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Resting-state Functional MRI in Parkinsonian Syndromes

Massimo Filippi, Elisabetta Sarasso, Federica Agosta
2019 Movement Disorders Clinical Practice  
Functional MRI (fMRI) has been widely used to study abnormal patterns of functional connectivity at rest in patients with movement disorders such as idiopathic Parkinson's disease (PD) and atypical parkinsonisms  ...  , and to continue technical advances to fully realize the potential of fMRI as a tool to monitor the efficacy of chronic therapies.  ...  of detecting blood flow fluctuations and blood oxygenation level-dependent signals in the brain and measuring neuronal activation by exploiting the paramagnetic properties of blood.  ... 
doi:10.1002/mdc3.12730 pmid:30838308 pmcid:PMC6384182 fatcat:ioyazemd3jfstmlqt3xgs72niy

Translational research of temporomandibular joint pathology: a preliminary biomarker and fMRI study

Andre Barkhordarian, Gary Demerjian, Francesco Chiappelli
2020 Journal of Translational Medicine  
The fMRI study of TMD patients showed an abnormal hyper-connected salience network and a diminished blood flow to the anterior frontal lobes when they did not wear their customized dental orthotics.  ...  Our findings highlight the importance of TMJ-CNS connections and use of fMRI as an investigative tool for understanding TMD and its related neurological pathologies.  ...  Bradley Jabour and his team for the fMRI analysis studies.  ... 
doi:10.1186/s12967-019-02202-0 pmid:31931814 pmcid:PMC6956559 fatcat:vdz5hnfl2fgzpb2mq57ftgbcqy

Altered insula–default mode network connectivity in fibromyalgia: a resting-state magnetoencephalographic study

Fu-Jung Hsiao, Shuu-Jiun Wang, Yung-Yang Lin, Jong-Ling Fuh, Yu-Chieh Ko, Pei-Ning Wang, Wei-Ta Chen
2017 The Journal of Headache and Pain  
Functional magnetic resonance imaging studies on FM have suggested altered brain connectivity between the insula and the default mode network (DMN).  ...  Fibromyalgia (FM) is a disabling chronic pain syndrome with unknown pathophysiology.  ...  have used fMRI to investigate the blood-oxygen-level-dependent (BOLD) signal fluctuations in the DMN structures of patients with FM and demonstrated altered connectivity with various regions associated  ... 
doi:10.1186/s10194-017-0799-x pmid:28831711 pmcid:PMC5567574 fatcat:r5ashue6ejaaxkfxmc3uu6v3yu

Resting state networks change in clinically isolated syndrome

Stefan D. Roosendaal, Menno M. Schoonheim, Hanneke E. Hulst, Ernesto J. Sanz-Arigita, Stephen M. Smith, Jeroen J. G. Geurts, Frederik Barkhof
2010 Brain  
Patients with clinically isolated syndrome showed increased synchronization in six of the eight resting state networks, including the default mode network and sensorimotor network, compared to controls  ...  No significant decreases were found in patients with clinically isolated syndrome.  ...  Acknowledgements The authors would like to express their gratitude to T. Schweigmann, K.  ... 
doi:10.1093/brain/awq058 pmid:20356855 fatcat:ublnrmnyozexdlrqhv2x4tocze

Using structural and functional MRI as a neuroimaging technique to investigate chronic fatigue syndrome/myalgic encephalopathy: a systematic review

Basim Almutairi, Christelle Langley, Esther Crawley, Ngoc Jade Thai
2020 BMJ Open  
ObjectiveThis systematic review aims to synthesise and evaluate structural MRI (sMRI) and functional MRI (fMRI) studies in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME).MethodsWe systematically  ...  Tasks with increasing load or complexity produced decreased activation in task-specific brain regions.ConclusionsThere were insufficient data to define a unique neural profile or biomarker of CFS/ME.  ...  NJT reviewed and edited the protocol, read full-text articles included in the systematic review for quality assessment, reviewed and edited data extraction and synthesis. and reviewed and edited the manuscript  ... 
doi:10.1136/bmjopen-2019-031672 pmid:32868345 fatcat:hmu2azebe5g5nkqyr5vmenw6hq

