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Protein homology modeling and structure-function relationship of 2009 swine influenza virus hemagglutinin (HA1): more human than swine

Mushtaq Hussain, Rafiq Khanani, Nusrat Jabeen, Shaheen Shoaib, Talat Mirza
2010 Biologia (Bratislava)  
The modeled proteins were compared with atomic coordinates of 1918 (Spanish flu strain) and 1930 HA1 (swine influenza strain).  ...  This implicated the relatively closer relationship of 2009 strain with 1918 strain rather than swine origin strain of 1930.  ...  Ironically, the genetic drift and shift are continuing, and has caused the emergence of a new strain(s) of H1N1, a swine flu virus that is the etiological agent of the recent pandemic of swine flu.  ... 
doi:10.2478/s11756-010-0003-0 fatcat:vmnrvmszqbfjzobiiccq2juxsu

Public views of the uk media and government reaction to the 2009 swine flu pandemic

Shona Hilton, Emily Smith
2010 BMC Public Health  
The first cases of influenza A/H1N1 (swine flu) were confirmed in the UK on 27th April 2009, after a novel virus first identified in Mexico rapidly evolved into a pandemic.  ...  This study examines public understandings of the pandemic, exploring how people deciphered the threat and perceived they could control the risks.  ...  Authors' contributions SH participated in the design, analysis, and drafted the manuscript. ES collected the data and commented on drafts of the manuscript.  ... 
doi:10.1186/1471-2458-10-697 pmid:21078169 pmcid:PMC2998491 fatcat:cvy5d4amn5edzhvhzo5kriypui

Molecular evolution of hemagglutinin gene of Influenza A virus

Antara De
2018 Frontiers in bioscience (Scholar edition)  
MOLECULAR EVOLUTION OF HA GENE IN THE COURSE OF PANDEMICS AND EPIDEMICS The pandemic influenza A viruses i.e. 1918-19 'Spanish flu', 1957 Asian flu, 1968 Hong Kong flu, 2009 'Swine flu' The 'Spanish  ...  Molecular evolution of HA gene in the course of pandemics and epidemics 6.1. The pandemic influenza A viruses i.e. 1918-19 'Spanish flu', 1957 Asian flu, 1968 Hong Kong flu, 2009 'Swine flu' 6.2.  ... 
doi:10.2741/s502 pmid:28930520 fatcat:olcycjmbvfa3nbomdfawaalhwu

Carta do Editor

Jaime Benchimol
2009 História, Ciências, Saúde: Manguinhos  
In our May-August 2003 issue (v. 10, no. 2), Luiz Antonio Teixeira commented on another must-read: Gina Kolata's Flu, the story of the great influenza pandemic of 1918 and the search for the virus that  ...  In the article "Revisiting the Spanish flu: the 1918 influenza pandemic in Rio de Janeiro," Adriana da Costa Goulart analyzed how the epidemic served the purpose of political engineering and also examined  ... 
doi:10.1590/s0104-59702009000200001 fatcat:syzlryubobff5jrt6pticugksi

The Modes of Evolutionary Emergence of Primal and Late Pandemic Influenza Virus Strains from Viral Reservoir in Animals: An Interdisciplinary Analysis

Dany Shoham
2011 Influenza Research and Treatment  
1510, the antigenic profile of the last 10 pandemic strains since 1847, and the genomic profile of the last 5 pandemic strains since 1918, until present.  ...  The mentioned viral genesis modes were then analyzed, compatibly with common denominators and flexibility that mark the geographic profile of the last 18 pandemic strains, which reputedly emerged since  ...  rise to at least the past 1918 and the recent, 2009 pandemic swine flu strains-has been shaping.  ... 
doi:10.1155/2011/861792 pmid:23074663 pmcid:PMC3447294 fatcat:4ku4t5ba3bfkzcttgdxoknkosm

