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NAMNIs: Neuromodulation And Multimodal NeuroImaging software

Temmuz Karali, Frank Padberg, Valerie Kirsch, Sophia Stoecklein, Peter Falkai, Daniel Keeser
2019 Zenodo  
The basic requirements in neuroimaging research are rapidly changing due to the growing size of data sets and multimodal approaches with ever more complex, time-consuming, diverse and fast-moving standards. NAMNIs offers a ready-made, open-source pipeline for pre- and post-processing of multimodal neuroimaging and neuromodulation data with a strong focus on reproducibility and multi-platform parallelization support. NAMNIs consists of a processing pipeline for multimodal magnetic resonance
more » ... ng (MRI) data analysis using parallel processing. It performs various pre-processing steps with the aforementioned data that calculate relevant metrics such as the number of activated voxels (spatial extent), within regions of interest (ROIs) effects, ROI-to-whole-brain calculations, probabilistic values, motion parameters, connectivity strength values (standardized in z scores), and more. These steps are performed in parallel with different topologies to enable the processing of large data sets in a reasonable time. It is applicable to High Performance Computing (HPC) and is provided as research software which is free and open-source software (FOSS). Already in the proof-of-concept and prototype phase, the project was published as abstracts of international conferences (Karali et al., 2017) (Karali et al., 2019).
doi:10.5281/zenodo.3530897 fatcat:ndk4rm2qyngxpahf722ori7y2a

Hersenactiviteit tijdens een paniekaanval

Andrés Guevara, Daniel Keeser, Sonja Verhagen-Schouten, Marion Stobbe-Meijers, Jan Berend Deijen, Hessel Engelbregt
2018 GGZ Vaktijdschrift  
De vraag is hoe specifiek de diagnose is bij de betreffende onderzoeksgroep aangezien Keeser et al. vergelijkbare resultaten vonden bij een groep mensen met ernstige depressie (Keeser et al., 2013).  ...  Kara en Polo beschrijven in een overzichtsartikel, gebaseerd op 3 artikelen (Engelbregt, Keeser, Promes, Verhagen-Schouten, & Deijen, 2012; Hayashi, Makino, Hashizume, Nakano, & Tsuboi, 2010; Lopes et  ... 
doi:10.31739/ggzv.2018.1.2 fatcat:g6ddpawdqnextfodfanesnanze

Intrinsic Network Activity Reflects the Ongoing Experience of Chronic Pain [article]

Pauline Jahn, Bettina Deak, Astrid Mayr, Anne Stankewitz, Daniel Keeser, Ludovica Griffanti, Viktor Witkovsky, Stephanie Irving, Enrico Schulz
2021 biorxiv/medrxiv   pre-print
AbstractAnalyses of intrinsic network activity have been instrumental in revealing cortical processes that are altered in chronic pain patients. However, such studies have not accounted for variable time courses of network activity and subjective pain experience. In a novel approach, we aimed to elucidate how intrinsic functional networks evolve in regard to the fluctuating intensity of the experience of chronic pain.In a longitudinal study with 156 fMRI sessions, 20 chronic back pain patients
more » ... nd 20 chronic migraine patients were asked to continuously rate the intensity of their endogenous pain. Using group independent component analysis and dual-regression, we extracted the time courses of 100 independent components separately for chronic back pain and chronic migraine. We investigated the relationship between the fluctuation of intrinsic network activity with the time course of subjective pain ratings.For chronic back pain, we found increased cortical network activity for the salience network and a local pontine network, as well as decreased network activity in the anterior and posterior default mode network for higher pain intensities. Higher pain intensities in chronic migraine were accompanied with lower activity in a prefrontal cortical network.By taking the perspective of the individual, we focused on the processes that matter for each patient, which are phases of relatively low pain and more straining phases of relatively high pain. The present design of ongoing assessment of the endogenous pain can be a powerful and promising tool to assess the signature of a patient's endogenous pain encoding over weeks and months.
doi:10.1101/2021.06.30.450604 fatcat:4phvbasnu5h2rgjk6ncrtqisxe

Concurrent TMS-fMRI: Technical Challenges, Developments, and Overview of Previous Studies

