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Direction of self-motion is perceived from optical flow

William H. Warren, Daniel J. Hannon
1988 Nature  
Warren Jr & Daniel J.  ...  Hannon Departments of Psychology and Cognitive and Linguistic Sciences, Brown University, Providence, Rhode Island 02912, USA Fig. 1 Fig. 2 12 Optical velocity field produced by observer translation  ... 
doi:10.1038/336162a0 fatcat:dm72degivzbatk7u3gff7q22ju

RNA-interference-directed chromatin modification coupled to RNA polymerase II transcription

Vera Schramke, Daniel M. Sheedy, Ahmet M. Denli, Carolina Bonila, Karl Ekwall, Gregory J. Hannon, Robin C. Allshire
2005 Nature  
Denli, Carolina Bonila, Karl Ekwall, Gregory J. Hannon & Robin C. Allshire Nature 435, 1275-1279 (2005) and the Supplementary Figures remain valid.We thank S. Kimber and A.  ...  Sher & J. P. Attfield Nature 436, 829-832 (2005) interference-directed chromatin modification coupled to RNA polymerase II transcription Vera Schramke, Daniel M. Sheedy, Ahmet M.  ... 
doi:10.1038/nature03652 pmid:15965464 fatcat:7iq5eqqkp5hfnh5sm4seakxrhu

Psychophysical Evidence for Losses in Rod Sensitivity in the Aging Visual System

JOSEPH F STURR, LAN ZHANG, HARVEY A TAUB, DANIEL J HANNON, MARY M JACKOWSKI
1997 Vision Research  
In addition, future psychophysical experiments applying the increment threshold technique and mathematical models (Hood & Greenstein, 1990; Sturr & Hannon, 1991; Schefrin et al., 1992) would be useful  ...  originallyplotted scatter plots of the thresholdin o 0 Ofb c) 00 Oo 0 t%' Og o Q3 Oo 0 A Males O Females 20 40 60 80 100 Age (years) 560 nm %$ A A Males O Females J  ... 
doi:10.1016/s0042-6989(96)00196-4 pmid:9156178 fatcat:5rpug7juvrh3vjdjh46dhpsciy

Erratum: RNA-interference-directed chromatin modification coupled to RNA polymerase II transcription

Vera Schramke, Daniel M. Sheedy, Ahmet M. Denli, Carolina Bonila, Karl Ekwall, Gregory J. Hannon, Robin C. Allshire
2005 Nature  
Denli, Carolina Bonila, Karl Ekwall, Gregory J. Hannon & Robin C. Allshire Nature 435, 1275-1279 (2005) and the Supplementary Figures remain valid.We thank S. Kimber and A.  ...  has declined to sign this retraction as she maintains that the original conclusions are correct. interference-directed chromatin modification coupled to RNA polymerase II transcription Vera Schramke, Daniel  ... 
doi:10.1038/nature04181 pmid:16222304 fatcat:sfqyzhnlbzchtlcdarfjdxszq4

SHORT-TERM EFFECTS OF TIMBER HARVEST ON ABUNDANCE, TERRITORY CHARACTERISTICS, AND PAIRING SUCCESS OF OVENBIRDS IN RIPARIAN BUFFER STRIPS

J. Daniel Lambert, Susan J. Hannon
2000 The AUK: A Quarterly Journal of Ornithology  
BELANGER, J. HUOT,  ...  Hannon unpubl. data).  ... 
doi:10.1642/0004-8038(2000)117[0687:steoth]2.0.co;2 fatcat:chy2andm35awjfjkam3v6jkowu

Major surgery induces acute changes in DNA methylation associated with activation of the immune response [article]

