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Databases and software for the analysis of mutations in the human p53 gene, human hprt gene and both the lacI and lacZ gene in transgenic rodents
1998
Nucleic Acids Research
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We have created databases and software applications for the analysis of DNA mutations at the human p53 gene, the human hprt gene and both the rodent transgenic lacI and lacZ loci. ...
Each database has a separate software analysis program. The software created for these databases permit the filtering, ordering, report generation and display of information in the database. ...
This brief communication describes databases and software for analysis of mutations at the human p53 gene, the human hprt gene and both the transgenic lacI and lacZ loci. ...
doi:10.1093/nar/26.1.198
pmid:9399835
pmcid:PMC147201
fatcat:evveq7xr25gprj6hoeqdlfpy4y
Databases and software for the analysis of mutations in the human p53 gene, the human hprt gene and both the lacI and lacZ gene in transgenic rodents
1997
Nucleic Acids Research
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A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
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We have created databases and software applications for the analysis of DNA mutations at the human p53 gene, the human hprt gene and both the rodent transgenic lacI and lacZ locus. ...
The software created for these databases permit the filtering, ordering, report generation and display of information in the database. ...
This brief communication describes databases and software for analysis of mutations at the human p53 gene, the human hprt gene and both the transgenic lacI and lacZ locus. ...
doi:10.1093/nar/25.1.136
pmid:9016522
pmcid:PMC146381
fatcat:gcz7i3kx3zh4phychxdzjicurq
The Molecular Biology Database Collection: 2002 update
2002
Nucleic Acids Research
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Short, searchable summaries and updates for each of the databases included in the Collection are available through the Nucleic Acids Research Web site at http:// nar.oupjournals.org. ...
The databases included in this Collection provide new value to the underlying data by virtue of curation, new data connections or other innovative approaches. ...
/dnam/mainpage.html Mutations in human p53 and hprt; rodent transgenic lacI and lacZ mutations Human PAX2 Allelic Variant Database http://www.hgu.mrc.ac.uk/Softdata/PAX2/ Mutations in human PAX2 gene Human ...
doi:10.1093/nar/30.1.1
pmid:11752241
pmcid:PMC99169
fatcat:n46iu5l6oreapd5yxswe7pmg5m
The lacI gene as a target for mutation in transgenic rodents and Escherichia coli
1998
Genetics
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This popularity and available knowledge resulted in the use of the lacI gene in transgenic rodents for the study of mutagenesis in mammals, where it resides in approximately 40 repeated copies. ...
The lacI gene has been used extensively for the recovery and analysis of mutations in bacteria with various DNA repair backgrounds and after exposure to a wide variety of mutagens. ...
Copyright 1998 by the Genetics Society of America
The lacl Gene as a Target for Mutation in Transgenic Rodents and Escherichia coli
Johan G. de Boer and Barry W. ...
pmid:9560364
pmcid:PMC1460077
fatcat:zt3776iqpjcqbaywd3cgp4cb4a
Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene
2004
Proceedings of the National Academy of Sciences of the United States of America
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Of the 9 mutations (6 single-and 1 triple-site mutation), 2 were at the most frequently mutated codons in human cancers (c.248 and c.273). ...
To date, there has been no way to examine induced human p53 gene mutations in cell cultures exposed to mutagenic factors, other than by restriction site analysis. ...
typhimurium test, the BigBlue (LacI) and MutaMouse (LacZ) rodent systems, and the yeast-based Functional Analysis of Separated Alleles in Yeast (FASAY)] or are based on mutation of non-cancer-related ...
doi:10.1073/pnas.0308607101
pmid:14976251
pmcid:PMC365728
fatcat:6rcsgiu7pbbh7m7m75f6x3db4e
Computational analysis of mutation spectra
2003
Briefings in Bioinformatics
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In general, the DNA sequence context of mutation hotspots is a fingerprint of interactions between DNA and DNA repair/ replication/modification enzymes, and the analysis of hotspot context provides evidence ...
Spectra of spontaneous and induced mutations are used for illustration of the complexities and pitfalls of such analyses. ...
