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Objective-To estimate overall survival (OS), progression-free survival (PFS), imaging responses, and toxicities of bevacizumab plus carboplatin for the treatment of recurrent malignant glioma. The secondary objective was to estimate the agreement between post-contrast T1weighted and T2-weighted magnetic resonance imaging. Methods-A retrospective analysis of 9 patients who received bevacizumab (10 mg/kg intravenously) and carboplatin (AUC 5 intravenously) for recurrent malignant glioma (Worlddoi:10.1227/01.neu.0000370918.51053.bc pmid:20559095 pmcid:PMC4905718 fatcat:aodireny35gtxc6gtvl7hwbuoe
more »... lth Organization grades III and IV) is presented. Eight of 9 patients received this regimen at first recurrence. Results-The median age and Karnofsky performance score were 51 years and 70, respectively. For the 5 patients with grade III gliomas, the median PFS was 126 days, whereas median OS was not attained at 517 days of follow-up. Six-month PFS was 40%, whereas 6-month OS was 60%. For the 4 patients with grade IV gliomas, the median PFS was 216 days, whereas the median OS was not attained at 482 days of follow-up. Six-month PFS was 50%, whereas 6-month OS was 75%. The agreement between contrast-enhanced T1-weighted and T2-weighted images to determine recurrence was moderate (kappa = 0.5714). Three patients had grade 3 and 4 toxicities including hyponatremia and thrombocytopenia. Conclusion-Patients who received the combination of bevacizumab plus carboplatin for recurrent malignant glioma had reasonable PFS, OS, and toxicities. The median OS in our series is
provides unprecedented opportunities to promote PA and intergenerational interactions. Alternative high school (AHS) students have especially low levels of PA as compared to peers in traditional high schools and could benefit from feeling connected to a non-family adult, but little is known about social media use or intergenerational interactions among AHS students. The purpose of this descriptive study was to assess intergenerational interactions, social media use, and PA among AHS studentsdoi:10.1016/j.jadohealth.2013.10.158 fatcat:5c7xy6w7kzfgrnexvakerao34m
more »... older adults ( > / ¼ 60 years). Methods: We used data from two pilot surveys conducted in Central Texas in spring/summer of 2013. We administered one survey to students in one AHS (n ¼ 25; mean age 17.7 years; 92% youth of color; 67% low socioeconomic status) and a separate survey to older adults participating in a community program (n ¼ 35; mean age 72.97 years; 85.7% people of color; 68% with yearly income < $20,000). We used descriptive statistics to calculate proportions for a variety of questions related to intergenerational interactions, social media use, and PA. Results: 64% of AHS students and 62% of older adults reported interacting with at least one non-family member of the opposite generation. Cell phones were the most common way for AHS students (80%) and older adults (54%) to access the internet. All AHS students and 24% of older adults reported using at least one social networking site (SNS). Over half (56%) of AHS students used SNSs to access health information; 40% and 24% used SNSs to communicate with non-parental adults and grandparents, respectively. Only 26% of AHS students reported getting > / ¼ 30 minutes of PA every day during the past week. Half (48%) of AHS students participated in weekly pick-up sports games. Fewer participated in organized sports, including community (39%) and school (26%) teams. Among older adults, 41% reported getting > / ¼ 30 minutes of moderate PA five days a week or > / ¼ 20 minutes of vigorous PA three days a week. 27% of older adults engaged in strength and flexibility activities at least once a week. Conclusions: Social support and connectedness are well-established correlates of PA. Social media provides unprecedented opportunities for promoting interactions between groups who may not regularly cross paths. Our findings revealed low levels of PA among both generations and suggest many AHS students interact with at least one non-family older adult, but not necessarily through social media. Findings provide a baseline for moving forward with the development of an intergenerational, social media-based PA intervention. A successful intervention should blend concepts of healthy youth development and healthy aging (e.g., skill-building, service, connectedness) into a process we call "healthy intergenerational development," by tapping into the strengths of both generations (e.g., SNS expertise of AHS students; altruism and wisdom of older adults).
We analyze new data on the production and use of IT around the world to assess the impact of changes in IT production in the 1990's on economic development. We provide empirical evidence on a fundamental question: Besides the direct effect on GDP, does an emphasis on IT production have a spillover effect on the level of IT diffusion? We show that the results of our diffusion model indicates that the correlation between production of IT goods and use of goods is confined to specific scenariosdoi:10.1080/1019678032000135545 fatcat:4on7vl25ajh5rc2blaz5l66jp4
more »... , in the case of developing economies, may have a substitution effect. Based on our analysis, we conclude that the experiences of developing economies with respect to production of IT may not include the same demand stimulation effect that has been enjoyed in developed economies. This has an impact on the computer development policies of developing economies.