Yuki Mizutani-Tiebel, Martin Tik, Kai-Yen Chang, Frank Padberg, Aldo Soldini, Zane Wilkinson, Cui Ci Voon, Lucia Bulubas, Christian Windischberger, Daniel Keeser
2022 Frontiers in Psychiatry  
Copyright © 2022 Mizutani-Tiebel, Tik, Chang, Padberg, Soldini, Wilkinson, Voon, Bulubas, Windischberger and Keeser.  ... 
doi:10.3389/fpsyt.2022.825205 pmid:35530029 pmcid:PMC9069063 fatcat:jszhajpsnndmbo2ioiry4uj7p4

The COVID-19 Pandemic Mental Health Questionnaire (CoPaQ): psychometric evaluation and compliance with countermeasures in psychiatric inpatients and non-clinical individuals

Stephanie V. Rek, Markus Bühner, Matthias A. Reinhard, Daniel Freeman, Daniel Keeser, Kristina Adorjan, Peter Falkai, Frank Padberg
2021 BMC Psychiatry  
Background The COVID-19 pandemic has greatly impacted people's lives across a broad spectrum of psychosocial domains. We report the development and psychometric evaluation of the self-report COVID-19 Pandemic Mental Health Questionnaire (CoPaQ), which assesses COVID-19 contamination anxiety, countermeasure necessity and compliance, mental health impact, stressor impact, social media usage, interpersonal conflicts, paranoid ideations, institutional & political trust, conspiracy beliefs, and
more » ... l cohesion. Further, we illustrate the questionnaire's utility in an applied example investigating if higher SARS-Cov-2 infection rates in psychiatric patients could be explained by reduced compliance with preventive countermeasures. Methods A group of 511 non-clinical individuals completed an initial pool of 111 CoPaQ items (Open Science Framework: and additional scales measuring psychological distress, well-being, and paranoia to assess construct validity and lifetime mental health diagnosis for criterion validity. Factor structure was determined by exploratory factor analyses and validated by conducting confirmatory factor analysis in the accompanying longitudinal sample (n = 318) and an independent psychiatric inpatient sample primarily admitted for major depressive-, substance abuse-, personality-, and anxiety disorders (n = 113). Internal consistency was assessed by Cronbach's Alpha and McDonald's Omega. For the applied research example, Welch t-tests and correlational analyses were conducted. Results Twelve out of 16 extracted subscales were retained in the final questionnaire version, which provided preliminary evidence for adequate psychometric properties in terms of factor structure, internal consistency, and construct and criterion validity. Our applied research example showed that patients exhibited greater support for COVID-19 countermeasures than non-clinical individuals. However, this requires replication in future studies. Conclusions We demonstrate that the CoPaQ is a comprehensive and valid measure of the psychosocial impact of the pandemic and could allow to a degree to disentangle the complex psychosocial phenomena of the pandemic as exemplified by our applied analyses.
doi:10.1186/s12888-021-03425-6 pmid:34465319 fatcat:orlzcgiu4neytngalvhahehvzm

Effect of smoking status on neuronal responses to graphic cigarette warning labels

Tobias Rüther, Yannick Schultz, Christina Wirth, Agnieszka Chrobok, Andrea Rabenstein, Daniel Keeser, Birgit Ertl-Wagner, Oliver Pogarell, Susanne Karch
2018 PLoS ONE  
Smoking is responsible for a large proportion of cancer, respiratory and cardiovascular deaths. Nevertheless the health risks of smoking are still underestimated in many smokers. The present study aimed to examine neurobiological responses to graphical warnings on cigarette packings in non-smokers and patients with tobacco dependence. Twenty non-smokers and twenty-four patients with tobacco dependence participated in a functional MRI study during that pictures of different categories were
more » ... ted ((a) EU-warning pictures, (b) text-only warnings, (c) neutral pictures with short information). Patients contributed twice in the experiment (after 10 hours nicotine withdrawal / about 5 minutes after nicotine consumption). Smokers during withdrawal demonstrated increased neuronal responses predominantly in subcortical, temporal and frontal brain regions that are associated with emotional and cognitive processes during the presentation of graphical warnings compared to neutral pictures. In smokers after smoking and non-smokers, the differences between graphical warnings and neutral pictures were increased compared to smokers during withdrawal. The comparison of the graphical warnings with text-only labels demonstrated the importance of affective brain regions especially in smokers after smoking and in non-smokers. During withdrawal, the neural responses associated with graphical warnings and text-only labels differed only marginally. The results suggest that emotional and cognitive reactions to graphical warnings are predominantly seen in smokers after smoking and in non-smokers. The impact of these pictures during withdrawal seems to be less pronounced; in this case, more unspecific processes seem to be important, including the projection of sensory signals to the cerebral cortex.
doi:10.1371/journal.pone.0201360 pmid:30235214 pmcid:PMC6147412 fatcat:pqkd2ni76vgd3pyhthnwndb4ja

