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Data-driven modelling of the FRC network for studying the fluid flow in the conduit system
2017
Engineering applications of artificial intelligence
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The FRC network model is then used to analyze the fluid flow through the network. A first observation is that the pressure gradient is approximately linear, which suggests homogeneity of the network. ...
We present a computational method to model the geometry of the FRC network. ...
The generated FRC network is finally used to study the fluid flow through lymph node conduits in Section 4. ...
doi:10.1016/j.engappai.2016.10.007
fatcat:idg7yhpkvzadhel6t35ircsva4
Communication, construction, and fluid control: lymphoid organ fibroblastic reticular cell and conduit networks
2021
Trends in immunology
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Moreover, FRCs produce and ensheath a network of extracellular matrix (ECM) microfibers called the conduit system. ...
We discuss the intricate relationships between the cellular FRC and the fibrillar conduit networks, which together form the basis for efficient communication between immune cells and the tissues they survey ...
Acknowledgments This study received financial support from the Swiss National Science Foundation (grants 177208 and 166500 to B.L.), a European Research Council starting grant (LNEXPANDS to S.E.A.), a ...
doi:10.1016/j.it.2021.07.003
pmid:34362676
fatcat:lnjkhh5qhfantnwgomvoigxn6i
Integrative Computational Modeling of the Lymph Node Stromal Cell Landscape
2018
Frontiers in Immunology
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Lastly, we discuss briefly the importance of hybrid and multi-scale modeling approaches in immunology and the technical challenges involved. ...
We explore various mathematical studies of intranodal T cell motility and migration, their interactions with the LN-resident stromal cells, and computational models of functional chemokine gradient fields ...
Data-driven modeling of the FRC network for studying the fluid 91. Barabasi AL, Oltvai ZN. Network biology: understanding the cell’s functional
flow in the conduit system. ...
doi:10.3389/fimmu.2018.02428
pmid:30405623
pmcid:PMC6206207
fatcat:jhfxoeoenbbnjkiiwnjaesu7cu
The microanatomy of T-cell responses
2008
Immunological Reviews
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The success rate of such interactions is extremely low, because the precursor frequency of a naive T cell recognizing a specific antigen is in the range of 1:10 5 -10 6 . ...
We describe the association between fibroblastic reticular cell, conduit, DC, and T cell as the essential functional unit of the T-cell cortex. ...
Consequently, all blood vessels in the LN are shielded from the permeable sinus and are embedded into the filtrating conduit system of the FRC network. ...
doi:10.1111/j.1600-065x.2008.00592.x
pmid:18275473
fatcat:ekmhnmjr7fc7zlxl5mmwyqifti
Tumor-induced stromal reprogramming drives lymph node transformation
2016
Nature Immunology
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Here we show that FRCs specifically of TDLNs proliferate in response to tumor-derived cues and that the network they form is remodeled. ...
Principal component analysis Principal Component Analysis (PCA) was performed using the R "stats" package. Log2 transformed data was used as input for the analysis. ...
We wish to thank the CIMR flow cytometry core facility for advice and support in flow cytometry and cell sorting applications. Work ...
doi:10.1038/ni.3492
pmid:27400148
pmcid:PMC4994871
fatcat:3je7bd3pmbchpa45iqvojf434u
The Biophysics of Lymphatic Transport: Engineering Tools and Immunological Consequences
2019
iScience
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Finally, we discuss the current understanding for how changes in lymphatic transport and lymph node biomechanics contribute to pathogenesis of conditions including cancer, aging, neurodegeneration, and ...
Here we review the functional role of lymphatic transport and lymph node biomechanics in immunity. ...
flow of filtered lymph through the conduit system. ...
doi:10.1016/j.isci.2019.11.005
pmid:31739172
pmcid:PMC6864335
fatcat:tjy6sjl2wvdbrcwi4elesjm5uu
Mechanical Forces during Lymph Node Expansion Govern Fibroblastic Reticular Network Remodeling
[article]
2021
bioRxiv
pre-print
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Together this study demonstrates mechanical forces are generated and sensed through the FRC network to determine lymph node expansion required for an adaptive immune response. ...
We found that FRC network tension is a critical cue in controlling lymph node expansion gating the initiation of FRC proliferation. ...
We thank Ki Hng, Andrew Vaughan, and the core staff at MRC-LMCB for light microscopy expertise and Dr Yanping Guo at the UCL Cancer institute flow cytometry facility for assistance in the work contained ...
doi:10.1101/2021.05.27.446027
fatcat:mnjrtuuwwzezxh5uwpyczmp7em
Exploring the role of stromal osmoregulation in cancer and disease using executable modelling
2018
Nature Communications
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We present an executable model of osmotic regulation and membrane transport in mammalian cells, providing a mechanistic explanation for phenotype change in varied disease states, and accurately predicting ...
Furthermore, we predict and verify a synergistic drug combination in vitro, of sodium and chloride channel inhibitors, which target the osmoregulatory network to reduce cancer-associated phenotypes in ...