The spine journal
BACKGROUND CONTEXT: There have been no trials of optimal chiropractic care in terms of number of office visits for spinal manipulation and other therapeutic modalities. PURPOSE: To conduct a pilot study to make preliminary identification of the effects of number of chiropractic treatment visits for manipulation with and without physical modalities (PM) on chronic low back pain and disability. STUDY DESIGN/SETTING: Randomized controlled trial with a balanced 4×2 factorial design. Conducted indoi:10.1016/j.spinee.2004.02.008 pmid:15363431 fatcat:eqvdiqo5djar7dyb3yuw6ngyfa
more »... faculty practice of a chiropractic college outpatient clinic. PATIENT SAMPLE: Seventy-two patients with chronic, nonspecific low back pain of mechanical origin. MAIN OUTCOME MEASURES: Von Korff pain and disability (100-point) scales. METHODS: Patients were randomly allocated to visits (1, 2, 3 or 4 visits/week for 3 weeks) and to treatment regimen (spinal manipulation only or spinal manipulation with PM). All patients received high-velocity low-amplitude spinal manipulation. Half received one or two of the following PM at each visit: soft tissue therapy, hot packs, electrotherapy or ultrasound. RESULTS: Pain intensity: At 4 weeks, there was a substantial linear effect of visits favoring a larger number of visits: 5.7 points per 3 visits (SEϭ2.3, pϭ.014). There was no effect of treatment regimen. At 12 weeks, the data suggested the potential for a similar effect of visits on patients receiving both manipulation and PM. Functional disability: At 4 weeks, a visits effect was noted (pϭ.018); the slope for group means was approximately 5 points per 3 visits. There were no group differences at 12 weeks. CONCLUSIONS: There was a positive, clinically important effect of the number of chiropractic treatments for chronic low back pain on pain intensity and disability at 4 weeks. Relief was substantial for patients receiving care 3 to 4 times per week for 3 weeks. Ć 2004 Elsevier Inc. All rights reserved.
The original goal for the Oregon Health & Science University (OHSU) TREC 2002 Interactive Track experiments was to perform some preliminary experiments comparing searching on tablet devices versus ordinary personal computers. Unfortunately, the vendor who had promised the devices we planned to use was unable to deliver them in time for the experiments. We therefore shifted our experimental focus to assessing user factors found in previous experiments to be associated with success, with adblp:conf/trec/HershMKSO02 fatcat:6ribqsappvdv7fwaeovsgsnefm
more »... lar desire to assess the role of spatial visualization. A variety of studies have demonstrated that spatial visualization is associated with successful computer use. Egan and Gomez have shown that spatial visualization is associated with two processes in text editing: finding the location of characters to be edited and generating a syntactically correct sequence of actions to complete the task  . Similarly, Vincente et al. have found that the ability to use a hierarchical file system is associated with spatial visualization as well as vocabulary skills  . In addition, Allen has demonstrated that this trait is associated with the appropriate selection of key words in searching  . We have previously found that the ability of medical and nurse practitioner students to answer clinical questions found spatial visualization to be highly predictive of success  . (Spatial visualization actually demonstrated multicollinearity with whether a searcher was a medical or nurse practitioner student, which may have been the actual predictive factor.) In previous TREC Interactive Track experiments, our results showed a trend towards spatial visualization being predictive of searching success in instance recall tasks, although they did not achieve statistical significance  . Methods Our methods employed the consensus approach agreed upon by track participants and posted on the track Web site (http://www-nlpir.nist.gov/projects/t11i/guidelines.html). We used the .GOV Web collection created for the TREC 2002 Web Track as the searching data. The collection was accessed by using the Panoptic search engine. We followed the experimental protocol developed for the TREC-9 Interactive Track, which was designed to allow the comparison of two systems or system variants using a minimum of 16 searchers. Each searcher performed eight tasks, which are listed in Table 1 .
Objective: To determine the feasibility of a behavioral faith-based PREMIER study modified hypertension (HTN) control intervention in a semi urban African-American (AA) church. Methods: In a prospective longitudinal study design, a 12-week behavioral HEALS (Healthy Eating and Living Spiritually) intervention was tested for its feasibility and efficacy in a semi urban AA church. High-risk adult church members with HTN were recruited. Program sessions were weekly delivered by the trained churchdoi:10.4236/ojim.2014.43015 fatcat:f7izgahagjb6vjmnld3usxwtdm
more »... mbers. Data were analyzed using repeated measures ANOVA. Results: 22 of 34 subjects (65% retention) provided complete information on the outcome measures. Mean systolic blood pressure (SBP) reduction from baseline was 22 mmHg (p < 0.001) and 6.5 mmHg for diastolic BP (p = 0.0048). Mean weight reduction of 3.11 kg from the baseline (p < 0.0001) was also observed. 91% subjects attended 7 -9 sessions. Conclusion: Promoting behavioral HTN control interventions in high risk AAs by empowering AA church communities is feasible and efficacious.
