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Let I be a regular proper ideal in a Noetherian ring R, let e > 2 be an integer, let T_e = R[u,tI,u^1/e]' ∩ R[u^1/e,t^1/e] (where t is an indeterminate and u =1/t), and let r_e = u^1/e T_e. ... Further, if uW = Q^e and k = qe is a multiple of e, then there exists a unit θ_e∈ V^* such that V^* = W[θ_e,u^1/k] is a finite free integral extension domain of W, QV^* = N^*^q, N^* = u^1/kV^*, and [V^ ... 1 e T e . ...arXiv:1607.05341v1 fatcat:ziswfv4g5vff7nehuvgyymcuq4
(B-E) Subnuclear colocalization of GI with other subnuclear marker proteins: DAPI for chromatin (B), U2B for Cajal bodies (C), H2B for chromatin and nucleoli (D), and SCL28 for spliceosomes (E). ... ., 2000; Kim et al., 2007) . GI protein interacts with the cytosolic F box protein ZEITLUPE (ZTL), which acts to regulate endogenous rhythms through phase-specific proteolysis (Kim et al., 2007) . ... Both GI and ELF4 have a similar circadian phase (David et al., 2006; Fowler et al., 1999; Khanna et al., 2003; Kikis et al., 2005; Kim et al., 2007; Kolmos et al., 2009; McWatters et al., 2007; Mizoguchi ...doi:10.1016/j.celrep.2013.02.021 pmid:23523352 pmcid:PMC3917306 fatcat:fz7neoq6rbgybf4vqpvczc6kwe
Note that experimental data of both protein and mRNA profiles, x(t) and g m (t), are available enough for a wide range of time in the cases of PRR7 and PRR5 (Figs. 2a, e and 3a, c). ... Control PRR7 levels at and after t = 18 h in d, when averaged over three repeats at each time point and then rescaled together, are almost identical to x(t) in a. e Existing experimental data of PRR7 mRNA ...doi:10.1038/s42003-018-0217-1 pmid:31924881 arXiv:1811.10360v1 fatcat:u2f6trwntvdljigk2r2ocyfsp4
Thus, an advantage of warm inflation is that φ does not have to travel as far in field space to get the same number of e-folds. ... The observable amounts of e-folds occur as φ is approaching its critical value φ c ≡ M g , which induces the phase transition. ... interactions between the inflaton particles and the thermal bath are sufficiently fast for them to be thermalized then they approach a Bose-Einstein distribution, which at horizon crossing is given by n BE = e ...arXiv:1910.07525v1 fatcat:7xoqsinthrae7cn7pkgg42fpc4
Objective-To test the hypothesis that rapamycin inhibits induced microvascular hyperpermeability directly in vivo. Methods-Male golden Syrian hamsters (80-120g) were treated with either rapamycin (at 0.1, 0.5, 2, and 10 mg/kg i.p.) or vehicle at 24 hours and at one hour prior to preparation of the cheek pouch. Caveolin-1 scaffolding (1 mg/kg; positive inhibitory control) was injected i.p. 24 hours prior to the experiment. 10 −8 M vascular endothelial growth factor (VEGF) or 10 −7 Mdoi:10.1111/j.1549-8719.2009.00012.x pmid:20163539 pmcid:PMC2925471 fatcat:gazbxmm2g5cl3lbvbjuwndukyq
more »... ating factor (PAF) were topically applied to the cheek pouch. Microvascular permeability and arteriolar diameter were assessed using integrated optical intensity (IOI) and vascular wall imaging, respectively. Results-Rapamycin at 0.1 mg/kg and 0.5 mg/kg significantly reduced VEGF-stimulated mean IOI from 63.0±4.2 to 9.7±5.0 (85% reduction, P<0.001) and 3.6±2.7 (95% reduction, P<0.001), respectively. Rapamycin at 2 mg/kg also lowered VEGF-stimulated hyperpermeability (40% reduction, P<0.05). However, 10 mg/kg rapamycin increased VEGF-induced microvascular hyperpermeability. Rapamycin at 0.5 mg/kg attenuated VEGF-induced vasodilation and PAFinduced hyperpermeability, but did not inhibit PAF-induced vasoconstriction. Conclusions-At therapeutically relevant concentrations, rapamycin inhibits VEGF-and PAFinduced microvascular permeability. This inhibition is 1) a direct effect on the endothelial barrier, and 2) independent of arteriolar vasodilation. Rapamycin at 10 mg/kg stimulates effectors that increase microvascular permeability.
