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Response to the Letter to the Editor by Rob Armstrong

Robert H. Six, David R. Young, Melanie R. Myers, Sean P. Mahabir
2017 Parasites & Vectors  
In a recent Letter to the Editor, Armstrong raises concern that the design of the study reported by Six et al. was not consistent with the product label for treatment of Amblyomma americanum, since fluralaner  ...  In his Letter to the Editor, Armstrong raised concern that the efficacy of fluralaner was evaluated at times outside the label administration recommendations [2] .  ... 
doi:10.1186/s13071-017-2142-4 pmid:28446205 pmcid:PMC5406881 fatcat:2fkj4xll2rdfbimngjwcldzkz4

Reply

Peter J. Armstrong, David P. Franklin, David J. Carey, James R. Elmore
2003 Journal of Vascular Surgery  
We appreciate the opportunity to reply to this interesting work by Drs Ghilardi and Biondi regarding our article. 1 We utilized gene microarray analysis to compare aneurysmal, occlusive, and control tissue from human aorta. We found a difference in MMP expression only in MMP-9 out of 16 different MMPs evaluated. MMP-3 values were not significantly different between the three groups, but interestingly, the highest values were in the control group. These investigators have identified a potential
more » ... ssociation between a polymorphism in the MMP-3 gene promoter and AOD. The importance of this genetic polymorphism to the pathophysi-ology of AOD remains to be established. Nevertheless, the findings raise a number of questions and identify several areas of future investigation. Although statistically significant, the association between AOD and the 6A/6A polymorphism is not particularly robust. Less than half of the AOD patients exhibit this polymorphism. The frequency of homozygosity for this polymorphism in AOD patients is only 60% higher than controls (47% of AOD patients versus 29% of control patients). Thus, this MMP-3 polymorphism might contribute to the AOD phenotype in some, but not all, patients. There could exist other genetic polymorphisms or environmental factors that cooperate with this MMP-3 genotype to produce the AOD phenotype, but there is no information at the present time to suggest such a mechanism. It is possible this polymorphism produces subtle differences in MMP-3 expression that cannot be detected by gene microarray analysis, which in most cases can reliably detect changes of twofold or greater. The fact that not all AOD patients display the 6A/6A genotype further reduces the likelihood that a difference in expression would be detected by gene microarray analyses that average expression data within groups of patients. This illustrates a potential weakness of large-scale gene microarray analyses, which are not suited to identifying small changes or changes that are variable within a study group. In this regard, it would be informative to compare MMP-3 expression levels in AOD and control patients with 5A/5A and 6A/6A genotypes. This could establish the physiologic effect of the promoter genotype on MMP-3 expression in a physiologic setting and provide information on relative differences in MMP-3 expression between AOD and aortic control tissue.
doi:10.1067/mva.2003.45 pmid:12514626 fatcat:zivphcmpqbhk7kr3lizvxkh3ty

Obituary

Gorden de Q. Robin, David Dalgliesh, H. G. R. King, Terence Armstrong
1988 Polar Record  
Terence Armstrong Maj-Gen R. A. SMART CBE died on 6 November Robin was awarded the Polar Medal in 1957.  ...  David Dalgliesh L. M. FORBES.  ... 
doi:10.1017/s0032247400009049 fatcat:sltsp3awubbspgdsdjmh4bs6y4

In Memoriam: Melbourne Armstrong Carriker, Jr., 1879–1965

David A. Wiedenfeld, Melbourne R. Carriker
2007 The AUK: A Quarterly Journal of Ornithology  
Melbourne Armstrong Carriker, Jr., a Fellow of the AOU, was one of the outstanding ornithological collectors and explorers in the Neotropics in the early 20th century.  ... 
doi:10.1093/auk/124.1.342 fatcat:fvo42rg455aebl4p3mzjt3jbhm

Widespread introgression across a phylogeny of 155 Drosophila genomes [article]

