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Dietary-Induced Low-Grade Inflammation in the Liver

Nicole Power Guerra, Luisa Müller, Kristin Pilz, Annika Glatzel, Daniel Jenderny, Deborah Janowitz, Brigitte Vollmar, Angela Kuhla
2020 Biomedicines  
The literature describes a close correlation between metabolic disorders and abnormal immune responses, like low-grade inflammation (LGI), which may be one mechanistic link between obesity and various comorbidities, including non-alcoholic fatty liver disease (NAFLD). In our study, we investigated the influence of dietary composition on obesity-derived LGI in the liver. We used a dietary induced obesity mouse model of C57BL/6J mice fed with high fat diet (HFD, 60% fat, 20% protein, 20%
more » ... ates) and two different controls. One was rich in carbohydrates (10% fat, 20% protein, 70% carbohydrates), further referred to as the control diet (CD), and the other one is referred to as the standard diet (SD), with a more balanced macronutrient content (9% fat, 33% protein, 58% carbohydrates). Our results showed a significant increased NAFLD activity score in HFD compared to both controls, but livers of the CD group also differed in their macroscopic appearance from healthy livers. Hepatic fat content showed significantly elevated cholesterol concentrations in the CD group. Histologic analysis of the cellular immune response in the liver showed no difference between HFD and CD and expression analysis of immunologic mediators like interleukin (IL)-1β, IL-6, IL-10 and tumor necrosis factor alpha also point towards a pro-inflammatory response to CD, comparable to LGI in HFD. Therefore, when studying diet-induced obesity with a focus on inflammatory processes, we encourage researchers to carefully select controls and not use a control diet disproportionally rich in carbohydrates.
doi:10.3390/biomedicines8120587 pmid:33317065 fatcat:ywzbbqtb2ngbjaoalgjjcnf24y

Sterilization Regret in Sri Lanka: A Retrospective Study

Dennis Hapugalle, Barbara Janowitz, Sharon Weir, Deborah L. Covington, Lynne Wilkens, Celene Aluvihare
1989 International family planning perspectives  
By Dennis Hapugalle, Barbara Janowitz, Sharon Weir, Deborah L.  ...  Sharon Weir was senior research analyst, Barbara Janowitz was associate direc- tor and Deborah L.  ... 
doi:10.2307/2133275 fatcat:wg6blzj3gnasfnevazyrlacy6y

White matter lesions

Mohamad Habes, Aristeidis Sotiras, Guray Erus, Jon B. Toledo, Deborah Janowitz, David A. Wolk, Haochang Shou, Nick R. Bryan, Jimit Doshi, Henry Völzke, Ulf Schminke, Wolfgang Hoffmann (+3 others)
2018 Neurology  
Objectives To investigate spatial heterogeneity of white matter lesions or hyperintensities (WMH). Methods MRI scans of 1,836 participants (median age 52.2 ± 13.16 years) encompassing a wide age range (22-84 years) from the cross-sectional Study of Health in Pomerania (Germany) were included as discovery set identifying spatially distinct components of WMH using a structural covariance approach. Scans of 307 participants (median age 73.8 ± 10.2 years, with 747 observations) from the Baltimore
more » ... ngitudinal Study of Aging (United States) were included to examine differences in longitudinal progression of these components. The associations of these components with vascular risk factors, cortical atrophy, Alzheimer disease (AD) genetics, and cognition were then investigated using linear regression. Results WMH were found to occur nonuniformly, with higher frequency within spatially heterogeneous patterns encoded by 4 components, which were consistent with common categorizations of deep and periventricular WMH, while further dividing the latter into posterior, frontal, and dorsal components. Temporal trends of the components differed both cross-sectionally and longitudinally. Frontal periventricular WMH were most distinctive as they appeared in the fifth decade of life, whereas the other components appeared later in life during the sixth decade. Furthermore, frontal WMH were associated with systolic blood pressure and with pronounced atrophy including AD-related regions. AD polygenic risk score was associated with the dorsal periventricular component in the elderly. Cognitive decline was associated with the dorsal component. Conclusions These results support the hypothesis that the appearance of WMH follows age and diseasedependent regional distribution patterns, potentially influenced by differential underlying pathophysiologic mechanisms, and possibly with a differential link to vascular and neurodegenerative changes. ‡These authors contributed equally to this work. Glossary AD = Alzheimer disease; BLSA = Baltimore Longitudinal Study of Aging; deep = deep white matter; dors. = dorsal periventricular; fron. = frontal periventricular; post. = posterior periventricular; SHIP = Study of Health in Pomerania; WMH = white matter hyperintensities; WMHC = white matter hyperintensities component. Academy of Neurology. Unauthorized reproduction of this article is prohibited. , education, and SHIP subcohorts. d Models were adjusted for age, sex, education, and SHIP subcohorts.
doi:10.1212/wnl.0000000000006116 pmid:30076276 pmcid:PMC6139818 fatcat:26j4otbdo5catgglup6oj3cj4a

