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Post-Influenza Vaccine Subdeltoid bursitis

Marenda Jenkins, David Rupp, Lynne J Goebel
2020 Cureus  
A 61-year-old female presented three months following an influenza vaccination with ongoing pain since the injection and was diagnosed by MRI with subdeltoid bursitis. The patient received a short course of prednisone and several months of physical therapy before returning to pain-free function. The primary reason for injection-related subdeltoid bursitis is improper administration. It is a preventable issue, and improved training of healthcare workers on proper vaccine administration may decrease its occurrence.
doi:10.7759/cureus.10764 pmid:33154837 pmcid:PMC7606224 fatcat:3wd3q5d53zberljczynclwzo64

Association between cognition and gene polymorphisms involved in thrombosis and haemostasis

Terence J. Quinn, Jahad Alghamdi, Sandosh Padmanabhan, David J. Porteous, Blair H. Smith, Lynne Hocking, Ian J. Deary, John Gallacher, Martina Messow, David J. Stott
2015 Age  
An association between blood markers of thrombosis and haemostasis and cognitive decline has been described. These results may be confounded by lifestyle and environmental factors. We used a Mendelian Randomisation approach to describe association between thrombosis/haemostasis genotypes and cognition. We studied genetic variants (single nucleotide polymorphisms) of circulating markers of thrombosis and haemostasis. Our chosen blood factors and associated polymorphisms were: D-dimer
more » ... , fibrinogen [rs1800789], plasminogen activator inhibitor [rs2227631], von Willebrand factor [rs1063857]). We described association with multidomain cognitive test scores using data from the Scottish Family Health Study. Cognitive data were analysed for individual tests and combined to give a general cognitive factor. In 20,288 subjects we found no evidence of association between cognitive function (individual tests and combined scores) and any of the above-mentioned single nucleotide polymorphisms. Lower scores on cognitive measures were associated with:increasing age, socioeconomic deprivation, blood pressure, waist-hip ratio, smoking, and vascular comorbidity (all p<0.001). In a post-hoc sensitivity analysis restricted to those aged over 50 years there was still no signal of association. Our data add to our understanding of determinants of cognition but are not definitive, the variation in blood levels explained by SNPs was modest and our sample size may have been insufficient to detect a modest association.
doi:10.1007/s11357-015-9820-y pmid:26228839 pmcid:PMC5005822 fatcat:5r6nn6oqifg2zbifw7iy37sd7a

What Is Hypopnea, Anyway?

Neal J. Moser, Barbara A. Phillips, David T.R. Berry, Lynn Harbison
1994 Chest  
What is hypopnea, anyway? http://chestjournal.org/cgi/content/abstract/105/2/426 services can be found online on the World Wide Web at: The online version of this article, along with updated information and ).
doi:10.1378/chest.105.2.426 pmid:8306740 fatcat:3cqt7u3pdbekpn74ev3c5pirbm

Lymphangioleiomyomatosis: a clinical review

Anne M. O'Mahony, Evelyn Lynn, David J. Murphy, Aurelie Fabre, Cormac McCarthy
2020 Breathe  
Lymphangioleiomyomatosis (LAM) is a diffuse cystic lung disease. There are two main types of LAM: sporadic, and LAM associated with the tuberous sclerosis complex (TSC), which is caused by mutations in the TSC1 and TSC2 genes. LAM is characterised by cystic lung disease resulting in progressive dyspnoea, renal angiomyolipomas and lymphatic complications. Pneumothorax occurs frequently (70%) and definitive management with pleurodesis is recommended as the risk of recurrence is high.
more » ... c thin-walled cysts are seen on computed tomography and the presence of elevated serum levels of a vascular endothelial growth factor-D has good diagnostic specificity. Currently, no single clinical or serological factor has been shown to predict prognosis. However, over the past decade, significant advances in our understanding of the pathophysiology of LAM has led to improved recognition of this rare disease and identification of treatment options. Mechanistic target of rapamycin inhibitors slow the rate of lung function decline and can resolve chylous effusion and regress angiomyolipomas. Life expectancy in patients with LAM is favourable, with a mean transplant-free survival >20 years from the time of diagnosis. Continued advances in understanding the molecular basis of LAM will lead to improved therapeutic targets and the development of more robust prognostic indicators.Educational aimsTo illustrate the clinical features, common presentations and radiological features of LAMTo outline the diagnostic approach to LAM, including the role of VEGF-DTo review the current prognostic indicators in LAM, and outline the impact of lung function, hormonal status, VEGF-D and clinical presentation on outcomeTo inform clinicians on the management options for LAM both pharmacological and nonpharmacological
doi:10.1183/20734735.0007-2020 pmid:33304400 pmcid:PMC7714539 fatcat:icj3wgfbe5c5dm2k56dr5cpdiy