Acknowledgements We thank the Hall and Shields groups, Alex Gaunt, Stephen Woodhouse, and Phil Jones for useful discussions. ...
doi:10.1038/s41467-018-05414-y
pmid:30069015
pmcid:PMC6070494
fatcat:eruqr77hhnazdodusn74y2426a
Expansion of Cortical and Medullary Sinuses Restrains Lymph Node Hypertrophy during Prolonged Inflammation
2012
Journal of Immunology
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We are grateful to Laurent Renia (Singapore Immunology Network) for the gift of the anti-CD62L Ab and Bronislaw Pytowski (ImClone Systems) for the gift of anti-VEGFR3 and VEGFR2 Abs. ...
(Flow Cytometry Lab, National University of Singapore) for sharing expertise. ...
Because other groups described that interstitial flow can modulate FRC organization and function (43) and, in our model, extranodal VEGF-A may be transported within the FRC conduit system and subsequently ...
doi:10.4049/jimmunol.1101854
pmid:22430738
fatcat:oc43qkwqpfgb3k6kehreobyoyu
Stromal cell contributions to the homeostasis and functionality of the immune system
2009
Nature reviews. Immunology
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A defining characteristic of the immune system is the constant movement of many of its constituent cells through the secondary lymphoid tissues, mainly the spleen and lymph nodes, where crucial interactions ...
What has only recently been recognized is the role that nonhaematopoietic stromal elements have in multiple aspects of immune cell migration, activation and survival. ...
Acknowledgments The authors would like to thank I. Ifrim for invaluable assistance with immunohistochemistry to generate the images in the figures, A. O. Anderson, J. Egen, and W. ...
doi:10.1038/nri2588
pmid:19644499
pmcid:PMC2785037
fatcat:v3u6yjjhwjcmtg6i3xpnhol2ye
Lymph node conduits transport virions for rapid T cell activation
2019
Nature Immunology
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These results reveal that it is possible for even large virions to flow through LN conduits and infect dendritic cells within the T cell zone to prime CD8+ T cells. ...
Notably, many rapidly infected cells in the LN interior were adjacent to LN conduits. Through the use of confocal and electron microscopy, we clearly visualized virions within conduits. ...
Pierson (Viral Pathogenesis Section, Laboratory of Viral Diseases, NIAID) for assistance with ZIKV infection and J. ...
doi:10.1038/s41590-019-0342-0
pmid:30886418
pmcid:PMC6474694
fatcat:bx2brmac6jbg5kwbng2fyonkny
Immune function and dysfunction are determined by lymphoid tissue efficacy
2022
Disease Models & Mechanisms
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Understanding the role of lymphoid tissues in immune responses to a wide range of pathologies allows us to take a fuller systemic view of disease progression. ...
We discuss the functional role of lymphoid tissue in disease progression and explore the changes to lymphoid tissue structure and function driven by infection, chronic inflammatory conditions and cancer ...
Viruses have evolved mechanisms to utilise the FRC network to evade the immune system. ...
doi:10.1242/dmm.049256
pmid:35072206
pmcid:PMC8807573
fatcat:opi5is3wmnfxvfdyp43wmccqma
A novel bacterial artificial chromosome-transgenic Podoplanin–Cre mouse targets lymphoid organ stromal cells in vivo
2011
Frontiers in Immunology
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This study received financial support from the Swiss National Science Foundation (CRSII3_125447 and 130823/1 to Burkhard Ludewig) and from the Austrian Genome Research Programme GEN-AU II and III (Austromouse ...
ACKNOWLEDGMENTS We would like to thank Rita de Giuli and Eva Allgäuer for technical support. ...
Furthermore, FRCs form the microvascular conduit system that distributes small lymph-borne antigens within the lymphoid tissue (Sixt et al., 2005) . ...
doi:10.3389/fimmu.2011.00050
pmid:22566840
pmcid:PMC3342134
fatcat:e4vzjcvdazbrreikx4fwja3boa
Development and Immunological Function of Lymph Node Stromal Cells
2021
Journal of Immunology
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In this review, we go over recent advances in genetic models and high-resolution transcriptomic analyses that have propelled the finer resolution of the stromal cell infrastructure of lymph nodes, revealing ...
Moreover, we discuss how changes in the activation state of poised stromal cell-underpinned niches rather than on-demand differentiation of new stromal cell subsets govern the efficient interaction of ...
Moreover, the physical stretching of the FRC network during inflammation may promote temporary conduit permeability (60, 61) , which in turn has been shown to promote the passive entry of IgM into conduits ...
doi:10.4049/jimmunol.2000914
pmid:33397739
fatcat:bcvxkopzhnd7fafbyieppnt4mm
Lymph node stromal cell subsets – emerging specialists for tailored tissue-specific immune responses
2021
International Journal of Medical Microbiology
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for the modulation of adaptive immune responses. ...
In this review, we summarize current advances on the pivotal roles that LNSCs play in orchestrating adaptive immune responses during homeostasis and infection, and highlight the imprinting of location-specific ...
Acknowledgements This work was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) in the framework of the priority program SPP1656 "Intestinal microbiotaa microbial ecosystem ...
doi:10.1016/j.ijmm.2021.151492
pmid:33676241
fatcat:ejmxk65735dkxgyzb4b3v42kim
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