Anton Suvorov, Bernard Y. Kim, Jeremy Wang, Ellie E. Armstrong, David Peede, Emmanuel R. R. D'Agostino, Donald K. Price, Peter Wadell, Michael Lang, Virginie Courtier-Orgogozo, Jean R. David, Dmitri Petrov (+3 others)
2020 bioRxiv   pre-print
We used the R package MCMCtreeR (Puttick, 2019) to visualize the calibrated tree.  ...  Armstrong and D. Price, described in Armstrong et al. (in prep) and available at NCBI BioProject PRJNA593822; sequences and/or assemblies of five nannoptera group species were provided by M.  ... 
doi:10.1101/2020.12.14.422758 fatcat:ztvaof7qvbeffoodbr2ck6cmae

Internal fixation for treating distal radius fractures in adults

Christopher P Hoare, David R Dickson, Daniel J Armstrong, David Nuttall, Adam C Watts
2017 The Cochrane library  
doi:10.1002/14651858.cd011213.pub2 fatcat:dj4fq5yd2bgzxchs3vjmpr6z6u

Monodentate coordination of the normally chelating chiral diamine (R,R)-TMCDA

Ana I. Ojeda-Amador, Antonio J. Martínez-Martínez, Alan. R. Kennedy, David R. Armstrong, Charles T. O'Hara
2017 Chemical Communications  
Contrary to previous studies, this work shows that the chiral diamine (R,R)-TMCDA can bind to a metal in a monodentate manner.  ...  Scheme 1 1 Syntheses of [{(R,R)-TMCDA}Á(NaHMDS) 2 ] N 1 and [{k 2 -(R,R)-TMCDA}Á(NaHMDS) 2 {k 1 -(R,R)-TMCDA}] 2.  ...  R)-TMCDA}Á(NaHMDS) 2 {k 1 -(R,R)-TMCDA}] 2 (Fig. 3) .  ... 
doi:10.1039/c6cc07190b pmid:27958607 fatcat:mozha7xj2nbxrhhyol4aw75zj4

Synthesis and structural elucidation of solvent-free and solvated lithium dimethyl (HMDS) zincates

David R. Armstrong, Emma Herd, David V. Graham, Eva Hevia, Alan R. Kennedy, William Clegg, Luca Russo
2008 Dalton Transactions  
Computational Details The geometry of the molecules was optimized using Gaussian 03. 1 Exploratory ab initio calculations at the Hartree Fock (HF) level were performed, utilising the 6-31g* basis set. 2 The resultant optimised geometries were subject to a frequency analysis and the refined by further density functional theory (DFT) calculations 3 using the B3LYP functionals 45 and the 6-311G** basis set. 67 The geometrical structural features from the DFT calculations are reported here while
more » ... total energy value from the DFT calculation is adjusted by including the zero-point energy abstracted from the HF calculation modified by the factor 0.91. 1/3 (LiHMDS) 3 + Me 2 Zn [LiZn(HMDS)Me 2 ] ΔΕ = +3.80 kcal/mol 1/3 [LiZn(HMDS)Me 2 ] 3 ΔΕ = -3.24 kcal/mol 1/2 [LiZn(HMDS)Me 2 ] 2 ΔΕ = -1.20 kcal/mol
doi:10.1039/b716494g pmid:18305844 fatcat:2rir6mqa65hfhfolhgkatd2mme

Differential gene expression in human abdominal aorta: Aneurysmal versus occlusive disease

Peter J. Armstrong, Jason M. Johanning, William C. Calton, Jason R. Delatore, David P. Franklin, David C. Han, David J. Carey, James R. Elmore
2002 Journal of Vascular Surgery  
TNF-βR has been linked to regulation of proliferation, cytokine production, and apoptosis. 20, 21 A correlation between ICAM-1 and TNF-βR has been shown in autoimmune diseases. 22 TNF-βR has also been  ...  TNF-βR is one of two known tumor necrosis factor membrane receptors.  ... 
doi:10.1067/mva.2002.121071 pmid:11854734 fatcat:on3bkkjzofg57d4niav6efjp4q

Respiratory gating of anatomical optical coherence tomography images of the human airway

