXiv:2201.06360v1 fatcat:x4pjp2b7ojbdfeqv2rerm3nyga
One of the most extensively used techniques in Drosophila is the Gal4/UAS binary system, which allows tissue-specific misexpression or knockdown of specific genes of interest. The original UAS vector, UASt, can only be activated for transgene expression in somatic tissues and not in the germline cells. Rorth (1998) generated UASp, a modified UAS vector that is responsive to Gal4 in both somatic and germline tissues, by replacing both the hsp70 promoter and the SV40 3UTR with the P transposasedoi:10.1101/290726 fatcat:mllej22i6rfftpw723gm7zllie
more »... omoter and the K10 3UTR respectively. At present, the mechanisms by which UASt is silenced in germline cells are not fully understood. Here, we report that the piRNA pathway is involved in suppressing UASt expression in ovarian germline cells. Individually knocking down or mutating components of the piRNA biogenesis pathway (e.g., Piwi, AGO3, Aub, Spn-E, and Vasa) resulted in the expression of the UASt-reporter (GFP or RFP) in the germline. An RNA-seq analysis of small RNAs revealed that the hsp70 promoter of UASt is targeted by piRNAs, and in the aub mutant ovary, the amount of piRNAs targeting the hsp70 promoter is reduced by around 40 folds. In contrast, the SV40 3UTR of the UASt, which happens to be targeted by the Nonsense-mediated RNA decay (NMD) pathway, is not responsible for germline UASt suppression, as UASt-reporters with NMD-insensitive 3UTRs fail to show germline expression. Taken together, our studies reveal a crucial role of the piRNA pathway, potentially via the suppression of the hsp70 promoter, in germline UASt silencing in Drosophila ovaries.
P2X 1 receptors and adrenoceptors are mainly responsible for vasoconstriction in a variety of blood vessels. However, previous studies have shown that a,b-methylene adenosine 5 0 -triphosphate (a,b-MeATP), a stable analogue of ATP, can induce both pressor and depressor responses in laboratory animals. In this study, the effects of increasing intravenous doses of a,b-MeATP and noradrenaline (NA) (0-30 nmol/kg) administered at 20 min intervals on systolic (SBP), diastolic (DBP) and mean (MBP)doi:10.1016/j.apsb.2012.04.005 fatcat:77cwb4wczbeh7jtnadeijd7hre
more »... d pressure in groups of anesthetized mice (n¼ 6) were compared. Both a,b-MeATP and NA caused transient, dose-dependent increases in SBP, DBP and MBP but the effect of a,b-MeATP was more rapid and significantly larger at doses of 10 and 30 nmol/kg (Po0.01). At the dose of 30 nmol/kg, a,b-MeATP increased SBP, DBP and MBP by 65.877.0, 65.775.0 and 65.775.5 mmHg, respectively, compared to increases of 36.874.6, 33.374.9 and 34.574.7 mmHg, respectively, produced by NA. These results indicate P2X 1 receptors play an important role in BP regulation although purinergic vasoconstriction alone may not explain the more potent pressor response to a,b-MeATP in the anesthetized mouse.
We investigate the Einstein-Podolsky-Rosen (EPR) steering and its criticality in quantum phase transition. It is found that the EPR steerability function of the ground state of XY spin chain exhibits nonanalytic feature in the vicinity of a quantum phase transition by showing that its derivative with respect to anisotropy parameter diverges at the critical point. We then verify the universality of the critical phenomena of the EPR steerability function in the system. We also use two-qubitarXiv:1201.0243v2 fatcat:og3qzocnxbbitjvqwodvdao5ti
more »... eering inequality to explore the relation between EPR steering and quantum phase transition.
The mechanism of avian navigation is an important question for global scientists. One of the most famous candidates is the radical pair mechanism (RPM), which shows that avian navigation is achieved by detecting the amount of products from chemical reactions, which exhibit different properties for singlet and triplet spin states. Based on the theory, we explore the amount of the the singlet recombination product by changing the coupling strength and direction of the magnetic field. The radicalarXiv:2203.01805v1 fatcat:t6wkqi4ihnc7tfmm7drm3dodlm
more »... air in our model is coupled with a Lipkin-Meshkov-Glick (LMG) bath, which proposes attractive results at quantum phase transition (QPT) point, especially when the magnetic field is parallel with the original direction of the pair. We find weakest navigation ability in QPT point according to one of our proposing methods. And we find invariant subspace in our Hamiltonian when the magnetic field is vertical to the plane of the radical pair and the bath, which will greatly speed up our calculation. Our results could help the exploration of the design principle of artificial avian navigation.
molecular target to reduce DOX resistance (100) lncRNA UCA1 N/A (101) circ_UBE2D2 BC cells Mice Providing new insights into the boost of the effectiveness of tamoxifen on BC (104) Yi ... cancer diagnosis and prognosis (69) miR-424 miR-423 miR-660 let7-i miR-373 miR-101 Serum Urine BC tissues Upregulation N/A A promising non-invasive alternative (70) (Continued) Yi ...doi:10.3389/fonc.2021.738945 pmid:34707990 pmcid:PMC8544822 fatcat:yhvxc2b7abcypch6rezi5t33ee
Alpha-fetoprotein is a well-known tumor marker in the screening and follow-up of hepatocellular carcinoma. In Taiwanese society, a high prevalence of hepatitis and hepatoma and elevation of alpha-fetoprotein associated with liver function impairment usually suggested clinics undertake further examination for liver or genital tumor. We report the case of 45-yearold man who was found to have an alpha-fetoprotein-producing esophageal adenocarcinoma with an initial presentation of liver functiondoi:10.1016/j.kjms.2012.08.018 pmid:23347813 fatcat:npcnnfkunrehdhit55sxdbqraa
more »... airment and rapid elevation of alphafetoprotein. Esophageal cancer was diagnosed via endoscope and a biopsy proved the presence of adenocarcinoma. A small endoscopic biopsy specimen failed to identify the alphafetoprotein positive tumor cell. Esophagectomy was performed and histopathological study of surgical specimen revealed grade II adenocarcinoma with regional metastatic lymphadenopathy. Immunohistochemical study was focal positive for alpha-fetoprotein. Serum alphafetoprotein declined transiently after esophagectomy and fluctuation of alpha-fetoprotein level was noted during the treatment with adjuvant chemotherapy. Finally, 19 months after the operation, the patient died due to multiple organ metastases with multiple organ failure. Thus, a small specimen for upper endoscopy may not be sufficient in the presence of alphafetoprotein-producing adenocarcinoma. Monitoring of serum alpha-fetoprotein may be useful in the evaluation and follow-up of esophageal alpha-fetoprotein-producing adenocarcinoma.
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