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Databases and software for the analysis of mutations in the human p53 gene, human hprt gene and both the lacI and lacZ gene in transgenic rodents

N. Cariello
1998 Nucleic Acids Research  
We have created databases and software applications for the analysis of DNA mutations at the human p53 gene, the human hprt gene and both the rodent transgenic lacI and lacZ loci.  ...  Each database has a separate software analysis program. The software created for these databases permit the filtering, ordering, report generation and display of information in the database.  ...  This brief communication describes databases and software for analysis of mutations at the human p53 gene, the human hprt gene and both the transgenic lacI and lacZ loci.  ... 
doi:10.1093/nar/26.1.198 pmid:9399835 pmcid:PMC147201 fatcat:evveq7xr25gprj6hoeqdlfpy4y

Databases and software for the analysis of mutations in the human p53 gene, the human hprt gene and both the lacI and lacZ gene in transgenic rodents

N. F. Cariello, G. R. Douglas, M. J. Dycaico, N. J. Gorelick, G. S. Provost, T. Soussi
1997 Nucleic Acids Research  
We have created databases and software applications for the analysis of DNA mutations at the human p53 gene, the human hprt gene and both the rodent transgenic lacI and lacZ locus.  ...  The software created for these databases permit the filtering, ordering, report generation and display of information in the database.  ...  This brief communication describes databases and software for analysis of mutations at the human p53 gene, the human hprt gene and both the transgenic lacI and lacZ locus.  ... 
doi:10.1093/nar/25.1.136 pmid:9016522 pmcid:PMC146381 fatcat:gcz7i3kx3zh4phychxdzjicurq

The Molecular Biology Database Collection: 2002 update

A. D. Baxevanis
2002 Nucleic Acids Research  
Short, searchable summaries and updates for each of the databases included in the Collection are available through the Nucleic Acids Research Web site at http:// nar.oupjournals.org.  ...  The databases included in this Collection provide new value to the underlying data by virtue of curation, new data connections or other innovative approaches.  ...  /dnam/mainpage.html Mutations in human p53 and hprt; rodent transgenic lacI and lacZ mutations Human PAX2 Allelic Variant Database http://www.hgu.mrc.ac.uk/Softdata/PAX2/ Mutations in human PAX2 gene Human  ... 
doi:10.1093/nar/30.1.1 pmid:11752241 pmcid:PMC99169 fatcat:n46iu5l6oreapd5yxswe7pmg5m

The lacI gene as a target for mutation in transgenic rodents and Escherichia coli

J G de Boer, B W Glickman
1998 Genetics  
This popularity and available knowledge resulted in the use of the lacI gene in transgenic rodents for the study of mutagenesis in mammals, where it resides in approximately 40 repeated copies.  ...  The lacI gene has been used extensively for the recovery and analysis of mutations in bacteria with various DNA repair backgrounds and after exposure to a wide variety of mutagens.  ...  Copyright 1998 by the Genetics Society of America The lacl Gene as a Target for Mutation in Transgenic Rodents and Escherichia coli Johan G. de Boer and Barry W.  ... 
pmid:9560364 pmcid:PMC1460077 fatcat:zt3776iqpjcqbaywd3cgp4cb4a

Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene

Z. Liu, M. Hergenhahn, H. H. Schmeiser, G. N. Wogan, A. Hong, M. Hollstein
2004 Proceedings of the National Academy of Sciences of the United States of America  
Of the 9 mutations (6 single-and 1 triple-site mutation), 2 were at the most frequently mutated codons in human cancers (c.248 and c.273).  ...  To date, there has been no way to examine induced human p53 gene mutations in cell cultures exposed to mutagenic factors, other than by restriction site analysis.  ...  typhimurium test, the BigBlue (LacI) and MutaMouse (LacZ) rodent systems, and the yeast-based Functional Analysis of Separated Alleles in Yeast (FASAY)] or are based on mutation of non-cancer-related  ... 
doi:10.1073/pnas.0308607101 pmid:14976251 pmcid:PMC365728 fatcat:6rcsgiu7pbbh7m7m75f6x3db4e

