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Delineation of Skin Strata in Reflectance Confocal Microscopy Images using Recurrent Convolutional Networks with Toeplitz Attention [article]

Alican Bozkurt, Kivanc Kose, Jaume Coll-Font, Christi Alessi-Fox, Dana H. Brooks, Jennifer G. Dy, Milind Rajadhyaksha
2017 arXiv   pre-print
In this study, we use a recurrent neural network with attention on convolutional network features.  ...  We apply it to delineate skin strata in vertically-oriented stacks of transverse RCM image slices in an interpretable manner.  ...  Introduction Reflectance confocal microscopy (RCM) is a non-invasive optical imaging technology that enables users to examine mosaics of small field of view (FOV) images of 1.5 µm thick layers ("optical  ... 
arXiv:1712.00192v1 fatcat:hjlgqomie5ghpcjhtqvxlfipe4

Delineation of Skin Strata in Reflectance Confocal Microscopy Images with Recurrent Convolutional Networks

Alican Bozkurt, Trevor Gale, Kivanc Kose, Christi Alessi-Fox, Dana H. Brooks, Milind Rajadhyaksha, Jennifer Dy
2017 2017 IEEE Conference on Computer Vision and Pattern Recognition Workshops (CVPRW)  
In this study, we use deep recurrent convolutional neural networks to delineate skin strata in stacks of RCM images collected at consecutive depths.  ...  Reflectance confocal microscopy (RCM) is an effective, non-invasive pre-screening tool for cancer diagnosis.  ...  This work was supported in part by the National Cancer Institute (NCI) under grants R01CA156773 and R01CA199673, the National Institute of Biomedical Imaging and Bioengineerings (NIBIB) Image Guided Interventions  ... 
doi:10.1109/cvprw.2017.108 dblp:conf/cvpr/BozkurtGKABRD17 fatcat:umhdlkk5azehzmtonp2l2weike

A Clinical Perspective on the Automated Analysis of Reflectance Confocal Microscopy in Dermatology

Joseph N Mehrabi, Erica G Baugh, Alexander Fast, Griffin Lentsch, Mihaela Balu, Bonnie A Lee, Kristen M Kelly
2021 Lasers in Surgery and Medicine  
One such technology is reflectance confocal microscopy (RCM), which uses low power, near-infrared laser light to enable real-time in vivo visualization of superficial human skin from the epidermis down  ...  The automated detection of skin cancers requires more development, but future applications are truly boundless, and it is compelling to envision the role that AI will have in the practice of dermatology  ...  Fig. 1 . 1 A reflectance confocal microscopy slice of the skin. Note the highly reflective cells near the dermal papillae representing melanin in the epidermis.  ... 
doi:10.1002/lsm.23376 pmid:33476062 fatcat:wxg7xg5qrvfwtgmdbvee5vjyqi

Skin strata delineation in reflectance confocal microscopy images using recurrent convolutional networks with attention

Alican Bozkurt, Kivanc Kose, Jaume Coll-Font, Christi Alessi-Fox, Dana H. Brooks, Jennifer G. Dy, Milind Rajadhyaksha
2021 Scientific Reports  
In this study, we automate DEJ localization using deep recurrent convolutional neural networks to delineate skin strata in stacks of RCM images collected at consecutive depths.  ...  AbstractReflectance confocal microscopy (RCM) is an effective non-invasive tool for cancer diagnosis.  ...  A version of this manuscript was published as a part of 43 .  ... 
doi:10.1038/s41598-021-90328-x pmid:34131165 fatcat:opy3pqaw2fbmjntuy2wpgcxj5a

The rapid developmental rise of somatic inhibition disengages hippocampal dynamics from self-motion [article]

Robin F Dard, Erwan Leprince, Julien Denis, Shrisha RAO-BALAPPA, Cathrine Lopez, Marie Giorgi-Kurz, Tom Szwagier, Theo Dumont, Herve Rouault, Marat Minlebaev, Agnes Baude, Rosa Cossart (+1 others)
2021 bioRxiv   pre-print
We show that the first postnatal week ends with an abrupt switch in the representation of self-motion in CA1.  ...  calcium imaging of neuronal somata and axons in non-anesthetized pups, viral tracing and chemogenetics.  ...  Example confocal images from the CA1 region of the hippocampus of a P9 mouse pup injected with the inhibitory DREADD and treated with CNO for 5 days.  ... 
doi:10.1101/2021.06.08.447542 fatcat:cxr6x5jxebcl7lzs5lymibsise

Poster Presentations

2021 Australasian Journal of Dermatology  
It is thought to occur due to immune reactions to M. tuberculosis or its antigens within the skin, in individuals with strong anti-tuberculous cell-mediated immunity.  ...  Accordingly, ustekinumab 45 mg was selected and commenced with concurrent isoniazid, in consultation with respiratory and infectious diseases teams.  ...  Future research aimed at investigating the skin microbiome in particular dermatological disease states may offer insight into novel therapy targets and management of dysbiosis.  ... 
doi:10.1111/ajd.13279 fatcat:5qpyympdlbhnfhvwgbw6vbcoau

