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Quantification Improvements of 1H MRS Signals [chapter]

Maria I., Anca R. Croitor Sava, Diana M., Flemming U., Uwe Himmelreich, Sabine Van
2012 Magnetic Resonance Spectroscopy  
the quantification method AQSES (Poullet et al., 2007) : a) filtering of residual water, b) lineshape estimation, c) baseline estimation and d) inclusion of spatial constraints in MRSI quantification.  ...  resonances can be visualized.  ...  This baseline influences the quantification causing the mis-fitting of individual peaks or metabolite profiles.  ... 
doi:10.5772/31546 fatcat:zxzib7nkdrdw3pjp2j7bgmdoia

Terminology and concepts for the characterization of in vivo MR spectroscopy methods and MR spectra: Background and experts' consensus recommendations

Roland Kreis, Vincent Boer, In-Young Choi, Cristina Cudalbu, Robin A de Graaf, Charles Gasparovic, Arend Heerschap, Martin Krššák, Bernard Lanz, Andrew A Maudsley, Martin Meyerspeer, Jamie Near (+8 others)
2020 NMR in Biomedicine  
With a 40-year history of use for in vivo studies, the terminology used to describe the methodology and results of magnetic resonance spectroscopy (MRS) has grown substantially and is not consistent in  ...  This work covers terms used to describe all aspects of MRS, starting from the description of the MR signal and its theoretical basis to acquisition methods, processing and to quantification procedures,  ...  with 13 different combinations of slice-selective inversion pre-pulses jMRUI Java-based Magnetic Resonance User Software package for processing and fitting MR spectroscopy data using 14,15 Interface TD  ... 
doi:10.1002/nbm.4347 pmid:32808407 fatcat:ibl2d4sgrbgtnmtffgofqygf2a

Common processing ofin vivo MR spectra

HJA in 't Zandt, M van der Graaf, A Heerschap
2001 NMR in Biomedicine  
Subsequently, common steps in the processing of MR spectra such as pre-processing, normalisation and quantification and the use of prior knowledge are described.  ...  Simonetti (MSc) and Dr L. Buydens for useful discussions.  ...  We thank the EU for support (IST project -1999-10310 (INTERPRET) and TMR project ERBFMRXCT970160 (Advanced Signal Processing for Medical MRI/MRS)).  ... 
doi:10.1002/nbm.707 pmid:11410940 fatcat:zeqssptltzditfzsi4iijto22y

1H NMR metabolomics identifies underlying inflammatory pathology in osteoarthritis and rheumatoid arthritis synovial joints

James R. Anderson, Susama Chokesuwattanaskul, Marie M. Phelan, Tim JM Welting, Lu-Yun Lian, Mandy J Peffers, Helen L. Wright
2018 Journal of Proteome Research  
We used 1H nuclear magnetic resonance (NMR) spectroscopy to identify differences in metabolite profiles in low volumes of OA and RA synovial fluid (SF).  ...  We demonstrate that quantifiable differences in metabolite abundance can be measured in low volumes of SF by 1H NMR spectroscopy, which may be clinically useful to aid diagnosis and improve understanding  ...  Samuli-Petrus Korhonen and Docent Kari Tuppurainen  ... 
doi:10.1021/acs.jproteome.8b00455 pmid:30229649 pmcid:PMC6220363 fatcat:rh2c4czluzecza7bg7jevfivmq

Tensor Based Method for Residual Water Suppression in $^{1}$ H Magnetic Resonance Spectroscopic Imaging

Bharath Halandur Nagaraja, Otto Debals, Diana M. Sima, Uwe Himmelreich, Lieven De Lathauwer, Sabine Van Huffel
2018 IEEE Transactions on Biomedical Engineering  
Objective: Magnetic resonance spectroscopic imaging (MRSI) signals are often corrupted by residual water and artifacts.  ...  Residual water suppression plays an important role in accurate and efficient quantification of metabolites from MRSI. A tensor-based method for suppressing residual water is proposed.  ...  ACKNOWLEDGMENT The authors would like to thank the University Hospitals of Leuven for data acquisition.  ... 
doi:10.1109/tbme.2018.2850911 pmid:29993479 fatcat:ybwvlhuanjggxjvkv7yyg3qvji

