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An MDA Approach Towards Integrating Formal and Informal Modeling Languages [chapter]

Soon-Kyeong Kim, Damian Burger, David Carrington
2005 Lecture Notes in Computer Science  
The Model Driven Architecture (MDA) involves automated transformations between software models defined in different languages at different abstraction levels. This paper takes an MDA approach to integrate a formal modeling language (Object-Z) with an informal modeling language (UML) via model transformation. This paper shows how formal and informal modeling languages can be cooperatively used in the MDA framework and how the transformations between models in these languages can be achieved
more » ... an MDA development environment. The MDA model transformation techniques allow us to have a reusable transformation between formal and informal modeling languages. The integrated approach provides an effective V&V technique for the MDA.
doi:10.1007/11526841_30 fatcat:ocj35wcl6fcgbiyve2gkdldjli

CMAS: fully integrated portable centrifugal microfluidic analysis system for on-site colorimetric analysis

Monika Czugala, Damian Maher, Fiachra Collins, Robert Burger, Frank Hopfgartner, Yang Yang, Jiang Zhaou, Jens Ducrée, Alan Smeaton, Kevin J. Fraser, Fernando Benito-Lopez, Dermot Diamond
2013 RSC Advances  
A portable, wireless system capable of in-situ reagent-based colorimetric analysis is demonstrated. The system is based on a reconfigurable low cost optical detection method employing a paired emitter detector diode device, which allows a wide range of centrifugal microfluidic layouts to be implemented. Due to the wireless communication, acquisition parameters can be controlled remotely and results can be downloaded in distant locations and displayed in real time. The stand-alone capabilities
more » ... the system, combined with the portability and wireless communication, provide the flexibility crucial for on-site water monitoring. The centrifugal microfluidic disc presented here is designed for nitrite detection in water samples, as a proof of principle. A limit of detection of 9.31 ppb, along with similar coefficient of correlation and precision, were obtained from the Centrifugal Microfluidic Analysis System compared with the same parameters measured using a UV-Vis spectrophotometer.
doi:10.1039/c3ra42975j fatcat:27mcprxxj5enji3z3c76okq2iq

Quantitative Cerebral Blood Flow Measurements in the Rat Using a Beta-Probe and H215O

Bruno Weber, Nicolas Späth, Matthias Wyss, Damian Wild, Cyrill Burger, Ross Stanley, Alfred Buck
2003 Journal of Cerebral Blood Flow and Metabolism  
Beta-probes are a relatively new tool for tracer kinetic studies in animals. They are highly suited to evaluate new positron emission tomography tracers or measure physiologic parameters at rest and after some kind of stimulation or intervention. In many of these experiments, the knowledge of CBF is highly important. Thus, the purpose of this study was to evaluate the method of CBF measurements using a beta-probe and H 2 15 O. CBF was measured in the barrel cortex of eight rats at baseline and
more » ... fter acetazolamide challenge. Trigeminal nerve stimulation was additionally performed in five animals. In each category, three injections of 250 to 300 MBq H 2 15 O were performed at 10-minute intervals. Data were analyzed using a standard one-tissue compartment model (K 1 ‫ס‬ CBF, k 2 ‫ס‬
doi:10.1097/01.wcb.0000095799.98378.7d pmid:14663341 fatcat:uoyvcmeye5aqbk5qakdhj4ryqu

Development of portable CdZnTe spectrometers for remote sensing of signatures from nuclear materials

Arnold Burger, Michael Groza, Yunlong Cui, Utpal N. Roy, Damian Hillman, Mike Guo, Longxia Li, Gomez W. Wright, Ralph B. James
2005 Physica Status Solidi. C, Current topics in solid state physics  
/Autor C:\Documents and Settings\burgera\Desktop\Warsaw paper\warsaw burger et al.doc &R310; insgesamt 7 Seiten Diskette 14.09.2004 Bearb.: [2] W.  ...  .: W0000/Autor C:\Documents and Settings\burgera\Desktop\Warsaw paper\warsaw burger et al.doc &R31; insgesamt 7 Seiten Diskette 14.09.2004 Bearb.: Fig 000000 physica (c) 0002/1 WordXP Art.: W0000  ... 
doi:10.1002/pssc.200460839 fatcat:43rdahxdxre6zmonq5jyvyqypa

Comparison of [18F]FDG PET/CT with magnetic resonance imaging for the assessment of human brown adipose tissue activity

