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Michael Brennan is a Research Associate with the Trinity Irish Art Research Centre (TRIARC) at TCD. ... This may be because David Wells is, and has been for decades, an established scholar and author. He references twenty-three of his own publications in the book's extensive and useful bibliography. ...doi:10.33232/bims.0071.71.73 fatcat:uqaukxswwfhm3hdvs26psskozq
This is the case of a 69-year-old woman with chronic obstructive pulmonary disease who rapidly lost consciousness during an air flight, necessitating emergency landing shortly after takeoff. Noncontrast computed tomography of the brain showeddoi:10.1017/cjn.2016.288 pmid:27514457 fatcat:lyhpmedwdbbi7myh74ddy33qji
We recommend you cite the published version. The publisher's URL is http://dx.doi:10.1177/0276146709352221 fatcat:ka5hcwpepjbr7kkokq2mzrco3i
Insightful discussions with team members and with Brian Colle, Tim Hewson, Ken Johnson, Rebecca Morss, David Radell, and Jeff Waldstreicher helped clarify and improve the work. ...doi:10.1175/2008waf2222142.1 fatcat:wfquh2s3dncybfoytqrwlajlxq
Natural policy gradient methods are popular reinforcement learning methods that improve the stability of policy gradient methods by preconditioning the gradient with the inverse of the Fisher-information matrix. However, leveraging natural policy gradient methods in an optimal manner can be very challenging as many implementation details must be set to achieve optimal performance. To the best of the authors' knowledge, there has not been a study that has investigated strategies for settingarXiv:2201.09104v1 fatcat:rdl4ozkzpva2poru6z3rhlbyfm
more »... details for natural policy gradient methods to achieve high performance in a comprehensive and systematic manner. To address this, we have implemented and compared strategies that impact performance in natural policy gradient reinforcement learning across five different second-order approximations. These include varying batch sizes and optimizing the critic network using the natural gradient. Furthermore, insights about the fundamental trade-offs when optimizing for performance (stability, sample efficiency, and computation time) were generated. Experimental results indicate that the proposed collection of strategies for performance optimization can improve results by 86% to 181% across the MuJuCo control benchmark, with TENGraD exhibiting the best approximation performance amongst the tested approximations. Code in this study is available at https://github.com/gebob19/natural-policy-gradient-reinforcement-learning.
This study explored the expression of several miRNAs reported to be deregulated in age-related macular degeneration (AMD). Total RNA was isolated from sera from patients with dry AMD (n = 12), wet AMD (n = 14), and controls (n = 10). Forty-two previously investigated miRNAs were selected based on published data and their role in AMD pathogenesis, such as angiogenic and inflammatory effects, and were co-analysed using a miRCURY LNA miRNA SYBR® Green PCR kit via quantitative real-time polymerasedoi:10.3390/ijms222212321 pmid:34830203 pmcid:PMC8625913 fatcat:mieuk2ayfnbgpp7n2fnhpr7ymu
more »... hain reaction (qRT-PCR) to validate their presence. Unsupervised hierarchical clustering indicated that AMD serum specimens have a different miRNA profile to healthy controls. We successfully validated the differentially regulated miRNAs in serum from AMD patients versus controls. Eight miRNAs (hsa-let-7a-5p, hsa-let-7d-5p, hsa-miR-23a-3p, hsa-miR-301a-3p, hsa-miR-361-5p, hsa-miR-27b-3p, hsa-miR-874-3p, hsa-miR-19b-1-5p) showed higher expression in the serum of dry AMD patients than wet AMD patients and compared with healthy controls. Increased quantities of certain miRNAs in the serum of AMD patients indicate that these miRNAs could potentially serve as diagnostic AMD biomarkers and might be used as future AMD treatment targets. The discovery of significant serum miRNA biomarkers in AMD patients would provide an easy screening tool for at-risk populations.
Telerehabilitation refers to the delivery of rehabilitation services via information and communication technologies. Clinically, this term encompasses a range of rehabilitation and habilitation services that include assessment, monitoring, prevention, intervention, supervision, education, consultation, and counseling. Telerehabilitation has the capacity to provide service across the lifespan and across a continuum of care. Just as the services and providers of telerehabilitation are broad, sodoi:10.5195/ijt.2010.6063 pmid:25945175 pmcid:PMC4296793 fatcat:3fbojac7cvf6zfqbcqgxodiwoe
more »... e the points of service, which may include health care settings, clinics, homes, schools, or community-based worksites. This document was developed collaboratively by members of the Telerehabilitation SIG of the American Telemedicine Association, with input and guidance from other practitioners in the field, strategic stakeholders, and ATA staff. Its purpose is to inform and assist practitioners in providing effective and safe services that are based on client needs, current empirical evidence, and available technologies. Telerehabilitation professionals, in conjunction with professional associations and other organizations are encouraged to use this document as a template for developing discipline-specific standards, guidelines, and practice requirements.