Ryoichi Sadahiro, Bridget Knight, Ffion James, Eilis Hannon, John Charity, Ian Daniels, Joe Burrage, Olivia Knox, Bethany Crawford, Neil J Smart, Jonathan Mill
2019 bioRxiv   pre-print
Surgery is an invasive procedure evoking acute inflammatory and immune responses that are believed to mediate risk for postoperative complications including cognitive dysfunction and delirium. Although the specific mechanisms driving these responses have not been well-characterized, they are hypothesized to involve the epigenetic regulation of gene expression. We quantified genome-wide levels of DNA methylation in purified peripheral blood mononuclear cells (PBMCs) longitudinally collected from
more » ... 55 elderly patients undergoing three types of major surgery (elective colorectal and hip replacement surgery, and emergency hip fracture surgery), comparing samples collected at baseline to those collected immediately post-operatively and at discharge from hospital. Results: Major surgery was associated with acute changes in DNA methylation at sites annotated to immune system genes, paralleling changes in serum-levels of markers including C-reactive protein (CRP) and Interleukin 6 (IL-6) measured in the same individuals. Although many of the observed changes in DNA methylation are consistent across the three types of surgery, there is notable heterogeneity between surgery types at certain loci. The acute changes in DNA methylation induced by surgery are relatively stable in the post-operative period, generally persisting until discharge from hospital. Conclusions: Our results highlight the dramatic alterations in gene regulation induced by invasive surgery, primarily reflecting upregulation of the immune system in response to trauma, wound healing and anaesthesia.
doi:10.1101/706184 fatcat:oawkvppww5g57gt55u65u2cnui

Return to Sport and Performance After Anterior Cruciate Ligament Reconstruction in National Football League Linemen

Mark E. Cinque, Charles P. Hannon, Daniel D. Bohl, Brandon J. Erickson, Nikhil N. Verma, Brian J. Cole, Bernard R. Bach
2017 Orthopaedic Journal of Sports Medicine  
Tears of the anterior cruciate ligament (ACL) are common in the National Football League (NFL). The impact of these injuries on the careers of NFL linemen is unknown. Purpose: To define the percentage of NFL linemen who return to sport (RTS) after ACL reconstruction, the mean time to RTS, and the impact on performance compared with matched controls. Study Design: Cohort study; Level of evidence, 3. Methods: Data on NFL offensive and defensive linemen who sustained an ACL tear and underwent ACL
more » ... econstruction between 1980 and 2015 were analyzed. Players were identified through NFL team websites, publicly available injury reports, player profiles, and press releases. Demographics and mean in-game performance data preinjury and post-ACL reconstruction were recorded. A player was deemed to have returned to sport if he played in at least 1 NFL game after his ACL reconstruction. A healthy control group was selected to compare in-game performance data and was matched with the study group on several parameters. Results: Overall, 73 NFL linemen met the inclusion criteria; 47 (64.3%) returned to play after ACL reconstruction (62.5% of offensive linemen, 65.9% of defensive linemen). All offensive linemen successfully returned to play the season after injury. No difference existed in number of seasons, total number of games played, mean number of games played, or mean number of games started per season when offensive linemen who RTS after ACL reconstruction were compared with matched controls (all P > .05). Among defensive linemen who RTS, most returned the season after injury (88.9%). There was no difference between defensive linemen who RTS after ACL reconstruction and matched controls in any performance metrics as an average over the remainder of their career (all P > .05). However, NFL defensive linemen who tore their ACL played fewer total seasons than matched controls (P ¼ .020). Conclusion: Overall, 64.3% of NFL offensive and defensive linemen who undergo ACL reconstruction returned to play. Linemen who RTS do so at a high level, with no difference in in-game performance or career duration when compared with matched controls.
doi:10.1177/2325967117711681 pmid:28680893 pmcid:PMC5480637 fatcat:7u65ajvbmvdj5oo5kkhsegyfta

Interaction between genetic predisposition, smoking, and dementia risk: a population-based cohort study

Na Zhang, Janice M. Ranson, Zhi-Jie Zheng, Eilis Hannon, Zhenwei Zhou, Xuejun Kong, David J. Llewellyn, Daniel A. King, Jie Huang
2021 Scientific Reports  
AbstractWe evaluated whether the association between cigarette smoking and dementia risk is modified by genetic predisposition including apolipoprotein E (APOE) genotype and polygenic risk (excluding the APOE region). We included 193,198 UK Biobank participants aged 60–73 years without dementia at baseline. Of non-APOE-ε4 carriers, 0.89% (95% CI 0.73–1.08%) current smokers developed dementia compared with 0.49% (95% CI 0.44–0.55%) of never smokers (adjusted HR 1.78; 95% CI 1.39–2.29). In
more » ... t, of one APOE-ε4 allele carriers, 1.69% (95% CI 1.31–2.12%) current smokers developed dementia compared with 1.40% (95% CI 1.25–1.55%) of never smokers (adjusted HR 1.06; 95% CI 0.77–1.45); of two APOE-ε4 alleles carriers, 4.90% (95% CI 2.92–7.61%) current smokers developed dementia compared with 3.87% (95% CI 3.11–4.74%) of never smokers (adjusted HR 0.94; 95% CI 0.49–1.79). Of participants with high polygenic risk, 1.77% (95% CI 1.35–2.27%) current smokers developed dementia compared with 1.05% (95% CI 0.91–1.21%) of never smokers (adjusted HR 1.63; 95% CI 1.16–2.28). A significant interaction was found between APOE genotype and smoking status (P = 0.002) while no significant interaction was identified between polygenic risk and smoking status (P = 0.25). APOE genotype but not polygenic risk modified the effect of smoking on dementia risk.
doi:10.1038/s41598-021-92304-x pmid:34155245 pmcid:PMC8217565 fatcat:sbneub4g7vgrxgko5a7mhsfklq

