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Data Integration Issues in the Reconstruction of the Genome-Scale Metabolic Model of Zymomonas Mobillis [chapter]

José P. Pinto, Oscar Dias, Anália Lourenço, Sónia Carneiro, Eugénio C. Ferreira, Isabel Rocha, Miguel Rocha
Advances in Soft Computing  
Genome-scale model reconstruction represents a major tool in the field of Metabolic Engineering .This paper reports on a study about data integration issues in the process of genome-scale reconstruction  ...  of the metabolic model of the bacterium Zymomonas mobilis, a promising organism for bioethanol production.  ...  The genome-scale metabolic reconstruction is imperative for the feasibility of ongoing studies since there is no available genome-scale metabolic model for this organism.  ... 
doi:10.1007/978-3-540-85861-4_12 fatcat:g3mnbmqczvc6td2uopdsrjocjy

Advanced biofuel production in microbes

Pamela P. Peralta-Yahya, Jay D. Keasling
2010 Biotechnology Journal  
Here, we review recent developments in the engineering of metabolic pathways for the production of known and potential advanced biofuels by microorganisms.  ...  We concentrate on the metabolic engineering of genetically tractable organisms such as Escherichia coli and Saccharomyces cerevisiae for the production of these advanced biofuels.  ...  A limitation of the metabolic engineering/systems biology cycle is the time and resource allocation necessary to execute functional genomic studies, integrate the system-wide data into models, and predict  ... 
doi:10.1002/biot.200900220 pmid:20084640 fatcat:6v4lb6yxbvdn5fgpqiqexq252m