Robert A. McLaughlin, Julian J. Armstrong, Sven Becker, Jennifer H. Walsh, Arpit Jain, David R. Hillman, Peter R. Eastwood, David D. Sampson
2009 Optics Express  
R.  ... 
doi:10.1364/oe.17.006568 pmid:19365482 fatcat:isgxh35kibbxrpnzsnmqlwmuu4

Effect of evacuation and displacement on the association between flooding and mental health outcomes: a cross-sectional analysis of UK survey data

Alice Munro, R Sari Kovats, G James Rubin, Thomas David Waite, Angie Bone, Ben Armstrong, Thomas David Waite, Charles R Beck, Angie Bone, Richard Amlôt, R Sari Kovats, Ben Armstrong (+3 others)
2017 Lancet Planetary Health  
National Study of Flooding and Health study group members Thomas David Waite, Charles R Beck, Angie Bone, Richard Amlôt, R Sari Kovats, Ben Armstrong, Giovanni Leonardi, G James Rubin, and Isabel Oliver  ... 
doi:10.1016/s2542-5196(17)30047-5 pmid:28944321 pmcid:PMC5597543 fatcat:xctvsu3tarab7gl7b4e2xcarse

First result from Qweak

David S. Armstrong, M. Battaglieri, A. D'Angelo, R. De Vita, A. Pascolini, G. Salmè
2014 EPJ Web of Conferences  
doi:10.1051/epjconf/20147307008 fatcat:wrobtogacfh5nn6264jpqaoire

Different lasers and techniques for proliferative diabetic retinopathy

Tanya Moutray, Jennifer R Evans, David J Armstrong, Augusto Azuara-Blanco
2016 The Cochrane library  
David Armstrong has no conflicts of interest. Tunde Peto has no conflicts of interest. Noemi Lois has no conflicts of interest. Augusto Azuara-Blanco has no conflicts of interest.  ...  R E F E R E N C E S References to studies included in this review C H A R A C T E R I S T I C S O F S T U D I E S Characteristics of included studies [ordered by study ID] Bandello 1993 Methods  ...  Notes Awaiting translation D A T A A N D A N A L Y S E S D I F F E R E N C E S B E T W E E N P R O T O C O L A N D R E V I E W We modified the inclusion criteria.  ... 
doi:10.1002/14651858.cd012314 fatcat:rvz5g244n5al7c4o3cdbituixm

Catecholamines inhibit steroidogenesis by cultured porcine thecal cells

Paul Morley, Franco R. Calaresu, David T. Armstrong
1990 FEBS Letters  
The ovaries of many species contain catecholamines and /&adrenergic receptors. The present studies were done to determine if catecholamines play a role in the regulation of androgen production by porcine theta cells. Basal and luteinizing hormone (LH)-stimulated androstenedione production was significantly inhibited by noradrenaline and isoproterenol, The inhibitory effects were dose-dependent and were enhauced when the cultures contained the carboxy-O-methyl transferase inhibitor, U-0521. The
more » ... nhibitory effect of isoproterenol was reversed by the /%adrenergic antagonist, metoprolol. Isoproterenol caused a generalized inhibition of LH-stimulated steroidogenesis, decreasing the accumulation of pregnenolone, progesterone, androstenedione and estradiol in the culture medium. These studies suggest that catecholamines may be important regulators of thecal androgen production.
doi:10.1016/0014-5793(90)81441-p pmid:2262003 fatcat:2cfnb6norzbkvlnjq5m5cv3lma

Zymosan-Induced Peritonitis

Lizzie L. Monroe, Michael G. Armstrong, Xia Zhang, Jennifer V. Hall, Tammy R. Ozment, Chuanfu Li, David L. Williams, Donald B. Hoover
2016 Shock  
Heart rate (HR) was determined from R-R intervals, and HR variability (HRV) was calculated as the mean difference in sequential HRs for the entire set of ECG signals analyzed (22, 23) .  ...  David L. Williams. Statistical analysis Statistical comparisons and graphing of data were accomplished using GraphPad Prism version 6.0 (GraphPad Software, San Diego, CA).  ... 
doi:10.1097/shk.0000000000000669 pmid:27380533 pmcid:PMC5110391 fatcat:jlnqvqmdyfgpdlhzdxdxuq75f4
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