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Potassium channels contribute to activity-dependent regulation of dendritic inhibition

Jeremy T. Chang, Michael J. Higley
2018 Physiological Reports  
potentials in dendritic spines and shafts of cortical pyramidal neurons.  ...  GABAergic inhibition plays a critical role in the regulation of neuronal activity.  ...  Back-propagating action potentials (bAPs) were evoked using a brief depolarizing current pulse (0.5 msec, 1.5-2.5 nA) through the recording pipette.  ... 
doi:10.14814/phy2.13747 pmid:29939492 pmcid:PMC6016672 fatcat:g27acp52hrf6fnfn27emhbokmi

Robustness to axon initial segment variation is explained by somatodendritic excitability in rat substantia nigra dopaminergic neurons

Estelle Moubarak, Dominique Engel, Martial A. Dufour, Mónica Tapia, Fabien Tell, Jean-Marc Goaillard
2019 Journal of Neuroscience  
rat SNc DA neurons to determine cell-to-cell variations in AIS and ABD geometry, and their influence on neuronal output (spontaneous pacemaking frequency, action potential [AP] shape).  ...  We combined current-clamp somatic and dendritic recordings, outside-out recordings of dendritic sodium and potassium currents, morphological reconstructions and multicompartment modeling on male and female  ...  Introduction In mammalian neurons, it is currently accepted that the action potential (AP) is initiated in the axon initial segment (AIS), a subcellular compartment comprising a particularly high density  ... 
doi:10.1523/jneurosci.2781-18.2019 pmid:31028116 pmcid:PMC6595954 fatcat:cgpzjtxvozfellzpbdl5ghpbsq

Emergence of synaptic organization and computation in dendrites

Jan H. Kirchner, Julijana Gjorgjieva
2021 Neuroforum  
These capabilities derive in part from the precise arrangement of synaptic inputs on the neurons' dendrites.  ...  While the full computational benefits of this arrangement are still unknown, a picture emerges in which synapses organize according to their functional properties across multiple spatial scales.  ...  Computational modeling suggests that local, structural plasticity in conjunction with an attenuating back-propagating action potential is sufficient to produce species-specific dendritic maps (Kirchner  ... 
doi:10.1515/nf-2021-0031 pmid:35881644 pmcid:PMC8887907 fatcat:5e37siu7srfztmyo2ewm5bfjd4

A GPU-based computational framework that bridges Neuron simulation and Artificial Intelligence [article]

Yichen Zhang, Gan He, Xiaofei Liu, J.J.Johannes Hjorth, Alexander Kozlov, Yutao He, Shenjian Zhang, Lei Ma, Jeanette Hellgren Kotaleski, Yonghong Tian, Sten Grillner, Kai Du (+1 others)
2022 bioRxiv   pre-print
We investigated how spatial patterns of spine inputs affects neuronal excitability in a detailed human pyramidal neuron model with 25,000 spines; and examined how dendrites protect morphologically detailed  ...  Here, we present a novel Dendritic Hierarchical Scheduling (DHS) method to markedly accelerate such process.  ...  Action potential processing in a detailed purkinje cell model reveals a critical role for axonal compartmentalization. Frontiers in Cellular Neuroscience 9 (2015).  ... 
doi:10.1101/2022.06.12.495784 fatcat:wwzl22pydnbn3aylmvnpdihfbe

Synaptic Democracy in Active Dendrites

Clifton C. Rumsey, L. F. Abbott
2006 Journal of Neurophysiology  
This result, obtained originally in models with unbranched passive cables, also arises in multicompartment models with branched and active dendrites that feature backpropagating action potentials, including  ...  Additionally, when dendrites support the local generation of action potentials, anti-STDP prevents runaway dendritic spiking and locally balances the numbers of dendritic and backpropagating action potentials  ...  As in the cylindrical cable model, anti-STDP equalizes synaptic efficacies, but now synaptic efficacy refers to both the probability of evoking a back-propagating action potential and also the likelihood  ... 
doi:10.1152/jn.00149.2006 pmid:16837665 fatcat:bi33ziepjbdufephw4beri6i5e

Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model

Daniel B Dorman, Joanna Jędrzejewska-Szmek, Kim T Blackwell
2018 eLife  
in a dendritic branch while inducing pattern-specific plasticity.  ...  Here, we develop a biologically realistic computational model of striatal spiny projection neurons with sophisticated calcium dynamics, based on data from rodents of both sexes, to investigate how spatiotemporally  ...  Just as a somatic action potential can back-propagate to enhance spine calcium elevation, we investigated whether a cluster of synaptic inputs, in the absence of a somatic action potential, can enhance  ... 
doi:10.7554/elife.38588 pmid:30355449 pmcid:PMC6235562 fatcat:jxfqrnpaf5chriobuao46mbsma

Local Glutamate-Mediated Dendritic Plateau Potentials Change the State of the Cortical Pyramidal Neuron [article]

Peng P Gao, Joseph W Graham, Wen-Liang L Zhou, Jinyoung Jang, Sergio Angulo, Salvador Dura-Bernal, Michael Hines, William W Lytton, Srdjan D Antic
2019 bioRxiv   pre-print
sodium spikelets, local plateau potentials, and backpropagating action potentials, superimposed on each other.  ...  Plateau potentials propagating from dendrite to soma, and action potentials propagating from soma to dendrite, created complex voltage waveforms in the middle of the thin basal dendrite, comprised of local  ...  Simulation fitting was done by hand in a 235 single full multicompartment morphology over several thousand simulation runs. 240 Voltage waveforms of plateau potentials in basal and oblique dendrites  ... 
doi:10.1101/828582 fatcat:ktcl6jy34vghbhmun4dhoey6vm

Energy-efficient information transfer at thalamocortical synapses

Julia Jade Harris, Elisabeth Engl, David Attwell, Renaud Blaise Jolivet, Volker Steuber
2019 PLoS Computational Biology  
Here, we investigate information transmission and postsynaptic energy use at the next synapse along the visual pathway: from relay neurons in the thalamus to spiny stellate cells in layer 4 of the primary  ...  Using both multicompartment Hodgkin-Huxley-type simulations and electrophysiological recordings in rodent brain slices, we find that increasing or decreasing the postsynaptic conductance of the set of  ...  The authors wish to thank anonymous reviewers for suggesting the use of transfer entropy to measure information transfer between neurons and for insightful discussion about the meaning of these findings  ... 
doi:10.1371/journal.pcbi.1007226 pmid:31381555 pmcid:PMC6695202 fatcat:tcmcg3vtmrg6rjmi5x25dauehy

Integration of Biochemical and Electrical Signaling-Multiscale Model of the Medium Spiny Neuron of the Striatum

Michele Mattioni, Nicolas Le Novère, Huibert D. Mansvelder
2013 PLoS ONE  
The model comprises over a thousand dendritic spines, where the electrical model interacts with the respective instances of a biochemical model.  ...  The algorithm is implemented in the TimeScales framework. We demonstrate its use by simulating a new multiscale model of the Medium Spiny Neuron of the Neostriatum.  ...  Acknowledgments The authors are grateful to Jason Moyer for the discussions about the model of electrical aspiny Medium Spiny Neuron which has been used as base for our model, to Lu Li for the discussions  ... 
doi:10.1371/journal.pone.0066811 pmid:23843966 pmcid:PMC3700997 fatcat:2kneuokecberhjdgach4k2frqi

Inhibitory control of somatodendritic interactions underlying action potentials in neocortical pyramidal neurons in vivo: An intracellular and computational study

D. Paré, E.J. Lang, A. Destexhe
1998 Neuroscience  
The effect of synaptic inputs on somatodendritic interactions during action potentials was investigated, in the cat, using in vivo intracellular recording and computational models of neocortical pyramidal  ...  Relative to action potentials evoked by current injection, spikes elicited by cortical microstimuli were reduced in amplitude and duration, with stimuli delivered at proximal (somatic) and distal (dendritic  ...  L. supported by a NINDS post-doctoral fellowship.  ... 
doi:10.1016/s0306-4522(97)00530-7 pmid:9539211 fatcat:nbod22vncvf2tkf6nrcbtbym5y

