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Decoding Complex Chemical Mixtures with a Physical Model of a Sensor Array

Julia Tsitron, Addison D. Ault, James R. Broach, Alexandre V. Morozov, Christopher V. Rao
2011 PLoS Computational Biology  
However, the complex pattern of receptor responses to even a single analyte, coupled with the nonlinearity of responses to mixtures of analytes, makes quantitative prediction of compound concentrations  ...  We also derive design principles that enable accurate mixture discrimination with cross-specific sensor arrays.  ...  Physical model of the sensor array Single-receptor, single-ligand model. We start with the simplest case in which a receptor interacts with a single ligand.  ... 
doi:10.1371/journal.pcbi.1002224 pmid:22046111 pmcid:PMC3202980 fatcat:uwo2prvfbbbrhj5nx2twnusvhm

Independent component analysis of nanomechanical responses of cantilever arrays

Rick Archibald, Panos Datskos, Gerald Devault, Vincent Lamberti, Nickolay Lavrik, Don Noid, Michael Sepaniak, Pampa Dutta
2007 Analytica Chimica Acta  
Furthermore, it is demonstrated that the knowledge of how the sensor array reacts to individual analytes in isolation is sufficient information to decode mixtures of analytes-a substantial benefit, significantly  ...  The development of functionalized cantilever arrays with nanomechanical sensing is an important step towards this goal.  ...  Support was also provided by the Y-12 National Security Complex Plant Directed Research and Development program.  ... 
doi:10.1016/j.aca.2006.11.007 pmid:17386591 fatcat:wm2zph5swvc77eyh6bnrau2jvi

Mimicking Biological Design and Computing Principles in Artificial Olfaction

Baranidharan Raman, Mark Stopfer, Steve Semancik
2011 ACS Chemical Neuroscience  
Modern approaches to chemical sensing have been based on the biological principle of combining cross-selective chemical sensors with a pattern recognition engine to identify odors.  ...  capable of distinguishing different chemicals with a pattern recognition module to detect and identify odors. 4À7 Here, we first identify and discuss biological design and computing principles that we  ...  Figure 4 . 4 Bioinspired approaches for odor delivery and chemical sensor array design. (a) A realistic physical model of the canine nasal cavity.  ... 
doi:10.1021/cn200027r pmid:22081790 pmcid:PMC3212736 fatcat:ir7rrhmp6ff4jhfeuy5aklzk5u

Spatio-temporal information in an artificial olfactory mucosa

M. A Sanchez-Montanes, J. W Gardner, T. C Pearce
2008 Proceedings of the Royal Society A  
For this purpose, we develop here a new measure of spatio-temporal information that combined with an analytical model of the artificial mucosa, chemosensor and noise dynamics completely characterizes the  ...  Deploying chemosensor arrays in close proximity to stationary phases imposes stimulusdependent spatio-temporal dynamics on their response and leads to improvements in complex odour discrimination.  ...  The detection capability of a chemical sensor array for complex (multicomponent) odour analysis is determined by both sensor noise and the degree to which response properties can be made stimulus specific  ... 
doi:10.1098/rspa.2007.0140 fatcat:2ltkfr3jvrhtfe3hfgbrxszwia

Biomarker Metabolite Signatures Pave the Way for Electronic-nose Applications in Early Clinical Disease Diagnoses

Alphus Dan Wilson
2017 Current Metabolomics  
Analysis of complex mixtures of disease biomarkers provides effective diagnostic clues for detecting the presence of specific disease processes occurring in the body.  ...  Mechanisms of disease (pathogenesis) result in the production of unique mixtures of abnormal volatile organic compounds (VOCs), referred to as disease biomarker metabolites when associated with specific  ...  SUPPLEMENTARY MATERIAL Supportive material is available on the publisher's website along with the published article.  ... 
doi:10.2174/2213235x04666160728161251 fatcat:zipjdp5jdzcgjjtnvxjjhb2v34

Multichannel sampling schemes for optical imaging systems

Andrew D. Portnoy, Nikos P. Pitsianis, Xiaobai Sun, David J. Brady
2008 Applied Optics  
We present a complete f =2:1 optical system with a thickness of 2:2 mm.  ...  The resolution is maintained in the thin optical system by an integrated design of the encoding scheme, the process of making the coding elements, and the decoding algorithms.  ...  We first present a unifying model of optical imaging systems with lenslet arrays. A.  ... 
doi:10.1364/ao.47.000b76 pmid:18382553 fatcat:vvrb3binxjen5m5xsfcur5raki

Selective detection of complex gas mixtures using point contacts: concept, method and tools

Alexander P Pospelov, Victor I Belan, Dmytro O Harbuz, Volodymyr L Vakula, Lyudmila V Kamarchuk, Yuliya V Volkova, Gennadii V Kamarchuk
2020 Beilstein Journal of Nanotechnology  
Using the point-contact spectroscopic profile of a complex gas mixture it is possible to get a functional dependence of the concentration of particular breath components on the amplitude of the sensor  ...  Point-contact sensors allow us to obtain a spectroscopic profile of the mixture.  ...  complex gas mixture.  ... 
doi:10.3762/bjnano.11.146 pmid:33178548 pmcid:PMC7607434 fatcat:unlhchpttfetzciv65vsyhqx7a