Brennan Pursell DeSales University Brennan.Pursell@desales.edu doi 10.1163/22141332-00501008-10 Downloaded from Brill.com04/26/2019 07:38:19AM via free access ...doi:10.1163/22141332-00501008-10 fatcat:jvjldidqfnhkzfl35ybosttpgi
The White's seahorse Hippocampus whitei was listed as an Endangered species in 2020 on Australian state and federal legislation, as a result of population declines across its range attributed to habitat loss over the past decade. A captive-bred reintroduction program has been implemented as a possible management tool for species recovery, however, the viability of such a reintroduction program for seahorses has not been assessed to date. This study implemented a pilot captive-breeding programdoi:10.3389/fmars.2022.867352 doaj:77479f73bc1143f987567aa37be7e223 fatcat:r2b76g3hvfdjhfikrkw5jejxsa
more »... ing adult H. whitei from Sydney Harbour, Australia, as brood stock. A total of 90 captive-bred seahorses were released into the wild on two different artificial habitat types ("seahorse hotels" and protective swimming net). Following release, a monthly post-release monitoring program was implemented for 12 months that involved underwater visual census surveys of the tagged seahorses. Sightings of captive-bred seahorse numbers were found to gradually decline over the 12-month period, with fewer seahorses found on the swimming net compared to the seahorse hotels and higher resighting probability of captive-bred animals on the seahorse hotels. After 12 months, 20% of the captive-bred seahorses were detected on the seahorse hotels, whilst two individuals were still observed 18 months after release on the hotels. Only 2% of captive-bred seahorses were observed on the swimming net after 12 months, with two individuals still detected on the net after two years. Nine of the captive-bred seahorses were found to reproduce in the wild, with two individuals observed mating with the wild population. This pilot study indicates that captive-bred seahorses can survive for up to two years in the wild, as well as contribute to local population recovery through reproductive success. However, while conservation stocking shows promise as a potential management tool to assist with threatened seahorse species recovery, there are several factors such as existing threats to the species that need to be addressed before such a program is implemented [...]
Organosilicon Chemistry: 2
Tensor network methods are incredibly effective for simulating quantum circuits. This is due to their ability to efficiently represent and manipulate the wave-functions of large interacting quantum systems. We describe the challenges faced when scaling tensor network simulation approaches to Exascale compute platforms and introduce QuantEx, a framework for tensor network circuit simulation at Exascale.arXiv:2110.09894v1 fatcat:pwhxulbcrjfxplhv6nxacfezbe
Scientific communities are drawn to the open source model as an increasingly utilitarian method to produce and share work. Initially used as a means to develop freely available soft- ware, open source projects have been applied to hardware including scientific tools. Increasing convenience of 3D printing has fueled the proliferation of open labware projects aiming to develop and share designs for scientific tools that can be produced in-house as cheap alter- natives to commercial products. Wedoi:10.1101/109231 fatcat:5bbba43yj5bvfgn3fhbghkcv6u
more »... esent our design of a micropipette that is assembled from 3D-printable parts and some hardware that works by actuating a disposable syringe to a user adjustable limit. Graduations on the syringe are used to accurately adjust the set point to the desired volume. Our open design printed micropipette is assessed in comparison to a commercial pipette and meets ISO 8655 standards.
The Visual Computer
This paper describes a novel terrain synthesis method based on distances in a weighted graph. A height field is determined by least-cost paths in a weighted graph from a set of generator nodes. The shapes of individual terrain features, such as mountains, hills, and craters, are specified by a monotonically decreasing profile describing the cross-sectional shape of a feature. The locations of features in the terrain are specified by placing the generators; secondary ridges are placed bydoi:10.1007/s00371-009-0332-6 fatcat:ismp4logqrhodevkryopr5wrdi
more »... We show the method to be robust and easy to control, even making it possible to embed images in terrain shadows. The method can produce a wide range of realistic synthetic terrains such as mountain ranges, craters, cinder cones, and hills. The ability to manually place terrain features that incorporate multiple profiles produces heterogeneous terrains that compare favorably to existing methods.
The CWS acronym derives from the initials of its creators, David J. ...doaj:30747f39bdcc4ed790eff12d3411ece5 fatcat:6u27ucgzmfhrljk6m4yhv4qs34
Vitamin D, unlike the micronutrients, vitamins A, E, and K, is largely obtained not from food, but by the action of solar ultraviolet (UV) light on its precursor, 7-dehydrocholesterol, in skin. With the decline in UV light intensity in winter, most skin production of vitamin D occurs in summer. Since no defined storage organ or tissue has been found for vitamin D, it has been assumed that an adequate vitamin D status in winter can only be maintained by oral supplementation. Skeletal muscledoi:10.3390/nu12113270 pmid:33114526 fatcat:ehixohha6zfdpadtazmdc3osxu
more »... have now been shown to incorporate the vitamin D-binding protein (DBP) from blood into the cell cytoplasm where it binds to cytoplasmic actin. This intracellular DBP provides an array of specific binding sites for 25-hydroxyvitamin D (25(OH)D), which diffuses into the cell from the extracellular fluid. When intracellular DBP undergoes proteolytic breakdown, the bound 25(OH)D is then released and diffuses back into the blood. This uptake and release of 25(OH)D by muscle accounts for the very long half-life of this metabolite in the circulation. Since 25(OH)D concentration in the blood declines in winter, its cycling in and out of muscle cells appears to be upregulated. Parathyroid hormone is the most likely factor enhancing the repeated cycling of 25(OH)D between skeletal muscle and blood. This mechanism appears to have evolved to maintain an adequate vitamin D status in winter.
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