Getting to the Heart of Influenza

J. W. Yewdell, D. J. Spiro, H. Golding, H. Quill, A. Mittelman, G. J. Nabel
2013 Science Translational Medicine  
Pandemic influenza occurred in 1918, 1957, 1968, and 2009 due to the introduction of novel influenza A viruses from both avian and swine reservoirs.  ...  Antigenic shift refers to the introduction of new glycoproteins from zoonotic into human influenza viruses, as occurred with the recent introduction of the swine origin influenza virus in 2009, H1N1.  ... 
doi:10.1126/scitranslmed.3006735 pmid:23803701 pmcid:PMC4784681 fatcat:tzdplgqborau7e2mqf6s6zlpvq

A year of terror and a century of reflection: perspectives on the great influenza pandemic of 1918–1919

Michaela E. Nickol, Jason Kindrachuk
2019 BMC Infectious Diseases  
In the century following the emergence of the 1918 pandemic virus we have landed on the Moon, developed the electronic computer (and a global internet), and have eradicated smallpox.  ...  In addition, we discuss the pathophysiology associated with the 1918 virus and its predilection for the young and healthy, the rise of influenza therapeutic research following the pandemic, and, finally  ...  In April 2009, the 2009-2010 swine flu pandemic, subtype H1N1, began with nearly simultaneous outbreaks in Mexico and the US, before spreading globally over the next 6 weeks.  ... 
doi:10.1186/s12879-019-3750-8 pmid:30727970 pmcid:PMC6364422 fatcat:bevgdtqsyzes7isgmjqryfmnbm

Laboratory Investigation and Molecular Epidemiology of H1N1pdm Virus 2012-2013 from India

Shashi Sharma Gaurav Joshi
2015 Journal of Phylogenetics & Evolutionary Biology  
In the course of its evolution, 2009-2013 the virus acquired many mutations and which could be responsible for severity of this virus and emergence of new virus subtypes.  ...  The recent emergence of H7N9 in China is the result of new and recent reassortmant of Influenza A virus.  ...  Kaushik Director Defence Research and Development Establishment, Ministry of Defence, Government of India, for his support, constant inspiration and providing the necessary facilities for this study.  ... 
doi:10.4172/2329-9002.1000139 fatcat:gb6gjg6sszaenf5luxlev57c7m

The first influenza pandemic in the new millennium: lessons learned hitherto for current control efforts and overall pandemic preparedness

Carlos Franco-Paredes, Peter Carrasco, Jose Preciado
2009 Journal of Immune Based Therapies and Vaccines  
In this regard, responding to the current pandemic and preparing for future ones requires critical planning for the early phases where there is no availability of pandemic vaccine with rapid deployment  ...  Influenza viruses pose a permanent threat to human populations due to their ability to constantly adapt to impact immunologically susceptible individuals in the forms of epidemic and pandemics through  ...  Acknowledgements All authors (CFP, PC, JIS) participated equally in the design and the writing of this manuscript. No conflicts of interest to disclose  ... 
doi:10.1186/1476-8518-7-2 pmid:19664217 pmcid:PMC2731762 fatcat:74o2l2jnnzclxb6x2pw5epf5qy

Glycyrrhizic acid derivatives as influenza A/H1N1 virus inhibitors

Lidia A. Baltina, Vladimir V. Zarubaev, Lia A. Baltina, Iana A. Orshanskaya, Alina I. Fairushina, Oleg I. Kiselev, Marat S. Yunusov
2015 Bioorganic & Medicinal Chemistry Letters  
Thus modification of GL is a perspective route in the search of new antivirals, and some of GL derivatives are potent as anti-influenza A/H1N1 agents.  ...  This Letter describes the synthesis and antiviral activity study of some glycyrrhizic acid (GL) derivatives against influenza A/H1N1/pdm09 virus in MDCK cells.  ...  Acknowledgments This work was financially supported by the Russian Science Foundation (grant 14-03-01307).  ... 
doi:10.1016/j.bmcl.2015.02.074 pmid:25801933 pmcid:PMC7127794 fatcat:rp4fw72nmfd4fpjw25tifmqdry

