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Decoding human fetal liver haematopoiesis

Dorin-Mirel Popescu, Rachel A. Botting, Emily Stephenson, Kile Green, Simone Webb, Laura Jardine, Emily F. Calderbank, Krzysztof Polanski, Issac Goh, Mirjana Efremova, Meghan Acres, Daniel Maunder (+44 others)
2019 Nature  
Definitive haematopoiesis in the fetal liver supports self-renewal and differentiation of haematopoietic stem cells and multipotent progenitors (HSC/MPPs) but remains poorly defined in humans.  ...  Our integrated map of fetal liver haematopoiesis provides a blueprint for the study of paediatric blood and immune disorders, and a reference for harnessing the therapeutic potential of HSC/MPPs.  ...  The human embryonic and fetal material was provided by the Joint MRC / Wellcome (MR/R006237/1) Human Developmental Biology Resource (www.hdbr.org).  ... 
doi:10.1038/s41586-019-1652-y pmid:31597962 pmcid:PMC6861135 fatcat:z4ftvzz4ljfq3jjxkq7o2ud3ai

Decoding the development of the blood and immune systems during human fetal liver haematopoiesis [article]

Dorin-Mirel Popescu, Rachel A Botting, Emily Stephenson, Kile Green, Laura Jardine, Emily F Calderbank, Mirjana Efremova, Meghan Acres, Daniel Maunder, Peter Vegh, Issac Goh, Yorick Gitton (+42 others)
2019 bioRxiv   pre-print
Definitive haematopoiesis in the fetal liver supports self-renewal and differentiation of haematopoietic stem cells/multipotent progenitors (HSC/MPPs), yet remains poorly defined in humans.  ...  Our integrated map of fetal liver haematopoiesis provides a blueprint for the study of paediatric blood and immune disorders, and a valuable reference for understanding and harnessing the therapeutic potential  ...  liver. 220 221 Fetal liver and NLT haematopoiesis 222 Following ab initio identification of fetal liver cells, we leveraged the real-time data from liver samples 223 across the gestational stages to infer  ... 
doi:10.1101/654210 fatcat:bgbtcb5hdrcsbmfvhmqs5sy5cm

Humanised mouse models for haematopoiesis and infectious diseases

2017 Swiss Medical Weekly  
Humanised" mouse models have emerged over past years as powerful tools for investigating human haematopoiesis and immunity.  ...  This review focuses on recent advances in the study of human haematopoiesis and immunity in humanised mouse models, underlining their relevance and limitations.  ...  human fetal liver / fetal bone marrow, umbilical cord blood and adult bone marrow [24] [25] [26] [27] [28] [29] [30] .  ... 
doi:10.4414/smw.2017.14516 pmid:29120027 fatcat:4jo6xqz7h5agbb6oduml7iii3q

Proliferatic Potential of Hematopoietic Stem Cells (HSC) and its Application in Human Diseases

Pallavi Singh, Naman Naik, Lakhan L. Naik
2016 International Journal of Current Research and Academic Review  
Fetal Hematopoietic System 5.  ...  Currently, no other type of stem cell -adult, fetal or embryonic, has attained such status.  ... 
doi:10.20546/ijcrar.2016.403.010 fatcat:mewm5iq32ra6fmhn6op5rwkri4

Megakaryocyte production is sustained by direct differentiation from erythromyeloid progenitors in the yolk sac until midgestation

Lorea Iturri, Laina Freyer, Anne Biton, Pascal Dardenne, Yvan Lallemand, Elisa Gomez Perdiguero
2021 Immunity  
We uncovered here the heterogeneity of yolk sac erythromyeloid progenitors, at the single cell level, and discriminated multipotent from committed progenitors, prior to fetal liver colonization.  ...  By contrast, the second originates later, from Myb-dependent bipotent progenitors expressing Csf2rb and colonize the fetal liver, where they give rise to megakaryocytes and to large numbers of erythrocytes  ...  Decoding human fetal liver haematopoiesis. Nature 574, 365-371. https://doi.org/10. 1038/s41586-019-1652-y.  ... 
doi:10.1016/j.immuni.2021.04.026 pmid:34062116 fatcat:ojxfchkhyvcnpdm7nniysjctmi

A regulatory circuit comprising GATA1/2 switch and microRNA-27a/24 promotes erythropoiesis

