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Postsynaptic Currents in Deep Cerebellar Nuclei

Davide Anchisi, Bibiana Scelfo, Filippo Tempia
2001 Journal of Neurophysiology  
Postsynaptic currents in deep cerebellar nuclei. J Neurophysiol 85: 323-331, 2001.  ...  Postsynaptic currents were studied by whole cell recordings in visually identified large neurons of the deep cerebellar nuclei (DCN) in slices of 4-to 11-day-old mice.  ...  I N T R O D U C T I O N Deep cerebellar nuclei (DCN) neurons provide the main output of the cerebellum and receive collaterals from the two main cerebellar afferent systems, climbing fibers and mossy fibers  ... 
doi:10.1152/jn.2001.85.1.323 pmid:11152732 fatcat:5sxsj6rugzhqxa63hf25j5tpny

Bilateral representation in the deep cerebellar nuclei

Demetris S. Soteropoulos, Stuart N. Baker
2008 Journal of Physiology  
We conclude that the deep cerebellar nuclei have a bilateral movement representation, and relatively direct, powerful access to limb muscles on both sides of the body.  ...  We tested this by making microelectrode penetrations into the deep cerebellar nuclei (mainly nucleus interpositus) of monkeys trained to perform a reach and grasp task with either hand.  ...  Brainstem and spinal projections of the deep cerebellar nuclei in the monkey, with observations on the brainstem projections of the dorsal column nuclei. Brain Res 286, 299-322.  ... 
doi:10.1113/jphysiol.2007.144220 pmid:18187463 fatcat:64yutdauxzdrtlwidrjyqjtz5e

Deep Cerebellar Nuclei Segmentation via Semi-Supervised Deep Context-Aware Learning from 7T Diffusion MRI [article]

Jinyoung Kim, Remi Patriat, Jordan Kaplan, Oren Solomon, Noam Harel
2020 arXiv   pre-print
Deep cerebellar nuclei are a key structure of the cerebellum that are involved in processing motor and sensory information.  ...  It is thus a crucial step to accurately segment deep cerebellar nuclei for the understanding of the cerebellum system and its utility in deep brain stimulation treatment.  ...  Of the cerebellum system, deep cerebellar nuclei (DCN) integrate signals from cerebellar cortex and relay them to cerebral cortex or brainstem.  ... 
arXiv:2004.09788v3 fatcat:io34ocviqnfq7eeudkjxdyefgy

Cerebellar deep nuclei involvement in cognitive adaptation and automaticity

D. Callu, J. Lopez, N. El Massioui
2013 Learning & memory (Cold Spring Harbor, N.Y.)  
Deep nuclei lesions were shown to play a particular role in acquisition and reversal learning (Joyal et al. 2001) .  ...  More recently, lesions of the interpositus nuclei were shown to prevent the development of habit-based behavior with overtraining, without altering the initial goal-directed behavior, suggesting that deep  ...  Deep nuclei lesions were shown to play a particular role in acquisition and reversal learning (Joyal et al. 2001) .  ... 
doi:10.1101/lm.030536.113 pmid:23772087 fatcat:hvnhaus56fei3p7xzgquemku2u

Implications of functional anatomy on information processing in the deep cerebellar nuclei

Yuval Baumel
2009 Frontiers in Cellular Neuroscience  
CEREBELLAR NUCLEI TYPES OF NEURONS The deep cerebellar nuclei (DCN) consist of three nuclei: the fastigial (medial) nucleus, the interposed nucleus and the dentate (lateral) nucleus.  ...  Theories of cerebellar timing typically emphasize the role of the cerebellar cortex while overlooking the role of the deep cerebellar nuclei (DCN) that provide the sole output of the cerebellum.  ... 
doi:10.3389/neuro.03.014.2009 pmid:19949453 pmcid:PMC2783015 fatcat:yqidodv7ybgwhhwkli3vl5qylq