Functional Neural Network Connectivity in Myalgic Encephalomyelitis

Marcie Zinn, Mark Zinn, Leonard Jason
2016 NeuroRegulation  
Here, we focus on recent emergent principles of complex cortical systems, suggesting how subtle disruptions of network properties could be related to significant disruptions in cognition and behavior found  ...  This review, therefore, discusses how electrical neuroimaging methods with time-dependent metrics (e.g., coherence, phase, cross-frequency coupling) can be a useful approach for the understanding of the  ...  Psychosocial factors involved in memory and cognitive failures in people with myalgic encephalomyelitis/chronic fatigue syndrome.  ... 
doi:10.15540/nr.3.1.28 fatcat:qyjecxtzingqvku32rdcrgz5tu

The posterior medial cortex in urologic chronic pelvic pain syndrome

Katherine T. Martucci, William R. Shirer, Epifanio Bagarinao, Kevin A. Johnson, Melissa A. Farmer, Jennifer S. Labus, A. Vania Apkarian, Georg Deutsch, Richard E. Harris, Emeran A. Mayer, Daniel J. Clauw, Michael D. Greicius (+1 others)
2015 Pain  
Collectively, these findings indicate that in patients with urologic chronic pelvic pain syndrome, regions of the PMC are detached from the default mode network, whereas neurological processes of self-referential  ...  Using dual regression and seed-based analyses, we observed significantly decreased FC of the default mode network to 2 regions in the posterior medial cortex (PMC): the posterior cingulate cortex (PCC)  ...  The hippocampus is implicated in default mode network processes and is functionally connected to the PCC [28] .  ... 
doi:10.1097/j.pain.0000000000000238 pmid:26010458 pmcid:PMC4545714 fatcat:vgxmuhflwfftdbmgbxazr3zfce

Structural and Functional Brain Patterns of Non-Motor Syndromes in Parkinson's Disease

Tino Prell
2018 Frontiers in Neurology  
This review provides an up-to-date description of structural and functional brain alterations in patients with PD with cognitive deficits, visual hallucinations, fatigue, impulsive behavior disorders,  ...  Advanced magnetic resonance imaging, positron emission tomography, and functional magnetic resonance imaging can render the view toward understanding the neural basis of these non-motor syndromes, as they  ...  The fMRI measures brain activity by detecting changes associated with blood flow because cerebral blood flow and neuronal activation are coupled [blood oxygen level-dependent contrast imaging (BOLD)].  ... 
doi:10.3389/fneur.2018.00138 pmid:29593637 pmcid:PMC5858029 fatcat:acg4f4vsffhf3l2lhgmi2ncoie

A Comparison of Neuroimaging Abnormalities in Multiple Sclerosis, Major Depression and Chronic Fatigue Syndrome (Myalgic Encephalomyelitis): is There a Common Cause?

Gerwyn Morris, Michael Berk, Basant K. Puri
2017 Molecular Neurobiology  
sclerosis, major depression or chronic fatigue syndrome (CFS) (myalgic encephalomyelitis).  ...  There is copious evidence of abnormalities in resting-state functional network connectivity states, grey and white matter pathology and impaired cerebral perfusion in patients afforded a diagnosis of multiple  ...  Compliance with Ethical Standards Conflict of Interest The authors declare that they have no conflicts of interest.  ... 
doi:10.1007/s12035-017-0598-z pmid:28516431 pmcid:PMC5842501 fatcat:djcg2xeh3bgnlmu4bcghihxl5i

Fatigue in inflammatory rheumatic disorders: pathophysiological mechanisms

2019 Rheumatology  
Jointly, these actions result in increased glutamatergic and decreased monoaminergic neurotransmission.  ...  Fourth, proinflammatory cytokines increase the level of enzyme indoleamine-2, 3-dioxygenase activity and shunt tryptophan away from the serotonin pathway.  ...  Disclosure statement: The authors have declared no conflicts of interest.  ... 
doi:10.1093/rheumatology/kez413 pmid:31682277 pmcid:PMC6827268 fatcat:3ukmnfpnc5bxrm5lypmnw6hxpm