Validity and Reliability of a Commercially-Available Velocity and Power Testing Device

Andrew Askow, Jason Stone, Daniel Arndts, Adam King, Shiho Goto, Joseph Hannon, J. Garrison, James Bothwell, Phil Esposito, Andrew Jagim, Margaret Jones, Will Jennings (+1 others)
2018 Sports  
Given the relationship between explosive-type training and power adaptation, tracking movement velocity has become popular. However, unlike previous variables, tracking velocity necessitates the use of a valid and reliable tool to monitor adaptation over time. Therefore, the primary purpose of this research was to assess the validity and reliability of a commercially-available linear position transducer (LPT). Nine resistance-trained men completed four sessions consisting of a single set of
more » ... ell back squat to volitional failure at 75% or 90% one-repetition maximum. Kinetic and kinematic data were captured for each repetition by the LPT and a 3-dimensional motion capture system and bipedal force platforms. In total, 357 instances of data from both systems were analyzed using intraclass correlations (ICC), effect size estimates, and standard error of measurement. Overall, the LPT yielded excellent ICCs (all ≥0.94) and small/trivial differences (d < 0.60). When categorized by median values, ICCs remained high (all ≥0.89) and differences remained small or trivial with the exception of high peak velocities (d = −1.46). Together, these data indicate that the commercially-available LPT is a valid and reliable measure for kinetic and kinematic variables of interest with the exception of high peak velocities.
doi:10.3390/sports6040170 pmid:30544687 pmcid:PMC6316018 fatcat:ieqywgeievfh7fr6kutr77mehi

Patient Perspectives of Midlevel Providers in Orthopaedic Sports Medicine

Blaine T. Manning, Daniel D. Bohl, Charles P. Hannon, Michael L. Redondo, David R. Christian, Brian Forsythe, Shane J. Nho, Bernard R. Bach
2018 Orthopaedic Journal of Sports Medicine  
Midlevel providers (eg, nurse practitioners and physician assistants) have been integrated into orthopaedic systems of care in response to the increasing demand for musculoskeletal care. Few studies have examined patient perspectives toward midlevel providers in orthopaedic sports medicine. Purpose: To identify perspectives of orthopaedic sports medicine patients regarding midlevel providers, including optimal scope of practice, reimbursement equity with physicians, and importance of the
more » ... an's midlevel provider to patients when initially selecting a physician.
doi:10.1177/2325967118766873 pmid:29662915 pmcid:PMC5898664 fatcat:ami3f74uqfbz5g3qcnbhbgeqyi

Rates and Determinants of 5-Year Outcomes After Atrial Fibrillation–Related Stroke