Kommentar II zum Fall: "'Die kommen alle her und gaffen.' Hohes Körpergewicht als medizinische, ethische und gesellschaftliche Herausforderung"

Deborah Janowitz
2020 Ethik in der Medizin  
Hohes Körpergewicht als medizinische, ethische und gesellschaftliche Herausforderung" Deborah Janowitz © Der/die Autor(en) 2020 "Die kommen alle her und gaffen."  ...  Janowitz ( )  ...  Janowitz gibt an, dass kein Interessenkonflikt besteht. ). Dadurch suchen sie noch seltener und zu spät den Kontakt zum Gesundheitssystem (Sikorski et al. 2011).  ... 
doi:10.1007/s00481-020-00578-y fatcat:aogtvt56bffdbhkxdtqzqkpjp4

The Impact of Childhood Trauma and Depressive Symptoms on Body Mass Index

Lara N. Schulze, Sandra Van der Auwera, Deborah Janowitz, Johannes Hertel, Katharina Wittfeld, René Walk, Nele Friedrich, Henry Völzke, Hans J. Grabe
2019 Global Psychiatry  
This is a serious public and individual health problem since obesity is associated with several somatic diseases and increased psychological burden (Janowitz et al. 2014; McCarthy-Jones and McCarthy-Jones  ... 
doi:10.2478/gp-2019-0008 fatcat:6v2oexwc7rejbljxrryhuisi4e

The Effect of Counseling on Sterilization Acceptance by High-Parity Women in Nigeria

Alexander E. Omu, Sharon S. Weir, Barbara Janowitz, Deborah L. Covington, Peter R. Lamptey, Nadine N. Burton
1989 International family planning perspectives  
Weir, Barbara Janowitz, Deborah L. Covington, Peter R. Lamptey and Nadine N.  ...  director; Deborah L.  ... 
doi:10.2307/2133484 fatcat:53dsd3as4jetzoxohgujegc7fu

Vitamin D moderates the interaction between 5-HTTLPR and childhood abuse in depressive disorders

Sarah Bonk, Johannes Hertel, Helena U. Zacharias, Jan Terock, Deborah Janowitz, Georg Homuth, Matthias Nauck, Henry Völzke, Henriette Meyer zu Schwabedissen, Sandra Van der Auwera, Hans Jörgen Grabe
2020 Scientific Reports  
AbstractA complex interplay between genetic and environmental factors determines the individual risk of depressive disorders. Vitamin D has been shown to stimulate the expression of the tryptophan hydroxylase 2 (TPH2) gene, which is the rate-limiting enzyme for serotonin production in the brain. Therefore, we investigate the hypothesis that serum vitamin D levels moderate the interaction between the serotonin transporter promotor gene polymorphism (5-HTTLPR) and childhood abuse in depressive
more » ... orders. Two independent samples from the Study of Health in Pomerania (SHIP-LEGEND: n = 1 997; SHIP-TREND-0: n = 2 939) were used. Depressive disorders were assessed using questionnaires (BDI-II, PHQ-9) and interview procedures (DSM-IV). Besides serum vitamin D levels (25(OH)D), a functional polymorphism (rs4588) of the vitamin D-binding protein is used as a proxy for 25(OH)D. S-allele carriers with childhood abuse and low 25(OH)D levels have a higher mean BDI-II score (13.25) than those with a higher 25(OH)D level (9.56), which was not observed in abused LL-carriers. This significant three-way interaction was replicated in individuals with lifetime major depressive disorders when using the rs4588 instead of 25(OH)D (p = 0.0076 in the combined sample). We conclude that vitamin D relevantly moderates the interaction between childhood abuse and the serotonergic system, thereby impacting vulnerability to depressive disorders.
doi:10.1038/s41598-020-79388-7 pmid:33372187 fatcat:6d22nisyjna67miynmqkxbsncy