Computational analysis of mutation spectra

I. B. Rogozin
2003 Briefings in Bioinformatics  
In general, the DNA sequence context of mutation hotspots is a fingerprint of interactions between DNA and DNA repair/ replication/modification enzymes, and the analysis of hotspot context provides evidence  ...  Spectra of spontaneous and induced mutations are used for illustration of the complexities and pitfalls of such analyses.  ...  Databases and software applications for the analysis of DNA mutations at the human p53 gene, the human hprt gene and both the rodent transgenic lacI and lacZ loci have been developed. 73 The databases  ... 
doi:10.1093/bib/4.3.210 pmid:14582516 fatcat:bqn7bdferzdihmbknphzlbcc7m

Bayesian analysis of mutational spectra

D B Dunson, K R Tindall
2000 Genetics  
In this article, we propose a Bayesian hierarchical modeling approach for the analysis of mutational spectra.  ...  Studies that examine both the frequency of gene mutation and the pattern or spectrum of mutational changes can be used to identify chemical mutagens and to explore the molecular mechanisms of mutagenesis  ...  ., 1997 Databases and software for the analysis of dose groups, our procedure allows testing for a dosemutations in the human p53 gene, the human hprt gene and related trend in the category probabilities  ... 
pmid:11063712 pmcid:PMC1461324 fatcat:43hyghh6xrbpxcmwi5vzemtlvi

Gramene (rice and other grasses database) [chapter]

2008 Encyclopedia of Genetics, Genomics, Proteomics and Informatics  
The loss or mutation in a gene controlling protein p53 may lead to tumorigenesis presumably due to lack of function of this suppressor gene.  ...  Molecular markers greatly facilitate tracing of the path of genes in human and other populations. Analysis of the mitochondrial DNA, X and Y chromosomes are the most useful tools for this purpose.  ...  Mutation in a 1-2 Mb fragment encoding the testisspecific protein (TSPY) near the centromere in the short arm of the human Y chromosome may be responsible for it.  ... 
doi:10.1007/978-1-4020-6754-9_7111 fatcat:dsqojxeco5gwhgpgdcm22jb33y

Gout [chapter]

2008 Encyclopedia of Genetics, Genomics, Proteomics and Informatics  
The loss or mutation in a gene controlling protein p53 may lead to tumorigenesis presumably due to lack of function of this suppressor gene.  ...  Molecular markers greatly facilitate tracing of the path of genes in human and other populations. Analysis of the mitochondrial DNA, X and Y chromosomes are the most useful tools for this purpose.  ...  Mutation in a 1-2 Mb fragment encoding the testisspecific protein (TSPY) near the centromere in the short arm of the human Y chromosome may be responsible for it.  ... 
doi:10.1007/978-1-4020-6754-9_7078 fatcat:igkfa5bydfeehhe7ekrw5dudny

Scientific Opinion on the risks to public health related to the presence of nickel in food and drinking water

2015 EFSA Journal  
The highest sensitivity was reported for the analysis of drinking water with a limit of quantification (LOQ) of 0.001 µg/L (for both ICP-MS and AAS).  ...  In food, ICP-MS showed the lowest LOQ for the analysis of 'Alcoholic beverages' (0.002 µg/kg) while the lowest LOQ reported with AAS was 1 µg/kg for samples of 'Fish and seafood' and 'Sugar and confectionery  ...  Mayer et al. (1998) investigated the genotoxic effects of Ni subsulphide in vivo in LacZ transgenic CD2F1 mice and in lacI transgenic F34 rats used for comet assay and mutagenicity analysis, respectively  ... 
doi:10.2903/j.efsa.2015.4002 fatcat:46jmmicso5hvjppucrlco3mh4m

The Genetic Toxicity of Polycyclic Aromatic Hydrocarbons: A Cross-Tissue, Multi-Endpoint Study in the Transgenic MutaMouse

Alexandra Long, Université D'Ottawa / University Of Ottawa, Université D'Ottawa / University Of Ottawa
2017
This thesis assessed the in vivo genotoxicity of 9 PAHs and 6 PAH mixtures following sub-chronic oral exposure of transgenic Muta™Mouse (i.e., adduct and lacZ mutant frequency across 5 tissues).  ...  There is a paucity of in vivo genotoxicity information for most PAHs and PAH mixtures.  ...  Additional funding was provided by Naturvårdsverket (Swedish Environmental Protection Agency) and ADME (French Environment and Energy Management Agency) via PACMAN, a SNOWMAN Network project.  ... 
doi:10.20381/ruor-20554 fatcat:nnj62gatzjewvocotm3e7adul4