The use of telemedicine is growing, but its efficacy for achieving comparable or improved clinical outcomes has not been established in many medical specialties. The objective of this systematic review was to evaluate the efficacy of telemedicine interventions for health outcomes in two classes of application: home-based and office/hospital-based. Methods: Data sources for the study included deports of studies from the MEDLINE, EMBASE, CINAHL, and HealthSTAR databases; searching ofdoi:10.1186/1472-6947-1-5 pmid:11737882 pmcid:PMC60664 fatcat:aipf7dvnyjhy3ous6jhhm5x5n4
more »... s of review and other articles; and consultation of printed resources as well as investigators in the field. We included studies that were relevant to at least one of the two classes of telemedicine and addressed the assessment of efficacy for clinical outcomes with data of reported results. We excluded studies where the service did not historically require face-to-face encounters (e.g., radiology or pathology diagnosis). All included articles were abstracted and graded for quality and direction of the evidence. Results: A total of 25 articles met inclusion criteria and were assessed. The strongest evidence for the efficacy of telemedicine in clinical outcomes comes from home-based telemedicine in the areas of chronic disease management, hypertension, and AIDS. The value of home glucose monitoring in diabetes mellitus is conflicting. There is also reasonable evidence that telemedicine is comparable to face-to-face care in emergency medicine and is beneficial in surgical and neonatal intensive care units as well as patient transfer in neurosurgery. Conclusions: Despite the widespread use of telemedicine in virtually all major areas of health care, evidence concerning the benefits of its use exists in only a small number of them. Further randomized controlled trials must be done to determine where its use is most effective.
Over one million of these devices were deployed in 2007 and five million are projected for 2008 (Sharma and Kraemer 2008) . ... Second, we contribute to the literature on IT penetration and the global digital divide (see, e.g., Dewan and Kraemer 2000 , Caselli and Coleman 2001 , Kiiski and Pohjola 2002 , Corrocher and Ordanini ...doi:10.1287/isre.1080.0219 fatcat:ed53conc65bkfdvgg6t2khug2e
The goal of the TREC Genomics Track is to improve information retrieval in the area of genomics by creating test collections that will allow researchers to improve and better understand failures of their systems. The 2004 track included an ad hoc retrieval task, simulating use of a search engine to obtain documents about biomedical topics. This paper describes the Genomics Track of the Text Retrieval Conference (TREC) 2004, a forum for evaluation of IR research systems, where retrieval in thedoi:10.1186/1747-5333-1-3 pmid:16722581 pmcid:PMC1440302 fatcat:47rfw3fwafa3nm2huaaxu57de4
more »... nomics domain has recently begun to be assessed. A total of 27 research groups submitted 47 different runs. The most effective runs, as measured by the primary evaluation measure of mean average precision (MAP), used a combination of domain-specific and general techniques. The best MAP obtained by any run was 0.4075. Techniques that expanded queries with gene name lists as well as words from related articles had the best efficacy. However, many runs performed more poorly than a simple baseline run, indicating that careful selection of system features is essential. Various approaches to ad hoc retrieval provide a diversity of efficacy. The TREC Genomics Track and its test collection resources provide tools that allow improvement in information retrieval systems.
Inflammatory bowel disease (IBD) can disrupt normal sleep physiology and amplify a negative perception about quality of life. Evidence suggests increased circulation of inflammatory cytokines, such as tumor necrosis factor-alpha and interleukin-1, may play a role. A total of 56 patients completed the Pittsburgh Sleep Quality Index (PSQI) to measure 7 sleep domains: sleep quality, sleep latency, sleep duration, sleep efficacy, sleep disturbance, sleep medications, and daytime dysfunction. Domainpmid:29559875 pmcid:PMC5855429 fatcat:7scb6a3gafdb7ekeivc33w5ese
more »... scores were summed to determine the presence or absence of sleep impairment. We compared patients taking immunomodulators or biologic agents to patients not on immunomodulator or biologic agent therapy. Demographics and IBD-related clinical information were collected to adjust for potential confounders that may secondarily affect sleep, such as body mass index, depression/anxiety, and sleep-affecting medications. The majority of patients with IBD (46 [82%]) reported poor sleep quality; 22 (79%) of the patients taking immunomodulators or biologic agents and 24 (86%) of the patients not on these therapies had a global PSQI score ≥5, suggestive of poor sleep quality. However, we found no significant difference between the 2 groups. When we analyzed the 7 PSQI sleep domains individually, we found improved sleep duration in the group taking immunomodulators or biologic agents compared to the group not on therapy, although the difference was not statistically significant. The majority of patients with IBD experience some degree of sleep impairment, and treatment with immunomodulators and biologic agents does not appear to improve sleep quality. A multicenter study with a larger sample size is warranted to better assess the diverse population of patients with IBD and the factors that impact their sleep. Routine assessment of sleep quality during IBD clinical encounters is recommended.