Jonas Gabriel William Fischer, Claudia Irene Maushart, Anton S. Becker, Julian Müller, Philipp Madoerin, Alin Chirindel, Damian Wild, Edwin E. G. W. ter Voert, Oliver Bieri, Irene Burger, Matthias Johannes Betz
2020 EJNMMI Research  
Brown adipose tissue (BAT) is a thermogenic tissue which can generate heat in response to mild cold exposure. As it constitutes a promising target in the fight against obesity, we need reliable techniques to quantify its activity in response to therapeutic interventions. The current standard for the quantification of BAT activity is [18F]FDG PET/CT. Various sequences in magnetic resonance imaging (MRI), including those measuring its relative fat content (fat fraction), have been proposed and
more » ... luated in small proof-of-principle studies, showing diverging results. Here, we systematically compare the predictive value of adipose tissue fat fraction measured by MRI to the results of [18F]FDG PET/CT. We analyzed the diagnostic reliability of MRI measured fat fraction (FF) for the estimation of human BAT activity in two cohorts of healthy volunteers participating in two prospective clinical trials (NCT03189511, NCT03269747). In both cohorts, BAT activity was stimulated by mild cold exposure. In cohort 1, we performed [18F]FDG PET/MRI; in cohort 2, we used [18F]FDG PET/CT followed by MRI. Fat fraction was determined by 2-point Dixon and 6-point Dixon measurement, respectively. Fat fraction values were compared to SUVmean in the corresponding tissue depot by simple linear regression. In total, 33 male participants with a mean age of 23.9 years and a mean BMI of 22.8 kg/m2 were recruited. In 32 participants, active BAT was visible. On an intra-individual level, FF was significantly lower in high-SUV areas compared to low-SUV areas (cohort 1: p < 0.0001 and cohort 2: p = 0.0002). The FF of the supraclavicular adipose tissue depot was inversely related to its metabolic activity (SUVmean) in both cohorts (cohort 1: R2 = 0.18, p = 0.09 and cohort 2: R2 = 0.42, p = 0.009). MRI FF explains only about 40% of the variation in BAT glucose uptake. Thus, it can currently not be used to substitute [18F] FDG PET-based imaging for quantification of BAT activity. ClinicalTrials.gov. NCT03189511 , registered on June 17, 2017, actual study start date was on May 31, 2017, retrospectively registered. NCT03269747 , registered on September 01, 2017.
doi:10.1186/s13550-020-00665-7 pmid:32699996 fatcat:vvurpa6kfrdbnp3gweykczs7qa

Proton pump inhibitors (PPIs) impact on tumour cell survival, metastatic potential and chemotherapy resistance, and affect expression of resistance-relevant miRNAs in esophageal cancer

Kirsten Lindner, Christiane Borchardt, Maren Schöpp, Anja Bürgers, Christian Stock, Damian J Hussey, Jörg Haier, Richard Hummel
2014 Journal of Experimental & Clinical Cancer Research  
Neoadjuvant treatment plays a crucial role in the therapy of advanced esophageal cancer. However, response to radiochemotherapy varies widely. Proton pump inhibitors (PPIs) have been demonstrated to impact on chemotherapy in a variety of other cancers. We analyzed the impact of PPI treatment on esophageal cancer cell lines, and investigated mechanisms that mediate the effect of PPI treatment in this tumour. Methods: We investigated the effect of esomeprazole treatment on cancer cell survival,
more » ... hesion, migration and chemotherapy in human adeno-(OE19) and squamous-cell-carcinoma (KYSE410) cell lines. Furthermore, we investigated the effect of PPI treatment on intra-/extracellular pH and on expression of resistance-relevant miRNAs. Results: Esomeprazole significantly inhibited tumour cell survival (in a dose-dependent manner), adhesion and migration in both tumour subtypes. Furthermore, esomeprazole augmented the cytotoxic effect of cisplatin and 5-FU in both tumour subtypes. Surprisingly, PPI treatment led to a significant increase of intracellular pH and a decrease of the extracellular pH. Finally, we found esomeprazole affected expression of resistance-relevant miRNAs. Specifically, miR-141 and miR-200b were upregulated, whereas miR-376a was downregulated after PPI treatment in both tumour types. Conclusion: Our study demonstrates for the first time that PPIs impact on tumour cell survival, metastatic potential and sensitivity towards chemotherapy in esophageal cancer cell lines. Furthermore, we observed that in this tumour entity, PPIs do not lead to intracellular acidification, but affect the expression of resistance-relevant miRNAs.
doi:10.1186/preaccept-2789512291251271 pmid:25175076 pmcid:PMC4431491 fatcat:jh2t3s5gpvhhnheizvanhr2rd4

Proton pump inhibitors (PPIs) impact on tumour cell survival, metastatic potential and chemotherapy resistance, and affect expression of resistance-relevant miRNAs in esophageal cancer