Derek T. Hayden, Niamh Hannon, Elizabeth Callaly, Danielle Ní Chróinín, Gillian Horgan, Lorraine Kyne, Joseph Duggan, Eamon Dolan, Killian O'Rourke, David Williams, Sean Murphy, Peter J. Kelly
2015 Stroke  
A trial fibrillation (AF) confers a 5-fold increase in stroke risk and is reported in 13% to 31% of incident ischemic stroke in population studies. 1,2 The prevalence of AF rises steeply with increasing age and is projected to increase 2.5fold within the next 40 years as a result of population growth and aging. 3 These demographic trends in AF incidence and prevalence may yield a substantial rise in the societal burden of AF-related stroke (AF-stroke) in the coming decades. 4, 5 It is well
more » ... lished that AF-stroke is associated with greater early severity, disability, fatality, and cost compared with non-AF stroke. 6-9 However, little population-based data exist on late outcomes and utilization of secondary prevention medication in survivors after AF-stroke. Such data are important when counseling individual patients and families in clinical practice. Accurate data are also essential to inform populationwide health service planning to improve AF detection, stroke Background and Purpose-Demographic trends in atrial fibrillation (AF) incidence may yield a substantial rise in the societal burden of AF-related stroke (AF-stroke). Accurate population-wide outcome data are essential to inform health service planning to improve AF-stroke prevention, and provision of rehabilitation, nursing home, and community supports for AF-stroke survivors. Methods-We investigated rates and determinants of 5-year fatality, stroke recurrence, functional outcomes, and prescribing of secondary prevention medications in AF-stroke in the North Dublin Population Stroke Study. Ascertainment included hot and cold pursuit using multiple overlapping sources. Survival analysis was performed using lifetables and Kaplan-Meier survival curves, and Cox proportional hazard modeling was performed to identify predictors of death and recurrent stroke. Results-Five hundred sixty-eight patients with new stroke were identified, including 177 (31.2%) AF-stroke. At 5 years, 39.2% (confidence interval, 31.5-46.8) of ischemic AF-stroke patients were alive. Congestive heart failure, hypertension, age <65, 65-74 years, and ≥75 years, diabetes mellitus, prior stroke, transient ischemic attack or thromboembolism, vascular disease and female sex (CHA 2 DS 2 -VASc) score (hazard ratio [HR], 1.34; P<0.001), CHADS 2 score (HR 1.42, P=0.004), National Institute of Health Stroke Scale (HR, 1.09; P<0.0001), and subtherapeutic international normalized ratio (<2.0) at stroke onset (HR, 3.29; P=0.003) were independently associated with 5-year fatality, whereas warfarin (HR, 0.40; P=0.001) and statin use after index stroke (HR, 0.52; P=0.005) were associated with improved survival. The 5-year recurrence rate after ischemic AF-stroke was 21.5% (confidence interval, 14.5-31.3). Trends toward greater risk of recurrence were observed for persistent AF (HR, 3.09; P=0.07) and CHA 2 DS 2 -VASc score (HR, 1.34; P=0.07). Nursing home care was needed for 25.9% of patients. Conclusions-AF-stroke is associated with considerable long-term morbidity, fatality, stroke recurrence, and nursing home requirement. Adequately resourced national AF strategies to improve AF detection and prevention are needed. (D.W., S.M.). The online-only Data Supplement is available with this article at http://stroke.ahajournals.org/lookup/suppl/
doi:10.1161/strokeaha.115.011139 pmid:26470776 fatcat:4gkcaordbjegjorygd4pw7q3ry

Regulation of inflammatory and lipid metabolism genes by eicosapentaenoic acid-rich oil

Peter J. Gillies, Sujata K. Bhatia, Leigh A Belcher, Daniel B. Hannon, Jerry T. Thompson, John P. Vanden Heuvel
2012 Journal of Lipid Research  
doi:10.1194/jlr.m022657 pmid:22556214 pmcid:PMC3540848 fatcat:vv7afxihhfdklayvezlti47yp4

Major surgery induces acute changes in measured DNA methylation associated with immune response pathways

Ryoichi Sadahiro, Bridget Knight, Ffion James, Eilis Hannon, John Charity, Ian R. Daniels, Joe Burrage, Olivia Knox, Bethany Crawford, Neil J. Smart, Jonathan Mill
2020 Scientific Reports  
Surgery is an invasive procedure evoking acute inflammatory and immune responses that can influence risk for postoperative complications including cognitive dysfunction and delirium. Although the specific mechanisms driving these responses have not been well-characterized, they are hypothesized to involve the epigenetic regulation of gene expression. We quantified genome-wide levels of DNA methylation in peripheral blood mononuclear cells (PBMCs) longitudinally collected from a cohort of
more » ... patients undergoing major surgery, comparing samples collected at baseline to those collected immediately post-operatively and at discharge from hospital. We identified acute changes in measured DNA methylation at sites annotated to immune system genes, paralleling changes in serum-levels of markers including C-reactive protein (CRP) and Interleukin 6 (IL-6) measured in the same individuals. Many of the observed changes in measured DNA methylation were consistent across different types of major surgery, although there was notable heterogeneity between surgery types at certain loci. The acute changes in measured DNA methylation induced by surgery are relatively stable in the post-operative period, generally persisting until discharge from hospital. Our results highlight the dramatic alterations in gene regulation induced by invasive surgery, primarily reflecting upregulation of the immune system in response to trauma, wound healing and anaesthesia.
doi:10.1038/s41598-020-62262-x pmid:32238836 pmcid:PMC7113299 fatcat:ut6kj27rhbbcjl7tcnke245wym

