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Prospects for Theranostics in Neurosurgical Imaging: Empowering Confocal Laser Endomicroscopy Diagnostics via Deep Learning

Mohammadhassan Izadyyazdanabadi, Evgenii Belykh, Michael A. Mooney, Jennifer M. Eschbacher, Peter Nakaji, Yezhou Yang, Mark C. Preul
2018 Frontiers in Oncology  
We also briefly review advances in the deep learning approaches used for CLE image analysis in other organs.  ...  We present an overview and discuss deep learning models for automatic detection of the diagnostic CLE images and discuss various training regimes and ensemble modeling effect on the power of deep learning  ...  (52) proposed a CNN architecture for classifying CLE images from three subcategories of Barret's esophagus: intestinal metaplasia (IM), gastric metaplasia (GM), and neoplasia (NPL).  ... 
doi:10.3389/fonc.2018.00240 pmid:30035099 pmcid:PMC6043805 fatcat:vozwoi32szfufod5hq37etx4ji

Towards automatic protein co-expression quantification in immunohistochemical TMA slides

Leslie Solorzano, Carla Pereira, Diana Martins, Raquel Almeida, Fatima Carneiro, Gabriela Almeida, Carla Oliveira, Carolina Wahlby
2020 IEEE journal of biomedical and health informatics  
The proposed pipeline provides not only computational tools forwarding current pathology practices to explore co-expression, but also a framework for merging data and transferring information in learning-based  ...  Immunohistochemical (IHC) analysis of tissue biopsies is currently used for clinical screening of solid cancers to assess protein expression.  ...  ACKNOWLEDGMENT The authors thank Dina Leitão and Gilza Gonçalves for the technical support with TMA slides processing, Mário Seixas for technical support with TMA slides digitalization and Johan Öfverstedt  ... 
doi:10.1109/jbhi.2020.3008821 pmid:32750958 fatcat:c5mhh3j3xng5rfgtn7znazgafa

USCAP 2018 Abstracts: Gastrointestinal Pathology (657–893)

2018 Laboratory Investigation  
Conclusions: We quantify pathologist dependent factors, which predict diagnostic concordance for BE dysplasia diagnosis at expert level.  ...  These data will allow rational formulation of quality assurance criteria and revision strategies for guideline development.  ...  Whole slide images were captured and the tumor area with greatest mitotic activity was manually identified.  ... 
doi:10.1038/labinvest.2018.9 pmid:29551806 fatcat:evk75ih3fvaijfyuw4cce63r24

Gastrointestinal Pathology

2015 Modern Pathology  
Immunoreactions for intestinal markers (MUC2, CDX2, CD10) and for gastric markers (MUC5AC, MUC6) were performed on representative sections of each SBA.  ...  Sequencing analysis of KRAS, NRAS, and BRAF hot spot regions revealed KRAS mutations in 3 of 9 cases: we found mutations in codon 12 exon 2 in 2 cases and in codon 61 exon 3 in the other one.  ...  Background: Intestinal metaplasia (IM) of the stomach in adults has been associated with an increased risk for gastric cancer.  ... 
doi:10.1038/modpathol.2015.15 fatcat:j45srjgg7bbzvnqg3ftfiblvc4


2003 Gut  
Neo-expression occurs in gastric intestinal metaplasia and ectopic gastric expression of Cdx2 leads to an intestinalised mucosa in transgenic mice.  ...  Performing multiple endoscopies for individual patients resulted in only a modest increase in detection of intestinal metaplasia, with no new cases of intestinal metaplasia being diagnosed after the third  ...  Methods: A postal questionnaire was sent to 200 members of the BSG. Number of NAFLD cases per month; parameters are used for diagnosis; indications for biopsy; treatment and follow up were requested.  ... 
doi:10.1136/gut.52.suppl_1.a1 fatcat:mkx6ohpgjfds5ns6j3hf3itft4

33rd European Congress of Pathology – Abstracts

2021 Virchows Archiv  
In the remaining 20 patients (80%), the diagnosis was made on the assessment of cardiac pathological features.  ...  Conclusion: Recent research has suggested the important initiating and driving factor for PPCM is the shift in angiogenic balance and development of anti-angiogenic environment.  ...  Pathologists annotated, in high-resolution mode, of H&E whole-slide images, assisted by re-stained and aligned immunofluorescence or consecutive chromogenic IHC whole slide images.  ... 
doi:10.1007/s00428-021-03157-8 pmid:34448894 pmcid:PMC8390845 fatcat:6rprtaw7mvg3tdw74h56pxuht4


1999 Journal of Pathology  
The number of positively stained crypt profiles were documented on each level and the total number of crypts in the sample was determined by counting crypt profiles on a median section.  ...  The frequency of MT positive crypts was assessed by two separate observers.  ...  This new method of PCIA offers the advantages of being able to process very large, whole slide, images without transformation and subsequent loss of resolution together with the analysis of very precisely  ... 
doi:10.1002/j.1096-9896.1999.tb00001.x fatcat:ug7xrgqtrbc55jv6s6hdchpuri

Optical aspects of a miniature fluorescence microscope for super-sensitive biomedical detection