Association between serum neuron-specific enolase, age, overweight, and structural MRI patterns in 901 subjects

Johanna Hoffmann, Deborah Janowitz, Sandra Van der Auwera, Katharina Wittfeld, Matthias Nauck, Nele Friedrich, Mohamad Habes, Christos Davatzikos, Jan Terock, Martin Bahls, Annemarie Goltz, Angela Kuhla (+2 others)
2017 Translational Psychiatry  
Serum neuron-specific enolase (sNSE) is considered a marker for neuronal damage, related to gray matter structures. Previous studies indicated its potential as marker for structural and functional damage in conditions with adverse effects to the brain like obesity and dementia. In the present study, we investigated the putative association between sNSE levels, body mass index (BMI), total gray matter volume (GMV), and magnetic resonance imaging-based indices of aging as well as Alzheimer's
more » ... se (AD)-like patterns. Subjects/Methods: sNSE was determined in 901 subjects (499 women, 22-81 years, BMI 18-48 kg/m 2 ), participating in a population-based study (SHIP-TREND). We report agespecific patterns of sNSE levels between males and females. Females showed augmenting, males decreasing sNSE levels associated with age (males: p = 0.1052, females: p = 0.0363). sNSE levels and BMI were non-linearly associated, showing a parabolic association and decreasing sNSE levels at BMI values >25 (p = 0.0056). In contrast to our hypotheses, sNSE levels were not associated with total GMV, aging, or AD-like patterns. Pathomechanisms discussed are: sex-specific hormonal differences, neuronal damage/differentiation, or impaired cerebral glucose metabolism. We assume a sex-dependence of age-related effects to the brain. Further, we propose in accordance to previous studies an actual neuronal damage in the early stages of obesity. However, with progression of overweight, we assume more profound effects of excess body fat to the brain.
doi:10.1038/s41398-017-0035-0 pmid:29217819 pmcid:PMC5802579 fatcat:fxc2e5u6nzgophtflef5kbaoaa

Stigma as a barrier to recognizing personal mental illness and seeking help: a prospective study among untreated persons with mental illness

Georg Schomerus, Susanne Stolzenburg, Simone Freitag, Sven Speerforck, Deborah Janowitz, Sara Evans-Lacko, Holger Muehlan, Silke Schmidt
2018 European Archives of Psychiatry and Clinical Neuroscience  
doi:10.1007/s00406-018-0896-0 pmid:29679153 fatcat:hbhqwqmuu5frje5vmoguibpdwy

Fibroblast Growth Factor 21 as a Potential Biomarker for Improved Locomotion and Olfaction Detection Ability after Weight Reduction in Obese Mice

Nicole Power Guerra, Alisha Parveen, Daniel Bühler, David Leon Brauer, Luisa Müller, Kristin Pilz, Martin Witt, Änne Glass, Rika Bajorat, Deborah Janowitz, Olaf Wolkenhauer, Brigitte Vollmar (+1 others)
2021 Nutrients  
Obesity is one of the most challenging diseases of the 21st century and is accompanied by behavioural disorders. Exercise, dietary adjustments, or time-restricted feeding are the only successful long-term treatments to date. Fibroblast growth factor 21 (FGF21) plays a key role in dietary regulation, but FGF21 resistance is prevalent in obesity. The aim of this study was to investigate in obese mice whether weight reduction leads to improved behaviour and whether these behavioural changes are
more » ... ociated with decreased plasma FGF21 levels. After establishing a model for diet-induced obesity, mice were subjected to three different interventions for weight reduction, namely dietary change, treadmill exercise, or time-restricted feeding. In this study, we demonstrated that only the combination of dietary change and treadmill exercise affected all parameters leading to a reduction in weight, fat, and FGF21, as well as less anxious behaviour, higher overall activity, and improved olfactory detection abilities. To investigate the interrelationship between FGF21 and behavioural parameters, feature selection algorithms were applied designating FGF21 and body weight as one of five highly weighted features. In conclusion, we concluded from the complementary methods that FGF21 can be considered as a potential biomarker for improved behaviour in obese mice after weight reduction.
doi:10.3390/nu13092916 pmid:34578793 pmcid:PMC8470262 fatcat:sghqn5hpzbgyjav7thvocf4i4a