Mixing Apples and Oranges in Assessing Outcomes of Repetitive Transcranial Stimulation Meta-Analyses

Andre R. Brunoni, Martijn Arns, Chris Baeken, Daniel Blumberger, Jerome Brunelin, Linda L. Carpenter, Jonathan Downar, Daniel Keeser, Berthold Langguth, Fady Rachid, Alexander T. Sack, Fidel Vila-Rodriguez (+1 others)
2019 Psychotherapy and Psychosomatics  
published version features the final layout of the paper including the volume, issue and page numbers. Link to publication General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal
more » ... r the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal. If the publication is distributed under the terms of Article 25fa of the Dutch Copyright Act, indicated by the "Taverne" license above, please follow below link for the End User
doi:10.1159/000504653 pmid:31794971 fatcat:3q65icj7cfcqvmig4z6xqszwiu

There is no magic in speaker policies: creating gender equality at brain stimulation conferences

Anna-Katharine Brem, Soili M. Lehto, Daniel Keeser, Frank Padberg
2017 European Archives of Psychiatry and Clinical Neuroscience  
doi:10.1007/s00406-017-0854-2 pmid:29159504 fatcat:4xhfspfo5nghlhwwxo4d5czguq

Increased Event-Related Potentials and Alpha-, Beta-, and Gamma-Activity Associated with Intentional Actions

Susanne Karch, Fabian Loy, Daniela Krause, Sandra Schwarz, Jan Kiesewetter, Felix Segmiller, Agnieszka I. Chrobok, Daniel Keeser, Oliver Pogarell
2016 Frontiers in Psychology  
Objective: Internally guided actions are defined as being purposeful, self-generated and offering choices between alternatives. Intentional actions are essential to reach individual goals. In previous empirical studies, internally guided actions were predominantly related to functional responses in frontal and parietal areas. The aim of the present study was to distinguish event-related potentials and oscillatory responses of intentional actions and externally guided actions. In addition, we
more » ... pared neurobiological findings of the decision which action to perform with those referring to the decision whether or not to perform an action. Methods: Twenty-eight subjects participated in adapted go/nogo paradigms, including a voluntary selection condition allowing participants to (1) freely decide whether to press the response button or (2) to decide whether they wanted to press the response button with the right index finger or the left index finger. Results: The reaction times were increased when participants freely decided whether and how they wanted to respond compared to the go condition. Intentional processes were associated with a fronto-centrally located N2 and P3 potential. N2 and P3 amplitudes were increased during intentional actions compared to instructed responses (go). In addition, increased activity in the alpha-, beta-and gamma-frequency range was shown during voluntary behavior rather than during externally guided responses. Conclusion: These results may indicate that an additional cognitive process is needed for intentional actions compared to instructed behavior. However, the neural responses were comparatively independent of the kind of decision that was made (1) decision which action to perform; (2) decision whether or not to perform an action). Significance: The study demonstrates the importance of fronto-central alpha-, beta-, and gamma oscillations for voluntary behavior.
doi:10.3389/fpsyg.2016.00007 pmid:26834680 pmcid:PMC4722116 fatcat:ovkab23sarfbrkiuxhpwydsedu


Nina Filipova, Alkomiet Hasan, Daniel Keeser, Wolfgang Strube
2018 Schizophrenia Bulletin  
doi:10.1093/schbul/sby018.994 fatcat:nofkrlxhm5g4rbkbdkuzic7n5i

Effect of aerobic exercise on cortical thickness in patients with schizophrenia – a dataset