Deep Cerebellar Nuclei Segmentation via Semi-Supervised Deep Context-Aware Learning from 7T Diffusion MRI

Jinyoung Kim, Remi Patriat, Jordan Kaplan, Oren Solomon, Noam Harel
2020 IEEE Access  
Deep cerebellar nuclei are a key structure of the cerebellum that are involved in processing motor and sensory information.  ...  It is thus a crucial step to accurately segment deep cerebellar nuclei for the understanding of the cerebellum system and its utility in deep brain stimulation treatment.  ...  Of the cerebellum system, deep cerebellar nuclei (DCN) integrate signals from cerebellar cortex and relay them to cerebral cortex or brainstem.  ... 
doi:10.1109/access.2020.2998537 pmid:32656051 pmcid:PMC7351101 fatcat:ihkyozka7vbhvk7gxa4qkohxqy

Passive models of neurons in the deep cerebellar nuclei: the effect of reconstruction errors

V STEUBER
2004 Neurocomputing  
We performed whole-cell recordings of deep cerebellar nucleus neurons in brain slices, reconstructed the neuronal morphologies and converted them into detailed compartmental models.  ...  Introduction The deep cerebellar nuclei (DCN) provide the main output from the cerebellum.  ...  Three di erent types of DCN neurons have been described: large glutamatergic neurons which project to the thalamus, red nucleus and other brain stem nuclei, smaller GABAergic neurons which carry feedback  ... 
doi:10.1016/s0925-2312(04)00100-6 fatcat:dwl7rdej7bbvrchnkajrg5dd6y

Coding of Tactile Response Properties in the Rat Deep Cerebellar Nuclei

Nathan C. Rowland, Dieter Jaeger
2005 Journal of Neurophysiology  
Coding of tactile response properties in the rat deep cerebellar nuclei. .  ...  It is unclear, however, how these responses contribute to the ultimate output of the cerebellum from the deep cerebellar nuclei (DCN).  ...  Deep cerebellar nuclei neurons receive input from mossy fiber and climbing fiber collaterals and from Purkinje cells.  ... 
doi:10.1152/jn.00285.2005 pmid:16061491 fatcat:mdzwcl2vkjefhnojt5bpwmq5ne

An electrophysiological analysis of deep cerebellar nuclei, with particular focus on Kv3 channels

M. Lamont
2009 Bioscience Horizons  
Deep cerebellar nuclei (DCN) form three symmetrical, bilateral nuclei, deep within the white matter of the cerebellum and represent the sole output of the cerebellum to the central nervous system.  ...  Using whole-cell patch clamp techniques, electrophysiological recordings from the dentate nucleus were obtained from coronal cerebellar slices of Wistar rats (P $ 12) in both current and voltage clamp  ...  cortex, which makes up the grey matter in the cerebellum, and the deep cerebellar nuclei (DCN), situated deep in the white matter of the cerebellum. 2, 3 DCN form three separable, symmetrical bilateral  ... 
doi:10.1093/biohorizons/hzp010 fatcat:fe3avrmnmbf5heiboof7yyfrru

Maturation of membrane properties of neurons in the rat deep cerebellar nuclei

Desheng Wang, Bernard G. Schreurs
2014 Developmental Neurobiology  
Patch clamp recordings of neurons in the adult rat deep cerebellar nuclei have been limited by the availability of viable brain slices.  ...  Using a new slicing technique, this study was designed to explore the maturation of membrane properties of neurons in the deep cerebellar nuclei (DCN),an area involved in rat eyeblink conditioning.  ...  Neurons from the cerebellar deep nuclei were identified morphologically through a 40X water immersion objective using DIC-IR optics (Olympus BX50WI, Dulles, VA).  ... 
doi:10.1002/dneu.22203 pmid:24931427 pmcid:PMC4211972 fatcat:ypp7g6z2a5alxa73ce24onls7i

Kv3.3b: a novel Shaw type potassium channel expressed in terminally differentiated cerebellar Purkinje cells and deep cerebellar nuclei