Neuro-oNcology To evaluate efficacy and MRI findings after intravenous bevacizumab and/or carboplatin in a human glioma animal model, we randomized male nude rats with intracerebral UW28 human glioma xenografts to four groups: (1) controls (n 5 9), (2) bevacizumab 10 mg/kg (n 5 6), (3) carboplatin 200 mg/m 2 (n 5 6), and (4) bevacizumab 1 carboplatin (n 5 6). MRI was performed on the day of treatment (day 7-10) and 1 week later, and rats were followed for survival. Dynamic MRI was done in threedoi:10.1215/15228517-2008-077 pmid:18772353 pmcid:PMC2718985 fatcat:2hhefs6adbdcvnzvags3byxesq
more »... controls and three rats treated with bevacizumab with or without carboplatin before and 24 h after treatment. Median overall survival (OS) was as follows: group 1, 16 days; group 2, 23 days; group 3, 22 days; group 4, 36 days. OS was significantly longer in group 4 than in group 1 (p 5 0.0011), group 2 (p 5 0.0014), and group 3 (p 5 0.0015), and rats had significantly larger tumors. No objective tumor responses were observed on MR images at 1 week after treatment; however, after bevacizumab, dynamic MRI showed reduced gadolinium enhancement intensity and increased time to peak, consistent with ). decreased vascular permeability. Carboplatin 1 bevacizumab is effective and superior over bevacizumab or carboplatin monotherapy in this animal model. Increased survival concomitant with increased asymptomatic tumor volume is suggestive that vascular targeting with reduced peritumoral edema and mass effect contributes to the efficacy of bevacizumab. The promising survival data warrant future clinical trials using bevacizumab 1 carboplatin.
Few studies explore the clinical features of youth suicide by poisoning. The use of both social and clinical features of self-poisoning with suicidal intent could be helpful in enhancing existing and creating new prevention strategies. We sought to characterize self-poisonings with suicide intent in ages 0 to 21 years reported to three regional poison control centers from 2003-2012. Methods: This study was a blinded retrospective review of intentional self-poisonings by those age 21 or youngerdoi:10.5811/westjem.2015.5.25459 pmid:26265960 pmcid:PMC4530906 fatcat:ioqu6sm3jrawjjtcu2bksqipea
more »... aptured by the Poison Information Control Network. Age, sex, substance(s) used, medical outcome, management site, clinical effects, and therapies were described using counts and percentages and analyzed using chi-square tests. We analyzed the medical outcome ranging from no effect to death using the Wilcoxon rank-sum test. Serious medical outcome was defined as death or major outcome. Results: We analyzed a total of 29,737 cases. The majority were females (20,945;70.5%), of whom 274 (1.3%) were pregnant. Most cases were 15-18 year olds (15,520;52.2%). Many experienced no effects (9,068;30.5%) or minor medical outcomes (8,612;29%). Males had more serious medical outcomes (p<0.0001), but females were more likely to be admitted to a critical care unit (p<0.0001). There were 17 deaths (0.06%), most in males (10;p=0.008). Of the 52 substances reported in the death cases, 12 (23.1%) were analgesics. In eight (47.1%) of the deaths, over two substances were used. Overall, drowsiness/lethargy (7,097;19.3%) and single-dose charcoal (8,815;16.3%) were frequently reported. Nearly 20% were admitted to critical care units (5,727;19.3%) and 28.7% went to psychiatric facilities (8,523). Of those admitted to hospitals (8,203), nearly 70% (5,727) required critical care units. Almost half <10 years old were evaluated and released (43;47.2%). Of the 114 reported substances for this population, 22.8% involved psychotropic medications, 15.8% analgesics, and 14% Attention Deficit-Hyperactive Disorder (ADHD) medications. Analgesics (13,539;33.6%) were the most common medication category used by all age groups. Typically only one substance (20,549;69.1%) was used. Conclusion: Undiagnosed ADHD may be a potential underlying cause for self-harming behaviors in the very young. Gender-specific suicide prevention strategies may be more effective at identifying those at risk than traditional measures alone. Further study into admitting practices by emergency physicians is needed to understand the difference in critical care admission rates based on gender. Once identified to be at-risk for suicidal behavior, access to analgesics and psychotropics should be monitored by care-givers especially in those between the ages of 15-18. [West J Emerg Med. 2015;16(4):497-502.]
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