2017 ASCB Annual Meeting Abstracts

David G. Drubin
2017 Molecular Biology of the Cell  
To increase temporal resolution during imaging, we employed total internal reflection fluorescence combined with structured illumination microscopy to visualize organelle dynamics at very high temporal-spatial  ...  Our research is focused on delineating novel regulatory mechanisms that control signaling by PAR1 and closely-related family members in normal physiology and disease.  ...  We addressed this problem by imaging the cortical actin at high resolution while simultaneously tracking individual membrane proteins in live mammalian cells.  ... 
doi:10.1091/mbc.e17-10-0618 pmid:29237772 pmcid:PMC5739290 fatcat:3msjrn3omzcybfanlagykayauy

Proceedings of the World Molecular Imaging Congress 2021, October 5-8, 2021: General Abstracts

2022 Molecular Imaging and Biology  
In general, the values of CNR reached a plateau at around 8 iterations with an average improvement factor of about 1.7 for processed MRI images.  ...  Results: In all of the phantom and patients' MRI studies the post-processed images proved to have higher resolution and contrast as compared with images reconstructed by conventional methods.  ...  The nanocluster system with a high selectivity showed the potential for fluorescence imaging and the integrating of gold and MMAE demonstrated excellent concurrent chemotherapy-radiotherapy efficacy, which  ... 
doi:10.1007/s11307-021-01693-y pmid:34982365 pmcid:PMC8725635 fatcat:4sfb3isoyfdhfbiwxfr55gvqym


2012 Journal of Thoracic Oncology  
CTCs were also identified by confocal microscopy of cytospins made from buffy coat by labelling with both anti-γ-H2AX and anti-cytokeratin antibodies.  ...  Controlling for clinical stage, MASI was associated with a greater risk of recurrence compared with no MASI (M>W: HR=2.79; p=0.016; M=W: HR=3.51, p=0.028).  ...  Cells were imaged utilizing live-cell confocal microscopy and their characteristics evaluated in a semi-quatitative method.  ... 
doi:10.1097/jto.0b013e318269fc07 fatcat:vdv3ahsyibgbritt6r5443vvci

Abstracts DEGRO 2019

2019 Strahlentherapie und Onkologie (Print)  
The incidence of the most common AE, skin reaction, but also other reported AEs were comparable to the rates observed in the phase III trials for patients with recurrent (EF-11) and newly diagnosed GBM  ...  /specificity in comparison with the the risk strata resulting from the miRNA signature and MGMT-PM alone .  ...  be mathematically described by the convolution of the lateral dose response functions with the dose profiles obtained with films .  ... 
doi:10.1007/s00066-019-01465-2 pmid:31098680 fatcat:fcz3dilx5fh5pb6cafl66thls4

ACNP 58th Annual Meeting: Poster Session III

2019 Neuropsychopharmacology  
The goal of this study was to use positron emission tomography (PET) brain imaging to investigate levels of prefrontal-limbic translocator protein (TSPO), a marker of microglia, in vivo in individuals  ...  Methods: A total of 23 individuals with PTSD (13M, 10F) and 26 trauma-exposed and non-exposed otherwise healthy individuals (18M, 8F) were imaged.  ...  W49 Methods: Recently a new technique-convolutional neural networks (CNN), which is a highly modifiable artificial intelligencebased image segmentation technique pioneered in the field of computer vision  ... 
doi:10.1038/s41386-019-0547-9 pmid:31801974 pmcid:PMC6957926 fatcat:dd7d43ysfvc5bbbstfl73szya4

UEG Week 2016 Oral Presentations

2016 United European Gastroenterology journal  
Biopsies were used to measure dilation of intercellular spaces with transmission electron microscopy as a morphological measure of impaired integrity and to investigate transepithelial electrical resistance  ...  Aims & Methods: We aimed to assess acid sensitivity and mucosal integrity of the proximal and distal esophageal segments separately in patients with gastroesophageal reflux disease (GERD) and to investigate  ...  Gut homing was assessed by in vivo confocal microscopy and flow cytometry of lamina propria cells.  ... 
doi:10.1177/2050640616663688 fatcat:vlhrwp4txbewzj3arcu3hriifu

Twentieth Annual Meeting of the Association for Chemoreception Sciences

1998 Chemical Senses  
Selected results will be used to demonstrate the relative merits of laser scanning confocal, two-photon and magnetic resonance imaging microscopies to follow not only cell lineages but also cell movements  ...  Using confocal microscopy, we observed immunofluorescence at, or near, the plasma membrane after staining with a monoclonal antibody against the rho.tag epitope.  ...  associated with a faster attack latency, and an increase in the amount of time subject males spent perched atop the corral.  ... 
doi:10.1093/chemse/23.5.545 fatcat:v2hv5w77onan7f6cs3tclcwmly

Novel envelopment dynamics in bovine herpesvirus 1 assembly

Ben Bleasdale, Gill Elliott, Mike Skinner, Medical Research Council (Great Britain)
high abundance of the protein VP8 in the BHV-1 tegument.  ...  We propose BHV-1 as an excellent model for further investigation of both the process of tegumentation and the role of L-particles in virus infection.  ...  This progression of localisation was reflected in subsequent strata of previously uninfected cells, forming concentric circles surrounding the progenitor cell.  ... 
doi:10.25560/49227 fatcat:nndzhzcfsbdxpot4ijgam6jcny