Fang Wang, Yong Zhu, Lihua Guo, Lei Dong, Huiwen Liu, Haixin Yin, Zhongzu Zhang, Yuxia Li, Changzheng Liu, Yanni Ma, Wei Song, Aibin He (+5 others)
2013 Nucleic Acids Research  
In contrast to miR-451 locus whose expression was restricted to the fetal liver in embryonic day (E) 16.5 mouse embryos, the major site of haematopoiesis and erythropoiesis at this stage of development  ...  The isolated CD34+ cells were cultured in IMDM supplemented with 30% fetal bovine serum (Hyclone), 1% BSA, 100 mM 2-ME, 2 ng/ml recombinant human IL-3, 100 ng/ml recombinant human SCF (Stem Cell Technologies  ... 
doi:10.1093/nar/gkt848 pmid:24049083 pmcid:PMC3874166 fatcat:k5zeeusrjvgjxorvlq2d7tknym

Deciphering cell–cell interactions and communication from gene expression

Erick Armingol, Adam Officer, Olivier Harismendy, Nathan E. Lewis
2020 Nature reviews genetics  
When cells do not properly interact or improperly decode molecular messages, disease ensues.  ...  CCC analysis also elucidated how erythroblasts interact with macrophages during haematopoiesis in the fetal liver 23 and was applied to liver organoid development to investigate how multilineage communication  ...  A recent analysis of human liver development used immunohistochemistry to verify VCAM1 production in macrophages and ITGA4 production in erythroid cells of the human fetal liver to suggest a possible interaction  ... 
doi:10.1038/s41576-020-00292-x pmid:33168968 pmcid:PMC7649713 fatcat:27ur3qmwbvbe3ptqjcechg6v4a

Humanised mouse models for haematopoiesis and infectious diseases

Veronika Lysenko, Donal McHugh, Lena Behrmann, Mary-Aude Rochat, Christian M Wilk, Larisa V Kovtonyuk, Jean-Pierre Bourquin, Christian Münz, Markus G Manz, Roberto F Speck, Alexandre P Theocharides
2017
Humanised" mouse models have emerged over past years as powerful tools for investigating human haematopoiesis and immunity.  ...  Summary "Humanised" mouse models have emerged over past years as powerful tools for investigating human haematopoiesis and immunity.  ...  human fetal liver / fetal bone marrow, umbilical cord blood and adult bone marrow [24] [25] [26] [27] [28] [29] [30] .  ... 
doi:10.5167/uzh-141558 fatcat:pcbkndauqvfcrfrw2otuz2umsm

Spatiotemporal analysis of human intestinal development at single-cell resolution

David Fawkner-Corbett, Agne Antanaviciute, Kaushal Parikh, Marta Jagielowicz, Ana Sousa Gerós, Tarun Gupta, Neil Ashley, Doran Khamis, Darren Fowler, Edward Morrissey, Chris Cunningham, Paul R.V. Johnson (+2 others)
2021 Cell  
We compile a publicly available online resource, spatio-temporal analysis resource of fetal intestinal development (STAR-FINDer), to facilitate further work.  ...  Development of the human intestine is not well understood. Here, we link single-cell RNA sequencing and spatial transcriptomics to characterize intestinal morphogenesis through time.  ...  Decoding human fetal liver haematopoiesis. Nature 574, 365-371. Pu, Y., Li, S., Xiong, H., Zhang, X., Wang, Y., and Du, H. (2018). Iron Promotes Intestinal Development in Neonatal Piglets.  ... 
doi:10.1016/j.cell.2020.12.016 pmid:33406409 pmcid:PMC7864098 fatcat:pv2efztaojddxpgw7ug5qenalm

Proceedings of the anatomical society of great britain and ireland and the anatomische gesellschaft

1995 Journal of Anatomy  
from the liver to establish adherent stromal layers capable of maintaining haematopoiesis in vitro.  ...  liver.  ... 
pmid:17103642 pmcid:PMC1167363 fatcat:puoop2mk3nedhc6otdlrhb5cpu