Core-6 fucose and the oligomerization of the 1918 pandemic influenza viral neuraminidase

Zhengliang L. Wu, Hui Zhou, Cheryl M. Ethen, Vernon N. Reinhold
2016 Biochemical and Biophysical Research Communications - BBRC  
The 1918 H1N1 influenza virus was responsible for one of the most deadly pandemics in human history. Yet to date, the structure component responsible for its virulence is still a mystery.  ...  In order to search for such a component, the neuraminidase (NA) antigen of the virus was expressed, which led to the discovery of an active form (tetramer) and an inactive form (dimer and monomer) of the  ...  Currently, influenza is an ongoing threat to human society [2, 3] , having caused the recent pandemics of the 2005 Hong Kong avian flu [4] and 2009 swine flu [5] .  ... 
doi:10.1016/j.bbrc.2016.03.096 pmid:27012207 pmcid:PMC4862876 fatcat:pga2opmnfrc2jetr2opov2mgdm

Achieving clinical equality in an influenza pandemic: patent realities

Eileen M Kane
2009 Seton Hall law review  
Identification of the causative influenza virus is the first step in pandemic management and precedes vaccine design, and the virus and its RNA sequence are both knowledge assets and inputs for vaccine  ...  inhibit the availability of pharmaceutical countermeasures, and offers preliminary observations on the emerging novel H1N1 pandemic.  ...  the production of national stockpiles and legislation prohibited pharmaceutical manufacturers from making a profit from swine flu vaccines. 128 Unlike most pharmaceuticals, the development of a pandemic  ... 
pmid:20718133 fatcat:3podoxkakndh7ippjpozhwxlta

Molecular Epidemiology and Complete Genome Characterization of H1N1pdm Virus from India

Shashi Sharma, Gaurav Joshi, Paban K. Dash, Maria Thomas, Thimmasandra N. Athmaram, Jyoti S. Kumar, Anita Desai, Ravi Vasanthapuram, Ishan K. Patro, Putcha V. L. Rao, Manmohan Parida, Jean-Pierre Vartanian
2013 PLoS ONE  
This was evidenced by recent emergence and continued prevalent 2009 swine origin pandemic H1N1 Influenza A virus, provoking first true pandemic in the past 40 years.  ...  In the course of its evolution, the virus acquired many mutations and multiple unidentified molecular determinants are likely responsible for the ability of the 2009 H1N1 virus to cause increased disease  ...  Kaushik Director Defence Research and Development Establishment, Ministry of Defence, Government of India, for his support, constant inspiration and providing the necessary facilities for this study.  ... 
doi:10.1371/journal.pone.0056364 pmid:23457559 pmcid:PMC3574146 fatcat:hcg3ejar6jeopokswn32mtvzcq

The Application of Genomics to Emerging Zoonotic Viral Diseases

Bart L. Haagmans, Arno C. Andeweg, Albert D. M. E. Osterhaus, Marianne Manchester
2009 PLoS Pathogens  
Interspecies transmission of pathogens may  ...  The 2009 outbreak of a new H1N1 virus (causing ''swine flu'') that started in Mexico further illustrates the pandemic potential of influenza A viruses.  ...  Spanish flu alone caused the deaths of more than 50 million people by the end of World War I in 1918.  ... 
doi:10.1371/journal.ppat.1000557 pmid:19855817 pmcid:PMC2734983 fatcat:3pupcegb6fgf5p73hnou2hrx3m


D Y Buowari, H D Ogundipe
2021 Annals of Ibadan Postgraduate Medicine  
the pandemic.  ...  New strains of different organisms, three of which has been caused by betacorona viruses (SARS-CoV, MERS-CoV and SARSCoV- 2) have caused epidemics and pandemics.  ...  Vol. 19 2021 COVID-19 Supplement of human swine flu pandemic occurred in 2009 affecting 135 countries with 94,512 cases and 429 deaths. 9 S69 14  ... 
pmid:35095373 pmcid:PMC8791400 fatcat:3q27a34oibhtfe5ozfn3wmzuva
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