Optimizing self-consistent field theory block copolymer models with X-ray metrology

Adam F. Hannon, Daniel F. Sunday, Alec Bowen, Gurdaman Khaira, Jiaxing Ren, Paul F. Nealey, Juan J. de Pablo, R. Joseph Kline
2018 Molecular Systems Design & Engineering  
Self-consistent field theory is optimized through comparisons with X-ray scattering metrology.
doi:10.1039/c7me00098g pmid:29892480 fatcat:ht3lw6ueo5b6pklufiwp57xekm

Acute Hospital, Community, and Indirect Costs of Stroke Associated With Atrial Fibrillation

Niamh Hannon, Leslie Daly, Sean Murphy, Samantha Smith, Derek Hayden, Danielle Ní Chróinín, Elizabeth Callaly, Gillian Horgan, Órla Sheehan, Bahman Honari, Joseph Duggan, Lorraine Kyne (+4 others)
2014 Stroke  
A trial fibrillation (AF) increases the risk of stroke, disability, dementia, and death, with a characteristic profile of more severe, disabling, and recurrent stroke compared with stroke without AF. [1] [2][3][4] With aging populations, the prevalence of AF is projected to increase ≥2-fold by 2050, accompanied by an increase in the frequency of AF-associated stroke. 5 Accurate health economic data are important to inform health policy decisions to respond to this societal increase in AF
more » ... nce, such as population screening programs. Reliable data on the cost of stroke associated with AF (AF-stroke) are also essential for rigorous cost-effectiveness studies of new oral anticoagulant agents, which guide reimbursement decisions for healthcare providers internationally. [6] [7] [8] [9] Existing hospital-based studies have described high costs of stroke associated with AF. 10-15 However, existing studies have been limited by the reporting of acute hospital costs only, or by the inclusion of selected AF-stroke subgroups, such as hospitalized patients, nonaphasic patients, those with first-ever stroke only, or 1-year survivors. No cost studies of AF-stroke have been performed in unselected patients, including costs of community healthcare and indirect costs associated with lost productivity, leading to substantial underestimation of the Background and Purpose-No economic data from population-based studies exist on acute or late hospital, community, and indirect costs of stroke associated with atrial fibrillation (AF-stroke). Such data are essential for policy development, service planning, and cost-effectiveness analysis of new therapeutic agents. Methods-In a population-based prospective study of incident and recurrent stroke treated in hospital and community settings, we investigated direct (healthcare related) and indirect costs for a 2-year period. Survival, disability, poststroke residence, and healthcare use were determined at 90 days, 1 year, and 2 years. Acute hospital cost was determined using a case-mix approach, and other costs using a bottom-up approach (2007 prices). (2006) , the total estimated 2-year cost was $33.84 million. In the overall sample, AF-stroke accounted for 31% (177) of patients, but a higher proportion of costs (40.5% of total and 45% of nursing home costs). On a per-patient basis compared with non-AF-stroke, AF-stroke was associated with higher total (P<0.001) and acute hospital costs (P<0.001), and greater nursing home (P=0.001) and general practitioner (P<0.001) costs among 90-day survivors. After stratification by stroke severity in survivors, AF was associated with 2-fold increase in costs in patients with mild-moderate (National Institutes of Health Stroke Scale, 0-15) stroke (P<0.001) but not in severe stroke (National Institutes of Health Stroke Scale ≥16; P=0.7). Conclusions-In our population study, AF-stroke was associated with substantially higher total, acute hospital, nursing home, and general practitioner costs per patient. Targeted programs to identify AF and prevent AF-stroke may have significant economic benefits, in addition to health benefits. (Stroke. 2014;45:3670-3674.) The online-only Data Supplement is available with this article at http://stroke.ahajournals.org/lookup/suppl/ Results-In 568 patients ascertained in 1 year
doi:10.1161/strokeaha.114.005960 pmid:25358697 fatcat:fl7eb7cgsnfazohwjaymetfwlm
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