An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability

Judith Schütte, Huange Wang, Stella Antoniou, Andrew Jarratt, Nicola K Wilson, Joey Riepsaame, Fernando J Calero-Nieto, Victoria Moignard, Silvia Basilico, Sarah J Kinston, Rebecca L Hannah, Mun Chiang Chan (+5 others)
2016 eLife  
Shown are X-Gal-stained whole-mount 805 embryos and paraffin sections of the dorsal aorta (DA, ventral side on the left/top) and foetal 806 liver (FL), sites of definitive haematopoiesis.  ...  The binding of transcription factor proteins 38 (TFs) to specific DNA sequence motifs represents the primary step of decoding genetic 39 information into specific gene expression patterns.  ...  (mm9), human (hg19), dog (canFam2), opossum (monDom5) and platypus (ornAna1). 1036 Nucleotides highlighted in black are conserved between all species analysed, nucleotides 1037 highlighted in grey are  ... 
doi:10.7554/elife.11469 pmid:26901438 pmcid:PMC4798972 fatcat:kilulyb7u5dcfdwcxvq4k3kfyu

Expanded encyclopaedias of DNA elements in the human and mouse genomes

Jill E. Moore, The ENCODE Project Consortium, Michael J. Purcaro, Henry E. Pratt, Charles B. Epstein, Noam Shoresh, Jessika Adrian, Trupti Kawli, Carrie A. Davis, Alexander Dobin, Rajinder Kaul, Jessica Halow (+52 others)
2020 Nature  
Here we summarize these efforts, which have produced 5,992 new experimental datasets, including systematic determinations across mouse fetal development.  ...  The human and mouse genomes contain instructions that specify RNAs and proteins and govern the timing, magnitude, and cellular context of their production.  ...  Human orthologues of accessible regions in fetal mouse tissues are enriched for human disease-associated variation in a tissue-restricted manner 14 .  ... 
doi:10.1038/s41586-020-2493-4 pmid:32728249 pmcid:PMC7410828 fatcat:ozll5a2uurhbhlkuakaf4ngc24

Investigation into experimental toxicological properties of plant protection products having a potential link to Parkinson's disease and childhood leukaemia†

Colin Ockleford, Paulien Adriaanse, Philippe Berny, Theodorus Brock, Sabine Duquesne, Sandro Grilli, Antonio F Hernandez‐Jerez, Susanne Hougaard Bennekou, Michael Klein, Thomas Kuhl, Ryszard Laskowski, Kyriaki Machera (+22 others)
2017 EFSA Journal  
In 2013, EFSA published a literature review on epidemiological studies linking exposure to pesticides and human health outcome.  ...  The Panel supports the use of the AOP framework to scientifically and transparently explore the biological plausibility of the association between pesticide exposure and human health outcomes, identify  ...  It has also been demonstrated that several bioflavonoids are capable of inducing the cleavage of the MLL gene in human cell lines (Strick et al., 2000; .  ... 
doi:10.2903/j.efsa.2017.4691 pmid:32625422 pmcid:PMC7233269 fatcat:5o4l5bfiivg3phngk2zonjocpa

Molecular definition of group 1 innate lymphoid cells in the uterus

Iva Filipovic, Apollo-University Of Cambridge Repository, Apollo-University Of Cambridge Repository, Graham Burton, Francesco Colucci
2019
Unique to the mouse uterus is a population of CD49a+Eomes+ g1 ILCs (trNK), resembling human uNK cells.  ...  Uterine NK cells (uNKs) are group 1 (g1) innate lymphoid cells (ILCs) that have been shown to regulate remodelling of uterine blood vessels, an event necessary to support fetal growth.  ...  Tissue-resident Eomes + CD49a + NK cells (trNK), which resemble human uterine NK cells, are most abundant during early pregnancy, and have gene signatures associated with TGF-β responses and interactions  ... 
doi:10.17863/cam.40753 fatcat:loc6qzfejra67mh5winjxfjc5q

A Krüppel-like factor 1 (KLF1) mutation associated with severe congenital dyserythropoietic anemia alters its DNA-binding specificity [article]

Klaudia Kulczynska, James J Bieker, Miroslawa Siatecka
2019 bioRxiv   pre-print
Various mutations are identified in the human KLF1 gene.  ...  Nuez, B., Michalovich, D., Bygrave, A., Ploemacher, R., and Grosveld, F. (1995) Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature 375, 316-318 7.  ...  L. (1994) Human red cell Aquaporin CHIP. II. Expression during normal fetal development and in a novel form of congenital dyserythropoietic anemia. J Clin Invest 94, 1050-1058 55.  ... 
doi:10.1101/774158 fatcat:uasyg3652nbpnd4oyx7clljada
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