Sex-Specific Associations of Brain-Derived Neurotrophic Factor and Cardiorespiratory Fitness in the General Population

Marie-Lena Schmalhofer, Marcello R.P. Markus, Jan C. Gras, Juliane Kopp, Deborah Janowitz, Hans-Jörgen Grabe, Stefan Groß, Ralf Ewert, Sven Gläser, Diana Albrecht, Ina Eiffler, Henry Völzke (+8 others)
2019 Biomolecules  
The brain-derived neurotrophic factor (BDNF) was initially considered to be neuron-specific. Meanwhile, this neurotrophin is peripherally also secreted by skeletal muscle cells and increases due to exercise. Whether BDNF is related to cardiorespiratory fitness (CRF) is currently unclear. We analyzed the association of serum BDNF levels with CRF in the general population (Study of Health in Pomerania (SHIP-TREND) from Northeast Germany; n = 1607, 51% female; median age 48 years). Sex-stratified
more » ... inear regression models adjusted for age, height, smoking, body fat, lean mass, physical activity, and depression analyzed the association between BDNF and maximal oxygen consumption (VO2peak), maximal oxygen consumption normalized for body weight (VO2peak/kg), and oxygen consumption at the anaerobic threshold (VO2@AT). In women, 1 mL/min higher VO2peak, VO2peak/kg, and VO2@AT were associated with a 2.43 pg/mL (95% confidence interval [CI]: 1.16 to 3.69 pg/mL; p = 0.0002), 150.66 pg/mL (95% CI: 63.42 to 237.90 pg/mL; p = 0.0007), and 2.68 pg/mL (95% CI: 0.5 to 4.8 pg/mL; p = 0.01) higher BDNF serum concentration, respectively. No significant associations were found in men. Further research is needed to understand the sex-specific association between CRF and BDNF.
doi:10.3390/biom9100630 pmid:31635145 pmcid:PMC6843272 fatcat:mplxherj4fgwlgmxowrvpex4me

Regional tract-specific white matter hyperintensities are associated with patterns of aging-related brain atrophy via vascular risk factors, but also independently

Mohamad Habes, Guray Erus, Jon B. Toledo, Nick Bryan, Deborah Janowitz, Jimit Doshi, Henry Völzke, Ulf Schminke, Wolfgang Hoffmann, Hans J. Grabe, David A. Wolk, Christos Davatzikos
2018 Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring  
We sought to investigate associations of regional white matter hyperintensities (WMHs) within white matter (WM) tracts with cardiovascular risk and brain aging-related atrophy throughout adulthood in the general population, leveraging state of the art pattern analysis methods. We analyzed a large sample (n = 2367) from the Study of Health in Pomerania, Germany (range 20-90 years). WMHs were automatically segmented on T1-weighted and fluid-attenuated inversion recovery magnetic resonance images,
more » ... and WMH volumes were calculated in WM regions defined using the John Hopkins University WM tractography atlas. Regions with the highest average WMH volume were selected. We calculated a subject-specific index, Spatial Pattern of Alteration for Recognition of Brain Aging, to measure age-related atrophy patterns. The Framingham cardiovascular disease risk score summarized the individual cardiovascular risk profile. We used structural equation models, independently for each region, using Spatial Pattern of Alteration for Recognition of Brain Aging as a dependent variable, age as an independent variable, and cardiovascular disease risk score and regional WMH volumes as mediators. Selected 12 WM regions included 75% of the total WMH burden in average. Structural equation models showed that the age effect on Spatial Pattern of Alteration for Recognition of Brain Aging was mediated by WMHs to a different extent in the superior frontal WM, anterior corona radiata, inferior frontal WM, superior corona radiata, superior longitudinal fasciculus, middle temporal WM, posterior corona radiata, superior parietal WM, splenium of corpus callosum, posterior thalamic radiation, and middle occipital WM (variance explained between 2.8% and 10.3%, P < .0001 Bonferroni corrected), but not in precentral WM. Our results indicate that WMHs, in most WM tracts, might accelerate the brain aging process throughout adulthood in the general population as a result of vascular risk factors, but also independent of them. Preventive strategies against WMHs (such as controlling vascular risk factors or microglia depletion) could delay brain aging.
doi:10.1016/j.dadm.2018.02.002 pmid:29644327 pmcid:PMC5889709 fatcat:a7ks2adn45d3lou3ywprlccs7i