Kirsten Lindner, Christiane Borchardt, Maren Schöpp, Anja Bürgers, Christian Stock, Damian J Hussey, Jörg Haier, Richard Hummel
2014 Journal of Experimental & Clinical Cancer Research  
Neoadjuvant treatment plays a crucial role in the therapy of advanced esophageal cancer. However, response to radiochemotherapy varies widely. Proton pump inhibitors (PPIs) have been demonstrated to impact on chemotherapy in a variety of other cancers. We analyzed the impact of PPI treatment on esophageal cancer cell lines, and investigated mechanisms that mediate the effect of PPI treatment in this tumour. Methods: We investigated the effect of esomeprazole treatment on cancer cell survival,
more » ... hesion, migration and chemotherapy in human adeno-(OE19) and squamous-cell-carcinoma (KYSE410) cell lines. Furthermore, we investigated the effect of PPI treatment on intra-/extracellular pH and on expression of resistance-relevant miRNAs. Results: Esomeprazole significantly inhibited tumour cell survival (in a dose-dependent manner), adhesion and migration in both tumour subtypes. Furthermore, esomeprazole augmented the cytotoxic effect of cisplatin and 5-FU in both tumour subtypes. Surprisingly, PPI treatment led to a significant increase of intracellular pH and a decrease of the extracellular pH. Finally, we found esomeprazole affected expression of resistance-relevant miRNAs. Specifically, miR-141 and miR-200b were upregulated, whereas miR-376a was downregulated after PPI treatment in both tumour types. Conclusion: Our study demonstrates for the first time that PPIs impact on tumour cell survival, metastatic potential and sensitivity towards chemotherapy in esophageal cancer cell lines. Furthermore, we observed that in this tumour entity, PPIs do not lead to intracellular acidification, but affect the expression of resistance-relevant miRNAs.
doi:10.1186/s13046-014-0073-x pmid:25175076 pmcid:PMC4431491 fatcat:u2qx3s2vnndqpjs6tx22boa5wm

Page 491 of Monatshefte Vol. 38, Issue 8 [page]

1946 Monatshefte  
Damian 491 Stehr is already known for the style of his introductory passages to individual chapters.  ...  In Damian there is an almost rhythmical alteration of reflective-philosophical and narrative-realistic passages.  ... 

Page 491 of Monatshefte Vol. 38, Issue 8 [page]

1946 Monatshefte  
Damian 491 Stehr is already known for the style of his introductory passages to individual chapters.  ...  In Damian there is an almost rhythmical alteration of reflective-philosophical and narrative-realistic passages.  ... 

Page 204 of Journal of the Medical Library Association Vol. 25, Issue 3 [page]

1937 Journal of the Medical Library Association  
WHO’S WHO OF THE BULLETIN’S CONTRIBUTORS PROFESSOR Doctor Neuburger and Professor Doctor Riesman, the Saints Cosmas and Damian of this issue of the Bulletin, re- quire not so much an introduction to, as  ...  Our Honorary Member, Professor Neu- burger, a pupil of Puschmann, and himself the founder of the Vienna Institute of the History of Medicine, has published many distinguished contributions both to medicine  ... 

Page 2546 of Mathematical Reviews Vol. , Issue 2002D [page]

2002 Mathematical Reviews  
equation, the KdV-Burgers equation and the Benney equation in three-dimensional space.  ...  Hongwei Chen (1-CNEW; Newport News, VA) 2002d:35103 35K57 65M12 Gheorghiu, Calin loan (R-CLUJ-IM; Cluj-Napoca) ; Trif, Damian (R-CLUJ; Cluj-Napoca) The numerical approximation to positive solution for  ... 

Page 2025 of Mathematical Reviews Vol. , Issue 99c [page]

1991 Mathematical Reviews  
Mu Sheng Wei (PRC-ECNU; Shanghai) 99¢:65188 65M70 65N35 Petrila, Titus (R-CLUJ; Cluj-Napoca) ; Trif, Damian (R-CLUJ; Cluj-Napoca) Numerical alternative method scheme for Burgers’ equation. Rev. Anal.  ...  The authors propose a numerical method for the one-dimensional Burgers equation u, + uu, = vux,.  ... 

Page 549 of National Union Catalog Vol. 139, Issue [page]

1942 National Union Catalog  
Title. 34-20132 Library of Congress NC1429.8563 _ Copy 2 Copyright A 74591 3 ™ Sograbe y Craibe, Damian de see Sogravo y Craibe, Damian de.  ...  Geo CATALOG OF PRINTED CARDS Der sogenannte St. ner prediger; aus der Frei- Sogtiano, Antonio, 1854- burger und der Karlsruher handscheift hreg. von Karl : . ‘ Rieder ...  ... 

Page 20 of Das Kunstwerk Vol. 11, Issue 3 [page]

1957 Das Kunstwerk  
Dezember— Januar „Damian, Appel, Täpies, Salles, Serpaon”. Galerie Arnaud: bis 10. 10.  ...  Die erste Ausstellung mit Bildern des jungen Ham- burger ge Armin Sandig wird am 12.  ... 

Page ii of The Journal of Investigative Dermatology Vol. 122, Issue 3 [page]

2004 The Journal of Investigative Dermatology  
Powles, Sarah Rogers, Ann Caird, Damian Smedley, Stephanie Halford, Lionel Fry, and Mark I.  ...  Tripp, Souyet Chang-Rodriguez, Patrizia Stoitzner, Sandra Holzmann, Hella Stdéssel, Patrice Douillard, Sem Saeland, Franz Koch, Adelheid Elbe- Burger, and Nikolaus Romani Corticosteroids But Not Pimecrolimus  ... 
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