Emergence of local irreversibility in complex interacting systems [article]

Christopher W. Lynn, Caroline M. Holmes, William Bialek, David J. Schwab
2022 arXiv   pre-print
xi→x i , . . ., j∈K x j xi→x i .  ...  For now, consider the marginal dynamics of pairs of elements i and j; namely, the marginal transition probabilities 16 ) P (x i → x i , x j ) = x −{i,j} P (x i → x i , x −i ) ( P (x j → x j , x i ) =  ... 
arXiv:2203.01916v1 fatcat:bypnfu3ro5hbbg6sfwvk5io5ky

Narrating palimpsestic spaces

David J Marshall, Lynn A Staeheli, Dima Smaira, Konstantin Kastrissianakis
2017 Environment and planning A  
The term 'palimpsest' refers to medieval manuscripts that have been multiply erased and inscribed with the overlapping texts of successive scribes. More recently and amongst academics, the term has become a metaphor for describing the city, including both the physical urban form as well as memories and experiences of everyday urban life. The palimpsest offers a way of thinking not only about urban transformation, where new and repurposed structures exist alongside the old, but also changes in
more » ... w the city is experienced, or how life stories are written upon and rewrite existing spaces. This paper focuses on the latter. Though the palimpsest metaphor has been used to describe material transformations of the urban, the question that this paper raises is: how can the notion of the palimpsest inform methodological approaches to researching how the city is lived and seen? Collaborative, digital storytelling that combines images, narration, and sound can provide a method that emphasizes the poli-vocality and multitemporality that the term palimpsest implies. A palimpsestic approach to digital storytelling, as a visual and narrative method, gestures at places as open to future readings and inscriptions. This is relevant to all cities, but perhaps most obviously in cities where historical narratives, memories of violence, and questions over the future political direction of the country in which the city is located are all highly contested. To illustrate these points, this paper draws upon research conducted with young people in Beirut, Lebanon as part of a wider study about how youth experience citizenship and belonging in divided societies.
doi:10.1177/0308518x17690531 fatcat:ulnjebnpszabjbagw4blm5qcgm

Depression, Guilt, and Tibetan Buddhism

Lynn E. O'Connor, Jack W. Berry, David J. Stiver, Rachna K. Rangan
2012 Psychology  
Green S, Lambon Ralph MA, Moll J, Deakin JF, Zahn R. (2012) have used functional MRI to study the brains of people with a history of major depression and a control group of people who never had depression  ... 
doi:10.4236/psych.2012.329122 fatcat:fbhcaogp65eiji3axbnntfqlfq

Decomposing the local arrow of time in interacting systems [article]

Christopher W. Lynn, Caroline M. Holmes, William Bialek, David J. Schwab
2021 arXiv   pre-print
where the sum runs over the states of all elements other than i and j.  ...  Saying that we know only about interactions among pairs, for example, is equivalent to saying that we know all the marginal distributions P i (x i → x i , x j ) = x −{i,j} P i (x i → x i , x −i ), (15)  ... 
arXiv:2112.14721v1 fatcat:37hxvici4rhipk3uppaxa7v7lu

The Charter on Professionalism for Health Care Organizations

Barry E. Egener, Diana J. Mason, Walter J. McDonald, Sally Okun, Martha E. Gaines, David A. Fleming, Bernie M. Rosof, David Gullen, May-Lynn Andresen
2017 Academic Medicine  
doi:10.1097/acm.0000000000001561 pmid:28079726 pmcid:PMC5526430 fatcat:2sp3hmf465bklnkp6kvqgrb3ge

Reply

David A. Plager, Michael J. Lynn, Scott R. Lambert, Edward G. Buckley, M. Edward Wilson
2014 American Journal of Ophthalmology  
We appreciate the interest in our paper (1) expressed by Drs. Sukhija, Ram and Kaur. The authors of the letter opine that the rate of secondary opacification of the visual axis, particularly in the intraocular lens (IOL) group, could have been decreased by more frequent administration of topical corticosteroids during the early postoperative period and used as evidence studies involving older children that showed lower rates of visual axis opacification. (2,3)
doi:10.1016/j.ajo.2014.09.019 pmid:25457713 pmcid:PMC5375036 fatcat:4af5n7ysvvb2xm5ssndwh567nu