High Speed Two-Photon Imaging of Calcium Dynamics in Dendritic Spines: Consequences for Spine Calcium Kinetics and Buffer Capacity

L. Niels Cornelisse, Ronald A. J. van Elburg, Rhiannon M. Meredith, Rafael Yuste, Huibert D. Mansvelder, Lin Mei
2007 PLoS ONE  
Calcium influx time course and calcium extrusion rate were both in the same range for spines and dendrites when fitted with a dynamic multicompartment model that included calcium binding kinetics and diffusion  ...  Calcium rise times in spines in response to single action potentials (AP) are almost never measured due to technical limitations, but they could be crucial for synaptic plasticity.  ...  In the model, changes in calcium concentration were due to influx through voltage-gated calcium channels induced by a back-propagating action potential, efflux through calcium pumps, radial diffusion and  ... 
doi:10.1371/journal.pone.0001073 pmid:17957255 pmcid:PMC2034355 fatcat:vvkml3vutjho7k7tgj4tisbyzq

Propagating waves in visual cortex: A large scale model of turtlevisual cortex

Z. Nenadic, B. Ghosh, P. Ulinski
2002 Mathematical and computer modelling  
This article describes a large-scale model of turtle visual cortex that simulates the propagating waves of activity seen in real turtle cortex.  ...  The model is limited in that it does not have a retina to provide realistic input to the geniculate, and the cortex and does not incorporate all of the biophysical details of real cortical neurons.  ...  When τ o = τ c , the synaptic conductance is given by a modified formula (see page 168). We would like to thank Reviewer 1 for pointing this out.  ... 
doi:10.1016/s0895-7177(02)00045-6 fatcat:obxy6uxm3jd4loyasvipleafqm

Real-Time Linux Dynamic Clamp: A Fast and Flexible Way to Construct Virtual Ion Channels in Living Cells

Alan D. Dorval, David J. Christini, John A. White
2001 Annals of Biomedical Engineering  
Tests were performed using a variety of complex models of nonlinear membrane mechanisms in excitable cells, including simulations of spatially extended excitable structures, and multiple interacting cells  ...  This device, based around the Real-Time Linux operating system, was tested specifically in the context of dynamic clamping, a demanding real-time task in which a computational system mimics the effects  ...  This work was supported by a Grant to J. A. W. from the National Science Foundation ͑BES 0085177͒.  ... 
doi:10.1114/1.1408929 pmid:11764320 fatcat:sh26d4xhsbbovi7tgcmqiy5jju

Self-Organized Synaptic Plasticity Contributes to the Shaping of γ and β OscillationsIn Vitro

Andrea Bibbig, Howard J. Faulkner, Miles A. Whittington, Roger D. Traub
2001 Journal of Neuroscience  
We chose to use a network model with relatively detailed (multicompartment) models of neurons and synapses for these reasons. (1) Past experience (Traub et al., 1996b has shown that detailed models are  ...  Even then, it was not obvious beforehand that learning principles that work in a network of integrateand-fire neurons would also work in a more complex network of synaptically interconnected multicompartment  ...  This occurs because the model voltagedependent calcium conductance, in basal dendrites, closely follows the depolarization induced by the somatic action potential; the latter readily and faithf ully propagates  ... 
doi:10.1523/jneurosci.21-22-09053.2001 pmid:11698616 fatcat:ssmijazzkvfb3h5mvp3zmbwk4a

NMDA/AMPA Ratio Impacts State Transitions and Entrainment to Oscillations in a Computational Model of the Nucleus Accumbens Medium Spiny Projection Neuron

J. A. Wolf
2005 Journal of Neuroscience  
Depolarization from action potentials traveled to the tips of the dendritic branches and increased Ca 2ϩ influx through voltage-gated Ca 2ϩ channels.  ...  We describe a computational model of the principal cell in the nucleus accumbens (NAcb), the medium spiny projection (MSP) neuron.  ...  Action potentials are initiated at the soma and voltage propagates to the distal tips of the dendrites.  ... 
doi:10.1523/jneurosci.2220-05.2005 pmid:16207867 fatcat:cv3kyjlrcbgbna22domu654oxq
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