Databases and software applications for the analysis of DNA mutations at the human p53 gene, the human hprt gene and both the rodent transgenic lacI and lacZ loci have been developed. 73 The databases ...
doi:10.1093/bib/4.3.210
pmid:14582516
fatcat:bqn7bdferzdihmbknphzlbcc7m
Bayesian analysis of mutational spectra
2000
Genetics
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In this article, we propose a Bayesian hierarchical modeling approach for the analysis of mutational spectra. ...
Studies that examine both the frequency of gene mutation and the pattern or spectrum of mutational changes can be used to identify chemical mutagens and to explore the molecular mechanisms of mutagenesis ...
., 1997 Databases and software for the analysis of dose groups, our procedure allows testing for a dosemutations in the human p53 gene, the human hprt gene and related trend in the category probabilities ...
pmid:11063712
pmcid:PMC1461324
fatcat:43hyghh6xrbpxcmwi5vzemtlvi
Gramene (rice and other grasses database)
[chapter]
2008
Encyclopedia of Genetics, Genomics, Proteomics and Informatics
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The loss or mutation in a gene controlling protein p53 may lead to tumorigenesis presumably due to lack of function of this suppressor gene. ...
Molecular markers greatly facilitate tracing of the path of genes in human and other populations. Analysis of the mitochondrial DNA, X and Y chromosomes are the most useful tools for this purpose. ...
Mutation in a 1-2 Mb fragment encoding the testisspecific protein (TSPY) near the centromere in the short arm of the human Y chromosome may be responsible for it. ...
doi:10.1007/978-1-4020-6754-9_7111
fatcat:dsqojxeco5gwhgpgdcm22jb33y
Gout
[chapter]
2008
Encyclopedia of Genetics, Genomics, Proteomics and Informatics
Preserved Fulltext
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The file type is application/pdf.
The loss or mutation in a gene controlling protein p53 may lead to tumorigenesis presumably due to lack of function of this suppressor gene. ...
Molecular markers greatly facilitate tracing of the path of genes in human and other populations. Analysis of the mitochondrial DNA, X and Y chromosomes are the most useful tools for this purpose. ...
Mutation in a 1-2 Mb fragment encoding the testisspecific protein (TSPY) near the centromere in the short arm of the human Y chromosome may be responsible for it. ...
doi:10.1007/978-1-4020-6754-9_7078
fatcat:igkfa5bydfeehhe7ekrw5dudny
Scientific Opinion on the risks to public health related to the presence of nickel in food and drinking water
2015
EFSA Journal
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The highest sensitivity was reported for the analysis of drinking water with a limit of quantification (LOQ) of 0.001 µg/L (for both ICP-MS and AAS). ...
In food, ICP-MS showed the lowest LOQ for the analysis of 'Alcoholic beverages' (0.002 µg/kg) while the lowest LOQ reported with AAS was 1 µg/kg for samples of 'Fish and seafood' and 'Sugar and confectionery ...
Mayer et al. (1998) investigated the genotoxic effects of Ni subsulphide in vivo in LacZ transgenic CD2F1 mice and in lacI transgenic F34 rats used for comet assay and mutagenicity analysis, respectively ...
doi:10.2903/j.efsa.2015.4002
fatcat:46jmmicso5hvjppucrlco3mh4m
The Genetic Toxicity of Polycyclic Aromatic Hydrocarbons: A Cross-Tissue, Multi-Endpoint Study in the Transgenic MutaMouse
2017
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This thesis assessed the in vivo genotoxicity of 9 PAHs and 6 PAH mixtures following sub-chronic oral exposure of transgenic Muta™Mouse (i.e., adduct and lacZ mutant frequency across 5 tissues). ...
There is a paucity of in vivo genotoxicity information for most PAHs and PAH mixtures. ...
Additional funding was provided by Naturvårdsverket (Swedish Environmental Protection Agency) and ADME (French Environment and Energy Management Agency) via PACMAN, a SNOWMAN Network project. ...
doi:10.20381/ruor-20554
fatcat:nnj62gatzjewvocotm3e7adul4