DS Goldman-Wohl, E Chan, D Baird, N Heintz
1994 Journal of Neuroscience  
cortex, but that it is also present in the deep cerebellar nuclei (Fig.  ...  Expression of this channel is highly enriched in the brain, particularly in the cerebellum, where its expression is confined to Purkinje cells and deep cerebellar nuclei.  ... 
doi:10.1523/jneurosci.14-02-00511.1994 pmid:8301351 fatcat:s2yxat4fsfg6ldba3pkbryabxm

Imaging the deep cerebellar nuclei: A probabilistic atlas and normalization procedure

J. Diedrichsen, S. Maderwald, M. Küper, M. Thürling, K. Rabe, E.R. Gizewski, M.E. Ladd, D. Timmann
2011 NeuroImage  
The deep cerebellar nuclei (DCN) are a key element of the cortico-cerebellar loop.  ...  The maps also quantify the variability of the anatomical location of the deep cerebellar nuclei after normalization.  ...  Visualizing deep cerebellar nuclei using susceptibility-weighted imaging Here we show the feasibility of using high-field (7 T) MRI to visualize the deep cerebellar nuclei in humans in the submillimeter  ... 
doi:10.1016/j.neuroimage.2010.10.035 pmid:20965257 fatcat:aik2bmghnncxbmx2pn57nyjpoy

Synchrony is Key: Complex Spike Inhibition of the Deep Cerebellar Nuclei

Tianyu Tang, Colleen Y. Suh, Timothy A. Blenkinsop, Eric J. Lang
2015 Cerebellum  
The control of deep cerebellar nuclear (DCN) neuronal firing is central to cerebellar function, but is not well understood.  ...  The DCN are central to cerebellar function, as their activity represents the majority of cerebellar output.  ...  At the end of the recording sessions the animal was perfused under deep anesthesia to allow histological reconstruction of the electrode track and verification of the location of the DCN recordings.  ... 
doi:10.1007/s12311-015-0743-z pmid:26559892 pmcid:PMC4729620 fatcat:yhxjocismnbrdgzggd33dgc6sy

Mechanisms Underlying LTP of Inhibitory Synaptic Transmission in the Deep Cerebellar Nuclei

Mohamed Ouardouz, Bhagavatula R. Sastry
2000 Journal of Neurophysiology  
Mechanisms underlying LTP of inhibitory synaptic transmission in the deep cerebellar nuclei. J Neurophysiol 84: 1414 -1421, 2000.  ...  Whole-cell recordings were used to investigate long-term potentiation of inhibitory synaptic currents (IPSCs) in neurons of deep cerebellar nuclei (DCN) in slices.  ...  FIG. 1 . 1 Long-term potentiation (LTP) of inhibitory postsynaptic currents (IPSCs) in deep cerebellar nuclear (DCN) neurons.  ... 
doi:10.1152/jn.2000.84.3.1414 pmid:10980014 fatcat:6sogszcgnngkzayknai2t6eflu

Phase response curve analysis of network properties in the deep cerebellar nuclei

Marylka Uusisaari, Benjamin Torben-Nielsen, Klaus M Stiefel
2010 BMC Neuroscience  
The deep cerebellar nuclei (DCN) are the final unit of cerebellar computation, where the excitatory input into the cerebellum is integrated with inhibitory input from the cerebellar Purkinje cells.  ...  Uusisaari M, Knöpfel T: GABAergic synaptic communication in the GABAergic and non-GABAergic cells in the deep cerebellar nuclei. Neuroscience 2008, 156:537-549. 3.  ...  The deep cerebellar nuclei (DCN) are the final unit of cerebellar computation, where the excitatory input into the cerebellum is integrated with inhibitory input from the cerebellar Purkinje cells.  ... 
doi:10.1186/1471-2202-11-s1-p49 pmcid:PMC3090936 fatcat:xf7nkz524vgajkwq2uopeq5pji
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