Novel NMR and MS Approaches to Metabolomics [chapter]

Ian A. Lewis, Michael R. Shortreed, Adrian D. Hegeman, John L. Markley
2012 Methods in pharmacology and toxicology  
Recently, several important advances in databases, software, instrumentation, and laboratory techniques have greatly simplified the most laborious tasks of metabolite identification and have made quantification  ...  In addition, we provide practical guidelines for designing studies and give the step-by-step protocols used in our lab for sample preparation, metabolite identification, and accurate quantification of  ...  Off-resonance effects are one of the many factors that can influence peak intensities observed in NMR experiments.  ... 
doi:10.1007/978-1-61779-618-0_7 fatcat:ofci7qhm3fgbvike7pcuhpkmnq

Explicit extraction of absorption peak positions, widths and heights using higher order derivatives of total shape spectra by nonparametric processing of time signals as complex damped multi-exponentials

Dževad Belkić, Karen Belkić
2018 Journal of Mathematical Chemistry  
The explicit procedure and the necessary analytical expressions are presented for reconstruction of the exact locations, widths and heights of all the retrieved physical resonances (spectral peaks).  ...  One deals with the general Breit-Wigner resonance formula and its first three derivatives. The other is concerned with the dFPT in clinical diagnostics of relevance to breast B Dževad Belkić  ...  cancer detection by magnetic resonance spectroscopy.  ... 
doi:10.1007/s10910-017-0852-7 fatcat:6vpmeedsjzdctitkoxxp656qja

Magnetic Resonance Biomarkers in Radiation Oncology

Kiaran P McGee, Ken Hwang, Daniel C Sullivan, John Kurhanewicz, Yanle Hu, Jihong Wang, Wen Li, Josef Debbins, Eric Paulson, Jeffrey R Olsen, Chia-Ho Hua, Lizette Warner (+4 others)
2021 Medical Physics (Lancaster)  
A magnetic resonance (MR) biologic marker (biomarker) is a measurable quantitative characteristic that is an indicator of normal biological and pathogenetic processes or a response to therapeutic intervention  ...  and improve clinical outcomes.  ...  Spectroscopy Magnetic resonance spectroscopy (MRS) describes the method of obtaining an MR signal from the nucleus of an atom which exhibits a net nuclear magnetic moment. 22 Due to its relative abundance  ... 
doi:10.1002/mp.14884 pmid:33864283 pmcid:PMC8361924 fatcat:ovov3g4weze43op2jixcftuepq

Exact quantification by the nonparametric fast Padé transform using only shape estimation of high-order derivatives of envelopes

Dževad Belkić, Karen Belkić
2017 Journal of Mathematical Chemistry  
Here, non-negative integer m is the order of differentiation and ν is the real linear sweep frequency.  ...  Hidden resonances, even those that are very weak, can be not only visualized, but also exactly quantified by the dFPT, despite performing shape estimations alone.  ...  This modality of MRS and MRSI is called derivative magnetic resonance spectroscopy (dMRS) and derivative magnetic resonance spectroscopic imaging (dMRSI), respectively.  ... 
doi:10.1007/s10910-017-0837-6 fatcat:snhhuiqxwfaw7lbtpziobmunky

Understanding the Kinetics of Nutrients Bioaccessibility by Modelling Foodomics Data

Carlo Mengucci, Alessandra Bordoni, Francesco Capozzi
2020 Current Opinion in Food Science  
Nuclear Magnetic 68 Resonance (NMR) spectroscopy and Mass Spectrometry 69 (MS), hyphenated or not to chromatographic separation 70 methods, are optimal techniques to comprehensively 71 characterize the  ...  analysis, 75 ii) metabolite profiling, iii) spectral fingerprinting, iv) 76 untargeted metabolite analysis and v) metabolomics, with 77 increasing discrimination capability. 78 To fully understand the  ...  and magnetic resonance imaging.  ... 
doi:10.1016/j.cofs.2020.04.001 fatcat:qj3lwjo46bbanh3p32ye4dyqdq