Shun Takahashi, Daniel Keeser, Boris-Stephan Rauchmann, Thomas Schneider-Axmann, Katriona Keller-Varady, Isabel Maurus, Peter Dechent, Thomas Wobrock, Alkomiet Hasan, Andrea Schmitt, Birgit Ertl-Wagner, Berend Malchow (+1 others)
2020 Data in Brief  
Keeser, B. Rauchmann, T. Schneider-Axmann, K. Keller-Varady, I. Maurus, P. Dechent, T. Wobrock, B. Ertl-Wagner, and B. Malchow report no conflicts of interest. A.  ...  Related research article Shun Takahashi, Daniel Keeser, Boris-Stephan Rauchmann, Thomas Schneider-Axmann, Katriona Keller-Varady, Isabel Maurus, Peter Dechent, Thomas Wobrock, Alkomiet Hasan, Andrea  ... 
doi:10.1016/j.dib.2020.105517 pmid:32395575 pmcid:PMC7210414 fatcat:w2zmzudo65c3vchji3zjni3ace

Multiple sclerosis and subclinical neuropathology in healthy individuals with familial risk: A scoping review of MRI studies

Matin Mortazavi, Öznur Hizarci, Lisa Ann Gerdes, Joachim Havla, Tania Kümpfel, Reinhard Hohlfeld, Sophia Stöcklein, Daniel Keeser, Birgit Ertl-Wagner
2021 NeuroImage: Clinical  
Multiple genetic and non-heritable factors have been linked to the risk of multiple sclerosis (MS). These factors seem to contribute to disease pathogenesis before the onset of clinical symptoms, as suggested by incidental MRI evidence of subclinical MS neuropathology in individuals without clinical symptoms. Individuals with high familial risk for MS, such as first-degree relatives of patients with MS, can be studied by MRI to characterize the neuropathology during a subclinical period of MS.
more » ... 6 studies published in English, which performed brain MRI on healthy individuals with high familial risk of MS were included in this scoping review. Studies suggest either no conclusive (5), or inconclusive yet considerable (4), or conclusive evidence (7) for the incidence of subclinical neuropathology, including focal and diffuse tissue damage. Across all studies, white matter lesions fulfilling MS criteria were observed in 86 of 613 individuals (14%). Future research is needed to evaluate the longitudinal dynamics and clinical relevance of preclinical imaging abnormalities in MS.
doi:10.1016/j.nicl.2021.102734 pmid:34171607 fatcat:gzjh7nykpbcnpgbysgjdwxmesu

Effects of Aerobic Exercise on Metabolic Syndrome, Cardiorespiratory Fitness, and Symptoms in Schizophrenia Include Decreased Mortality

Andrea Schmitt, Isabel Maurus, Moritz J. Rossner, Astrid Röh, Moritz Lembeck, Martina von Wilmsdorff, Shun Takahashi, Boris Rauchmann, Daniel Keeser, Alkomiet Hasan, Berend Malchow, Peter Falkai
2018 Frontiers in Psychiatry  
Schizophrenia is a severe psychiatric disorder with a lifetime prevalence of about 1%. People with schizophrenia have a 4-fold higher prevalence of metabolic syndrome than the general population, mainly because of antipsychotic treatment but perhaps also because of decreased physical activity. Metabolic syndrome is a risk factor for cardiovascular diseases, and the risk of these diseases is 2- to 3-fold higher in schizophrenia patients than in the general population. The suicide risk is also
more » ... her in schizophrenia, partly as a result of depression, positive, and cognitive symptoms of the disease. The higher suicide rate and higher rate of cardiac mortality, a consequence of the increased prevalance of cardiovascular diseases, contribute to the reduced life expectancy, which is up to 20 years lower than in the general population. Regular physical activity, especially in combination with psychosocial and dietary interventions, can improve parameters of the metabolic syndrome and cardiorespiratory fitness. Furthermore, aerobic exercise has been shown to improve cognitive deficits; total symptom severity, including positive and negative symptoms; depression; quality of life; and global functioning. High-intensity interval endurance training is a feasible and effective way to improve cardiorespiratory fitness and metabolic parameters and has been established as such in somatic disorders. It may have more beneficial effects on the metabolic state than more moderate and continuous endurance training methods, but to date it has not been investigated in schizophrenia patients in controlled, randomized trials. This review discusses physical training methods to improve cardiorespiratory fitness and reduce metabolic syndrome risk factors and symptoms in schizophrenia patients. The results of studies and future high-quality clinical trials are expected to lead to the development of an evidence-based physical training program for patients that includes practical recommendations, such as the optimal length and type of aerobic exercise programs and the ideal combination of exercise, psychoeducation, and individual weight management sessions.
doi:10.3389/fpsyt.2018.00690 pmid:30622486 pmcid:PMC6308154 fatcat:mivk5tctkzg4tidzwbbh5w5ofm