Neuroimaging for psychotherapy research: Current trends

Carol P. Weingarten, Timothy J. Strauman
2014 Psychotherapy Research  
Conclusions: The increasing use of neuroimaging methods in the study of psychotherapy continues to refine our understanding of both outcome and process.  ...  An introduction to neuroimaging methods is provided as background for the increasingly sophisticated breadth of methods and findings appearing in psychotherapy research.  ...  Funding This research was supported by National Institute on Drug Abuse (NIDA) Grant R01DA031579, which is supported by the NIH Common Fund and managed by the OD/Office of Strategic Coordination (OSC),  ... 
doi:10.1080/10503307.2014.883088 pmid:24527694 pmcid:PMC4135014 fatcat:sdxa7b46bnf3jnzfwemhgukmri

Synchronization within, and interactions between, the default mode and dorsal attention networks in relapsing-remitting multiple sclerosis

Muhua Huang, Fuqing Zhou, Lin Wu, Bo Wang, Hui Wan, Fangjun Li, Xianjun Zeng, Honghan Gong
2018 Neuropsychiatric Disease and Treatment  
and purpose: The effects of the interactions between the default mode network (DMN) and the dorsal attention network (DAN), which present anticorrelated behaviors, in relapsing-remitting multiple sclerosis  ...  Results: Compared with the healthy subjects, the RRMS patients in the remitting phase showed the following: 1) significantly decreased FC within the DAN in the postcentral gyrus and decreased FC within  ...  The authors thank their patients and volunteers for participating in this study.  ... 
doi:10.2147/ndt.s155478 pmid:29795982 pmcid:PMC5957478 fatcat:vxiokkdl7fafrejt5o4wz4vo2e

Clinical Evaluation and Treatment of Patients with Postconcussion Syndrome

Vijay Renga, Mamede de Carvalho
2021 Neurology Research International  
With the complexity created by premorbid conditions, psychosomatic issues, secondary gains, and litigations, providers often find themselves in a tough situation in the care of these patients.  ...  Postconcussion syndrome (PCS) is a complex set of symptoms occurring in a small percentage of patients following concussion.  ...  Functional disruption affecting the resting brain networks, especially the default mode network (DMN), has been demonstrated in TBI [25] .  ... 
doi:10.1155/2021/5567695 fatcat:o7p27m65tzahrejefhupxcluj4

Does Conservative Treatment Change the Brain in Patients with Chronic Musculoskeletal Pain? A Systematic Review

Jeroen Kregel, Iris Coppieters, Robby DePauw, Anneleen Malfliet, Lieven Danneels, Jo Nijs, Barbara Cagnie, Mira Meeus
2017 Pain Physician  
Many observational studies have demonstrated that chronic pain states are associated with brain alterations regarding structure and/or function.  ...  Rehabilitation of patients with chronic musculoskeletal pain may include cognitive, exercise, or multimodal therapies.  ...  due to changes in the level of oxygen in the blood (13) .  ... 
pmid:28339428 fatcat:ckgf56wpmjc5fhxbh5djz3ajiy

Intrinsic neural network dysfunction in quiescent Crohn's Disease

Anne K. Thomann, Martin Griebe, Philipp A. Thomann, Dusan Hirjak, Matthias P. Ebert, Kristina Szabo, Wolfgang Reindl, Robert C. Wolf
2017 Scientific Reports  
Brain regions associated with emotion regulation and self-referential processing, including areas assigned to the "default mode network" (DMN), could be promising candidates in this regard.  ...  We investigated the functional integrity of multiple intrinsic neural networks in remitted patients with Crohn's disease (CD) and sought to establish relationships between neural network connectivity and  ...  Acknowledgements The authors thank all participants for their time and interest in the study.  ... 
doi:10.1038/s41598-017-11792-y pmid:28912568 pmcid:PMC5599642 fatcat:2yla7ggg2zftznwceobuhbxwpi
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