Derivative NMR Spectroscopy for J-Coupled Multiplet Resonances using Short Time Signals (0.5KB) Encoded at Low Magnetic Field Strengths (1.5T). Part II: Water Unsuppressed

Dževad Belkić, Karen Belkić
2020 Journal of Mathematical Chemistry  
AbstractThe topic of this work is on reliable resolving of J-coupled resonances in spectral envelopes from proton nuclear magnetic resonance (NMR) spectroscopy.  ...  How much does water suppression during encoding time signals actually perturb the resonances near and farther away from the dominant water peak?  ...  as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.  ... 
doi:10.1007/s10910-020-01199-y fatcat:rcmikw3kybhtnbzusp2qw2ahru

Phospholipid Metabolites in Recurrent Glioblastoma: In Vivo Markers Detect Different Tumor Phenotypes before and under Antiangiogenic Therapy

Elke Hattingen, Oliver Bähr, Johannes Rieger, Stella Blasel, Joachim Steinbach, Ulrich Pilatus, Michael Platten
2013 PLoS ONE  
Metabolite concentrations from tumor tissue and their ratios were compared to contralateral normal-appearing tissue (control).  ...  Methods: 1 H and 31 P MRSI was prospectively performed in 32 patients with rGBMs before and under BVZ therapy at 8 weeks intervals until tumor progression.  ...  Acknowledgments The authors thank the clinical research associates Stephanie Pellikan and Maurice Hardt who assisted in the MR examinations, as well as the patients who participated in these studies and  ... 
doi:10.1371/journal.pone.0056439 pmid:23520454 pmcid:PMC3592858 fatcat:4qseimo4l5gdjd6rn5fepy3f64

Cumulative Subject Index, Volumes 1–20

2009 Journal of the American Society for Mass Spectrometry  
Ion scanning in positive mode, for phosphopeptide analysis, derivatization strategy for, 13:996 Ion selection, low-voltage, on-resonance, for FTMS, 9:931 Ion selection and accumulation, data-dependent  ...  Factors influencing the analytical performance of an ASGDI source as revealed via ionization dynamics modeling, 1315 Factors that influence the observed fast fragmentation of peptides in matrix-assisted  ...  , 11:578 Quantification of a potent 5-HT2a antagonist and an active metabolite in rat plasma and brain microdialysate by liquid chromatography-tandem mass spectrometry, 8:371 Quantitation of ion abundances  ... 
doi:10.1016/s1044-0305(09)00878-2 fatcat:farqphcssjfhdapopxo6mkezqq

Facing and Overcoming Sensitivity Challenges in Biomolecular NMR Spectroscopy

Jan-Henrik Ardenkjaer-Larsen, Gregory S. Boebinger, Arnaud Comment, Simon Duckett, Arthur S. Edison, Frank Engelke, Christian Griesinger, Robert G. Griffin, Christian Hilty, Hidaeki Maeda, Giacomo Parigi, Thomas Prisner (+7 others)
2015 Angewandte Chemie International Edition  
While substantial advances have been made in all these areas, numerous challenges remain in the quest of endowing NMR spectroscopy with the sensitivity that has characterized forms of spectroscopies based  ...  These challenges, and the ways by which scientists and engineers are striving to solve them, are also addressed.  ...  NMR, and its in vivo siblings magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) have the unique possibility to observe multiple nuclear species and their chemical environments  ... 
doi:10.1002/anie.201410653 pmid:26136394 pmcid:PMC4943876 fatcat:cpns6vyjrbaxzhw3qejzsqxaui

Nuclear Magnetic Resonance with the Distant Dipolar Field [article]

Curtis Andrew Corum
2005 arXiv   pre-print
A general introduction to magnetic resonance phenomenon is followed by a more in depth introduction to the DDF and its effects.  ...  Experimental verification has been accomplished by imaging the profile. The equations should be found generally applicable for those interested in DDF-based spectroscopy and imaging.  ...  The Holy Grail of in-vivo magnetic resonance spectroscopy (MRS) is the ability to localize and quantify metabolite peaks at high resolution and high signal-to-noise ratio.  ... 
arXiv:physics/0507103v1 fatcat:3bi3iwzfwnednpabt7qe32bpdu
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