Prediction of Treatment Outcome in Patients with Obsessive-Compulsive Disorder with Low-Resolution Brain Electromagnetic Tomography: A Prospective EEG Study

Daniela Krause, Malte Folkerts, Susanne Karch, Daniel Keeser, Agnieszka I. Chrobok, Michael Zaudig, Ulrich Hegerl, Georg Juckel, Oliver Pogarell
2016 Frontiers in Psychology  
The issue of predicting treatment response and identifying, in advance, which patient will profit from treating obsessive-compulsive disorder (OCD) seems to be an elusive goal. This prospective study investigated brain electric activity [using Low-Resolution Brain Electromagnetic Tomography (LORETA)] for the purpose of predicting response to treatment. Forty-one unmedicated patients with a DSM-IV diagnosis of OCD were included. A resting 32-channel EEG was obtained from each participant before
more » ... nd after 10 weeks of standardized treatment with sertraline and behavioral therapy. LORETA was used to localize the sources of brain electrical activity. At week 10, patients were divided into responders and non-responders (according to a reduction of symptom severity >50% on the Y-BOCS). LORETA analysis revealed that at baseline responders showed compared to non-responders a significantly lower brain electric activity within the beta 1 (t = 2.86, p < 0.05), 2 (t = 2.81, p < 0.05), and 3 (t = 2.76, p < 0.05) frequency bands and ROI analysis confirmed a reduced activity in alpha 2 (t = 2.06, p < 0.05) in the anterior cingulate cortex (ACC). When baseline LORETA data were compared to follow-up data, the analysis showed in the responder group a significantly lower brain electrical resting activity in the beta 1 (t = 3.17. p < 0.05) and beta 3 (t = 3.11. p < 0.05) frequency bands and equally for the ROI analysis of the orbitofrontal cortex (OFC) in the alpha 2 (t = 2.15. p < 0.05) frequency band. In the group of non-responders the opposite results were found. In addition, a positive correlation between frequency alpha 2 (rho = 0.40, p = 0.010), beta 3 (rho = 0.42, p = 0.006), delta (rho = 0.33, p = 0.038), theta (rho = 0.34, p = 0.031), alpha 1 (rho = 0.38, p = 0.015), and beta1 (rho = 0.34, p = 0.028) of the OFC and the bands delta (rho = 0.33, p = 0.035), alpha 1 (rho = 0.36, p = 0.019), alpha 2 (rho = 0.34, p = 0.031), and beta 3 (rho = 0.38, p = 0.015) of the ACC with a reduction of the Y-BOCS scores was identified. Our results suggest that measuring brain activity with LORETA could be an efficient and applicable technique to prospectively identify treatment responders in OCD.
doi:10.3389/fpsyg.2015.01993 pmid:26834658 pmcid:PMC4722125 fatcat:f24ye65mxbbnzkh5jr7kfaidcu

Improvement in daily functioning after aerobic exercise training in schizophrenia is sustained after exercise cessation

Peter Falkai, Isabel Maurus, Andrea Schmitt, Berend Malchow, Thomas Schneider-Axmann, Lukas Röll, Sergi Papiol, Thomas Wobrock, Alkomiet Hasan, Daniel Keeser
2021 European Archives of Psychiatry and Clinical Neuroscience  
Cognitive deficits in schizophrenia are crucially important for patients' functional outcome, but they do not significantly improve with currently available treatment options. On the basis of animal work indicating that physical activity stimulates neurogenesis in adults and enhances cognitive performance, several groups around the world performed aerobic exercise studies in schizophrenia (SZ). These studies demonstrated that physical exercise improves negative symptoms and cognitive
more » ... and indicated that the improvements in cognition may be related to improved brain plasticity in relevant brain regions, such as the hippocampus [1] . The neurobiological mechanisms proposed as drivers of these effects include synaptic plasticity and, more recently, oligodendrocyte differentiation [2]. However, unclear was
doi:10.1007/s00406-021-01282-8 pmid:34143287 pmcid:PMC8429390 fatcat:igpvbymeqnggtjdi7eowvix6dy
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