Yunfeng Nie, Aikio Sanna, Annukka Kokkonen, Teemu Sipola, Uusitalo Sanna, Simonetta Grilli, Heidi Ottevaere
2020 Zenodo  
We present optical design and the principle demonstrator of a miniature fluorescence microscope aiming for super-sensitive detection.  ...  Current commercial fluorescence microscopes are typically sophisticated, bulky and expensive, not suitable for low-volume or clinic routine biomedical detection.  ...  An improved method for the optical readout of voltage indicators is presented, whereby fluorescence from the whole surface of a neuron is integrated onto a single detector, dramatically increasing the  ... 
doi:10.5281/zenodo.3822435 fatcat:3eoome22a5grbmarbrktphfh7a

UEG Week 2016 Oral Presentations

2016 United European Gastroenterology journal  
., and Zambon for serving as a consultant and lecturer. L. Bergmann: Lars Bergmann is an employee of AbbVie Inc. and hold stock or stock options.  ...  Aims & Methods: We aimed to assess acid sensitivity and mucosal integrity of the proximal and distal esophageal segments separately in patients with gastroesophageal reflux disease (GERD) and to investigate  ...  The classification algorithm was programmed based on 296 features of each image (e.g., area, circularity, diameter, and perimeter of nuclei, and over 250 variables calculated by texture analysis of a whole  ... 
doi:10.1177/2050640616663688 fatcat:vlhrwp4txbewzj3arcu3hriifu

American Society of Cytopathology

2004 Acta Cytologica  
GENetic Imaginary Exploitation (GENIE) is a hybrid ge- netic algorithm that allows analysis of images through se- lection of learned spatio-spectral features.  ...  advantage in ASCUS+ pick-up rate of 2.3% for the Imager Review (p = .02). ¢ Slide productivity rates on a per hour basis showed a 33% increase in the number of slides reviewed for the Imager.  ... 
doi:10.1159/000326438 fatcat:7tceixy4tjbhnm5ercc6qzlxw4


2018 Virchows Archiv  
Seven were male and the mean age at diagnosis was 16 years (8-37). The presentation was nodal in 8 cases.  ...  We searched for differentially expressed genes (FDR<0.05) between the EBV+ and MSI-high molecular groups (nSolver Analysis Software).  ...  Background & Objective: Biomarker analysis is crucial for detection and management of colorectal and non-small cell lung cancer.  ... 
doi:10.1007/s00428-018-2422-1 pmid:30120593 fatcat:rxb6dv66m5de5ocytkqgtk5cba


2014 Der Pathologe  
Moreover, the usefulness of immunohistochemistry is limited, emphasizing the need for better molecular tools to assist in the diagnosis.  ...  The former cell-lines are reactive and non-neoplastic, the latter cell line is genetically unstable and responsible for the tumorous behaviour of the GCT. Imaging.  ...  For 3D reconstruction of the tumor based on H&E images we recaptured the spatial correspondence between neighboring slides by means of rigid image registration.  ... 
doi:10.1007/s00292-014-1944-9 fatcat:jxkoidekjjeh7gq2ivyrysuzwe

New Innovative Technologies Changing Cytology. 19th International Congress of Cytology. Yokohama, Japan, May 29-June 1, 2016: Abstracts

2016 Acta Cytologica  
Collaboration with global community of cytology has fostered academic atmosphere and improved overall standard of cytology practice for the country.  ...  of IHC markers on cell blocks in the last 5 years.  ...  WS31 Whole Slide Imaging (WSI) and Cytology: Advantages and Drawbacks with Live Demonstration Walid E. Khalbuss 1 *, Daniel F.  ... 
doi:10.1159/000446388 pmid:27226043 fatcat:xyvfetmpjjczlnkckr3bn3fh5q

Summer Meeting 2010. 198th Scientific Meeting of the Pathological Society of Great Britain & Ireland, 29 June-1 July

2010 Journal of Pathology  
Acknowledgments (Trade Exhibition) as at time of going to press Poster Abstracts Presenter = P  ...  algorithms can be integrated seamlessly for the manual or automated analysis of virtual slides.  ...  Assessments are based on published learning outcomes linked to all learning activities.  ... 
doi:10.1002/path.2770 pmid:21157838 fatcat:go5nqlpxnjatddy7le4gqqfcxe

Fourth Japan-US Joint Congress of Histochemistry and Cytochemistry: Thirty-fifth Annual Meeting of the Japan Society of Histochemistry and Cytochemistry and Forty-fifth Annual Meeting of the Histochemical Society-Abstracts

1994 Acta Histochemica et Cytochemica  
With these techniques, sites of macromolecular synthesis at subcellular level in various organ systems and quantitative changes due to aging have been analyzed with image analysis system in our laboratory  ...  The techniques of radioautography (RAG) can be classified into 3 categories from viewpoint of specimen size,i. e. whole body, light microscopic and electron microscopic, as well as into 2 from viewpoint  ...  Markovic Medical College of Pennsylvania, Philadelphia, PA 19129 Image analysis based quantitative enzyme cytochemistry can be successfully applied in pharmacology for measurement of subtle drug-cell  ... 
doi:10.1267/ahc.27.376 fatcat:s4wbvzdktrbljkzvg37hjkeohq
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