Relationships among wild relatives of the tomato, potato, and pepino

Eric J. Tepe, Gregory J. Anderson, David M. Spooner, Lynn Bohs
2016 Taxon  
.); J, sect. Petota (S. candolleanum Berthault); note articulation in the upper ¼ of the pedicel; K, sect. Herpystichum (S. pentaphyllum Bitter; photo by J.D. Tovar Durán); L, sect.  ...  Fig. 1A-J). The large clade that includes sect. Etuberosum, sect. 1 Ann. Missouri Bot. Gard. 59(2): 105-322 was published on 28 March 1973; see note on p. 478 of the same volume. Solanum sect.  ... 
doi:10.12705/652.4 fatcat:mrwgeggxjbbrba4ool5b4q4ndy

Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection [article]

Feargal J Ryan, Christopher Martin Hope, Makutiro Ghislain Masavuli, Miriam A Lynn, Zelalem Addis Mekonnen, Arthur Eng Lip Yeow, Pablo Garcia Valtanen, Zahraa Al-Delfi, Jason Anthony Gummow, Catherine Ferguson, Stephanie O'Connor, Benjamin Reddi (+7 others)
2021 medRxiv   pre-print
S1F-J ), though anti-RBD IgG3 and IgM appeared to decline more .  ...  There was no detectable difference in RBD-specific antibody responses between individuals recovering from mild/moderate or severe/critical disease at 12 or 16 wpi (Fig. 1I-J ).  ...  Count tables, metadata, and R code for all analyses (serology, flow cytometry and RNA-Seq) have been uploaded to the Lynn Laboratory BitBucket (https://bitbucket.org/lynnlab/covid-sa).  ... 
doi:10.1101/2021.07.30.21261234 fatcat:35vxzxfbovh5zjtlxcz7aaixcy

Transcription Factor ZBP-89 Regulates the Activity of the Ornithine Decarboxylase Promoter

G. Lynn Law, Hideaki Itoh, David J. Law, Gregory J. Mize, Juanita L. Merchant, David R. Morris
1998 Journal of Biological Chemistry  
Marcu and Amanda J. Patel for providing the MAZ antibody, the MAZHH expression plasmid, and helpful advice on this study. We thank Dr. Karol Bomsztyk for valuable technical advice.  ...  J. Romaniuk, and D. R. Morris, submitted for publication.  ...  M.) and DK45729 (to J. L. M.). The costs of publication of this article were defrayed in part by the payment of page charges.  ... 
doi:10.1074/jbc.273.32.19955 pmid:9685330 fatcat:qneenbw3zvfthlobu63s74537e

Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis

Katia Nones, Nicola Waddell, Nicci Wayte, Ann-Marie Patch, Peter Bailey, Felicity Newell, Oliver Holmes, J. Lynn Fink, Michael C. J. Quinn, Yue Hang Tang, Guy Lampe, Kelly Quek (+32 others)
2014 Nature Communications  
Oesophageal adenocarcinoma (EAC) incidence is rapidly increasing in Western countries. A better understanding of EAC underpins efforts to improve early detection and treatment outcomes. While large EAC exome sequencing efforts to date have found recurrent loss-offunction mutations, oncogenic driving events have been underrepresented. Here we use a combination of whole-genome sequencing (WGS) and single-nucleotide polymorphism-array profiling to show that genomic catastrophes are frequent in
more » ... with almost a third (32%, n ¼ 40/123) undergoing chromothriptic events. WGS of 22 EAC cases show that catastrophes may lead to oncogene amplification through chromothripsis-derived double-minute chromosome formation (MYC and MDM2) or breakage-fusion-bridge (KRAS, MDM2 and RFC3). Telomere shortening is more prominent in EACs bearing localized complex rearrangements. Mutational signature analysis also confirms that extreme genomic instability in EAC can be driven by somatic BRCA2 mutations. These findings suggest that genomic catastrophes have a significant role in the malignant transformation of EAC.
doi:10.1038/ncomms6224 pmid:25351503 pmcid:PMC4596003 fatcat:h55nlfruyff73ccutuds5m2ycq
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