Analog VLSI Circuit Implementation of an Adaptive Neuromorphic Olfaction Chip

Thomas Jacob Koickal, Alister Hamilton, Su Lim Tan, James A. Covington, Julian W. Gardner, Tim C. Pearce
2007 IEEE Transactions on Circuits and Systems I Fundamental Theory and Applications  
A chemical sensor array employing carbon black composite sensing materials with integrated signal processing circuitry forms the front end of the chip.  ...  The sensor signal processing circuitry includes a dc offset cancellation circuit to ameliorate loss of measurement range associated with chemical sensors.  ...  Other chemical sensing arrays [28] with higher density employ a multiplexing mechanism to provide access to individual sensors without any complex circuitry.  ... 
doi:10.1109/tcsi.2006.888677 fatcat:ywbuzhnolfc6tjveurj3o7kdja

Applications and Advances in Electronic-Nose Technologies

Alphus Wilson, Manuela Baietto
2009 Sensors  
The invention of many new e-nose sensor types and arrays, based on different detection principles and mechanisms, is closely correlated with the expansion of new applications.  ...  This paper is a review of the major electronicnose technologies, developed since this specialized field was born and became prominent in the mid 1980s, and a summarization of some of the more important  ...  Daniele Bassi (Department of Crop Science, University of Milan, Milan, Italy) and Francesco Ferrini (Department of Vegetable Flower and Fruit Culture, University of Florence, Florence, Italy) for providing  ... 
doi:10.3390/s90705099 pmid:22346690 pmcid:PMC3274163 fatcat:fvxlm4j6kzaxzi27o4b553mrru

Degradation Study of Thin-Film Silicon Structures in a Cell Culture Medium

Huachun Wang, Jingjing Tian, Bingwei Lu, Yang Xie, Pengcheng Sun, Lan Yin, Yuguang Wang, Xing Sheng
2022 Sensors  
, physical, and chemical properties during the hydrolysis.  ...  In this work, we experimentally investigated the dissolution of planar Si thin films and micropatterned Si pillar arrays in a cell culture medium, and systematically analyzed the evolution of their topographical  ...  By virtue of chemical analyses, the introduced foreign elementsincluding O, Ca, and P-suggest that corrosion products with complex mixtures of oxides or salt compounds formed after contacting the physiological  ... 
doi:10.3390/s22030802 pmid:35161547 pmcid:PMC8838160 fatcat:baj6wgjsiffcno7iwtyeztzxwm

Bridging the Brain to the World: A Perspective on Neural Interface Systems

John P. Donoghue
2008 Neuron  
Impressive progress has been made, including evaluation of neural control signals, sensor testing in humans, signal decoding advances, and proof-of-concept validation.  ...  This emerging field promises a range of neurotechnologies able to return communication, independence, and control to people with movement limitations.  ...  The author receives no compensation and has no equity share in I2S Microsystems, Inc, the new manufacturer of the sensor used in the BrainGate trial.  ... 
doi:10.1016/j.neuron.2008.10.037 pmid:18995827 fatcat:kxofajun7fehxna4dp6isjd4hm

Accurate Identification of Agricultural Inputs Based on Sensor Monitoring Platform and SSDA-HELM-SOFTMAX Model

Juan Zou, Hanjing Jiang, Qingxiu Wang, Ningxia Chen, Ting Wu, Ling Yang, Yuan Li
2021 Journal of Sensors  
The experiments showed that the combination of sensors and discriminant model could accurately classify different agricultural inputs.  ...  In this paper, a new detection method based on sensors and artificial intelligence algorithm was proposed in the detection of the commonly agricultural inputs in Agastache rugosa cultivation.  ...  In the model training process, physical and chemical parameter values of agricultural inputs as collected by the sensor were sent to the SAE input layer as training samples.  ... 
doi:10.1155/2021/1015391 fatcat:7u2ze6vainfhbhotmxbwxjszqe

Electronic Nose, Tongue and Eye: Their Usefulness for the Food Industry

Roberto Ordoñez-Araque, Johnny Rodríguez-Villacres, Julio Urresto-Villegas
2020 Revista Vitae  
Methods: A search was carried out in the main databases of indexed articles, with terms that allowed collecting the necessary information, and 89 articles were used that met different inclusion criteria  ...  Objectives: Find the main generalities of these mechanisms, their sensors, software, mechanism of action, and applications within the food industry.  ...  Electronic sensors are products of advanced chemical and physical sciences combined with the intuitive integration of microprocessors, computing, and statistics.  ... 
doi:10.17533/udea.vitae.v27n3a01 fatcat:wpanpp7oizhhnfifqcgkob6arm

Temporal responses of chemically diverse sensor arrays for machine olfaction using artificial intelligence

Shaun K. Ryman, Neil D.B. Bruce, Michael S. Freund
2016 Sensors and actuators. B, Chemical  
Processed sensor array responses, coupled with principal component analysis (PCA), will be used to develop a novel approach to classify odors in the presence of changing sensor responses associated with  ...  New methods for rapid dynamic temporal evaluation of chemical sensor arrays for the monitoring of analytes is explored in this work.  ...  Using more than one vapor at the same time, the sensors have been shown to have an additive ΔR/R response. 24 A sensor array of this type is capable of identifying complex mixtures of analytes.  ... 
doi:10.1016/j.snb.2016.03.059 fatcat:3xl2ggicvzh2fnbnrwnnxj5kbm

Electronic Tongue—A Tool for All Tastes?

Marta Podrażka, Ewa Bączyńska, Magdalena Kundys, Paulina Jeleń, Emilia Witkowska Nery
2017 Biosensors  
For that, we need to think of an electronic tongue not as a physical object containing several integrated sensors but rather as a set of sources of data obtained from a liquid sample, regardless to their  ...  In this review, we would like to take a closer look on what are real capabilities of electronic tongue systems, what can be achieved using mixed sensor arrays and by introduction of biosensors or molecularly  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/bios8010003 pmid:29301230 pmcid:PMC5872051 fatcat:5maam34dvrebhifuvvfbcyynmi
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