Simvastatin add-on to escitalopram in patients with comorbid obesity and major depression (SIMCODE): study protocol of a multicentre, randomised, double-blind, placebo-controlled trial

Christian Otte, Woo Ri Chae, Jan Nowacki, Michael Kaczmarczyk, Dominique Piber, Stefan Roepke, Stefanie Märschenz, Sandra Lischewski, Sein Schmidt, Barbara Ettrich, Hans Joergen Grabe, Ulrich Hegerl (+15 others)
2020 BMJ Open  
IntroductionMajor depressive disorder (MDD) and obesity are both common disorders associated with significant burden of disease worldwide. Importantly, MDD and obesity often co-occur, with each disorder increasing the risk for developing the other by about 50%–60%. Statins are among the most prescribed medications with well-established safety and efficacy. Statins are recommended in primary prevention of cardiovascular disease, which has been linked to both MDD and obesity. Moreover, statins
more » ... promising candidates to treat MDD because a meta-analysis of pilot randomised controlled trials has found antidepressive effects of statins as adjunct therapy to antidepressants. However, no study so far has tested the antidepressive potential of statins in patients with MDD and comorbid obesity. Importantly, this is a difficult-to-treat population that often exhibits a chronic course of MDD and is more likely to be treatment resistant. Thus, in this confirmatory randomised controlled trial, we will determine whether add-on simvastatin to standard antidepressant medication with escitalopram is more efficacious than add-on placebo over 12 weeks in 160 patients with MDD and comorbid obesity.Methods and analysisThis is a protocol for a randomised, placebo-controlled, double-blind multicentre trial with parallel-group design (phase II). One hundred and sixty patients with MDD and comorbid obesity will be randomised 1:1 to simvastatin or placebo as add-on to standard antidepressant medication with escitalopram. The primary outcome is change in the Montgomery-Åsberg Depression Rating Scale (MADRS) score from baseline to week 12. Secondary outcomes include MADRS response (defined as 50% MADRS score reduction from baseline), MADRS remission (defined as MADRS score <10), mean change in patients' self-reported Beck Depression Inventory (BDI-II) and mean change in high-density lipoprotein, low-density lipoprotein and total cholesterol from baseline to week 12.Ethics and disseminationThis protocol has been approved by the ethics committee of the federal state of Berlin (Ethik-Kommission des Landes Berlin, reference: 19/0226—EK 11) and by the relevant federal authority (Bundesinstitut für Arzneimittel und Medizinprodukte (BfArM), reference: 4043387). Study findings will be published in peer-reviewed journals and will be presented at (inter)national conferences.Trial registration numbersNCT04301271, DRKS00021119, EudraCT 2018-002947-27.
doi:10.1136/bmjopen-2020-040119 pmid:33262189 fatcat:5tmkbepshrd6fedmx4danfi73y

Mouse genomic variation and its effect on phenotypes and gene regulation

Thomas M. Keane, Leo Goodstadt, Petr Danecek, Michael A. White, Kim Wong, Binnaz Yalcin, Andreas Heger, Avigail Agam, Guy Slater, Martin Goodson, Nicholas A. Furlotte, Eleazar Eskin (+29 others)
2011 Nature  
doi:10.1038/nature10413 pmid:21921910 pmcid:PMC3276836 fatcat:zanry5schjgyhfirmzp23jejae

Childhood adversity impacts on brain subcortical structures relevant to depression

Thomas Frodl, Deborah Janowitz, Lianne Schmaal, Leonardo Tozzi, Henrik Dobrowolny, Dan J. Stein, Dick J. Veltman, Katharina Wittfeld, Theo G.M. van Erp, Neda Jahanshad, Andrea Block, Katrin Hegenscheid (+26 others)
2017 Journal of Psychiatric Research  
doi:10.1016/j.jpsychires.2016.11.010 pmid:27918926 pmcid:PMC5564511 fatcat:7a2ttuslh5hofbablha7cobioi
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