E) Stimulation slightly increased % time spent following (p = 0.04). ... We previously reported strong correlations between SPNs and direction-specific head velocity in freely moving mice (Kim et al., 2014) . ...doi:10.1101/386490 fatcat:my3h6xtlafg7bncqw2iajiu324
and S 3 . = log2(T(E 3 . ) + 1)) and the combined score is calculated as: V 1 # . = W S / . ... (E) Scatter plot comparing the log2 fold-change in phosphorylation of AKT1 T309 upon insulin stimulation before and after implementation of PhosR normalisation. ...doi:10.1101/2020.08.31.276329 fatcat:3kdd2v43dbbbdn5z4n2g3csrcu
1994 Topical Meeting on Optical Data Storage
Investigation of E-Beam HOEs. ... E-beam generation of the final HOEs requires using an e-beam pattern generator at the limits of its capability. ...doi:10.1117/12.190194 fatcat:6waf5xfkb5eqlha5qqzifdy7eq
David P. Archer Calgary, Alberta 928 CAN J ANESTH 2000 / 47: 9 / pp 928 Book Reviews ...doi:10.1007/bf03019685 fatcat:4zmhqpaxyfdnzfl7qtnbqn4eoa
Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease. Brain Res. Mol. Brain Res. 33, 174-178. . (1995). ... The 34 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's disease (AD). ... Multiple SNPs within and surrounding the apolipoprotein E gene influence cerebrospinal fluid apolipoprotein E protein levels. J. ...doi:10.1016/j.neuron.2009.06.026 pmid:19679070 pmcid:PMC3044446 fatcat:dxxuglxvwfaq7pxein7l2uw7my
This paper explores the use of interactive communication and dialogic relationship building strategies on political campaign Web sites. In contrast to presidential races that often feature substantially more sophisticated campaign Web sites, congressional candidates' ability and willingness to use the Web as an electioneering tool has varied greatly. The present research sought to address two broad research questions: 1) how candidates from the same electoral districts used their Web sitesdoi:10.4018/ijep.2013100104 fatcat:ruhefbmyj5eslllru4qi64mxc4
more »... g the 2006 and 2010 congressional elections; and 2) to what extent could several candidate and district level variables explain the differences in Web utilization. A typology was proposed to examine the first question, while content analysis was performed to collect empirical data that addressed the second question. Results indicate that while the use of interactive Web strategies may be concentrated among candidates with certain characteristics in 2006, the adoption of social media in political campaigns has trickled down from the presidential level, and that interactive tools have become a norm in the 2010 congressional election, with virtually no observable differences emerging among candidates. Theoretical and practical implication for online political public relations is discussed.
doi:10.1016/j.ijid.2014.08.014 pmid:25449255 fatcat:xxjx2jbporbgbk4wqiqwm7b7ty
Acknowledgements We thank the participants of Rosetta@home who made this work possible through their contributions of computing time, and the BOINC group headed by David Anderson for the development of ... Secondary structure features are designated as either helix (H), strand (E), or loop (L) as assigned by DSSP 26 . ... Fragments from homologs (PSI-BLAST e-value < 0.05 or same SCOP superfamily) were excluded from the fragment libraries. ...doi:10.1016/j.jmb.2009.07.063 pmid:19646450 pmcid:PMC2760740 fatcat:utunp26lzvfz7d4mhanyfkqfbm
accumulation induced by GSK126 in adipocytes was lipoprotein-dependent, and EZH2 inhibition or gene deletion promoted lipoprotein-dependent lipid uptake in vitro concomitant with up-regulated apolipoprotein E ... ApoE mRNA expression in human (D) and mouse adipocytes (E) treated with GSK126 or vehicle. ... (E) Intracellular triglyceride content. (F) mRNA expression of key DNL markers was determined by qPCR. **** p<0.0001; n.s.: not significant. ...doi:10.1074/jbc.ra118.006871 pmid:30971429 pmcid:PMC6544862 fatcat:k42n26gllfgv7dv5o77aq3gizy
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